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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Wilmar Maarisit
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Reski Anti; Jabes W. Kanter; Wilmar Maarisit; Reky R. Palandi; Nancy C. Pelealu; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Anti-Inflammatory Activity Test of Mangrove Root (Sonneratia alba) Ethanol Extract Gel Preparation in Carragenan-Induced White Rats (Rattus norvegicus) Alfared S. Simanjuntak; Jeane Mongi; Wilmar Maarisit; Yessie K. Lengkey; Christel N. Sambou; Douglas N. Pareta
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.493

Abstract

Nature provides various compounds that can provide anti-inflammatory activity, one of which is the compound contained in mangrove roots (Sonneratia alba). In these plants, especially in the roots, there are secondary metabolite compounds such as alkaloids, flavonoids, tannins, triterpenoids and from various reported research results, flavonoids have anti-inflammatory properties. The medicinal preparation that the researchers want to make is a gel preparation that is used for topical treatment therapy. The research was carried out with 15 rats into 5 test groups. Positive control group: given Diclofenac Sodium gel (Voltadex) 20 g (1%), negative control group: given gel without ethanol extract, 2.5% concentration group: given 2.5% ethanol extract gel, 5% concentration group: given 5% ethanol extract gel, 10% concentration group: 10% ethanol extract gel was given. The data was analyzed descriptively and presented in the form of tables and graphs. The research results showed that the Sonneratia alba ethanol extract gel preparation had anti-inflammatory activity. The research results show that the ethanol extract of Sonneratia alba mangrove roots can be used as a gel preparation and in in vivo testing the gel preparation of Sonneratia alba mangrove root ethanol extract has anti-inflammatory activity. The control group of Sonneratia alba mangrove root ethanol extract gel preparations of concentrations of 2.5%, 5% and 10% had a swelling inhibition percentage, which means that Sonneratia alba mangrove root ethanol extract gel preparations of 2.5%, 5% and 10% concentration had anti-inflammatory activity.
Evaluation of Ficus minahassae Fruit Extract as a Natural Agent against Propionibacterium acnes Abigail F. Maarisit; Cliveno Kojongian; Tesalonika Rondonuwu; Intan J. F. Rawung; Reine Kalalo; Arter Supit; Silvana L. Tumbel; Wilmar Maarisit
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.497

Abstract

Ficus minahassae fruit is known to contain bioactive compounds that have the potential to act as antibacterial agents. This study aims to determine the antibacterial activity of Propionibacterium acnes from F. minahassae fruit extract. F. minahassae fruit is extracted using ethanol. Antibacterial activity test using the disc diffusion method. Based on the results of the study, it was obtained that F. minahassae fruit extract was able to inhibit P. acnes bacteria at concentrations of 200, 300, 400, 500, and 600 mg/disc with inhibition zone diameters of 11.68, 13.33, 14.35, 15.47, and 17.82 mm, respectively. F. minahassae fruit extract can be developed as a raw material for drugs, especially anti-bacterial P. acnes, which causes acne.
Analysis Of Rhodamine B Dye Content In Lipstick At Beriman Tomohon Market Friska M. Montolalu; Christien Kiroh; Wilmar Maarisit; Jabes W. Kanter; Andry Natanel; Amal R. Ginting; Rachmat Santoso
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.521

Abstract

The use of cosmetics such as lipstick aims to improve the natural appearance of the lips and induce discoloration. A problem that is often worrying about today is the presence of prohibited dyes in lipstick preparations' main components. Rhodamine B is a synthetic dye prohibited in cosmetics, especially lipsticks. This research aims to analyze the Rhodamine B dye in lipsticks that do not have a distribution permit from BPOM circulating in the Beriman Tomohon market.The research method was Thin Layer Chromatography (TLC), followed by wavelength measurement on UV-Vis Spectrophotometry. The research population was all red lipstick preparations and 10 (ten) different lipsticks as a sample.Data analysis in this research is to find the RF value obtained from TLC then make a graph of the equation y = bx + a then look for the x value to measure the Rhodamine B content in lipstick. The results of this research were obtained from 1 (one) sample of lipstick label L(I) positive containing Rhodamine B. Visually, the lipstick of the L(I) label has a pink color and fluorescence orange when irradiated with 366nm UV, Rhodamine B has an Rf value of 0.85. In contrast, the L(I) sample has an Rf value of 0.84. Rhodamine B has a wavelength of 544nm, and the lipstick sample L(I) has an absorbance of 0.362 which has a Rhodamine B content of 0.4115%.
Antibacterial Activity Of Green Sirih Leaves (Piper betle Linn) Against Propionibacterium Acnes Douglas N. Pareta; Rainhard R. M. Tumiwuda; Silvana L. Tumbel; Wilmar Maarisit; Yessie K. Lengkey; Ferdy A. Karauwan; Mitra W. Timburas
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.522

Abstract

Betel is one of the medicinal plants often found around us. Because of its properties as an antiseptic and wound medicine, this plant can be cultivated. This research aimed to determine the antibacterial activity of green betel leaf essential oil against Propionibacterium acnes. This laboratory experimental research used a completely randomized design with three repetitions in five concentration treatments, one positive control and one negative control for Propionibacterium acnes bacteria. The test method used was the agar diffusion method. Data was collected by observing and measuring the inhibition zone on each Petri dish, which was then tabulated. The data obtained were analyzed descriptively. At a concentration of 10µl, green betel leaf essential oil can be an antibacterial agent against Propionibacterium acnes, according to the results of measuring the diameter of the inhibition zone produced.
Antipyretic Activity of Avocado Seed (Persea americana) Infusion in Pepton-Induced Fever in Male White Rats Rattus norvegicus Wilmar Maarisit; Dannari Sampetondok; Reky R. Palandi; Juliani R. Turang; Friska M. Montolalu; Hariyadi Hariyadi; Amal R. Ginting
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.525

Abstract

Avocado seeds (Persea americana) have long been used in traditional medicine and are empirically believed to reduce fever. This study aimed to evaluate the antipyretic activity of an avocado seed infusion in male white rats (Rattus norvegicus) induced with peptone. The infusion was prepared using distilled water at 90 °C. The antipyretic test consisted of five groups: a negative control (Na-CMC), a positive control (paracetamol), and three treatment groups receiving avocado seed infusion at doses of 100, 200, and 300 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight). Rectal temperature was recorded at 30-minute intervals for 3 hours. The results showed that all treatment doses reduced rectal temperature after 180 minutes. The greatest reduction was observed at a dose of 300 mg/200 g body weight, with a decrease of 2.16 °C, indicating that avocado seed infusion exhibits dose-dependent antipyretic activity.
Antimycobacterial Activity Test of Symbiotic Fungi Isolated from Stylissa Sp. Sponges Wilmar Maarisit; Devi Trisnawati; Douglas N. Pareta; Rachmat Santoso; Alter Y. Runtu; Selvana S. Tulandi
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.535

Abstract

Tuberkulosis (TB) merupakan penyakit menular kronis yang disebabkan oleh Mycobacterium dan masih menjadi masalah kesehatan global. Meskipun telah tersedia berbagai antibiotik, munculnya resistansi obat seperti multidrug-resistant Mycobacterium tuberculosis (MDR-TB) menjadi tantangan serius dalam pengendalian TB. Penelitian ini bertujuan untuk mengetahui aktivitas anti- Mycobacterium dari jamur simbion spons Stylissa sp. Serta mengidentifikasi jenis jamur simbion yang berpotensi. Penelitian dilakukan secara eksperimental di laboratorium menggunakan metode difusi cakram (paper disc). Ekstrak jamur simbion diuji dalam lima konsentrasi (200, 300, 400, 500, 600 µg/disc) dengan tiga kali ulangan, menggunakan streptomycin sulfat sebagai kontrol positif dan alkohol 70% sebagai kontrol negatif. Mikroorganisme uji adalah Mycobacterium smegmatis. Hasil penelitian menunjukkan bahwa 12 ekstrak jamur simbion memiliki aktivitas anti-Mycobacterium pada konsentrasi 250 µg/disc dengan zona hambat 7–9 mm. Ekstrak nomor 12 (LS-10) menunjukkan aktivitas tertinggi sehingga dilanjutkan pada uji MIC dan MBC dengan hasil masing-masing 2,18 µg/disc dan 8,72 µg/disc. Identifikasi menunjukkan bahwa jamur simbion LS-10 memiliki kemiripan dengan genus Aspergillus sp. Temuan ini menunjukkan potensi jamur simbion spons Stylissa sp. Sebagai sumber senyawa anti-Mycobacterium baru.
Anti-Mycobacterium smegmatis Activity of Marine Sponges Collected from Malalayang Waters Agnes H. Panebaren; Wilmar Maarisit; Rachmat S. Santoso; Nancy C. Pelealu; Silvana L. Tumbel; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.560

Abstract

Tuberkulosis merupakan penyakit infeksi yang masih menjadi masalah kesehatan global sehingga diperlukan pencarian sumber senyawa antimikobakteri baru, termasuk dari sponge laut yang diketahui kaya akan metabolit sekunder bioaktif. Penelitian ini bertujuan untuk menguji aktivitas anti-Mycobacterium smegmatis dari sponge laut asal Perairan Malalayang, menentukan nilai Minimum Inhibitory Concentration (MIC) dan Minimum Bactericidal Concentration (MBC), serta mengidentifikasi sponge yang aktif. Sebanyak 17 ekstrak sponge diekstraksi menggunakan etanol 96% melalui metode maserasi dan diuji terhadap M. smegmatis ATCC 19420 menggunakan metode difusi cakram (Kirby-Bauer). Hasil skrining menunjukkan enam ekstrak sponge, yaitu M2232, M2252, M2236, M2235, M2243, dan M2247, memiliki aktivitas antimikobakteri tertinggi dengan diameter zona hambat kategori sedang hingga kuat pada konsentrasi 100–500 µg/disc. Nilai MIC dan MBC terhadap M. smegmatis berturut-turut adalah 0,14 dan 0,56 µg/disc (M2232), 0,40 dan 1,60 µg/disc (M2252), 1,97 dan 7,60 µg/disc (M2236), 0,55 dan 2,20 µg/disc (M2235), 0,25 dan 1,00 µg/disc (M2243), serta 0,28 dan 1,12 µg/disc (M2247). Identifikasi morfologi menunjukkan bahwa sponge aktif tersebut termasuk Callyspongia aerizusa, Callyspongia sp., Leucetta sp., dan Rhabdastrella sp., sementara dua sampel lainnya belum teridentifikasi. Hasil penelitian menunjukkan bahwa sponge laut Perairan Malalayang berpotensi sebagai sumber senyawa antimikobakteri untuk pengembangan kandidat obat antituberkulosis baru.
Co-Authors Abigail F. Maarisit Agnes H. Panebaren Alfared S. Simanjuntak Alter Y. Runtu Amal R. Ginting Andry Natanel Arter Supit Christien Kiroh Cliveno Kojongian Dannari Sampetondok Devi Trisnawati Douglas N. Pareta Ferdy A. Karauwan Friska M. Montolalu Hariyadi Hariyadi Intan J. F. Rawung Jabes Wolter Kanter Jeane Mongi Juliani R. Turang Mitra W. Timburas Nancy C. Pelealu Rachmat S. Santoso Rachmat Santoso Rainhard R. M. Tumiwuda Reine Kalalo Reky R. Palandi Reski Anti Sambou, Christel N. Selvana S. Tulandi Silvana L. Tumbel Tesalonika Rondonuwu Yessie K. Lengkey Yessie K. Lengkey