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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Friska M. Montolalu
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Reski Anti; Jabes W. Kanter; Wilmar Maarisit; Reky R. Palandi; Nancy C. Pelealu; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Analysis Of Rhodamine B Dye Content In Lipstick At Beriman Tomohon Market Friska M. Montolalu; Christien Kiroh; Wilmar Maarisit; Jabes W. Kanter; Andry Natanel; Amal R. Ginting; Rachmat Santoso
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.521

Abstract

The use of cosmetics such as lipstick aims to improve the natural appearance of the lips and induce discoloration. A problem that is often worrying about today is the presence of prohibited dyes in lipstick preparations' main components. Rhodamine B is a synthetic dye prohibited in cosmetics, especially lipsticks. This research aims to analyze the Rhodamine B dye in lipsticks that do not have a distribution permit from BPOM circulating in the Beriman Tomohon market.The research method was Thin Layer Chromatography (TLC), followed by wavelength measurement on UV-Vis Spectrophotometry. The research population was all red lipstick preparations and 10 (ten) different lipsticks as a sample.Data analysis in this research is to find the RF value obtained from TLC then make a graph of the equation y = bx + a then look for the x value to measure the Rhodamine B content in lipstick. The results of this research were obtained from 1 (one) sample of lipstick label L(I) positive containing Rhodamine B. Visually, the lipstick of the L(I) label has a pink color and fluorescence orange when irradiated with 366nm UV, Rhodamine B has an Rf value of 0.85. In contrast, the L(I) sample has an Rf value of 0.84. Rhodamine B has a wavelength of 544nm, and the lipstick sample L(I) has an absorbance of 0.362 which has a Rhodamine B content of 0.4115%.
Antipyretic Activity of Avocado Seed (Persea americana) Infusion in Pepton-Induced Fever in Male White Rats Rattus norvegicus Wilmar Maarisit; Dannari Sampetondok; Reky R. Palandi; Juliani R. Turang; Friska M. Montolalu; Hariyadi Hariyadi; Amal R. Ginting
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.525

Abstract

Avocado seeds (Persea americana) have long been used in traditional medicine and are empirically believed to reduce fever. This study aimed to evaluate the antipyretic activity of an avocado seed infusion in male white rats (Rattus norvegicus) induced with peptone. The infusion was prepared using distilled water at 90 °C. The antipyretic test consisted of five groups: a negative control (Na-CMC), a positive control (paracetamol), and three treatment groups receiving avocado seed infusion at doses of 100, 200, and 300 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight). Rectal temperature was recorded at 30-minute intervals for 3 hours. The results showed that all treatment doses reduced rectal temperature after 180 minutes. The greatest reduction was observed at a dose of 300 mg/200 g body weight, with a decrease of 2.16 °C, indicating that avocado seed infusion exhibits dose-dependent antipyretic activity.
Antibacterial Activity of Ethanolic Leaf Extract of Lansium domesticum Corr. Against Propionibacterium acnes Friska M. Montolalu; Hapri j. Lalira; Silvana L. Tumbel; Hanna Rumagit; Ferdy A. Karauwan; selvana Tulandi
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.471

Abstract

Jerawat merupakan masalah kulit yang sering disebabkan oleh pertumbuhan bakteri Propionibacterium acnes. Penggunaan antibiotik yang berlebihan dapat menyebabkan resistensi bakteri sehingga diperlukan alternatif antibakteri dari bahan alam. Daun langsat (Lansium domesticum Corr.) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun langsat terhadap Propionibacterium acnes. Penelitian dilakukan menggunakan metode difusi cakram (Kirby-Bauer) dengan konsentrasi ekstrak 50, 75, dan 100 µg/disc. Clindamycin digunakan sebagai kontrol positif dan akuades sebagai kontrol negatif. Aktivitas antibakteri ditentukan berdasarkan diameter zona hambat yang terbentuk. Hasil penelitian menunjukkan bahwa ekstrak etanol daun langsat mampu menghambat pertumbuhan Propionibacterium acnes dengan rata-rata diameter zona hambat masingmasing sebesar 12,92 mm; 13,29 mm; dan 14,56 mm pada konsentrasi 50, 75, dan 100 µg/disc. Seluruh konsentrasi menunjukkan aktivitas antibakteri kategori kuat. Analisis ANOVA menunjukkan adanya perbedaan yang signifikan antar perlakuan (p<0,05). Berdasarkan hasil penelitian, ekstrak etanol daun langsat (Lansium domesticum Corr.) memiliki aktivitas antibakteri yang kuat terhadap Propionibacterium acnes dan berpotensi sebagai sumber antibakteri alami untuk pengobatan jerawat.
Anti-Mycobacterium smegmatis Activity of Marine Sponges Collected from Malalayang Waters Agnes H. Panebaren; Wilmar Maarisit; Rachmat S. Santoso; Nancy C. Pelealu; Silvana L. Tumbel; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.560

Abstract

Tuberkulosis merupakan penyakit infeksi yang masih menjadi masalah kesehatan global sehingga diperlukan pencarian sumber senyawa antimikobakteri baru, termasuk dari sponge laut yang diketahui kaya akan metabolit sekunder bioaktif. Penelitian ini bertujuan untuk menguji aktivitas anti-Mycobacterium smegmatis dari sponge laut asal Perairan Malalayang, menentukan nilai Minimum Inhibitory Concentration (MIC) dan Minimum Bactericidal Concentration (MBC), serta mengidentifikasi sponge yang aktif. Sebanyak 17 ekstrak sponge diekstraksi menggunakan etanol 96% melalui metode maserasi dan diuji terhadap M. smegmatis ATCC 19420 menggunakan metode difusi cakram (Kirby-Bauer). Hasil skrining menunjukkan enam ekstrak sponge, yaitu M2232, M2252, M2236, M2235, M2243, dan M2247, memiliki aktivitas antimikobakteri tertinggi dengan diameter zona hambat kategori sedang hingga kuat pada konsentrasi 100–500 µg/disc. Nilai MIC dan MBC terhadap M. smegmatis berturut-turut adalah 0,14 dan 0,56 µg/disc (M2232), 0,40 dan 1,60 µg/disc (M2252), 1,97 dan 7,60 µg/disc (M2236), 0,55 dan 2,20 µg/disc (M2235), 0,25 dan 1,00 µg/disc (M2243), serta 0,28 dan 1,12 µg/disc (M2247). Identifikasi morfologi menunjukkan bahwa sponge aktif tersebut termasuk Callyspongia aerizusa, Callyspongia sp., Leucetta sp., dan Rhabdastrella sp., sementara dua sampel lainnya belum teridentifikasi. Hasil penelitian menunjukkan bahwa sponge laut Perairan Malalayang berpotensi sebagai sumber senyawa antimikobakteri untuk pengembangan kandidat obat antituberkulosis baru.
Co-Authors Agnes H. Panebaren Amal R. Ginting Andry Natanel Christien Kiroh Dannari Sampetondok Ferdy A. Karauwan Hanna Rumagit Hapri j. Lalira Hariyadi Hariyadi Jabes Wolter Kanter Juliani R. Turang Nancy C. Pelealu Rachmat S. Santoso Rachmat Santoso Reky R. Palandi Reski Anti selvana Tulandi Silvana L. Tumbel Wilmar Maarisit