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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Reky R. Palandi
Department of Biology, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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 1 
Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Reski Anti; Jabes W. Kanter; Wilmar Maarisit; Reky R. Palandi; Nancy C. Pelealu; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Activity of Caulerpa racemosa Against Helicobacter pylori Bacteria Jekki J. F. Kalangi; Yessie K. Lengkey; Nerni O. Potalangi; Selvana S. Tulandi; Reky R. Palandi; Ferdy A. Karauwan
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.498

Abstract

Sea grapes (Caulerpa racemosa) contain various secondary metabolites with bioactive compounds that function as antibacterial agents. This study aimed to evaluate the antibacterial activity of ethanol extract from sea grapes (Caulerpa racemosa) against Helicobacter pylori. The method used was the agar diffusion technique with paper discs at four different extract concentrations: 500 µg, 600 µg, 700 µg, and 800 µg per disc. Extraction was carried out through maceration using 96% ethanol as the solvent, and antibacterial activity was assessed based on the formation of inhibition zones around the discs. The results showed that all extract concentrations exhibited very strong inhibitory effects on the growth of H. pylori, with inhibition zones of 27.23 mm, 28.51 mm, 29.91 mm, and 31.51 mm, respectively. The higher the extract concentration, the larger the inhibition zone formed. Based on antibacterial activity categorization, Caulerpa racemosa extract demonstrates potential as a strong antibacterial agent against Helicobacter pylori.
Antibacterial Activity Test of Scleria sumatrensis Leaf Extract against Staphylococcus aureus in Vitro Douglas N. Pareta; Reky R. Palandi; Selvana S. Tulandi; Juliani R. Turang; Alter Y. Runtu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.506

Abstract

Staphylococcus aureus bacteria is one of the important pathogens that can cause various types of infections, ranging from mild ones such as folliculitis and impetigo to life-threatening conditions such as nosocomial pneumonia, osteomyelitis, endocarditis, sepsis, and toxic shock syndrome. Due to its ability to develop resistance to antibiotics, new alternative treatments are needed, one of which is from natural ingredients. In this study, the antibacterial activity of Scleria sumatrensis extract was tested against Staphylococcus aureus with a concentration variation of 100 - 500 µg / disc. The results showed that at a concentration of 100 ?g / disc, the extract provided antibacterial activity in the moderate category, while at a concentration of 200 to 500 ?g / disc, the activity produced was included in the strong category. These findings indicate that Scleria sumatrensis extract has the potential as a natural antibacterial agent against Staphylococcus aureus, so it is worthy of further development as an alternative therapy for infections caused by S. aureus bacteria.
Antipyretic Activity of Avocado Seed (Persea americana) Infusion in Pepton-Induced Fever in Male White Rats Rattus norvegicus Wilmar Maarisit; Dannari Sampetondok; Reky R. Palandi; Juliani R. Turang; Friska M. Montolalu; Hariyadi Hariyadi; Amal R. Ginting
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.525

Abstract

Avocado seeds (Persea americana) have long been used in traditional medicine and are empirically believed to reduce fever. This study aimed to evaluate the antipyretic activity of an avocado seed infusion in male white rats (Rattus norvegicus) induced with peptone. The infusion was prepared using distilled water at 90 °C. The antipyretic test consisted of five groups: a negative control (Na-CMC), a positive control (paracetamol), and three treatment groups receiving avocado seed infusion at doses of 100, 200, and 300 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight). Rectal temperature was recorded at 30-minute intervals for 3 hours. The results showed that all treatment doses reduced rectal temperature after 180 minutes. The greatest reduction was observed at a dose of 300 mg/200 g body weight, with a decrease of 2.16 °C, indicating that avocado seed infusion exhibits dose-dependent antipyretic activity.
Antibacterial Activity of Macroalgae (Hypnea charoides) from Lumintang Coastal Waters, Southeast Minahasa Regency Against Helicobacter pylori Yessie K. Lengkey; feybi abram; Nerni O. Potalangi; Hariyadi Hariyadi; Joke L. Tombuku; Reky R. Palandi; Juliani I. A. Purukan
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.540

Abstract

Makroalga merupakan salah satu sumber daya hayati laut yang kaya akan senyawa bioaktif dan berpotensi dimanfaatkan sebagai sumber antibakteri alami. Salah satu jenis makroalga yang tumbuh di Perairan Pantai Lumintang, Kabupaten Minahasa Tenggara, adalah Hypnea charoides. Makroalga ini diketahui mengandung berbagai metabolit sekunder, seperti alkaloid, flavonoid, tanin, saponin, dan senyawa fenolik yang memiliki potensi dalam menghambat pertumbuhan bakteri patogen. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak Hypnea charoides terhadap bakteri Helicobacter pylori. Proses ekstraksi sampel dilakukan dengan metode maserasi menggunakan etanol 95% sebagai pelarut. Pengujian aktivitas antibakteri dilakukan dengan metode difusi cakram pada empat variasi konsentrasi, yaitu 100, 200, 300, dan 400 ?g/disk, masing-masing dengan tiga kali pengulangan. Diameter zona hambat yang terbentuk diukur menggunakan jangka sorong dan selanjutnya dianalisis secara deskriptif. Hasil pengujian menunjukkan bahwa seluruh konsentrasi ekstrak mampu menghambat pertumbuhan H. pylori dengan rata-rata diameter zona hambat masing-masing sebesar 10,71 mm; 11,37 mm; 11,37 mm; dan 11,38 mm. Sementara itu, kontrol negatif berupa akuades tidak menunjukkan adanya zona hambat. Temuan penelitian ini membuktikan bahwa ekstrak Hypnea charoides memiliki aktivitas antibakteri terhadap Helicobacter pylori. Oleh karena itu, makroalga ini berpotensi untuk dikembangkan lebih lanjut sebagai sumber senyawa antibakteri alami yang berasal dari ekosistem laut.
Co-Authors Alter Y. Runtu Amal R. Ginting Dannari Sampetondok Douglas N. Pareta Ferdy A. Karauwan feybi abram Friska M. Montolalu Hariyadi Hariyadi Jabes Wolter Kanter Jekki J. F. Kalangi Joke L. Tombuku Juliani I. A. Purukan Juliani R. Turang Nancy C. Pelealu Nerni O. Potalangi Reski Anti Selvana S. Tulandi Wilmar Maarisit Yessie K. Lengkey