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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Alter Y. Runtu
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity Test of Scleria sumatrensis Leaf Extract against Staphylococcus aureus in Vitro Douglas N. Pareta; Reky R. Palandi; Selvana S. Tulandi; Juliani R. Turang; Alter Y. Runtu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.506

Abstract

Staphylococcus aureus bacteria is one of the important pathogens that can cause various types of infections, ranging from mild ones such as folliculitis and impetigo to life-threatening conditions such as nosocomial pneumonia, osteomyelitis, endocarditis, sepsis, and toxic shock syndrome. Due to its ability to develop resistance to antibiotics, new alternative treatments are needed, one of which is from natural ingredients. In this study, the antibacterial activity of Scleria sumatrensis extract was tested against Staphylococcus aureus with a concentration variation of 100 - 500 µg / disc. The results showed that at a concentration of 100 ?g / disc, the extract provided antibacterial activity in the moderate category, while at a concentration of 200 to 500 ?g / disc, the activity produced was included in the strong category. These findings indicate that Scleria sumatrensis extract has the potential as a natural antibacterial agent against Staphylococcus aureus, so it is worthy of further development as an alternative therapy for infections caused by S. aureus bacteria.
Formulation And Evaluation Of Lip Balm Preparation From Watermelon Seed Extract (Citrullus lanatus) As Lip Moisturizer Alter Y. Runtu; Soniya Tumuju; Douglas N. Pareta; Andry Natanel; Anggelina A. Pangalila; Adolfina Sumagando; Marshella M. Mokoagouw
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.523

Abstract

This study aimed to formulate and evaluate a lip balm preparation containing watermelon seed extract (Citrullus lanatus) as a safe and effective natural lip moisturizer, in response to the increasing demand for plant-based cosmetic products. The extract was obtained using the maceration method, and four lip balm formulations were prepared with extract concentrations of 0%, 3%, 6%, and 9%. The preparations were evaluated through physical characterization tests, irritation assessment, hedonic evaluation, and stability testing over a 10-week storage period. The results indicated that all formulations were stable, exhibited acceptable pH values and melting points, and did not cause irritation. Increasing extract concentration significantly improved spreadability and moisturizing performance, with the 9% formulation receiving the highest preference among panelists. These findings suggest that watermelon seed extract has strong potential as a natural and safe active ingredient for lip care formulations.
Antimycobacterial Activity Test of Symbiotic Fungi Isolated from Stylissa Sp. Sponges Wilmar Maarisit; Devi Trisnawati; Douglas N. Pareta; Rachmat Santoso; Alter Y. Runtu; Selvana S. Tulandi
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.535

Abstract

Tuberkulosis (TB) merupakan penyakit menular kronis yang disebabkan oleh Mycobacterium dan masih menjadi masalah kesehatan global. Meskipun telah tersedia berbagai antibiotik, munculnya resistansi obat seperti multidrug-resistant Mycobacterium tuberculosis (MDR-TB) menjadi tantangan serius dalam pengendalian TB. Penelitian ini bertujuan untuk mengetahui aktivitas anti- Mycobacterium dari jamur simbion spons Stylissa sp. Serta mengidentifikasi jenis jamur simbion yang berpotensi. Penelitian dilakukan secara eksperimental di laboratorium menggunakan metode difusi cakram (paper disc). Ekstrak jamur simbion diuji dalam lima konsentrasi (200, 300, 400, 500, 600 µg/disc) dengan tiga kali ulangan, menggunakan streptomycin sulfat sebagai kontrol positif dan alkohol 70% sebagai kontrol negatif. Mikroorganisme uji adalah Mycobacterium smegmatis. Hasil penelitian menunjukkan bahwa 12 ekstrak jamur simbion memiliki aktivitas anti-Mycobacterium pada konsentrasi 250 µg/disc dengan zona hambat 7–9 mm. Ekstrak nomor 12 (LS-10) menunjukkan aktivitas tertinggi sehingga dilanjutkan pada uji MIC dan MBC dengan hasil masing-masing 2,18 µg/disc dan 8,72 µg/disc. Identifikasi menunjukkan bahwa jamur simbion LS-10 memiliki kemiripan dengan genus Aspergillus sp. Temuan ini menunjukkan potensi jamur simbion spons Stylissa sp. Sebagai sumber senyawa anti-Mycobacterium baru.
Co-Authors Adolfina Sumagando Andry Natanel Anggelina A. Pangalila Devi Trisnawati Douglas N. Pareta Juliani R. Turang Marshella M. Mokoagouw Rachmat Santoso Reky R. Palandi Selvana S. Tulandi Soniya Tumuju Wilmar Maarisit