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All Journal Science and Technology Indonesia Jurnal Kesehatan Farmasi
Munafri, Nur Alifia Karina
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Biopotential of Gorontalo Hulu’u Fish (Giuris margaritacea) Albumin in a Novel Spray Gel Formulation for the Treatment of BurnWounds: In Vivo Evaluation in Rats Paneo, Mohamad Aprianto; Djuwarno, Endah Nurrohwinta; Habibie, Sitty Ainsyah; Thomas, Nurain; Latif, Multiani S.; Munafri, Nur Alifia Karina; Anasiru, Rayhan Firman
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.389-404

Abstract

This study aimed to evaluate the efficacy of different concentrations of Hulu’u fish albumin-based spray gels in promoting wound healing in burn injuries in male white rats. The formulations included 10%, 15%, and 20% concentrations of Hulu’u fish albumin, which were compared to a commercial snakehead fish albumin gel (positive control) and a spray gel base without albumin (negative control). Wound diameter reduction was assessed over seven days. The results indicated a clear dose response relationship, with the 20% Hulu’u fish albumin formulation (F3) achieving the most significant reduction in wound diameter, averaging 1.57 mm (range: 1.5–1.6 mm), representing a 91.8% improvement compared to the negative control group, which showed an average reduction of 19.13 mm (range: 18.1–19.7 mm). The Positive Control (snakehead fish albumin gel) demonstrated a moderate reduction with an average of 6.97 mm (range: 6.6–7.6 mm). The 10% Hulu’u fish albumin (F1) and 15% Hulu’u fish albumin (F2) formulations showed moderate improvements, with average reductions of 4.73 mm (range: 4.4–5.1 mm) and 4.5 mm (range: 4.7–3.9 mm), respectively. These findings suggest that higher concentrations of Hulu’u fish albumin, particularly the 20% formulation, offer superior wound healing properties, outperforming both the negative control and the commercial snakehead fish albumin gel. The study highlights the potential of Hulu’u fish albumin as a novel bioactive compound for burn wound treatment and warrants further investigation for clinical applications.
GAMBARAN PENGGUNAAN CEFTRIAXONE SEBAGAI TERAPI DEMAM TIFOID DI RSUD M.M DUNDA LIMBOTO GORONTALO Husain, Gustirandawati; Abdulkadir, Widy Susanti; Ahmad, Hidayat; Akuba, Sitti Rahmadiana; Munafri, Nur Alifia Karina; Ismail, Mohamad Agil R; Eyato, Dhea Aulia
Jurnal Kesehatan Farmasi Vol 7 No 2 (2025): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v7i2.3681

Abstract

Latar Belakang: Demam tifoid merupakan infeksi sistemik yang disebabkan oleh Salmonella Typhi, dengan angka kejadian tinggi di Indonesia. Penanganan klinis yang tepat sangat penting guna mencegah komplikasi serius. Metode: Penelitian ini bertujuan untuk mengevaluasi penggunaan terapi antibiotik ceftriaxone pada pasien demam tifoid di RSUD Dunda Gorontalo Melalui studi kasus retrospektif terhadap seorang pasien perempuan berusia 20 tahun. Data diperoleh dari rekam medis dan dianalisis berdasarkan gejala klinis, pemeriksaan penunjang, serta respons terhadap terapi. Pasien didiagnosis dengan demam tifoid berdasarkan hasil tes widal dan gejala klinis yang sesuai. Terapi yang diberikan meliputi ceftriaxone intravena, omeprazole, antrain, serta sucralfate dan dilanjutkan dengan antibiotik oral cefixime saat pasien dipulangkan. Hasil: Hasil menunjukkan adanya respons positif terhadap terapi dengan perbaikan klinis signifikan dalam waktu lima hari. Kesimpulan: Studi ini mendukung penggunaan ceftriaxone sebagai terapi lini pertama yang efektif untuk pasien demam tifoid dengan gejala sedang hingga berat, serta pentingnya pendekatan terapi kombinasi yang disesuaikan dengan kondisi klinis pasien untuk mendukung pemulihan optimal. Kata Kunci: Antibiotik, Ceftriaxone, Demam Tifoid
Co-Authors Ahmad, Hidayat Akuba, Sitti Rahmadiana Anasiru, Rayhan Firman Endah Nurrohwinta Djuwarno Eyato, Dhea Aulia Husain, Gustirandawati Ismail, Mohamad Agil R Latif, Multiani S. Mohamad Aprianto Paneo Nur Ain Thomas Sitty Ainsyah Habibie Widy Susanti Abdulkadir