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All Journal Sari Pediatri Paediatrica Indonesiana Jurnal Respirologi Indonesia
Jasin, Madeleine Ramdhani
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia/ Rumah Sakit Dr. Cipto Mangunkusumo
Health Professions Medicine & Pharmacology

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Journal : Paediatrica Indonesiana

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Efficacy of sputum induction from lower respiratory tract in children Madeleine Ramdhani Jasin; Darmawan Budi Setyanto; Sri Rezeki Hadinegoro; Lisnawati Lisnawati; Pramita Gayatri; Nia Kurniati
Paediatrica Indonesiana Vol 55 No 2 (2015): March 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.119 KB) | DOI: 10.14238/pi55.2.2015.101-8

Abstract

Background Although sputum is a good specimen for variousexaminations, such as cytology and microbiological culture,sputum induction (SI) is not a routine procedure in children.Objective To identify the efficacy of SI to obtain specimen fromlower respiratory tract in children, identify side effects of SI, andthe results of microbiological examination.Methods A cross sectional study was performed in children (aged1 month to 18 years) who underwent SI. Sputum induction wasperformed by inhalation with hypertonic solution, consisted ofsalbutamol for 15 minutes continued with NaCl 3% solutionfor another 15 minutes. Sputum specimens were examined fornumber of alveolar macrophage cell, surfactant protein A (SP-A)concentration, also acid-fast bacili smear, and M. tuberculosisculture, or aerobic microbial culture.Results Forty subjects with lower respiratory tract infectionparticipated in this study, and SI was succesfully performed inall subjects. Youngest subject was 2 month old, the eldest was 16year 7 month old. Median duration of SI was 45 minutes, andmajority of volume was 3 or 4 mL. Side effects were nosebleeds(40%) and vomiting (2.5%). Macrophage alveolar more than 5cells in one specimen was found in 97.5% subjects. Surfactantprotein A examination was performed in 30 specimens, and SP-Awas detected in all specimens (median concentration 264.528 pg/mL). Culture for M. tuberculosis was positive in 1 of 27 subjects,while acid fast bacili smear was negative in all examined subjects.Aerobic microbial culture was positive in 5 of 13 subjects.Conclusions Sputum induction has good efficacy in obtaininglower respiratory tract specimen and it is safe to perform inchildren. Specimen from sputum induction yields good positiveresult for aerobic microbial cultures.
Scrofuloderma in a 1-year-old girl with severe malnutrition: a case report Jasin, Madeleine Ramdhani; Neldy, Fahreza Aditya; Setyanto, Darmawan Budi; Nugroho, Gufron; Sunhaji, Valerie; Ham, Maria Francisca
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.511-6

Abstract

Tuberculosis (TB) remains a global burden and a leading cause of mortality due to infectious diseases worldwide. In 2020, 845,000 new TB cases (312 per 100,000 population) were diagnosed, with 96,000 deaths, including 4,700 deaths of TB with HIV. Tuberculosis typically affects the lungs, but it can also affect other organs, a condition termed extrapulmonary TB. In 2020, 16% of all TB cases had extrapulmonary manifestations.1 The first case of TB affecting the skin was reported in 1826.2,3 There are many types of cutaneous TB; one of the most common is scrofuloderma, more often found in children and young adults.4 Scrofuloderma starts with a lesion in a lymph node, bone, muscle, or tendon that spreads to the skin.5 The lesion progresses very slowly and is usually not painful. Therefore, many patients wait to seek treatment until an advanced stage, leading to poor prognosis.3 In this report, we present a case of a severely malnourished one-year-old girl with scrofuloderma.
Co-Authors Araysi, Leo Alfath Ayuningtyas, Talitha Rahma Citra Estetika Gufron Nugroho Ham, Maria Francisca Hartono Gunardi Irawan Mangunatmadja Irawan Mangunatmadja Lisnawati Lisnawati Nastiti Kaswandani Neldy, Fahreza Aditya Nia Kurniati Nugroho, Gufron Pramita Gayatri Priestley, Fuka Rafli, Achmad Saharso, Ersal Rasyid Setyanto, Darmawan Budi Sjahrullah, Muhammad Azharry Rully Sri Rezeki Hadinegoro Sunhaji, Valerie Talitha Rahma Ayuningtyas The, Valensia Vivian Ufairah, Kamilia Rifani Wahyuni Indawati Wahyuni Indawati, Wahyuni Wirahmadi, Angga