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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol 11, No 1 (2014)" : 8 Documents clear

DAYA HAMBAT MINYAK ATSIRI DAN EKSTRAK LIMBAH SISA DESTILASI RIMPANG KUNIR PUTIH (Kaempferia rotunda L.) TERHADAP PERTUMBUHAN Candida albicans ATCC 10231 Christina Astutiningsih; Ratih Octaviani; Sri Suratiningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: White turmeric rhizome contains alkaloid, saponin, flavonoid, polifenol, and essentialoils. The purpose of this research is to determine the antifungal activity of essensial oil andresidual destillation of white turmeric rhizome against Candida albicans. Essential oils of whiteturmeric rhizome isolated by steam distillation method, the extraction of waste with soxhletasimethod. Antifungal activities were investigated by the paper disc method method. The test resultsshowed antifungal activity of essential oil of white turmeric rhizome in different concentrations(0.75, 1, 2, and 2.25%) were 0.0 ; 0.736 ; 0.894 ; 1.041 cm. The antifungal activities of theresidual distillation of extract (2.25, 2.5, 3, and 4%) were 0.0, 0.674, 0.743 and 0.874 cm. Therewas a difference of the zone of inhibition of Candida albicans growth between essential oils andresidual distillation of white turmeric rhizome.Keywords: White turmeric, Candida albicans, essential oils, extract of waste, inhibiton.

KAJIAN MOLEKULER RESISTENSI Candida albicans TERHADAP ANTIFUNGI Damiana Sapta Candrasari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Candida albicans is one of the species Candida which mostly cause infection inhuman. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used forCandida albicans infection treatment. The increasing using antifungal agent will causeantifungal resistance. Most of this resistance happen through gene mutation. This mutationmay influence efflux pumps, interaction of the drug and the target enzyme, the component offungal structure biosynthesis, and conformation of compound in fungal cell.Keywords: Candida albicans, antifungal agent, resistance, gene mutation

ANALISIS KUANTITATIF ISOFLAVON TEMPE SECARA CEPAT DAN SEDERHANA MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS- DENSITOMETRI Agustina Setiawati; Sri Hartati Yuliani; Enade Perdana Istyastono; Michael Raharja Gani; Evy Fenny Veronica; Dina Christin Ayuning Putri; Reza Eka Putra; David Chandra Putra; Agnes Mutiara Kurniawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Rapid and simple quantitative analysis isoflavones tempe using densitometric TLChas been done. The mobile phase of the system was chloroform: methanol: ethylacetate (45: 5:0.75). Thin layer chromatography was performed on aluminium TLC plates.Ascending distanceof 1 ?L sample was performanced 10 cm. Then the plate was scanned at 261 nm. A linearrelationship obtained at 0.08 - 2 ?g/spot with r= 0.9986. The LOD and LOQ of isoflavone were0.014 ?g/spot and 0.048 ?g/spot. Genistein contained in tempe was 0.151 0.005 % b/b.

PREPARASI NANOPARTIKEL KITOSAN-TPP/ EKSTRAK ETANOL DAGING BUAH MAHKOTA DEWA (Phaleriamacrocarpa (Scheff) Boerl) DENGAN METODE GELASI IONIK Rauhatun Napsah; Iis Wahyuningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) is one of the plants frequentlyused as anticancer. But mahkota dewa extract have a high toxicity. One of certain effort thatcould reduces the toxic effect of medicine is nanoparticle decivery. The aims of this study were tomake nanoparticle from chitosan-mahkota dewa extract using TPP as a cross linker and todetermine it's particle size, zeta potential, loading capacity and loading efficiency. Chitosannanoparticles extract of Phaleria macrocarpa fruits with TPP as cross linker by ionic gelationmethod. Chitosan was dissolved in acetic buffer solution at pH 4 with various concentrations(0.045 and 0.09 % b/v), meanwhile tripolyphosphate (0.009 dan 0.018 % b/v) with volumecompare (5 : 1). The characterizations of chitosan nanoparticles of extract were determined bymeasure its particle size, zeta potential, loading capacity, and determining efficiency valuenanoparticle process formed. The results showed that the most stable extract were onconcentration 0.68 and 0.9 mg/ml (kitosan 0.09 % b/v, TPP 0.018 % b/v) with 350 rpm stirringspeed. The average of nanoparticle size were 190.9 and 162.87 nm. The zeta potential were 48.5mV and 60.86 mV, the loading capacity were 2.96 and 5.33 %, than the loading efficiency were35.75 and 45.26 %. Preparation of chitosan-extract of mahkota dewa fruits by ionic gelationmethod can produced nanoparticles and has a short range of size distribution, grade ofuniformity and good stability.Key words: Mahkota dewa, nanoparticles, chitosan, ionic gelation.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOLIK DAGING BUAH BUNI (Antidesma bunius (L.) Spreng) TERHADAP Staphylococcus aureus ATCC 25922 dan Escherichia coli ATCC 25923 Brigitta Lynda Rakasiwi; C.J. Soegihardjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: The aim of the study was to determine the antibacterial activity of buni skin-pulpethanolic extract against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC25922. Profile of antibiotic resistance which is growing among Staphylococcus aureus andEscherichia coli need some exploration of antibacterial activity buni skin-pulp because thecontain of anthocyanin which has antibacterial activity. The research was purely experimentalresearch with randomized complete direct sampling design. The extraction method was done bymacerated in ethanol solvent. Tube tests and Thin Layer Chromatography (TLC) were used todetermine the content of the secondary metabolites substance in buni skin-pulp ethanolic extract.Antibacterial activity test was done by diffusion method, then followed with liquid dilutionmethod to determine the Minimum Inhibitory Concentration (MIC) and Minimum BactericidalConcentration (MBC). The antibacterial activity was evaluated based on the result of inhibitionzone diameter then analyzed with Kruskal-Wallis test followed with Mann-Whitney test.The results showed that the chemical substances of the buni skin-pulp ethanolic extract predictedwith TLC assay were phenolic, flavonoids, and anthocyanin compounds. The antibacterialactivity showed that the ethanolic extract only had antibacterial activity against Staphylococcusaureus ATCC 25923 with MIC and MBC values 30% and 33%, respectively.Keywords: antibacterial potency, buni skin-pulp, Staphylococcus aureus, Escherichia coli

ANALYTICAL METHOD VALIDATION OF BENZENE USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN BEVERAGE CONTAINING SODIUM BENZOATE AND ASCORBIC ACID Melania Perwitasari; Endang Lukitaningsih; Sudibyo Martono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Several countries reported discovering benzene in beverages containing benzoic acidand ascorbic acid. Benzoic acid decarboxylation by ascorbic acid will form benzene. AmericanBeverage Association (ABA) recommended the use of accelerated testing to test benzene inbeverages. High Performance Liquid Chromatography (HPLC) is one of several methods toanalyze benzene in a wide variety of samples, but there is no much information providedregarding the validation of analysis method of benzene. Therefore, developing analysis methodof benzene and its validation becomes a current need. The HPLC system consists of Hitachi L-2130 pump, sample injector with 20 L sample loop, and UV detector L-2420 operating at 205nm. The analytical column is a LiChrosorb Phenomenex RP-18 (250 x 4 mm, 10 m, 100 ?), themobile phase is acetonitrile:aquabidest (60:40 v/v) and pumped at a flow rate of 0,8 mL/min.Benzene separated from the matrix and follows the validation requirements. The developedanalytical method showed that resolution was 8.37, r = 0.995 with LOD and LOQ 6.52 ppb and19.75 ppb, with a precise of ?11% and recovery of 80-110%. Accelerated testing indicated thatbenzene levels increased with increasing of the temperature. Beverages containing 400 mg/mL ofascorbic acid and benzoic acid formed benzene which was detected as 699.38 ppb at 25 oC,799.61 ppb at 40 oC, and 808.94 ppb at 60 oC in 48 hours. In conclusion, the method was fullyvalidated and can be utilized to analyze benzene in beverages with the accelerated testing at 60 oC in 48 hours, so that benefits the producers and consumers in the end.Keywords : benzene, HPLC, validation method, ascorbic acid, benzoic acid

SINTESIS ASAM SINAMAT DARI BENZALDEHIDA DAN ASAM MALONAT DENGAN KATALIS DIETILAMINA Jeffry Julianus; Elvan Luckyvano
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Cinnamic acid is a natural compound that has known had activities as: antimicrobia; flavour in food; soap; cosmetic; and inhibitor proliferation of caco-2 cells. Cinammic acid compound commonly got by isolated kayu manis bark with yield 2.2%. There was a limitation amount of cinnamic acid that got by isolation so needed another effort to get much amount of cinnamic acid. There was an effort to get much amount of cinnamic acid that was by synthesized it. Synthesis process was carried out by reacted benzaldehyde 45 mmol (4.9 g) and malonic acid 45 mmol (4.5 ml) with catalyzed dietylamina for 7.5 hours at 80OC. Synthetic compound was carried out organoleptic test, solubility test, melting point test, gas chromatography, structure elucidation with ultraviolet spectrophotometry, infrared spectrophotometry, nuclear magnetic resonance spectroscopy (1H-NMR), mass spectroscopy; and amount of yield. Synthetic compound was white smooth crystal powder, and had a specific flavour with yield was4.68% and melting point was 132-133OC. Solubility test showed the synthetic compound dissolved in ethanol, methanol, chloroform, dimethyl sulfoxide, hot water, and acetone; very difficult soluble in water. Gas chromatography chromatogram showed one peak with retention time 13.321 minute. Based on structure elucidation conclude that synthetic compound was cinnamic acid.

PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA Lydia Setiawan; Inneke Devi Permatasari; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: The aim of this research is to investigate the protective activity of the infusion of seed ofPersea americana Mill. (IBPA) against carbon tetrachloride-induced hepatotoxicity andnephrotoxicity in rats. Healthy rats were weighed and randomly divided into 6 groups of 5animals in each. Group 1 were treated with olive oil (2ml/kg, i.p) as negative control. Group 2received carbon tetrachloride (2 ml/kg, i.p.). Group 3 received IBPA 360.7 mg/kg once daily for 6hours (control of dose IBPA). Group 4-6 received IBPA at doses 360.7 mg/kg orally once for 1, 4and 6 hours respectively received treated carbon tetrachloride. Blood sample from all groupswas obtained by sinus orbitalis for the estimation serum transaminase and creatinine. Thepretreatment 1,4 and 6 hours of infusion of seed of Persea americana Mill. has a potent protectiveactivity upon carbon tetrachloride-induced hepatic and nephron damage in rats.Keywords: Persea americana Mill., infusion, protective, carbon tetrachloride

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Florentinus Dika Octa Riswanto

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Daerah istimewa yogyakarta

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

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Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA