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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 7 Documents

Search results for , issue "Vol 16, No 1 (2019)" : 7 Documents clear

SIMPLE AND RAPID METHOD FOR ISOLATING ANTHOCYANIN FROM WILD MULBERRY (Morus nigra L.) Rollando Rollando; Christopher Daniel Kurniawan; Ririn Nurdiani; Sophia Yusnita Wahyu Timur; Paulina Genoveva Moza
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Wild mulberry (Morus nigra L.) is a kind of berries that has a high content of anthocyanin pigment. Anthocyanin is a natural pigment that has good biological activity so that widely be used as both food and drug ingredients. There are many studies conducted that have isolation anthocyanin from mulberry extract, but most of them used various expensive methods and the process included several steps that make them not cost-effective nor time-efficient. This research was conducted in order to do an isolation of anthocyanin from wild mulberry through a single step. The extraction of compounds was done by maceration and the isolation was done by thin layer chromatography method. The isolation product was identified with reagents, consisting of ferric chloride and sodium hydroxide, and with spectrophotometry methods, consisting of UV-Vis and infrared spectrophotometry. As result, this research was able to isolate anthocyanin from wild mulberry fruit by thin layer chromatography method. The identification with spectrophotometry methods indicated that the isolated compound hypothetically was anthocyanidin-3-O-rutinoside.

APPLICABILITY OF BACTERIAL ENDOTOXIN TEST (BET) FOR SOME RADIOPHARMACEUTICAL STERILE KITS BY THE USE OF TACHYPLEUS AMEBOCYTE LYSATE (TAL) Putra, Amal Rezka; Lestari, Enny; Kurniasih, Dede; Karyadi, Karyadi; Sarmini, Endang; Aries, Arni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The application of bacterial endotoxin test (BET) using TAL reagent on radiopharmaceutical kits is very important to conduct. The radiopharmaceutical kits that will be tested are macro aggregated albumin (MAA), tetrofosmin and ethambutol kits. Endotoxin testing stage was TAL 0.25 EU/mL verification test, inhibition/enhancement test, and endotoxin test for sample. Pyrogen testing using rabbits was also performed as a comparison test. The results of the TAL reagent verification test were all samples showed values corresponding to the standards of 2? = (+), 1? = (+), 1/2? = (-), 1/4? = (-), and negative water control (NWC) = (-). Furthermore, inhibition/enhancement tests for MAA, tetrofosmin, and ethambutol products show non-inhibiting or gel-inducing results, which are in accordance with acceptability standards, so that the samples can be tested using TAL reagents. The pH measurement results in each sample were MAA of 6.0, tetrofosmin of 7.0, and ethambutol of 8.0. The results of MAA, tetrofosmin, and ethambutol product testing were a sample = (-), positive product control (PPC) = (+), positive water control (PWC) = (+), and NWC = (-). In addition, the results of pyrogen testing also showed negative for MAA, tetrofosmin, and ethambutol.

FORMULATION OF CHLORPHENIRAMINE MALEATE TABLETS USING CO-PROCESSED EXCIPIENT AS A FILLER AND BINDER Yandi Syukri; Romdhonah Romdhonah; Anisa Nur Fazzri; Rio Fandi Sholehuddin; Aris Perdana Kusuma
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Co-Processed Excipient (CPE) is technological innovation for tablet preparation through the direct compression method with a quick and straight forward manufacturing process because it improves the compressibility and flowability. This research aimed to formulate and evaluate of chlorpheniramine maleate tablets using spray dried CPE as filler and binder. The spray dried CPE containing MCC PH 101, and Kollidon K30 was made into tablets through a direct compression method. Meanwhile, Ludipress and Avicel PH 102 were used as filler-binder comparators. All the prepared tablet formulations were then evaluated for weight variation, hardness, friability, disintegration time, content uniformity of active ingredient, and dissolution test. The physical properties of tablets with CPE as a filler and binder produced an average weight of 151.65 1.53 mg, 5.92 0.38 kg of hardness, 0.06 0.051% friability, 520.00 2.00 seconds of disintegration time, and 99.24 0.15% content uniformity of active ingredient. The comparators indicated better disintegration time than CPE (p0.05), while the dissolution test showed that more than 80% (Q) of the amount of active ingredient was dissolved in 30 minutes. CPE could be successfully used to prepare tablet dosage form, and the tablets had fulfilled the standards of pharmacopoeia.

PROFILE OF LYCOPENE UV-SPECTRA OF LACTIC ACID BACTERIA FERMENTED MILK-TOMATO PASTE Isnaeni Isnaeni; Nailatul Hidayah; Utari Ardiningdyah; Izza Rahmi Hidayah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Lycopene is one of the famous ingredients in tomatoes, because of its important role as a potent anti-oxidant. Besides being consumed as fresh fruit, tomato paste can be combined with probiotic fermented milk to increase its health benefits. Probiotics are lactic acid bacteria (LAB), which when consumed in sufficient quantities will benefit health. Probiotic fermented milk is reported to have various properties including anti-microbial, antioxidant, immunomodulatory and anti-cancer, so the combination with tomato paste is expected to increase its benefits for health. This research aimed to study the effect of probiotic fermented milk on the content of tomato paste lycopene. Lactobacillus acidophillus, Lactobacillus bulgaricus, and Lactobacillus casei were used as mixed probiotic cultures. It was found that at the ratio of 2:8 for the LAB fermented milk and tomato paste, the highest lycopene drive was obtained by spectrophotometric measurement at 663, 645, 505, and 453 nm. Determination of the lycopene content was performed according to the Nagata and Yamashita simple methods. In addition, the lycopene content in the LAB fermented milk-tomato paste was greater than the content in the tomato paste without fermented milk addition and was tested stable after storage for 14 days.

PHAGOCYTOSIS ACTIVITY OF BINAHONG (Anredera cordifolia (Tenore.) Steenis) FROM SECANG, MAGELANG, CENTRAL JAVA, INDONESIA Perdana Priya Haresmita; Dika Sotya Sakti; Nunung Yuniarti; Subagus Wahyuono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The use of medicinal plants is increasing due to the search for alternative resources to treat diseases such as hypertensions and infection. Along with the development in science, preventive action should take place to prevent our body from suffering from these diseases. This can be done by increasing the human immune status with immunomodulatory agents. Binahong empirically have benefits for wound healing. The purpose of this research was to investigate the immunomodulatory effect of ethanolic extract of binahong leaves. The non-specific modulatory effects of the ethanolic extracts of binahong leaves on the immune systems were measured based on phagocytosis index and phagocytosis capacity. Tests were conducted on strain Balb/C male mice at the age of 6-8 weeks. Mice were administered orally with the extract of binahong leaves (doses of 25, 50, 75 mg/kgBW) for 14 days. The test results with the index parameters and macrophages phagocytosis capacity at doses of 50 and 75 mg/kgBW did not significantly increased when compared with the controls. From these results, we concluded that the ethanolic extract of binahong leaves with a dose of 25, 50 and 75 mg/kgBW cannot significantly the activity of macrophages by phagocytosis index parameters and phagocytosis capacity significantly.

EFFECTS OF PARTICLE SIZE, EXTRACTION TIME, AND SOLVENT ON DAIDZEIN YIELD EXTRACTED FROM TEMPEH Sri Hartati Yuliani; Petrus Damiani Tosan Aji; Arini Safti Sandrapitaloka; Fransiska Revana Restiana; Michael Raharja Gani; Florentinus Dika Octa Riswanto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Daidzein, one of the isoflavone aglycones contained in tempeh, has several biological activities such as anti-inflammatory, anti-oxidant, anti-breast cancer, and suppression of expression of matrix metalloprotease-9. As a fermented product from soybeans, daidzein content in tempeh was found in higher concentration compared to the soybean raw material. It was important to optimize several factors affecting extraction process such as particle size of tempeh simplicia, extraction time, and solvent in order to develop an effective method for the daidzein isolation from the tempeh or other natural products. Evaluation of extraction factors was conducted by applying variations for each factor followed by quantitative analysis using HPLC methods. The optimization condition was performed by daidzein standard and achieved with the particle size of tempeh simplicia of 1.2 mm, extraction time of 360 minutes, and 70% ethanol was used as solvent. Furthermore, the optimized condition was applied for the daidzein isolation from tempeh, a soybean fermented product.

PREVENTION EFFECTS OF METHANOLIC EXTRACT OF Eurycoma longifolia ROOTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICY IN RATS Phebe Hendra; Eustachia Diajeng Wandansari; Elni Meilianti; Bella Anggelina; Damiana Sapta Candrasari; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The objective of this study was to investigate preventive effects of methanolic extract of Eurycoma longifolia roots (MEEL) against carbon tetrachloride-induced hepatotoxicity in rats. A total of 25 rats were randomly divided into five groups (n=5). Group I was treated with Sodium CMC 1% w/v (peroral, 6 days), and group II was treated with single dose of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection). Groups III-V received 75, 150, and 300 mg/kg BW of MEEL (peroral, 6 days), respectively, and administration of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection) on the seventh day. The hepatoprotective potential was estimated by measuring serum activity of biochemical parameters. Further, liver weight ratio and histopathological changes were determined. The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were significantly (p0.05) increased and albumin decreased significantly (p0.05) in the CCl4 treated group, but treatment with MEEL 75 mg/kg significantly (p0.05) prevented the elevation of ALT, AST, and LDH. Histopathological changes also indicated hepatic protection of the MEEL at 75 mg/kg. This finding suggested that methanolic extract of Eurycoma longifolia roots at 75 mg/kg was enough to give a protective effect against CCl4-induced hepatotoxicity

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Florentinus Dika Octa Riswanto

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Home Page

OAI Link

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Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

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Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

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Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA