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Florentinus Dika Octa Riswanto
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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 21 Documents
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Search results for , issue "Vol 22, No 1 (2025)" : 21 Documents clear
Quality Assessment of Extemporaneous Capsule Preparation containing Methylprednisolone, CTM, and Theophylline using Spectrophotometrics and Chemometrics Techniques Darmawangzah, Muhammad; Riswanto, Florentinus Dika Octa; Irnawati, Irnawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008772

Abstract

Currently, doctors in developing countries still prefer to prescribe compounding drugs because certain drugs are not available in ready-made dosage forms. It is considered that the capsule formulation can increase patient compliance because it requires a smaller amount of medication. In particular, for asthma patients, extemporaneous capsule preparation containing methylprednisolone, CTM, and theophylline is usually prescribed. However, theophylline, which has a narrow therapeutic index, combined with small doses of methylprednisolone and CTM, may result in inconsistent drug content in the compounded drug. This study aimed to assess the quality of the capsule mixture containing methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Community Health Center, Southeast Sulawesi, Indonesia. Extemporaneous capsules are tested using various methods such as organoleptic tests, water content tests, disintegration time tests, and content uniformity tests of compounding drugs. The quality test results of the compounding capsule with the active substance a combination of methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Health Center met the quality requirements with organoleptic tests, moisture content tests, and disintegration time tests. The content uniformity test does not meet the requirements according to the Indonesian Pharmacopoeia VI edition based on the acceptance values of L1% and L2%.
Determination of Sun Protection Factor Value and Physical Stability of Wungu Leaf (Graptophylum pictum (L.) Griff) Extract Spray Sunscreen Rahmayanti, Mayu; Buana Putra, M. Bayu Firdaus; Maulidina, Annisa Tri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006632

Abstract

Sunscreen can protect the skin from ultraviolet (UV) radiation. The inorganic active ingredients in sunscreens can have detrimental effects on the skin. Wungu leaf (Graptophylum pictum (L.) Griff) is a suitable alternative due to its antioxidant activity and similar mechanism of action to other antioxidants with lower side effects. This study employed a true experimental method, and the data were analyzed using one-way ANOVA and T-tests. The effectiveness of sunscreen is determined by the Sun Protection Factor (SPF) value. This study aims to determine the SPF value and physical stability of Wungu leaf extract spray sunscreen at concentrations of 500 ppm, 1,000 ppm, and 1,500 ppm. The results show that the spray sunscreens provide ultra-protection. The difference in extract concentration significantly affected the SPF value (p0.05). Stability tests showed a negligible effect on color variation and a notable effect on pH and spray diameter. Despite its noticeable impact, the outcome remains within an acceptable range. The study concluded that the Wungu leaf extract spray sunscreen provides excellent photoprotection, as demonstrated by the high SPF values observed for Formula 1 (18.63), Formula 2 (23.87) and Formula 3 (29.56). In addition, the product exhibits robust physical stability, as assessed by relevant parameters.
Health Related Quality of Life (HRQoL) in Type 2 Diabetes Mellitus Patients Based on Antidiabetic Prescription Patterns Sari, Seftika; Pratiwi, Erniza; Farahdilla, Dinda; Ghozali, MT; Sulistyaningrum, Indriyati Hadi; Pribadi, Prasojo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008444

Abstract

Diabetes mellitus is characterized as a multifaceted metabolic disorder marked by elevated blood sugar levels or hyperglycemia. Among its types, type 2 diabetes mellitus is the most common globally, significantly affecting a large portion of the population. In Indonesia, there has been a notable increase in the prevalence of type 2 diabetes, indicating a rising trend. This condition necessitates continuous care and management since it is incurable, requiring patients to undergo lifelong treatment. The various therapeutic approaches available for managing type 2 diabetes have a significant impact on the quality of life of patients, highlighting the necessity for quality-of-life assessments. The primary objective of this study was to assess the quality of life among individuals diagnosed with type 2 diabetes mellitus. It also aimed to investigate the effects of different patterns of antidiabetic drug prescriptions on the Health-Related Quality of Life (HRQoL), employing the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) for evaluation. This study was conducted as a quantitative, observational research using a cross-sectional approach and a descriptive analytical method. A total of 99 participants were included through purposive sampling, a non-probability sampling technique. The findings showed that the average quality of life score was 70.56, with 48 participants (48.5%) reported to have a good quality of life and 51 (51.5%) considered to have a poor quality of life. Importantly, significant results (p0.05) were found regarding the positive effects of combining oral antidiabetic drugs with insulin on enhancing the quality of life in individuals with type 2 diabetes, underscoring the influence of medication regimens on patient health outcomes.
Formulation of Lerak Extract (Sapindus rarak DC) and Aloe Vera Extract (Aloe vera Linn) as Paper Hand Soap: Application of Factorial Design Listyawati, Margaretta Berlinda; Putri, Ni Putu Aryaswari; Ayuning Putri, Dina Christin
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008106

Abstract

Soapberry contains saponin compounds and can be used as a surfactant in a soap. Aloe leaves contain lignin compounds as an emollient. Soapberry extract and aloe extract can be formulated into paper hand soap. This study aims to determine the optimum composition of soapberry extract and aloe extract in paper hand soap formulation. Quasi-experimental research was conducted using a 2-factor and 2-level factorial design. Physical property tests were done including organoleptic tests, pH, washing time, moisture content, foam height, reduction in Trans Epidermal Water Loss (TEWL) values and freeze-thaw physical stability tests. Data analysis used Design Expert version 13 (free-trial version) software with a two-way ANOVA test and 95% confidence level. The overlay plot obtained was used to determine the optimum composition area. The results found that the combination of soapberry extract and aloe extract had an effect on physical properties in the form of foam height and reduced TEWL and the optimum formula composition for soapberry extract was 63.5224 grams and aloe extract was 20.1866 grams.
Effectiveness of 70% Ethanol Extract of Pomegranate (Punica granatum Linn) Against the Healing Process of Incisions and Burns in Mice Dianti, Meilina Ratna; Maimunah, Siti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006779

Abstract

A wound is a traumatic occurrence that damages the skin's and subcutaneous tissue's continuity. For the treatment of skin wounds, it is normal practice in the medical community to administer analgesics, anti-inflammatories, antibiotics, and antiseptics. Anti-inflammatory, antibacterial, and antioxidant properties are required, as well as assistance for cell proliferation in the production of protein and collagen for the regeneration process. Pomegranate is frequently used as herbal medicine and is thought to heal various diseases and ailments, including burns. This investigation will assess the effects of 70% ethanol extract from pomegranate fruit on mouse incisions and second-degree burns. To assess the effect of the extract on the healing of cuts and burns in mice, wounds and second-degree burns were made and treated with a 70% ethanol extract of pomegranate at doses of 7%, 14%, and 28%. Administration of pomegranate fruit extract in 70% ethanol at the optimum dose of 28% was shown to considerably boost wound healing activity and this finding demonstrates the ability of pomegranate extract to treat wounds.
Formulation of Nanoemulsion Sunscreen of Centella asiatica (L.) Extract and Its Effectivity Test Dwiastuti, Rini; Kinanti, Valentina Putri Embun; Gelu, Maria Andriani; Setiawati, Agustina; Chabib, Lutfi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009910

Abstract

Sunscreen protects against ultraviolet (UV) rays. It has a Sun Protection Factor (SPF) value. Centella asiatica (L.) is a herbal plant that contains flavonoid and triterpenoid compounds as antiphotoaging agents. Development of Centella asiatica (L.) extract in nanoemulsion preparation increases its solubility in water and absorption. This study aims to obtain the optimum formula of Centella asiatica (L.) nanoemulsion preparation from the combined use of Tween-80 and Propylen glycol surfactants and determine the effectiveness of Centella asiatica (L.) extract in vitro. The effectiveness of Centella asiatica (L.) extract was tested in vitro using UV-Vis spectrophotometry expressed by SPF value. Development of Centella asiatica (L.) extract nanoemulsion formula using a combination of surfactants Tween-80 and Propylen glycol with factorial design 2 factors and 2 levels. P-value0.05 stated that there is a statistically significant difference in the formula. Centella asiatica (L.) extract has protective power against UV rays at concentrations of 120, 240, and 360 xg with SPF-values of 8.999, 19.219, and 29.569, respectively. Meanwhile, the nanoemulsion response analysis revealed the response of the nanoemulsion produced (p0.05). The optimum formula obtained was found in the nanoemulsion formula with a combination of Tween-80 and PG at a low level.
Antimicrobial Activity Test of Silver Nanoparticle Gel from Green Synthesis using Kelor Leaf (Moringa oleifera) as a Bioreductant Against Cutibacterium acne Pabuang, Afrianse; Dwiastuti, Rini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008272

Abstract

Moringa oleifera leaves contain flavonoid compounds that have the potential to act as bioreducers in the synthesis of silver nanoparticles. The antibacterial activity of silver nanoparticles can reduce topical antibiotic resistance, especially against acne-causing bacteria. This study aims to determine the antimicrobial activity of silver nanoparticles formulated in a gel form at concentrations F1 10%, F2 20%, and F3 30%, using Medi-Klin Gel® as a positive control. Testing was conducted on Nutrient Agar medium using the paper disk method with Cutibacterium acne bacteria, incubated for 24 hours at 37°C. Additionally, physical evaluations of the gel, including organoleptic properties, spreading ability, and pH, were performed. The results of the physical properties of the gel were analyzed using one-way ANOVA. Organoleptic evaluation results indicated that F1 had a more transparent gel color, while F2 and F3 had darker gel colors, and all three gels had a characteristic extract aroma. Physical evaluation results for spreading ability (5.5±0.25; 5.7±0.12; 6.27±0.08) and pH values (4.42±0.17; 5.35±0.15; 5.27±0.17) were obtained. Antimicrobial research results showed inhibition zones for F1 10% (7.53±0.20), F2 20% (9.43±0.32), F3 30% (11.16±0.12), and the positive control Medi-Klin Gel® (25.15±0.26). Based on this study, concentration differences influenced the physical evaluation results of the gel formulation. Our finding suggests that the formula with the highest concentration (30%) has physical properties reaching the requirements and exhibited the highest inhibitory effect and potential as an antibacterial agent for acne.
Knowledge and Attitudes towards Antibiotic Use among Non-Health Undergraduate Students at Andalas University Juwita, Dian Ayu; Almasdy, Dedy; Fitri, Maharani Reskia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007052

Abstract

The knowledge and understanding of the community about antibiotic usage are crucial to avoid inaccuracies in drug utilization. Negative impacts that can arise include the occurrence of resistance and the reduction in antibiotic effectiveness. Students with non-health related educational backgrounds are among the parts of the community that have a limited grasp of issues related to antibiotic usage. The aim of this research is to assess the level of knowledge and attitudes of non-health related major students towards antibiotic usage. This study utilized a cross-sectional method with validated questionnaires. Inclusion criteria for this research were non-health undergraduate students at Andalas University who were willing to complete the questionnaire comprehensively. The obtained data were statistically analyzed using SPSS version 26. The research findings indicate that non-health related major students at Andalas University possess moderate knowledge (54.7%) while their attitudes tend to be positive (71.1%) towards antibiotic usage. A significant correlation between students' knowledge and attitudes towards antibiotic usage was found, with a p-value 0.05. There was no significant correlation found between students' sociodemographic characteristics (faculty, age, gender, presence of family members working in the healthcare field) and their knowledge level. However, concerning attitudes, factors that influence include gender and the presence of family members working in the healthcare field.
The Predisposing Factors to Communicate Effectively in Providing Drug Information Hastama, Ryo; Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007028

Abstract

Effective communication in providing drug information is essential to achieve the expected outcome in implementing pharmaceutical care. This study aims to analyze factors that influence the occurrence of effective communication in providing drug information. Data were collected using a Likert-scale questionnaire survey technique with a cross-sectional design. The study involved 100 samples from all districts in Denpasar City, which were taken by convenience sampling technique. The characteristics of the respondents are described descriptively. Bivariate and multivariate tests are used to analyze the effect of independent variables on effective communication. The pharmacy atmosphere has no significant impact on effective communication. Pharmacists' technical and interpersonal communication skills can facilitate effective communication on the Chi-squared test, but only the interpersonal communication competencies of pharmacists can encourage effective communication in the logistic regression analysis (p-value 0.008; CI: 95%; OR 4.751: 1.492-15.133). Communication factors, in general, predispose to effective communication. Besides paying attention to the message's contents, pharmacists must pay more attention to how drug information is conveyed to patients. Thus, there is a common understanding between the communicator and the communicant. The patient will also be encouraged to use the drug according to the instructions given so that the ultimate goal of treatment can be achieved.
Routine Stock Opname in Enhancing Service of Halodoc's Order and Increasing Transactions Megantara, I Nyoman Arya Purnata; Hartayu, Titien Siwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008323

Abstract

In partnering with the e-commerce platform Halodoc, one of the challenges encountered is unfulfilled orders due to discrepancies between the system's stock and conventional stock. Therefore, the researcher aims to determine whether maintaining drug availability through routine stock opname in an online (e-commerce) setting can also enhance service quality. This study is quasi-experimental research conducted at Manut Farma Pharmacy from July to September 2023. The research involves daily routine stock opname of 312 registered drug items on the Halodoc application. These 312 drug items met the inclusion criteria, which were "Drugs included in the list of drugs available in the pharmacy and registered in the Halodoc program," and the exclusion criterion of "Physical stock of drugs having an expiration date of not less than 6 months." The research findings indicate that almost all incoming Halodoc orders can be served effectively (86%), which represents a significant increase of 19% (A sig. 0.003; p=0.05) compared to the previous three months (67%). The product is one of the key aspects of marketing, and by maintaining up-to-date stock conditions, it directly affects the fulfillment of incoming drug orders by enhancing the serving process. Routine stock opname can help improve the service of Halodoc orders, Although the number of incoming orders for Halodoc transactions is still relatively low, on the other hand, routine stock checks have also contributed to a 10% increase in conventional transactions.

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