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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 2,118 Documents

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Knowledge, attitude, and practice of underfive children stimulation of working and nonworking mothers Trie Hariweni; Muhammad Ali; Sri Sofyani; Iskandar Z Lubis
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Objective To assess and compare knowledge, attitude, and prac-tice of underfive children stimulation of working and nonworkingmothers and to determine the correlation between knowledge, at-titude, practice of stimulation and mothersâ€™ ages, educational level,number of children, and number of underfive children.Methods A cross-sectional study was performed in PT. IndofoodSukses Makmur, Tanjung Morawa, Medan from October 2002 un-til November 2002. Respondents were female workers havingunderfive children assigned as working mothers and wives of maleworkers (with similar inclusion criteria) assigned as nonworkingmothers. Selected respondents were interviewed using a struc-tured questionnaire. Sample size for each group was 58. Knowl-edge, attitude, and practice of stimulation were classified as good,less, and poor.Results There were 131 mothers interviewed. There were no sig-nificant differences in the ages, educational level, number of chil-dren, and number of underfive children. Good knowledge of stimu-lation of the working and nonworking mothers were 64.6% and97%, respectively; good attitude toward stimulation were 95.4%and 27.3%, respectively, while good practice of stimulation were58.5% and 22.7%, respectively. These differences were statisti-cally significant.Conclusion There were significant differences in knowledge, atti-tude, and practice of underfive children stimulation between work-ing and nonworking mothers. The knowledge of stimulation of theworking mothers was worse than that of the nonworking mothersand the attitude and practice of the working mothers were betterthan those of the nonworking mothers

Airway remodeling in asthma Roni Naning; MTS Darmawan
Paediatrica Indonesiana Vol 41 No 5-6 (2001): May 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi41.3.2001.125-131

Airway remodeling is the term given to a series of structural changes characterized by chronic,Â irreversible airway obstruction. Structural changes in the airway wall caused by chronic inflammation of asthma.Â Evidence for asthma airway remodeling demonstrating an accelerated decline of lung function that cannot be completelyÂ reversed with therapy. Combination therapy produced at least as much protection against inflammation as theuse of the higher dose of the inhaled corticosteroid.

The immunogenicity and safety of the new, Indonesian DTwP-HB-Hib vaccine compared to the DTwP/HB vaccine given with the Hib vaccine Novilia Sjafri Bachtiar; Kusnandi Rusmil; Sunarjati Sudigdoadi; Cissy B Kartasasmita; Hadyana Hadyana
Paediatrica Indonesiana Vol 57 No 3 (2017): May 2017
Publisher : Indonesian Pediatric Society

Background Haemophilus influenzae type b (Hib) causes infection with predominant manifestations of pneumonia, meningitis, and other invasive diseases, occurring primarily in children aged under 2 years, particularly in infants.Â The World Health Organization (WHO) and Indonesian Technical Advisory Group for Immunization recommend to include the Hib vaccine into the national immunization program. The newly developed DTwP-HB-Hib combination vaccine is anticipated to be the preferred choice for Hib vaccine introduction; it is efficient, simple, and has higher coverage.Objective To evaluate the immunogenicity and safety of a new, combined Bio Farma DTwP-HB-Hib vaccine, compared to the registered Hib monovalent vaccine given simultaneously with the local DTwP-HB vaccine, when used as the primary vaccination of Indonesian infants.Methods A prospective, randomized, open-label, phase II study was conducted on the DTwP-HB-Hib vaccine compared to the Hib (registered) vaccine given simultaneously with the DTwP-HB vaccine, in Bandung from July 2011 to January 2012. Infants were serially vaccinated at 6-11, 10-15, and 14-19 weeks. Serological assessments were done prior to the first vaccine dose and 28 days after the third dose. Safety was assessed from the time of first injection until 1 month after the last injection.Results Of 220 healthy infants enrolled, 211 completed the study, with 105 receiving the combined vaccine and 106 the two separate vaccines. All vaccines were well tolerated. No differences in rates of local and systemic reactions were seen between the two methods of administration. No serious adverse events were considered to be related to the vaccines. In the DTwP-HB-Hib primary-vaccination group, at least 98% of the infants reached protective levels of antibodies (seropositivity) against the antigens employed in the vaccines while 96% in the control group.Conclusion The DTwP-HB-Hib combined vaccine is immunogenic and safe, as well as comparable to the Hib vaccine given simultaneously with to the DTwP-HB vaccine.

Electrodiagnosis in Clinical Neurology - The Challenge for Pediatric Neurology in Indonesia Irawan Mangunatmadja; A. C. Van Huffelen; R. H. J. M Gooskens
Paediatrica Indonesiana Vol 36 No 11-12 (1996): November - December 1996
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi36.11-12.1996.228-38

IntroductionIn most cases the diagnosis in neurology is based upon clinical manifestations, anatomical abnormalities, physiological disturbances and biochemical investigations. Clinical manifestations can be investigated by history of illness and neurological examinations. Neurophysiological examination (electrodiagnosis) can provide information on physiological abnormalities of the central nervous system (CNS). In recent years computer tomography (CT) and magnetic resonance imaging (MRI) have made it possiÂ¬ble to visualize the morphologic anatomy of the CNS in detail and to diagnose the lesion.1IntroductionIn most cases the diagnosis in neurology is based upon clinical manifestations, anaÂtomical abnormalities, physiological disturbances and biochemical investigations. Clinical manifestations can be investigated by history of illness and neurological exÂaminations. Neurophysiological examination (electrodiagnosis) can provide information on physiological abnormalities of the central nervous system (CNS). In recent years computer tomography (CT) and magnetic resonance imaging (MRI) have made it possiÂble to visualize the morphologic anatomy of the CNS in detail and to diagnose the lesion.1

Risk of early onset pneumonia in neonates with abnormal gastric aspirate IB. Mahendra; I Wayan Retayasa; I Made Kardana
Paediatrica Indonesiana Vol 48 No 2 (2008): March 2008
Publisher : Indonesian Pediatric Society

Background Early onset neonatal pneumonia is the risk factorfor neonatal sepsis that increases risk for neonatal deaths.Recognition, prevention, and treatment of this problem is majorfactors in the managemant of high risk neonates. Analysis ofgastric aspirate, collected soon after birth is a useful screeningtest for predicting pneumonia.Objective To evaluate the risk of early onset of neonatalpneumonia in neonates with abnormal gastric aspirate.Methods A case control study was done on infants with earlyonset neonatal pneumonia born in Sanglah Hospital during theperiod of July 2004 until November 2005. The control groupconsisted of high risk infants without early onset pneumonia.Multiple logistic regressions was performed to determine theconfounding effects of multiple variables that were considered asrisk factors for early-onset neonatal pneumonia.Results Forty-five infants with early onset neonatal pneumoniawere recruited. Multivariate analysis showed that abnormal gastricaspirate and low APGAR score were significant factors associatedwith early-onset of neonatal pneumonia with OR 4.05 (95%CI1.26;13,02), P=0.019, and OR 6.95 (95%CI 2.45;19.77),P<0.0001, respectively.Conclusion Abnormal gastric aspirate and low APGAR score arerisk factors for early onset neonatal pneumonia in high risk infants.

The accuracy of a clinical parameters-based scoring system to predict spontaneous intracranial hemorrhage in children under one year old Harris Alfan; Rita Dewi Arifin; Erial Bahar; Syarif Darwin Ansori
Paediatrica Indonesiana Vol 55 No 3 (2015): May 2015
Publisher : Indonesian Pediatric Society

Background Previous studies show that most children aged less than 1 year had intracranial hemorrhage without any history of trauma. The sign and symptoms of spontaneous intracranial hemorrhage (SIH) in children varies. To minimize morbidity and mortality, early detection and accurate diagnosis are required. Head CT scans area widely used for diagnosing SIH. Unfortunately, not all health facilities in Indonesia have CT scans.Objective To determine the accuracy of a clinical parameters-based scoring system in predicting spontaneous intracranial hemorrhage (SIH) in children under one year old.Methods This diagnostic study included children aged under one year who were admitted to Mohammad Hoesin Hospital, Palembang. Patients who showed any signs of increased intracranial pressure were recruited. Data were collected from medical records from January 2007 to September 2013. Through the use of logistic regression analysis, clinical parameters showing significant relationships with computerized tomography (CT)-scan confirmed SIH were selected as predictors. Each predictor was given a score based on an adjusted ratio. The cut-off point of the total scores from all patients was determined using a receiver operating curve (ROC) analysis. The accuracy of the total scores was calculated using a 2x2 validity test.Results Of the 186 children included in this study, 98 (52.7%) had SIH and 93 (94.8%) were under 3 month-old. The predictors for SIH used included age (>3 months: score 0; 1-3 months: score 3), gender (female: score 0; male: score 1), pallor (no: score 0; yes: score 1), bulging fontanel (no: score 0; yes: score 1), pupil (isocoria: score 0; anisocoria: score 2) and history of shaken baby (no: score 0; yes: score 3). The ROC analysis showed that the area under the curve (AUC) was 95.3% with a cut-off point of 4.5, had a sensitivity of 88.7% and a specificity of 93.1%Conclusion This scoring system based on clinical parameters hadÂ good accuracy for predicting SIH in children under 1 year of age who exhibited signs of increased intracranial pressure.

Differences of antigenic profiles on immunoblotting of wild type measles virus and vaccine virus in Indonesia Made Setiawan; Agus Sjahrurachman; Fera lbrahim; Agus Suwandono
Paediatrica Indonesiana Vol 48 No 6 (2008): November 2008
Publisher : Indonesian Pediatric Society

Background Measles virus has a negative, single strand RNAgenome which codes for six important structural proteins. Thegenes of the wild type measles virus have many variances hencethe nucleotide sequences of each wild type virus and vaccine virusare different. This differences lead to the antigenic differencesbetween wild type and vaccine virus.Objective The purpose of this research is to investigate thedifferences in the antigenic profiles on immunoblotting betweenwild type and vaccine virus.Results The analysis results are 1) the antigen ofCAM-70 vaccinevirus was less able in cross reacting with the antibodies from G2,G3, 09, CAM-70 and Schwarz; 2) The antibody aga inst CAM-70 was only able to cross react with antigens of N protein and afew of antigens ofF proteins; 3) The wild type virus were veryimmunogenic, hence the antibody titers were very high; 4) TheCAM-70 and MMR vaccine virus were less immunogenic, hencetheir antibody were very low; 5) The antibody responses thatalways occurred from all immunized mice serum were antibodyfor N and F proteins. However, the antibody against CAM-70vaccine virus was still able to react with wild type virus (G2, G3and 09).Conclusion All antigen-antibody reaction on immunoblottingresulted in different profiles especially between wild type virusand CAM-70 vaccine virus. Although CAM-70 vaccine virusshowed clear differences compared to G2, G3 and 09 genotypes,antibodies against CAM-70 were still able to cross react withantigens from other genotypes (G2, G3 and D9).

Correlation between obesity with atopy and family history of atopy in children Putria Rayani Apandi; Budi Setiabudiawan; Abdurachman Sukadi
Paediatrica Indonesiana Vol 51 No 4 (2011): July 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.4.2011.227-33

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6âˆ’11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

Correlation of Interleukin-8, Pediatric Logistic Organ Dysfunction score and factors associated with systemic inflammatory response after cardiopulmonary bypass in children who have undergone open-heart surgery Ririe F Malisie; Antonius H Pudjiadi; Fathema D Rachmat; Jusuf Rachmat
Paediatrica Indonesiana Vol 50 No 4 (2010): July 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.4.2010.245-51

Background Cardiopulmonary bypass (CPB) provides a complex set of non-physiologic circumstances, induces systemic release of pro-inflammatory cytokines and initiates systemic inflammatory response. IL-8 is an important activator of neutrophil with chemotactic effect and are proposed to be major mediator of inflammation. The majority of general intensive care unit scoring system does not adequately address the specific characteristics of cardiac surgery patients. None of the study had been published the validation of PELOD score setting in pediatric cardiac intensive care unit (CICU).Objectives To evaluate the correlation between interleukin-8 (IL-8), Pediatric Logistic Organ Dysfunction (PELOD) score and factors associated with systemic inflammatory response after bypass (SIRAB) in children undergone cardiopulmonary bypass surgery.Methods A quasi-experimental study was conducted on children who have undergone cardiac surgery requiring CPB. There were 21 eligible children, two were excluded. Blood samples from mixed vein and coronary sinus were taken before, during and after surgery. The plasma level of IL-8 analyzed at 3 time points: baseline (before) CPB, at reperfusion period and 3 hours after aortic cross clamp-off. Cumulative organ dysfunctions were analyzed by PELOD score.Results The plasma level of IL-8 highly increase at the reperfusion period. IL-8 plasma level correlated with bypass-time (r > 0.49, p=0.003) and aortic cross clamp-time (r > 0.55, P=.014). Moderate association between age and PELOD score (r > 0.47, P=0.041). The correlations were significant between age and mechanical ventilation time support (r > 0.47, P=0.03), age and length of stay in CICU (r > 0.44, P=0.05). No correlation between IL-8 plasma level and PELOD score.Conclusion There was no correlation between IL-8 plasma level and PELOD score. IL-8 plasma level correlated with aortic cross clamp-time in children who undergo cardiopulmonary bypass surgery.

Mucocutaneous Lymph Node Syndrome Rusdi Ismail; Dahler Bahrun; Sawitri Sjaffar
Paediatrica Indonesiana Vol 19 No 9-10 (1979): September - October 1979
Publisher : Indonesian Pediatric Society

A case of Mucocutaneous Lymph Node Syndrome in a 12-year-old girl of Chinese parentage has been reported. This was the first case of MLNS reported from Indonesia.

Page 35 of 212 | Total Record : 2118

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