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INDONESIA
Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
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Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia Pustika Amalia Wahidiyat; Felix Liauw; Nitish Basant Adnani; Siti Ayu Putriasih
Paediatrica Indonesiana Vol 57 No 4 (2017): July 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.183 KB) | DOI: 10.14238/pi57.4.2017.176-80

Abstract

Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusion-transmitted infections (TTI), including hepatitis B and C. These diseases have serious implications and may affect the serum ferritin and aminotransferase levels of thalassemia major patients.Objectives To identify the prevalence of hepatitis B and/or C infections among thalassemia major patients and to evaluate its correlation with serum ferritin and aminotransferase levels.Methods This was across-sectional study conducted at the Thalassemia Center of Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia. The subjects were screened for hepatitis B and C infections, and their serum ferritin and aminotransferase levels were also measured.Results In total, 621 subjects were included in the study, among which 5 subjects tested positive for hepatitis B surface antigen (HBsAg) (0.8%), 111 subjects tested positive for anti-HCV (17.8%), and 5 subjects tested positive for both HBsAg and anti-HCV (0.8%). The subjects who tested positive for hepatitis B, hepatitis C, or both showed significantly higher values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum ferritin compared to their negative counterparts. Moreover, serum ferritin showed a positive, moderate correlation with both AST and ALT.Conclusion This study shows a significant association between hepatitis and serum ferritin as well as aminotransferase levels. Early detection and early management of hepatitis B and C infections is warranted to minimize the occurrence of liver damage in thalassemia major patients. 
Plasma lipid profile and leptin concentration in super-obese children Aryono Hendarto; Sri Sudaryati Nasar; Damayanti Rusli Sjarif
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.747 KB) | DOI: 10.14238/pi47.5.2007.221-5

Abstract

Background Leptin induced weight loss is completely specificfor adipose tissue loss, whereas food restriction result in both lossof adipose tissue and lean body mass in mammals. Most obeseperson has high endogenous leptin levels, indicating leptinresistance. There has been lack of data regarding plasma leptinlevel in Indonesian obese children.Objective This study was aimed to investigate the plasma leptinlevel and lipid profile in super-obese children.Methods This was a cross sectional study performed in PediatricOut Patient Clinic Mangunkusumo Hospital and Private Women& Children Hospital in Eastern part of Jakarta. Super-obese isdefined as children with BMI above 97 centiles CDC 2000 chart.Blood sample was obtained from all subjects, consisted ofperipheral blood picture, lipid profiles and leptin level.Results Seventy nine super-obese children were eligible with ageranged between 12 months and 180 months and mean of age was84.9 months (SD 36.8). More than 60% subjects had high LDLcholesterol, while 19% had low HDL level. The lowest leptinblood level was 2.877 μ g/dL, while the highest was 70.430 μ g/dL(mean 23.990; SD 12.726). Forty five subjects, all boys, hadincreased plasma leptin level.Conclusions In super-obese children, most of the subjectexperienced hyperlipidemia (LDL cholesterol) followed byhypertriglyceridemia. There was small number of low HDLcholesterol found. Super-obese girls had normal serum leptin level,in contrast, more than 60% super-obese boys had elevated serumleptin level.
Interleukin-6 and insulin resistance in obese adolescents Raynald Takumansang; Sarah M. Warouw; Hesti Lestari
Paediatrica Indonesiana Vol 53 No 5 (2013): September 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.907 KB) | DOI: 10.14238/pi53.5.2013.268-72

Abstract

Background Obesity has become a rapidly growing epidemic worldwide, increasing the risk of morbidity and mortality in adolescents. Obesity is due to an expansion of adipose tissue mass, which is an important source of cytokines and contributes to an increase in pro-inflammatory cytokines, such as interleukin-6 (IL-6). Interleukin-6 is significantly increased in obesity and may lead to a state of insulin resistance.Objective To assess for a correlation between IL-6 levels and insulin resistance in obese adolescentsMethods We conducted a cross-sectional study from January to April 2012 in Manado, North Sulawesi. Subjects were either obese or normal body mass index (BMI) teens aged 13-18 years. Data collected were anthropometric status, BMI, and blood specimens for fasting plasma glucose levels, fasting insulin levels, and IL-6 levels. Insulin resistance was expressed as homeostatic model assessment of insulin resistance (HOMA-IR) level >2.77. Data was analyzed by Pearson’s correlation and linear regression tests to assess for a possible correlation between IL-6 levels and insulin resistance.Results The mean BMI in the obese group was 31.21 (SD 3.61) kg/m2 while the mean BMI in the normal group was 19.52 (SD 2.38) kg/m2. There was no significant association between IL-6 and the occurrence of insulin resistance (P=0.309). The log regression coefficient value of IL-6 was negative (b = -0.329).Conclusion There is no correlation between IL-6 levels and incidence of insulin resistance in obese adolescents.
The effect of Ringer’s acetate versus Ringer’s lactate on aminotransferase changes in dengue hemorrhagic fever Mulya Rahma Karyanti; Hindra Irawan Satari; Damayanti Rusli Sjarif
Paediatrica Indonesiana Vol 45 No 2 (2005): March 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.2.2005.81-6

Abstract

Background Dengue hemorrhagic fever (DHF) infection causeshepatocelullar impairment. In management of DHF, World HealthOrganization (WHO) recommends the crystalloids Ringer’s acetate(RA) or Ringer’s lactate (RL), which are similar in composition toplasma. Acetate in RA is not metabolized in the liver, hence notburdening the liver, whereas lactate in RL is metabolized mostly inthe liver, thus placing a burden on the liver.Objective To compare aminotransferase changes as markers ofhepatocellular impairment subsequent to the use of RA and RL inthe management of DHF with and without shock.Methods This study was a double-blind randomized controlledtrial on DHF patients aged 1-18 years in Cipto MangunkusumoHospital who had not received prior treatment with crystalloids orcolloids. Subjects were randomly assigned to receive either RA orRL intravenously. Aminotransferase levels were examined on thefirst, second and third weeks from the onset of fever.Results Ninety-two patients who fulfilled inclusion criteria wereenrolled in this study, consisting of those without and with shock.Mean transaminase levels of patients without shock in the RA andRL groups did not differ significantly. Mean transaminase levels ofpatients with shock in the RA group were lower than those in theRL group, but this difference was not significant statistically. Meanalteration of transaminase levels in patients with and without shockwere not significantly different.Conclusion In DHF without shock, there is no significant differ-ence between aminotransferase level changes of patients receiv-ing RA and RL solutions. In DHF with shock, aminotransferaselevels of patients receiving RA tend to be lower than those receiv-ing RL, but this difference is insignificant
Clinical manifestations of allergic rhinitis in children at Denpasar Hospital Gary Adhianto; Hendra S
Paediatrica Indonesiana Vol 41 No 5-6 (2001): May 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi41.3.2001.160-5

Abstract

This is a retrospective study by collecting data from the medical record of children diagnosed as allergic rhinitis at the Pediatric Allergy & Immunology out patient clinic at Denpasar Hospital between January 1996 and December 2000. Reported data including identifying patient, signs and symptoms, atopic history of the family, skin prick test (SPT) result and the environmental factors. Fifty-five from 297 children (18.5%) attending the Pediatric Allergy & Immunology out patient clinic were diagnosed as allergic rhinitis. Thirty nine were male and 16 female. The age ranged from 6 months to 15 years old. The majority of signs and symptom were sneezing and rhinorrhea (26%), itchy nose (23%), blocked nose (14%) and itchy eyes(12%).. Four children had history of atopic dermatitis, 1 food allergy, 10 asthma, 3 urticaria, 2 drug allaaaergy, 4 h-ad history of both atopic dermatitis and urticaria, 13 both asthma and urticaria, 2 both asthma and drug allergy and 6 children had no history of allergic diseases. Thirty three (60%) one of the parents and 12 (21.8%) both parents ever had allergic diseases. According to SPT, 27 (55.1%) of this children had positive reaction to inhalant allergen, 13 (26.5%) to food allergen and 13 (26.5%) had negative reaction.
Portal Hypertension Inda D. Arif; Mardjanis Said; E.M Halimun
Paediatrica Indonesiana Vol 18 No 3-4 (1978): March - April 1978
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.178 KB) | DOI: 10.14238/pi18.3-4.1978.117-22

Abstract

A case of portal hypertension in a 9-year-old Indonesian female child is presented. The diagnosis was made by demonstrating oesophageal vanices radiologically and surgically, and by measuring the portal venous pressure. Portocaval side to side shunt was done resulting in diminishing of the oesophageal varices, disappearance of hypersplenism, and a normal portal venous pressure. Continuous observation is recommended despite the relative good prognosis.
Knowledge, attitude, and practices of parents with children of first time and recurrent febrile seizures Willy Gunawan; Komang Kari; Soetjiningsih Soetjiningsih
Paediatrica Indonesiana Vol 48 No 4 (2008): July 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi48.4.2008.193-8

Abstract

Background Febrile seizure is a condition of emotionally trauma-tize for most parents. It is believed that parents whose childrenexperienced febrile seizures before, have a better knowledge, at-titude, and practices (KAP) in responding to the seizure. Hencethe fear and emotional disruption that febrile seizures can causein the family, prevention should be addresses.Objective To find if there was any differences in KAP of parents ofchildren with recurrent febrile seizures compares to parents withchildren of first time febrile seizures.Methods A cross sectional study was conducted on parents whohave children aged between 6 months to 5 years old with eithersimple febrile seizures, complex febrile seizures or recurrent febrileseizures admitted to Pediatric Neurology Clinic ofSanglah Hospi-tal. Subjects were selected consecutively and were grouped intogroup of parents with children of first time seizures and parentswith children of recurrent febrile seizures group.Results Based from summated rated method, it seemed thatparents of children with recurrent febrile seizures have higherKAP of febrile seizures and was statistically different (A=O.OOO;P < 0.001). Analysis of covariance (ancova) showed that education(P=0.013) had an influence in the KAP of the parents. Otherancova revealed that children's age and sex have significantinfluence.Conclusion The KAP of parents with children of recurrent febrileseizures are higher and have statistically different compared withparents of children with first time febrile seizures.
Breast-feeding duration and children’s nutritional status at age 12-24 months Susilowati Susilowati; Kusharisupeni Kusharisupeni; Sandra Fikawati; Kusdinar Achmad
Paediatrica Indonesiana Vol 50 No 1 (2010): January 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.813 KB)

Abstract

Background Relation between breast-feeding duration and children’s nutritional status is still a controversy. Positive as well as negative relation were shown. This study aimed to support this current issue on breast feeding duration and nutritional status of children aged 12-24 months.Objective To analyze relationship between breast-feeding duration and nutritional status of children aged 12-24 months.Methods A cross sectional study was conducted with 246 proportional stratified random coupled samples (mothers and weaned children) with inclusion criteria: normal birth weight, full-term delivery and no physical and psychological problems. Data from children were measured using Seca® digital weight scale, wooden length board, while data from mothers were collected through 1x24 Hours Food Recall Form, and a questionnaire on mother’s knowledge.Results The average of breast-feeding duration was 15 months. The prevalence of malnutrition was quite low (<10%), but the prevalence of stunting was high enough (20.7%) while wasting was moderately high (10.6%). Breast-feeding duration was significantly associated to children’s nutritional status (height-for-age index and weight-for-height index). The highest correlation was found in height-for-age index (r = 0.403). Regression model revealed that breast-feeding duration, exclusive breast-feeding, diarrhea, working mother, mother’s knowledge, energy intake, and protein intake were independently associated with children’s nutritional status.Conclusions As this study found that the average of breast-feeding duration was 15 months and there was a significant association between breast-feeding duration and nutritional status (height-for-age index) of children 12-24 months old, thus these findings strengthen the recommendation of WHO to continue breast feeding up to 2 years old. [Paediatr Indones. 2010;50:56-61].
5-alpha-reductase deficiency: a case report Diana Mettadewi Jong; Aman B Pulungan; Bambang Tridjaja AAP; Jose RL Batubara
Paediatrica Indonesiana Vol 43 No 6 (2003): November 2003
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1279.494 KB) | DOI: 10.14238/pi43.6.2003.234-40

Abstract

The condition of 5-alpha-reductase type 2deficiency (5-ARD) is an inherited disorderresulting in the inability to converttestosterone to dihydrotestosterone(DHT).This disorder was previously termed asfamilial incomplete male pseudohermaphroditism type2, pseudovaginal perineoscrotal hypospadias.Clinical manifestation of 5-ARD is limited to malegenetic. The affected males are usually identifiedas female in childhood but undergo striking virilizationat puberty.While overall incidence for various countries arenot established, increased incidence is reported in theDominican Republic, some highland tribes in NewGuinea, Lebanon and Turkey. This was the firstdocumented case in Cipto Mangunkusumo (CM)Hospital.
Effectiveness of vitamin E as a treatment of primary dysmenorrhea in pubertal adolescents Wagito Wagito; Siska Mayasari Lubis; Melda Deliana; Hakimi Hakimi
Paediatrica Indonesiana Vol 51 No 1 (2011): January 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.1.2011.41-6

Abstract

Background Primary dysmenorrhea is a common complaint among adolescents. Absenteeism from work and school are associated with the severity of symptoms. Vitamin E is an alternative treatment for primary dysmenorrhea.Objective To evaluate the effectiveness of vitamin E as a treatment of primary dysmenorrhea.Methods We conducted a randomized, double-blind, controlled trial from August to October 2009. We included female adolescents 'With primary dysmenorrhea in this study. Subjects were divided into 2 groups by simple randomization. Each group received either 200 units of vitamin E or a placebo twice daily, beginning two days before menstruation and continuing until the third day of menstruation. Treatment was repeated for three menstrual cycles. Subjects recorded the severity and duration of pain in a daily diary. Data was analyzed using Chi􀁍square, Mann􀁍W hitney U􀁍test, and independent T-test.Results One hundred􀁍sixteen primary dysmenorrhea subjects enrolled in our study. By simple randomization, they were divided into two groups of 58 subjects each. There were no statistically significant differences between the two groups in the severity and duration of pain before the start of treatment and after 1 month of treatment. After treatment for 2 months and 3 months, there were statistically significant differences in pain severity (P=0.013, 95%CI -0.54 to -0.11; and P=0.0001, 95%CI -0.67 to -0.26, respectively) and pain duration (P=0.025, 95%CI -0.65 to -0.07 and P=0.007, 95%CI -0.75 to -0.12, respectively) between the 2 groups.Conclusion Vitamin E was effective in treatment of primary dysmenorrhea in pubertal adolescents after 2 and 3 months of treatment.

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