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INDONESIA
Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,135 Documents
 70   71   72   73   74 
The efficacy of single-dose albendazole for the treatment of ascariasis Deddy S Putra; W Dalimunthe; M Lubis; S Pasaribu; Chairuddin Lubis
Paediatrica Indonesiana Vol 45 No 3 (2005): May 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.3.2005.118-22

Abstract

Objective This study aims to assess the efficacy of single-dosealbendazole in treating mild, moderate, and severe ascariasis.Methods Stool specimens were collected from randomly selectedelementary school children in Suka village, Sumatera Utara, fromMarch to April 2002. Based on the number of eggs per gram feces(NEPG), samples were categorized as mild (NEPG < 7000), mod-erate (NEPG 7000-35,000), or severe (NEPG > 35,000) ascari-asis. All subjects then received 400 mg albendazole orally. NEPGcount was repeated on the 7 th , 14 th , 21 st and 28 th day after treat-ment. The chi-square test was used to compare cure rates be-tween subjects with mild, moderate, and severe ascariasis. TheANOVA and Kruskal-Wallis tests were employed to analyze quan-titative data.Results From the 134 specimens collected, we found mild ascari-asis in 57 (42.5%), moderate ascariasis in 57 (42.5%), and severeascariasis in 20 (15%). There was no significant difference be-tween the three groups in NEPG after treatment (P>0.05). Thecure rate and egg reduction rate on day 28 after treatment was 100%.Conclusion A single dose of 400 mg albendazole is effective forthe treatment of mild, moderate, and severe ascariasis.
Sonographic measurement of splenic length in children at Cipto Mangunkusumo Hospital H F Wulandari; Kemas Firman
Paediatrica Indonesiana Vol 45 No 3 (2005): May 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.3.2005.123-6

Abstract

Objectives The aim of this study was to determine the 10 th and90 th percentiles and medians of normal splenic lengths of Indone-sian children at Cipto Mangunkusumo Hospital by ultrasonogra-phy using a method introduced by Rosenberg et al .Methods The maximum splenic length was obtained in longitudi-nal coronal plane with the splenic hilum visualized. The age of thepatients were recorded. The medians and 10 th and 90 th percen-tiles for each age group were determined.Results Sixty-nine boys and 46 girls were examined at our institu-tion. The youngest subject was one month old and the oldest was15 years old. The 10 th percentile, median, and 90 th percentilesplenic length in the 1-3 months age group were 3.421 cm, 3.795cm, and 4.343 cm, respectively. In the 3-6 month age group thesemeasurements were 3.689 cm, 4.29 cm, and 5.094 cm, respec-tively; in the 6-12 month age group 4.016 cm, 4.72 cm, and 5.366cm, respectively; in the 1-2 years age group 4.558 cm, 5.04 cm,and 5.502 cm, respectively; in the 2-4 year age group 5.151 cm,6.225 cm, and 6.816 cm, respectively; in the 4-6 year age group5.774 cm, 6.415 cm, and 7.82 cm, respectively; in the 6-8 year agegroup 6.077 cm, 7.505 cm, and 8.228 cm, respectively; in the 8-10years age group 6.354 cm, 7.77 cm, and 8.602 cm, respectively;in the 10-12 years age group 6.354 cm, 7.77 cm, and 8.602 cm,respectively; and in the 12-15 year age group 7.934 cm, 9 cm, and9.919 cm, respectively. In all age groups, the 10 th percentiles,medians, and 90 th percentiles were smaller than those of Ameri-can children as reported by Rosenberg et al.Conclusion The normal splenic lengths of Indonesian childrenare smaller than those of American children as reported byRosenberg et al.
Specific immunotherapy for allergic diseases Ariyanto Harsono
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.137-44

Abstract

Specific allergen immunotherapy (SIT)involves the administration of allergenextracts to modify or abolish symptomsassociated with atopic allergy. The process isspecific, in that the treatment is targeted at thoseallergens recognized by the patient and physician asresponsible for symptoms. A decision to use SITtherefore demands a careful assessment of the patient’scondition and the role of allergic triggers.Immunotherapy was first developed at St Mary’sHospital, London at the end of the 19th century, andmany of the basic principles remain valid today.
Practices of growth assessment in children: Is anthropometric measurement important? Jose RL Batubara
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.145-53

Abstract

Assessing and monitoring growth iscommon practice in pediatric care, andhealth professionals accept routine growthmonitoring in children as a standardcomponent of community child health servicesthroughout the world. In clinical level, by theseactivities one can detect and intervene while growthfaltering happens. The internationally recommendedway to assess malnutrition at population level is to takeanthropometric measurements. In developedcountries, growth monitoring is an intrinsic part of‘well child’ clinics. As growth is a proxy for childhealth, the child who grows well is generally healthyand illness in a child is usually associated with poorgrowth. Interpretation of child growth is based onanthropometric indicators established in a referencepopulation with cut-off points to differentiate under-and overnutrition, short stature or tall stature,proportionate or disproportionate growth. Practicesof growth monitoring consist of regularly measuringthe weight and height of children, then plotting theinformation on a growth chart to make abnormalgrowth visible. When growth is abnormal, the healthworker does something in concert with the family andas a result of these actions the child receivesappropriate social or medical support, his or hernutrition improves, or a serious condition is diagnosedearlier.
Relationship between obesity and leptin serum among low socioeconomic primary school children aged 5-7 years Soenarto Soenarto; Helena Anneke Sendow-Tangkilisan
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.3.2010.166-9

Abstract

Background Obesity has become a major health problem globally, indicates as an epidemic problem by World Health Organization (WHO). Adiposity rebound period may represent critical period for the development of adiposity. Recent data suggest that, in industrialized countries, people of low socioeconomic group are more likely to be obese than their high socioeconomic counterparts. Level of serum leptin was reported to be higher in obese subjects. There has been lack of data regarding leptin serum level in Indonesian obese children.Objective This study aimed to investigate leptin serum level in low socioeconomic obese children. Methods This was a cross sectional study perfonned in Tuminting District, Manado. Obesity was defined based on body mass index for Asia􀁇Pacific condition, i.e., grade I obesity (BMI 25/29.9 kg/ mL), grade II (BM] 30-40 kg/ml), and grade III (BM] > 40 kg/m2 Low socioeconomic status was detennined based on Government's program Cash Direct Aid Program. loBod sample was obtained from inclusion subjects, consisted of leptin serum.Results Fifty􀁇two low socioeconomic obese children were eligible \\lith age ranged between 5 to 7 years. They were divided into grade ] obesity (43 or 82.7%), and grade II (9 or 17.3%). The lowest leptin blood level was 10,291 pg/mL, while the highest was 41,500 pg/dL. All girls had nonnal serum leptin level; in contrast all boys had increased serum leptin level. Conclusions Leprin level increased in those subjects whose BMI increased.
Comparison of pulmonary function test results before and after exercise in junior high school students Hendy Zulkarnain; Munar Lubis; Gabriel P.; Ridwan M. D.; Helmi M. Lubis
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.3.2010.176-80

Abstract

Background During exercise, bronchoconstriction occurs due to heat loss from mucosal respiratory ract. Exercise test can be performed to evaluate hyper-reactivity of the bronchus. The examination of pulmonary function is beneficial to confinn the diagnosis, to determine precipitating factors, and to evaluate disease severity and therapeutic response.Objective To compare pulmonary function test values before and after exercise in junior high school students aged 13 to 15 years.Methods Experimental study of 60 junior high school students from Bilah Hulu was performed using spirometry to evaluate pulmonary function before and after eight minutes of exercise. Results Functional vital capacity (FVC) values before and after eight􀁅minute exercise were 2.20 (SD 0.52) and 2.18 (SD 0.42), respectively. There was no significant difference between FVC values before and after exercise (P>0.05). The mean forced expiratory volume in 1 second (FEV 1) values before and aftereight minutes of exercise were 2.21 (SD 0.42) and 2.13 (SD 0.50) respectively. There was no significant difference between FEV 1 before and after the exercise (P>0.05).Conclusion Eight􀁅minute exercise does not influence the pulmonary function test results in healthy children.
Tuberous sclerosis complex in a child: diagnosis and management Prastiya Indra Gunawan; Aminuddin Harahap; Darto Saharso
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.3.2010.181-6

Abstract

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder affecting children and adults, resulted from mutations in one of two genes, TSC1 (encoding hamartin) or TSC2 (encoding tuberin) genes located on chromosomes 9 and 16 respectively.1,2 Synonyms of TSC are Bourneville Pringle syndrome, epiloia, or tuberosclerosis. This disorder is characterized by seizures, mental disability, and small noncancerous tumors on the skin and other body tissues, such as brain, eye, lung, and kidney. The classic triad are seizures, mental retardation, and cutaneous angiofibromas.3
Nutritional status changes in children with malignant solid tumor before and after chemotherapy Boris Januar; Sri S Nasar; Rulina Suradi; Maria Abdulsalam
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.166-70

Abstract

Background Although aggressive multimodal treatment programsin childhood cancer have significantly increased survival rates, themorbidity caused by protein energy malnutrition related to therapyis still high.Objective To describe nutritional status changes in children withmalignant solid tumors after 21 days of chemotherapy.Methods A descriptive prospective study with pre- and post-testdesign in children with malignant solid tumors was conducted inthe Department of Child Health, Medical School University of In-donesia/Cipto Mangunkusumo Hospital, Jakarta between Janu-ary and July 2004. Anthropometrics (body weight, BW and mid-upper-arm circumference, MUAC) and serum albumin measure-ments were performed before and after 21 days of chemotherapy.Results Twenty-two children were enrolled in this study. After 21days of chemotherapy, 8 children had decreased BW and 6 chil-dren had decreased MUAC, but 3 children gained weight and hadincreased MUAC. Based on MUAC-for-age, 7 children had de-creased nutritional status. Fifteen children had reduced serum al-bumin levels based on a 10% cut-off point. The number of childrenwho had reduced serum albumin was larger than those who hadreduced BW and MUAC. In the evaluation of average oral foodconsumption during 21 days, 7 out of 16 children could acceptmore than 2/3 portion of served food. All of the children who re-ceived enteral feeding could accept more than 2/3 portion of servedfood.Conclusion There was a decrease of nutritional status, BW,MUAC, and serum albumin in most of the subjects after chemo-therapy. Serum albumin level measurement was the more sensi-tive parameter in determining nutritional status changes. Enteralfeeding seems more appropriate to fulfill nutritional needs than oralfeeding
The impact of obesity on left ventricular mass and left ventricular systolic function in children Ria Nova; Bambang Madiyono; Sudigdo Sastroasmoro; Damayanti R Sjarif
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.171-6

Abstract

Background Obesity causes cardiovascular disturbances. Theincidence of cardiovascular disease is higher even in mildly obesepatients than in lean subjects.Objectives The purpose of this study was to compare left ven-tricular (LV) mass, LV internal dimensions, and LV systolic func-tion between obese and normal children; and to determine the as-sociation of the degree of obesity with LV mass and LV systolicfunction.Methods This cross-sectional study was conducted on elemen-tary school students in Jakarta from February to April 2003. Wemeasured the subjects’ body weight and height, and performedlipid profile and echocardiography examinations. Measurementsof LV mass, LV internal dimensions with regard to septum thick-ness, LV internal diameter, and LV posterior wall thickness; andLV systolic function as indicated by shortening fraction and ejec-tion fraction, were performed echocardiographically. The differ-ences in measurements between obese and normal children aswell as between obese children with and without lipid abnormalitywere analyzed. The correlation between the degree of obesity withLV size and systolic function was determined.Results Twenty-eight normal children and 62 obese children wereenrolled in the study. Mean LV mass was 35.7 (SD 5.16) g/cm 3 inobese children versus 24.0 (SD 3.80) g/cm 3 in normal children(P<0.0001). Mean septum thickness was 0.8 (SD 0.14) mm inobese children versus 0.6 (SD 7.90) mm in normal children (P<0.0001). Mean posterior wall thickness was 0.9 (SD 0.14) mm inobese children versus 0.6 (SD 9.97) mm in normal children(P<0.0001). Mean LV internal diameter was 4.0 (SD 0.34) mm inobese children versus 3.9 (SD 0.29) mm in normal children(P=0.300). There was strong correlation between the degree ofobesity and LV mass (r=0.838, P<0.0001). LV systolic function(shortening fraction) was 37.1 (SD 4.20) percent in obese childrenversus 35.8 (SD 4.99) percent in normal children (P=0.19). Ejec-tion fraction was 67.4 (SD 5.32) percent in obese children versus65.5 (SD 6.29) percent in normal children (P=0.13). There wasweak correlation between LV systolic function and the degree ofobesity (shortening fraction r=0.219, P=0.038; ejection fractionr=0.239, P=0.023).Conclusions Obese children had significantly greater LV mass,septum thickness, and posterior wall thickness than normal chil-Backgrounddren. Such significant difference was absent for LV internal diam-eter and measures of LV systolic function. There was no signifi-cant difference in LV mass and LV systolic function between obesechildren with or without abnormality of lipid profile. A strong corre-lation exists between the degree of obesity and LV mass, but thecorrelation between degree of obesity and LV systolic function wasweak
The prevalence of factor VIII inhibitor in patients with severe hemophilia-A and its clinical characteristics Harijadi Harijadi; Djajadiman Gatot; Arwin AP Akib
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.177-81

Abstract

Background Hemophilia is a hereditary blood-clotting disorderdue to factor VIII deficiency. Up to this date, the administration offactor VIII in preventing and managing bleeding has been the maintreatment. One of the complications, which may occur due to re-peated administrations of factor VIII, is the formation of factor VIIIantibody (factor VIII inhibitor).Objective To find out the prevalence of severe hemophilia-A withfactor VIII inhibitor and its clinical characteristics.Methods A cross-sectional descriptive study was performed onchildren with severe hemophilia-A at the National Hemophilia CareCentre, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, in June-August 2004.Results Out of 45 children studied, 16 had factor VIII inhibitor withaverage inhibitor titre of 1.15 Bethesda units (BU) (range 0.15-15BU). Most of them (12 patients) had inhibitor titre <5 BU. Chronicarthropathy was found in 17 out of 45 (37%) children with severehemophilia-A, consisting of nine patients from positive inhibitorgroup and 8 patients from negative inhibitor group. Thirty-ninepatients (86%) used an on-demand treatment pattern, among whom15 had positive inhibitor. Among patients receiving prophylactictreatment pattern, only one had positive inhibitor. There were 39patients (86%) treated using cryoprecipitate, among whom factorVIII inhibitor was found in 12, while among those treated with fac-tor VIII concentrate, the inhibitor was positive in 4/6. The averageamount of factor VIII transfused in positive and negative factor VIIIinhibitor groups was similar.Conclusion The prevalence of factor VIII inhibitor in severe he-mophilia-A patients was 35%. Chronic arthropathy occurred moreoften in patients with positive factor VIII inhibitor. Factor VIII inhibi-tor was found more frequently in patients with an on-demand treat-ment pattern and in those using factor VIII concentrate

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