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INDONESIA
JURNAL BIOMEDIK
Published by Universitas Sam Ratulangi
ISSN : 20859481     EISSN : 2597999X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions
JURNAL BIOMEDIK adalah JURNAL ILMIAH KEDOKTERAN yang diterbitkan tiga kali setahun pada bulan Maret, Juli, November. Tulisan yang dimuat dapat berupa artikel telaah (review article), hasil penelitian, dan laporan kasus dalam bidang ilmu kedokteran..
Arjuna Subject : -
Articles 499 Documents
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PERAN ESTROGEN DAN PROGESTERON TERHADAP KANKER PAYUDARA Suparman, Erna; Suparman, Eddy
JURNAL BIOMEDIK : JBM Vol 6, No 3 (2014): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.6.3.2014.6319

Abstract

Abstract: Sex steroid hormones estrogen and progesterone are the main compounds in hormone replacement therapy (HRT). Due to the Woman’s Health Initiative report 2002, the use of these compounds was controversial. It was reported that these hormones increased the risks of stroke, coronary heart disease, venous thromboembolism, and breast cancer, especially if they were used for a long period of time. The role of sex steroid hormones in inducing or promoting breast malignancy is still not clearly understood. Hypothetically, the polymorphism in receptors and steroidogenesis in breast tissues are involved in promoting the proliferation of breast cells that may trigger carcinogenesis. Although there is a significant benefit in administration of HRT for the menopausal women, there are also probable risks due to this therapy. After prolonged debates and controversies about HRT, it is accepted that there is a significant increase in breast cancers due to the use of combined HRT after 3-4 years. Due to the adverse outcome, the use of hormone therapy must start from the lowest dose and for the shortest period of time.Keywords: hormone replacement therapy, estrogen, progesterone, breast cancerAbstrak: Hormon seks steroid estrogen dan progesteron merupakan kandungan utama dari terapi sulih hormone (TSH). Penggunaan kedua hormon tersebut mendatangkan kontroversi setelah Woman’s Health Initiative pada tahun 2002 melaporkan peningkatan risiko stroke, penyakit jantung koroner, venous thromboembolism dan kanker payudara terutama pada penggunaan jangka panjang. Peran hormon steroid seks dalam meningkatkan keganasan payudara belum jelas dipahami. Secara hipotetik, polimorfisme pada reseptor dan kemampuan steroidogenesis dari jaringan payudara berperan dalam meningkatkan proliferasi sel-sel payudara dan memicu karsinogenesis. Meskipun terdapat keuntungan bermakna dari penggunaan TSH pada wanita menopause, namun terdapat juga kemungkinan risiko yang perlu dipertimbangkan. Setelah melalui berbagai perdebatan dan kontroversi mengenai TSH, disepakati bahwa terdapat peningkatan bermakna dari keganasan payudara setelah 3-4 tahun menggunakan TSH kombinasi. Oleh karena efek samping tersebut maka penggunaan TSH harus dimulai dengan dosis yang serendah mungkin dengan durasi pemakaian yang sesingkat-singkatnya.Kata kunci: terapi sulih hormon, estrogen, progesteron, kanker payudara
PROFIL PEMAKAIAN GIGI TIRUAN LEPASAN BERBASIS AKRILIK PADA MASYARAKAT KELURAHAN BAHU KECAMATAN MALALAYANG Khoman, Johanna A; Mariati, Ni Wayan; Siagian, Ellys D
JURNAL BIOMEDIK : JBM Vol 4, No 1 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.1.2012.751

Abstract

Abstract: A survey of denture wearing in Indonesia (2007) showed 4.5% used. This is caused by a low level of public knowledge about the actual function of dentures. The reasons that people do not wear dentures are: do not know about dentures, do not know the place of manufacturing, the expense of dentures, and the discomfort when wearing dentures. The purpose of this study was to find out the profile of using removable acrylic dentures (partial or full) among the people at Kelurahan Bahu Kecamatan Malalayang. This was a descriptive survey with a total sample of 154 respondents. The results showed that wearers of removable partial dentures were mostly females (39.6%), while wearers of full dentures were mostly males (13.7%). Removable partial denture wearers were mostly in the age group of 21-40 years (54.5%); and full denture wearers were mostly in the 60’s age group (16.9%). Aesthetics was the most frequent reason that respondents wore dentures (74%), compared to the restoration of the masticatory function (26%). Most wearers of removable dentures, either partial (41%) or full (9.7%), were high school educated. Conclusion: most denture wearers were high school educated and aesthetics was the most frequent reason. Wearers of removable partial dentures were mostly females while of full dentures were mostly males; and removable partial denture wearers were mostly in the younger ages comparing to the full denture ones. Keywords: denture wearer, removable denture, acrylic-based Abstrak: Survei pemakaian gigi tiruan di Indonesia (2007) menunjukkan tingkat pemakaian sebesar 4,5%. Hal ini antara lain disebabkan tingkat pengetahuan masyarakat tentang pemakaian gigi tiruan masih rendah sehingga masyarakat belum mengetahui fungsi gigi tiruan yang sebenarnya. Alasan tidak memakai gigi tiruan yakni tidak tahu tentang gigi tiruan, tidak mengetahui tempat pembuatan, harga yang mahal, dan kurang nyaman setelah menggunakan gigi tiruan. Tujuan penelitian ini untuk mengetahui gambaran pemakaian gigi tiruan lepasan berbasis akrilik pada masyarakat Kelurahan Bahu Kecamatan Malalayang, meliputi gigi tiruan sebagian lepasan (GTSL) dan gigi tiruan penuh (GTP). Jenis penelitian survei deskriptif dengan sampel total 154 responden. Hasil penelitian menunjukkan bahwa pengguna GTSL terbanyak pada responden perempuan (39,6%), sedangkan pengguna GTP terbanyak pada responden laki-laki (13,7%). Pengguna GTSL terbanyak pada kelompok usia 21-40 tahun (54,5%) dan pengguna GTP terbanyak pada kelompok usia > 60 tahun (16,9%). Estetik merupakan alasan utama memakai gigi tiruan (74%) dibandingkan mengembalikan fungsi pengunyahan (26%). Pengguna terbanyak gigi tiruan lepasan, baik GTSL (41%) maupun GTP (9,7%) memiliki tingkat pendidikan akhir SMA. Simpulan: pengguna gigi tiruan umumnya memiliki tingkat pendidikan akhir SMA dengan estetik sebagai alasan menggunakannya. GTSL terbanyak digunakan oleh responden perempuan sedangkan GTP terbanyak pada responden laki-laki; selain itu, kelompok usia GTSL lebih muda dibandingkan dengan GTP.Kata kunci : pemakai gigi tiruan, gigi tiruan lepasan berbasis akrilik
Perbandingan Kadar IL-1α antara Tindakan Debridement Tajam Agresif dan Debridement Tajam Konservatif pada Penderita Kaki Diabetik Tjiptadi, Vincent D.; Tangkilisan, Adrian
JURNAL BIOMEDIK : JBM Vol 10, No 1 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.1.2018.19000

Abstract

Abstract: Diabetic foot is a chronic complication of diabetes mellitus which is commonly found but very threatening due to its unsatisfied management, usually ended with amputation or death. Sharp debridement is the gold standard of diabetic foot, albeit, it has to be considered wisely due to the metabolic disorder, sepsis, and other comorbid factors of the patients. This study was aimed to compare the dynamics of Il-1α levels in patients with aggresive sharp debridement and with conservative sharp debridement associated with clinical improvement. This was an experimental analytical study. There were 38 patients with diabetic foot admitted at Prof. Dr. R. D. Kandou Hospital Manado with an age range of 30-60 years, obtained by using simple random sampling. The patients were divided inti two groups: aggressive sharp debridement dan conservative sharp debridement, each of 19 patients. Samples for laboratory examination were collected before and after debridement. In consevative sharp debridement group, the mean levels of IL-1α before treatment was 108,158±14,519 pg/ml meanwhile after treatment was 108,526±16,625 pg/ml that showed no significant elevation. In aggressive sharp debridement group, the mean levels of IL-1α before treatment was 93,263±15,172 pg/ml meanwhile after treatment was 104,052±18,807 pg/ml that showed a significant elevation. Conclusion: In patients with diabetic foot, elevation of IL-α levels after aggressive sharp debridement was greater than after conservative sharp debridement.Keywords: diabetic foot, sharp debridement, interleukin 1-αAbstrak: Kaki diabetes merupakan salah satu komplikasi kronik diabetes melitus yang sering dijumpai dan ditakuti oleh karena pengelolaannya sering mengecewakan dan berakhir dengan amputasi, bahkan kematian. Penanganan dengan debridemen tajam pada pasien dengan kaki diabetik merupakan baku emas tetapi masih dipertimbangkan akibat adanya gangguan metabolik, sepsis dan faktor komorbid lainnya. Penelitian ini bertujuan untuk menganalisis tindakan debridement tajam agresif dan konservatif pada pasien kaki diabetik dengan dinamika kadar IL-1α dan hasil perbaikan klinis. Jenis penelitian ialah eksperimental analitik. Populasi penelitian ialah pasien kaki diabetik yang dirawat di RSUP Prof. Dr. R. D. Kandou Manado dengan rentang usia 30-60 tahun. Subjek penelitian diperoleh dengan simple random sampling, terdiri dari 38 pasien, dibagi atas dua kelompok: tindakan debridemen tajam agresif dan debridemen tajam konservatif, masing-masing 19 pasien. Pengumpulan sampel untuk pemeriksaan laboratorik dilakukan sebelum dan setelah masing-masing tindakan. Pada kelompok tindakan konservatif didapatkan rerata nilai IL-1α sebelum tindakan ialah 108,158±14,519 pg/ml sedangkan setelah tindakan ialah 108,526±16,625 pg/ml yang menunjukkan tidak terdapat peningkatan bermakna. Pada kelompok tindakan agresif nilai IL-1α sebelum tindakan ialah 93,263±15,172 pg/ml sedangkan setelah tindakan ialah 104,052±18,807 pg/ml yang menandakan peningkatan bermakna. Simpulan: Peningkatan kadar IL-α setelah tindakan debrideman tajam agresif lebih besar dibandingkan setelah tindakan debrideman tajam konservatif pada penderita kaki diabetik.Kata kunci: kaki diabetik, debridemen tajam, interleukin 1-α
GAMBARAN HISTOPATOLOGIK LAMBUNG TIKUS WISTAR SETELAH DIINDUKSI DENGAN ASPIRIN Lintong, Poppy M; Loho, Lily L.; Anggran, Herman
JURNAL BIOMEDIK : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2044

Abstract

Abstract: Aspirin is one of the non-steroid-anti-inflammatory drugs. Its pharmacodynamic effects are as an analgesic, antipyretic, anti-inflammatory, anti-thrombotic, and uricosuric agent. The side effects of aspirin are on the respiratory tract, the gastrointestinal tract, blood, metabolic processes, endocrine functions, pregnancy, hypersensitivity, and drug interaction. The purpose of this study was to evaluate the macroscopic and microscopic features of wistar rat stomachs after the administration of aspirin. This was an experimental study, using nine wistar rats divided into three groups equally. Group I, the control group, was given a food pellet only. Group II was given the pellet, added with aspirin 21 mg daily for 10 days. Group I and Group II were terminated on day 11. Group III was given the pellet, added with aspirin 21 mg/day for 10 days, and was terminated on day 14. All the wistar rat stomachs were examined macroscopically and microscopically. The results showed that the control group had a macroscopically normal stomach architecture, and the mucosa layers and rugae were intact and looked pinkish white. The groups treated with aspirin still showed normal stomach architecture, and the mucosa layers and rugae were intact but looked more palid than that of the control group. Microscopically, the stomach walls of the control group were normal, but groups treated with aspirin for 10 days revealed edema of the lamina propria, dilatation of capillaries; and predominantly neutrophilic infiltration in the lamina propria. Ceasing of aspirin administration showed a resolution of the inflammatory process, marked by diminished infiltration of PMN cells and tisuue edema. Conclusion: Aspirin treatment of 21 mg a day for 10 days revealed histopathologically acute gastritis of the wistar rat stomach walls. The inflammatory reaction was diminished after the cessation of aspirin. Keywords: aspirin, histopathology, stomach.   Abstrak: Aspirin tergolong obat anti-inflamasi non-steroid (AINS) yang secara farmakodinamika mempunyai efek analgesik, anti-piretik, anti-inflamasi, anti-trombotik, dan urikosurik, namun mempunyai efek samping pada saluran  cerna terutama lambung. Penelitian ini bertujuan untuk mendapatkan gambaran histopatologik (makroskopik dan mikroskopik) lambung tikus Wistar setelah pemberian aspirin. Penelitian ini bersifat eksperimental dengan menggunakan sampel sembilan ekor tikus Wistar yang dibagi atas tiga kelompok. Kelompok I (kontrol) terdiri dari tiga ekor tikus yang diberi pelet biasa dan air minum. Kelompok II terdiri dari tiga ekor tikus yang diberi pelet biasa, air minum, dan aspirin dosis 21 mg/hari  selama 10 hari. Pada hari ke-11 kelompok I dan II diterminasi. Kelompok III terdiri dari tiga ekor tikus yang diberikan pelet biasa, air minum, dan aspirin dosis 21 mg/hari selama 10 hari, kemudian aspirin dihentikan dan tikus diterminasi pada hari ke-14. Setelah diterminasi, kelompok I-III diotopsi, diambil organ lambungnya, kemudian dilakukan pemeriksaan histopatologik. Hasil penelitian memperlihatkan makroskopik mukosa lambung tampak lebih pucat sedangkan mikroskopik menunjukkan tanda-tanda radang akut. Penghentian pemberian aspirin diikuti dengan resolusi reaksi inflamasi yang ditandai oleh penurunan infiltrasi sel-sel radang PMN dan edema jaringan. Sinpulan: Pemberian aspirin 21 mg/hari selama 10 hari mengakibatkan terjadinya gambaran histopatologik gastritis akut pada lambung tikus Wistar. Reaksi inflamasi menurun setelah penghentian pemberian aspirin. Kata kunci: aspirin, histopatologi, lambung.
KEAMANAN DALAM TINDAKAN ANESTESIA Sakliressy, Magdalena F; Kumaat, Lucky T; Wuwungan, Antje A
JURNAL BIOMEDIK : JBM Vol 4, No 3 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.3.2012.802

Abstract

Abstract: In general, anaesthetic means an act of relieving pain during surgery and or other procedures that cause pain in the body. In all anaesthetic procedures safety is of most concern, including the reduction of any risks of danger or related complications that can happen during anaesthesia. Understanding about the stages of anasthesia from pre-anesthesia until post-anasthesia, as well as techniques of anasthesia, is very important in creating the anaesthesia safety.Key words: safety, anaesthetic, anaesthesia, patientAbstrak: Secara umum, anestesia berarti suatu tindakan menghilangkan rasa nyeri saat melakukan pembedahan dan atau berbagai prosedur lainnya yang menimbulkan rasa nyeri pada tubuh. Dalam setiap tindakan anestesia harus diperhatikan segi keamanannya. Pemahaman mengenai tahap-tahap anaestesia sejak pre anestesia sampai dengan pasca anestesia serta tehnik-tehnik anestesia sangat diperlukan untuk mencapai keamanan dalam tindakan anestesiaKata Kunci: keamanan, tindakan, anestesia, pasien
Hubungan Kadar Interleukin 10 Serum dan Klasifikasi CT Marshall pada Pasien Cedera Otak Berat akibat Trauma Kurniawan, Melina O.; Prasetyo, Eko; Oley, Maximillian Ch.
JURNAL BIOMEDIK : JBM Vol 11, No 2 (2019): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.11.2.2019.23321

Abstract

Abstract: Increased level of interleukin 10 (IL 10) in patients with severe traumatic brain injury (TBI) has been documented, yet studies of its ability to predict the outcome based on the Marshall CT classification are still limited and lacks of clarity. This study was aimed to evaluate the relationship between serum level of IL 10 and the Marshall CT classification among patients with severe TBI. This was an analytical observational single-center study with a cross-sectional design. Immediate CT scans were used to determine the Marshall CT classification and to categorize the location (extra-axial, intra-axial, both), hemisphere (midline/diffuse, dextral, sinistral), and area (frontal, parietal, temporal, occipital, multiple) of the injury. Venous blood sample for IL 10 was taken less than 24 hours of trauma in the Intensive Care Unit. Age and gender were also recorded. Variable selection was run in stepwise forward fashion. Proportional odds models were conducted to assess the changes in the Marshall CT classification related to levels of IL 10. There were 25 patients admitted consecutively to the emergency room (ER) with severe TBI included in this study. The results showed that the mean IL 10 was 107.3 pg/ml (SD 16.2 pg/ml). Patients were distributed almost uniformly within four detected categories (diffuse injury II, III, V, and VI) of the CT Marshall classification. Final regression model consisted of IL 10, age, and injury on temporal area as predictors. Controlling for the others, every 10 pg/ml additional of IL 10 increased the odds to higher (worse) categories in the CT Marshall classification by about 1.95 (95% CI 1.16 – 3.30) times. Conclusion: Interleukin 10 is a potential predictor for the CT Marshall classification in patients with severe TBI.Keywords: IL 10, Marshall CT classification, TBIAbstrak: Peningkatan kadar serum interleukin 10 (IL 10) pada pasien dengan cedera otak traumatik (COT) berat telah didokumentasikan, namun studi tentang kemampuannya untuk memrediksi hasil berdasarkan klasifikasi CT Marshall masih terbatas dan belum jelas. Penelitian ini bertujuan untuk mengevaluasi hubungan antara kadar serum IL 10 dan klasifikasi CT Marshall pada pasien COT berat. Jenis penelitian ialah observasional analitik dengan desain potong lintang. CT scan digunakan untuk menentukan klasifikasi CT Marshall dan untuk mengategorikan lokasi (ekstra-aksial, intra-aksial, keduanya), hemisfer (garis tengah/ difus, dekstra, sinistra), dan area (frontal, parietal, temporal, oksipital, multipel) otak yang terkena cedera. Sampel darah vena untuk IL 10 diambil kurang dari 24 jam pasca trauma. Usia dan jenis kelamin juga dicatat. Seleksi variabel dilakukan secara bertahap. Digunakan model regresi proporsional odds untuk menilai perubahan klasifikasi CT Marshall terkait dengan kadar IL 10. Hasil penelitian mendapatkan 25 pasien dengan COT berat yang masuk ke Instalasi Rawat Darurat Bedah (IRDB). Rerata IL 10 ialah 107,3 pg/ml (SD 16,2 pg/ml). Pasien didistribusikan hampir seragam dalam empat kategori (cedera difus II, III, V, dan VI) dari klasifikasi CT Marshall. Model regresi akhir terdiri dari IL 10, usia, dan cedera pada area temporal sebagai prediktor. Sebagai kontrol, setiap peningkatan IL 10 sebanyak 10 pg/ml meningkatkan kemungkinan klasifikasi CT Marshall yang lebih tinggi (lebih buruk) sekitar 1,95 (95% CI 1,16-3,30) kali lebih tinggi. Simpulan: IL10 merupakan prediktor potensial untuk klasifikasi CT Marshall pada pasien dengan COT berat. Kata kunci: IL 10, klasifikasi CT Marshall, COT
HUBUNGAN PAJANAN BISING KONTINYU TROMOL EMAS DENGAN KELUHAN DISPEPSIA PADA MASYARAKAT DESA TATELU ., Bernie; Supit, Siantan; Engka, Joice N. A.
JURNAL BIOMEDIK : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2605

Abstract

Abstract: Gold is a mining commodity that has a high value. Tatelu’s gold processing is traditionally done with tromol machines that produce high intensity continous noise. Noise is a trigger of stress, which is one of the causes of dyspepsia. This study aimed to find out the relationship between continous noise exposure of the mining tromol and dyspepsia complaints among Tatelu villagers. The study was done by using a cross sectional design. The samples were divided into two groups: the control and the exposed groups. Each group consisted of 20 people. Interviews used structured questionnaires, and dyspepsia diagnostics were based on  Rome Consensus III. The characteristics of samples and the prevalence of dyspepsia complaints were assessed using univariate analysis. Chi square was used to assess the relationship between continous noise exposure of the tromols with complaints of dyspepsia. The results showed that in residential areas exposed to noise, 70% of the samples had complaints of dyspepsia, while in the control area there were only 25%. The results of the statistical analysis using the Chi square showed the value x2count (8.12) > x2table (3.84) and the P-value = 0.004 < 0.05 with α < 5%. Conclusion: There was a significant relationship between the continous noise exposure from the gold tromols with the complaints of dyspepsia among Tatelu villagers. Keywords: noise, stress, dyspepsia.     Abstrak: Emas merupakan komoditi tambang yang mempunyai nilai tinggi. Pengolahan emas di desa Tatelu dilakukan secara tradisional dengan menggunakan mesin tromol yang menghasilkan bising kontinyu dengan intensitas tinggi. Bising merupakan pemicu terjadinya stres yang merupakan salah satu penyebab terjadinya dispepsia. Penelitian ini bertujuan untuk mengetahui hubungan pajanan bising kontinyu tromol emas terhadap keluhan dispepsia pada masyarakat desa Tatelu. Penelitian ini menggunakan rancangan cross sectional. Sampel terdiri dari 20 orang kelompok kontrol dan 20 orang kelompok terpajan. Penelitian menggunakan teknik wawancara dengan kuesioner terstruktur. Diagnosis dispepsia ditegakkan dengan kriteria Konsensus Roma III. Karakteristik sampel dan prevalensi keluhan dispepsia dinilai dengan analisis univariat. Hubungan antara pajanan bising kontinyu tromol emas dengan keluhan dispepsia dinilai dengan chi square. Hasil penelitian menunjukan pada daerah terpajan bising 70% sampel mengalami dispepsia sedangkan pada daerah kontrol hanya 25%. Hasil analisis statistika dengan menggunakan chi square menunjukan nilai x2hitung (8,12) > x2tabel (3,84)  dan nilai P = 0,004 < 0,05 dengan  < 5 %. Simpulan: Terdapat hubungan bermakna antara pajanan bising kontinyu tromol emas dengan keluhan dispepsia pada masyarakat Desa Tatelu. Kata kunci: bising, stres, dispepsia.
Pengaruh latihan core-strengthening terhadap stabilitas trunkus dan keseimbangan pasien pasca stroke Wowiling, Paulina E.; Sengkey, Lidwina S.; Lolombulan, Julius H.
JURNAL BIOMEDIK : JBM Vol 8, No 1 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.1.2016.12334

Abstract

Abstract: This study aimed to analyze whether core-strengthening exercise could correct trunk stability and increase balance in post stroke patients. This was an experimental study with a pretest – posttest group design. Subjects were trained to perform the core strengthening exercise for 12 sessions. The trunk stability was evaluated with trunk impairment scale (TIS) and the balance was evaluated with Berg balance scale (BBS) and timed up and go test (TUG). Data were analyzed with the paired T-test and the Wilcoxon test. The results showed that there were 23 subjects that met the inclusion criteria. Of the 23 subjects, only 19 subjects completed the 12 sessions of exercise. The statistical analysis showed that there were significant increases of TIS (P <0.0001), BBS (P <0.0001), and TUG (P <0.0001) after the whole exercise. Conclusion: Core-strengthening exercise improved trunk stability as wel as static and dynamic balance in post stroke patients.Keywords: core-strengthening exercise, trunk stability, static and dynamic balanceAbstrak: Penelitian ini bertujuan untuk menganalisis sejauh mana latihan core-strengthening memperbaiki stabilitas trunkus dan meningkatkan keseimbangan pada pasien pascastroke. Jenis penelitian ini ialah eksperimental dengan pretest–posttest group design. Subjek penelitian ialah 23 pasien pasca stroke yang memenuhi kriteria inklusi. Perlakuan yang diberikan ialah latihan core-strengthening sebanyak12 sesi. Penilaian stabilitas trunkus menggunakan trunk impairment scale (TIS) sedangkan keseimbangan diukur dengan Berg balance scale (BBS) dan timed up and go test (TUG). Data dianalisis menggunakan uji T berpasangan dan uji Wilcoxon. Hasil penelitian memperlihatkan dari 23 subjek penelitian hanya 19 yang menyelesaian 12 sesi latihan, Analisis statistik menunjukkan bahwa setelah dilakukan latihan penguatan trunkus sebanyak 12 sesi didapatkan peningkatan bermakna dari TIS (P <0,0001), BBS (P <0,0001), dan TUG (P <0,0001). Simpulan: Latihan core-strengthening dapat memperbaiki stabilitas trunkus serta keseimbangan statik dan dinamik pada pasien pasca stroke.Kata kunci: Latihan core-strengthening, stabilitas trunkus, keseimbangan statik dan dinamik
SPOROTRIKOSIS LIMFOKUTAN DIAGNOSIS HISTOPATOLOGI DAN SITOLOGI Lintong, Poppy M.; Sumolang, Inneke V.
JURNAL BIOMEDIK : JBM Vol 2, No 1 (2010): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.2.1.2010.843

Abstract

Abstract: Diagnosis of sporotrichosis associated with lymphocutaneous nodules was made based on the histopathological examination of skin lesions and the cytology of fine needle aspiration biopsy (FNAB). A case of sporotrichosis in a 63-year-old man was reported with papules and nodules spread along the back of the left hand, forearm, and arm. The histopatho-logical examination showed infiltration of PMNs, granulomas, and giant cells in the dermis and epidermis, along with hyperplasia and microabscesses. Sporothrix schenckii was not found in the skin lesion tissues. However, in the FNAB cytology examination of lymphocutaneus nodules we found spores of Sporothrix schenckii in the cytoplasma of histiocytes besides granuloma and infiltration of PMNs. Key words: sporothrix schenckii, histopathology, FNAB cytology.  Abstrak: Diagnosis sporotrikosis kulit dengan nodul limfokutan ditegakkan melalui pemerik-saan histopatologi pada lesi kulit dan sitologi biopsi aspirasi jarum halus pada nodul limfo-kutan. Kami melaporkan kasus sporotrikosis pada laki-laki berusia 63 tahun dengan papul-papul dan nodul-nodul eritematosa pada dorsum manus, antebrakium, dan brakium sinistra. Pemeriksaan histopatologi jaringan biopsi dari lesi kulit menunjukkan reaksi radang, gambaran granuloma, dan sel datia dalam dermis dan epidermis, dengan mikroabses disertai hiperplasia. Tidak ditemukan jamur Sporothrix schenckii dalam potongan jaringan histopatologi. Hasil pemeriksaan sitologi biopsi aspirasi jarum halus pada nodul limfokutan memperlihatkan adanya spora-spora jamur Sporothrix schenckii dalam sitoplasma sel-sel histiosit disamping  terdapatnya bentuk granuloma dalam infiltrat radang. Kata kunci: sporothrix schenckii, histopatologi, sitologi biopsi aspirasi jarum halus.
Gambaran Makroskopik dan Mikroskopik Organ Tiroid pada Hewan Coba Postmortem Tangkelangi, Dwi P. A.; Kalangi, Sonny J. R.; Angmalisang, Elvin C.
JURNAL BIOMEDIK : JBM Vol 11, No 3 (2019): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.11.3.2019.26876

Abstract

Abstract: Macroscopic and microscopic changes of thyroid that occur after death can be used in determining the time of death. This study was aimed to obtain the macroscopic and microscopic changes of thyroid gland in an animal model during 24 hours postmortem. This was a descriptive and observational study. We used 5 male pigs aged 4-5 months and weighing more than 100 kg as animal model. The macroscopic changes were identified after 3 hours postmortem, as follows: darkened color, mushy consistency, dry surface, and decreased weight and size of the organ. At 7 hours postmortem, the surface texture became very wrinkled; however, up to 24 hours postmortem, there was no bad odor of the thyroid glands. The initial microscopic change was identified at 2 hours postmortem as degenerated follicles. At 24 hours postmortem, most follicles did not contain colloid anymore. In conclusion, the initial macroscopic change was observed at 3 hours postmortem meanwhile the microscopic change was identified at 3 hours postmortem as degenerated follicles that progressed until 24 hours postmortem, albeit, some follicles still could be identified at 24 hours postmortem.Keywords: thyroid gland, postmortem Abstrak: Perubahan organ tiroid secara makroskopik dan mikroskopik dapat dimanfaatkan dalam penentuan waktu kematian. Penelitian ini bertujuan untuk mengetahui perubahan makroskopik dan mikroskopik organ tiroid hewan coba babi selama 24 jam postmortem. Jenis penelitian ialah deskriptif-observasional. Hewan coba yang digunakan ialah 5 ekor babi jantan, usia 4-5 bulan dan berat badan lebih dari 100 kg. Hasil penelitian makroskopik teridentifikasi sejak 3 jam postmortem. Warna organ tiroid menjadi lebih gelap, konsistensi bagian dalam lunak, permukaan kering, serta berat dan ukuran organ berkurang. Pada 7 jam postmortem, tekstur permukaan organ menjadi sangat keriput. Pada 11 jam postmortem hingga 24 jam postmortem warna organ menjadi merah kehitaman. Hingga 24 jam postmortem, tidak ditemukan bau busuk pada organ tiroid. Hasil penelitian mikroskopik awal terlihat sejak 2 jam postmortem dengan ditemukannya degenerasi folikel yang terus berlangsung hingga pada 24 jam postmortem hampir seluruh folikel tidak berisi koloid. Simpulan penelitian ini ialah perubahan makroskopik awal terlihat pada 3 jam postmortem sedangkan perubahan mikroskopik telah teridentifikasi sejak 2 jam postmortem yaitu degenerasi folikel yang terus berlangsung namun sebagian folikel tiroid masih dapat diidentifikasi pada 24 jam postmortem.Kata kunci: organ tiroid, postmortem

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