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INDONESIA
Journal of Medicine and Health
Published by Universitas Kristen Maranatha
ISSN : 24425227     EISSN : -     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.
Arjuna Subject : -
Articles 264 Documents
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Role of Elastography in Early Detection of Liver Cirrhosis Susanto, David; Irawan, Visakha R
Journal of Medicine and Health Vol 1, No 5 (2017)
Publisher : Maranatha Christian University

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Abstract

Liver cirrhosis is a condition in which the liver slowly deteriorates and is unable tofunction usually due to chronic, or long lasting, injury. Fibrotic tissue replaces healthy livertissue and partially blocks the flow of blood through the liver. Fibrosis increases liver stiffness.Liver palpation on the early physical examination has been used to assess liver stiffness.Though, palpation has some limitations, such as highly subjective, very operator dependent,and sometimes even impossible to perform. At present, liver biopsy remains the current goldstandard for assessing liver fibrosis, even though the diagnostic accuracy is limited by thespecimen size, invasive procedure, and long duration for getting the result. Elastography is analternative method to liver biopsy in patients with chronic liver disease.Keywords: chronic liver disease, elastography, liver cirrhosis
The Correlation between Fasting Blood Glucose Level with Infiltrated Axillary Limph Node Rate in Infiltrating Ductal Carcinoma of the Breast Aribowo, Thomas; Soewoto, Widyanti
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

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Abstract

Cancer cell have been shown to extensively use glucose for proliferation, even at hypoxia environment. The consumption of glucose in a hypoxia environment induced HIF and VEGF, which play a role in cancer cell infiltration process . The objective of study is to determine the relationship between fasting blood glucose levels with the amount of infiltrated axillary lymph node in patients with infiltrating ductal carcinoma. This is an analytic observational study with cross sectional design. The data obtained were tested with chi-square test (α < 0.05). This study was conducted on 24 infiltrating ductal carcinoma patients. The results showed p value of 0.004, indicating there is a significant correlation between fasting blood glucose levels with the amount of infiltrated axillary lymph nodes. The correlation coefficient ( r) value was 0.505; indicating medium level correlation. As conclusion, there is a significant correlation between fasting blood glucose levels with the amount of infiltrated axillary lymph node in patients with infiltrating ductal carcinoma.Keywords: axillary lymph nodes, breast cancer, fasting blood glucose level, infiltrating ductal carcinoma
PEER REVIEW Team, Editorial
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

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Abstract

We would like to thank our peer reviewers for the precious contributions in providing clinical, scientific, and methodological expertise for JMH Volume 1 Number 6. We appreciate every thoughtful review of submitted manuscripts and for making important contributions to improve the scientific quality of articles published in JMH. We listed the names in alphabetical order. Adhi Kristianto Sugianli, dr., Sp.PK(K), M.KesAndri Rezano,dr.,M.Kes,Ph.DCindra Paskaria,dr., MKMCherry Azaria,dr., M.KesDrs. Eko Suhartono, M.ScDR.Guswan Wiwaha, dr., MMDR. Hana Ratnawati, dr., M.Kes., PA(K)Hanna, dr., M.Kes., Ph.D., AIFOJuly Ivone, dr., MKK., MPd.KedLarissa, dr., Sp.PK, MMRSDR. Meilinah Hidayat, dr., M.KesDR. Oeij Anindita Adhika,dr., M.Kes., PA(K)Rizna Tyrani, dr., M.KesStella Tinia Hasianna, dr., M.KesDR. Teresa Liliana Wargasetia, S.Si., M.Kes., PA(K)Vinna Kurniawati, drg., M.Kes
Efficacy of Profilactic and Therapeutic Antibiotic in Congenital Hydrocephalus Shunt Infection Imron, Akhmad; Wiriadisastra, Kahdar
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Abstract

Prophylactic dose antibiotic are indicated in patients having neurosurgical clean operations with implant surgery. The aim of this study is to evaluate the efficacy of prophylactic dose antibiotic in shunt infection. Between 1 October 2009 until 31 September 2011, 102 patients with congenital hydrocephalus who underwent VP shunt surgery. Fifty-one received profilactic antibiotic (ceftriaxone 50-75 mg/kgBW), 30-60 minutes before surgery until 5 days post-operative, and 51 patients received therapeutic antibiotic  (ceftriaxone 50-75 mg/kgBW), 30-60 minutes before surgery until 1 days post-operative. All patient were followed for 1-6 months to evaluate shunt infection. Collected data will be statistically analyzed. The study found that the rate of infection is 17,6% (9 patients of 51 patients) who received therapeutic antibiotic, and 17,6% (9 patients of 51 patients) who received profilactic antibiotic.There is not statistically significant between all group in shunt infection (p=1,000). Others risk factors significantly influence shunt infection are enlargement of the head (p=0,002), length of surgery (p=0,00327), time of surgery (p=0,00077) and nutrition status (p=0,01343). The results of this study indicate that profilactic antibiotic effective to prevent shunt infection in congenital hydrocephalus. Others risk factors significantly influence are enlargement of the head, length of surgery, time of surgery and nutrition status. Keywords:  antibiotic,  prophylactic, infection, VP shunt, congenital hydrocephalus
The Effect of Mangosteen Peel Extract on Sperm Motility and Sperm Count of Swiss Webster Mice Induced by Hard Physical Exercise Prawira, Ardi; Hasianna, Stella T.; Soeng, Sylvia
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Abstract

High-intensity physical exercises can increase oxidative stress, causing damage to reproductive system. The purpose of this study was to determine the effect of mangosteen peel extract on sperm motility and  sperm count of  Swiss Webster mice induced by high-intensity physical exercise. This was a real experimental with complete randomized design. Twenty five  male Swiss Webster mice were divided into five groups (n = 5). Negative control (KN) was without any treatment, positive control (KP) was given  treadmill exercise only, the treatment groups (KM1, KM2, KM3) were given mangosteen peel extract orally 2, 4, 8 mg respectively as well as treadmill exercises. The treadmill exercises was conducted for 35 days. The sperm motility (mm/second) and the sperm count (per mm3) were assessed manually using Improved Neaubauer chamber. The result were analyzed using one-way ANOVA followed by Tukey HSD. The result showed high significant differences of sperm motility and sperm count between KM2 and KP, also between KM2 with  KM1 and  KM3 (p=0,000). The conclusion was mangosteen peel extract improved the sperm motility and sperm count of Swiss Webster mice induced by high-intensity physical exercise with 4 mg as the optimal dose. Keywords: mangosteen peel, sperm motility, sperm count
STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Soemardji, Andreanus A.; Anisa, Ita N.; Damayanti, Nareswari Alka
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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Abstract

“Rumput Mutiara” or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, β-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, “baihua she she cao su” (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.  Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb. Keywords:  Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.
PHYTOPREVENTIVE EFFECT OF BUAH MERAH (Pandanus conoideus Lam.) OIL IN COLITIS-ASSOCIATED CARCINOGENESIS Adhika, Oeij Anindita
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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Abstract

Colorectal cancer has provided a paradigm for the connection between inflammation and cancer. Modulation of intracellular signaling involved in chronic inflammatory response by anti-inflammatory agents represents an important strategy in molecular target-based chemoprevention. The aim of this research is to study the effect of buah merah oil on  IL-6  serum level and histopathology of colon in colitis-associated cancer (CAC) mice model. BALB/c mice were randomly divided into four groups. The negative control and buah merah control were given aquabidest and buah merah, respectively, without CAC induction. The AOM/DSS control and buah merah treatment were given azoxymethane (AOM) followed by dextran sulfate sodium (DSS) to induce CAC. The AOM/DSS control was given aquabidest while the buah merah treatment was given buah merah. Data were analyzed by One-Way ANOVA continued with Tukey-HSD. The result showed that IL-6 level in mice administrated with buah merah was significantly lower than the AOM/DSS control (p=0.000). Histopathological analysis scores  of colon were analyzed by Kruskal-Wallis continued with Mann-Whitney. The result showed that histopathological analysis score in buah merah treatment was significantly lower than in the AOM/DSS control (p=0.002). Taken together, buah merah oil lowered IL-6 level and histopathological analysis score of colon in CAC mice model. Keywords: CAC, buah merah oil,  IL-6 level, histopathological  analysis scores of  colon
Cytopathology Lymphadenopathy Feature in HIV Positve Patient: Diagnosis Tools Comorbidities Agustina, Hasrayati; Wisudarma, Yenni; Kristiana, Ris; Hernowo, Bethy S.
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

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Abstract

Lymphadenopathy is enlarged lymph nodes caused by infection, inflammation or malignancy. On HIV positive patients, lymphadenopathy is one of the most common clinical manifestations and it is usually persistent. Fine-needle aspiration biopsy (FNAB) is an effective cytology technique in determining the diagnosis of lymphadenopathy. This study aimed to describe the cytopathology of lymphadenopathy in HIV positive patients. This is a descriptive study of 21 cases of lymphadenopathy in patients with HIV positive who underwent FNAB examination in Anatomical Pathology Department of Dr.Hasan Sadikin Hospital between 2013-2014. Medical data was taken from the patient medical records including age, sex, location, size and cytopathological diagnosis. Cytopathology overview of FNAB specimens were reassessed by 2 pathologists. In this study, lymphadenopathy in HIV positive patients were mainly found in men (n = 15.71%) with an average age between 20-30 years. The most frequent location was the neck (n = 20.95.2%). The lymph nodes size were found between 0.5-3 cm. Most diagnosis was tuberculous lymphadenitis (n = 15.71%) with the most common cytology feature was granulomatous lymphadenitis (n = 5.33.3%) and suppurative lymphadenitis (n = 5.33.3%). FNAB examination in lymphadenopathy is very helpful to identify the cause of infection in HIV positive patients. Keywords: FNAB, HIV, lymphadenopathy, cytopathology
Free Fibular Osteoseptocutaneus Flap for Reconstruction of Giant Ameloblastoma Wiardi, Rachmat; W., Irra R.
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

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Abstract

Ameloblastoma is a tumor originating from odontogenic epithelial cells. The tumor islocated in the gray zone between benign and malignant neoplasm. These tumors can occur atany age. Although traditionally divided as solid and cystic ameloblastoma, nearly all showedcystic changes. These tumors are invasive and have a very high recurrence rate. The operativetherapy of choice is radical resection of the affected parts of the jaw, followed byreconstruction. Bridging titanium plate can be used to replace part of lost bone and serves as ameans of reconstruction. Various methods of reconstruction of the mandible can be done byusing a bone graft from the calcaneus, fibula, ribs, scapula, iliac crest, or flap reconstruction.We reported a case of a 18 years old male patient with lump under the tongue that emerged 8years ago, accompanied by eating and speaking difficulty, and shortness of breath. Thediagnosis of mandible ameloblastoma was confirmed by anatomical pathology examination.The patient went through segmental mandibulectomy and free fibular osteoseptocutaneous freeflap with multiple osteotomy. Patients went home with improved condition.Keywords: ameloblastoma, free fibular flap osteoseptocutaneus
The Effect of Jati Belanda Leaves (Guazuma ulmifolia Lamk.) Ethanol Extract on Microscopic Features of Atherosclerotic Animal Model’s Aorta Permana, Ryan J.; Azaria, Cherry; Rosnaeni, Rosnaeni
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

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Abstract

“Jati Belanda” leaves (Guazuma ulmifolia Lamk.) possesses antidyslipidemia effect and in this study we assessed the effect of "Jati Belanda” leaves ethanol extract in delaying the progression of atherosclerosis in aorta of the rats.Thirty atherosclerosis animal models were divided into six groups, which are three variant dose of “Jati Belanda” leaves (EEDJB 1-2-3), standard control (SC), negative control (NC) and Comparative control/ CC (simvastatin). The parameters measured were the wall thickness and lumen diameter (both in mm), and the amount of foam cells. The result for Kruskal Wallis test showed highly significant differences (p=0.00) of wall thickness Dose2 (0.056 mm) and Dose3 (0.056 mm) compared to NC (0.075 mm) and non-significant compared to CC (0.055 mm). ANOVA result for lumen diameter, p=0.773.  ANOVA result for foam cells amount, p=0.000, Duncan test showed significantly different between EEDJB and NC group.It is concluded that “Jati Belanda” leaves ethanol extract reduced aortic wall thickness and the amount of foam cells, but did not increase lumen diameter on the athersclerotic aorta, and had an equal therapeutic effect compared to simvastatin in delaying the progression of atherosclerosis. Keywords: atherosclerosis, Jati Belanda, wall thickness, lumen diameter, foam cell

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