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Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Pembangunan Nasional Veteran Jakarta
ISSN : 02163438     EISSN : 26211122     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 252 Documents
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Histopathological Evaluation of the Hepatoprotective Effect of Pineapple Peel Extract (Ananas comosus) in Paracetamol-Induced Wistar Rats Teja Koswara; Tamara Putri Rahayu; Elly Noer Rochmah; Endah Hamidah Abbas
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 20 No 1 (2026): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v20i1.14051

Abstract

Paracetamol is a leading cause of drug-induced liver injury (DILI) through the formation of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), which induces oxidative stress and hepatocellular damage. Natural antioxidants have potential as hepatoprotective agents. Pineapple peel (Ananas comosus), an agricultural by-product, contains bioactive compounds such as bromelain, flavonoids, and vitamin C with antioxidant and anti-inflammatory properties. This study aimed to evaluate the hepatoprotective effect of pineapple peel extract against paracetamol-induced liver injury in Wistar rats. This experimental study used a post-test only control group design with 30 male Wistar rats divided into six groups (n = 5): negative control, positive control (paracetamol 2.5 g/kg body weight), and four treatment groups receiving pineapple peel extract at doses of 250, 500, 750, and 1,000 mg/kg body weight prior to paracetamol induction. Liver tissues were examined histopathologically using Hematoxylin–Eosin staining and assessed with the Suzuki scoring system. Data were analyzed using Kruskal–Wallis and Mann–Whitney tests. There was a significant difference in liver damage scores among groups (p = 0.003). The 750 mg/kg dose showed the most effective hepatoprotective effect (p = 0.043). In conclusion, pineapple peel extract exhibits hepatoprotective potential against paracetamol-induced liver injury. Keywords: Ananas comosus, hepatoprotective, paracetamol, liver histopathology.
Patellofemoral Tracking After Total Knee Arthroplasty: Etiology, Diagnosis, Management, and the Emerging Role of Robotic-Assisted Alignment Ludwig Andre Pontoh
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 19 No 2 (2025): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v19i2.14095

Abstract

Patellofemoral maltracking remains a major cause of pain, instability, poor function, and dissatisfaction after total knee arthroplasty (TKA). Despite advances in implant design and surgical technique, patellofemoral complications continue to contribute to revision surgery and inferior outcomes. This review summarizes the etiology, diagnosis, prevention, and management of patellofemoral tracking abnormalities after TKA, including a comparison between conventional and robotic-assisted techniques. The most common causes of maltracking include internal rotation of the femoral or tibial component, excessive valgus alignment, soft-tissue imbalance, patella baja, anterior overstuffing, and implant design mismatch. Internal femoral malrotation is consistently identified as the leading factor causing lateral patellar tilt, subluxation, and instability. Clinical evaluation includes anterior knee pain, crepitus, apprehension, and extensor lag, while radiographs and computed tomography are important for assessing patellar tilt, shift, and component rotation. Treatment depends on the underlying cause. Revision of malrotated components, lateral release, tibial tubercle transfer, medial patellofemoral ligament reconstruction, and secondary patellar resurfacing may be required. Robotic-assisted TKA improves component alignment and intra-operative assessment, but current evidence has not shown superior functional outcomes compared with conventional TKA.

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