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Chimica et Natura Acta
Published by Universitas Padjadjaran
ISSN : 23550864     EISSN : 25412574     DOI : -
Core Subject : Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology
Chimica et Natura Acta diterbitkan oleh Departemen Kimia, FMIPA, Universitas Padjadjaran tiga kali setiap tahun pada bulan April, Agustus dan Desember. Artikel yang dimuat mencakup Kimia Analisis dan Pemisahan, Kimia Material, Kimia Energi dan Lingkungan, Kimia Organik Bahan Alam dan Sintesis, Biomolekular Pangan dan Kesehatan serta topik-topik lain yang berhubungan dengan ilmu Kimia.
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol 12, No 3 (2024)" : 8 Documents clear
The Role of Transforming Growth Factor-Beta, Fibroblast Growth Factor, Platelet-derived Growth Factor, Epidermal Growth Factor, Insulin-like Growth Factor, Vascular Endothelial Growth Factor, and Sonic Hedgehog in the Non-syndromic cleft lip with or without cleft palate development: A Scoping Review Ullah, Irfan; Khan, Muhammad Salman; Nasroen, Saskia Lenggogeni; Maskoen, Ani Melani; Sarilita, Erli
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.51493

Abstract

Non-syndromic cleft lip with or without cleft palate (NSCLP) birth defect, it imposes an enormous stress on society and requires nutrition, dental, speech, behavioural, and surgical therapies. The NSCLP multifactorial aetiology, including the environment and genetic factors. The environment and genetic factors affect the cellular mechanism, cell proliferation, cell differentiation, and cell migration and signalling pathways. Genetic growth factors including Transforming Growth Factor-Beta (TGF-β), Fibroblast Growth factors (FGFs), Platelet-derived Growth factors (PDGFs), Epidermal Growth factor (EGF), Insulin-like growth factors (IGF), Vascular Endothelial Growth factor (VEGF), Sonic Hedgehog (SHH). The study aims to understand the role of the growth factors “TGF-β, FGFs, PDGFs, EGF, IGF, VEGF, and SHH” in NSCLP development. Preferential Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards were followed when performing this scoping review. The 942 articles were extracted, and the following inclusion and exclusive criteria 43 articles were eligible for review. Twenty-seven studies identify 26 genes and 25 single-nucleotide polymorphisms (SNPs)/variants of the growth factors that are a significant risk for NSCLP development. In conclusion, the analysis of diverse populations and growth factors including TGF-β, FGFs, PDGFs, EGF, IGF, VEGF, and SHH were associated with NSCLP. The growth factors were involved in the cellular mechanism, cell proliferation, cell differentiation cell migration and signalling pathways that lead to the pathogenesis of NSCLP.
Development of Photo Electrocatalytic Chemical Oxygen Demand Design (PECOD) Sensor using Highly Ordered Titanium Dioxide Nanotube Arrays Electrodes Utami, Chichi Amne; Syauqi, Muhammad Iqbal; Ningsih, Sherly Kasuma Warda; Wibowo, Rahmat; Gunlazuardi, Jarnuzi
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.49333

Abstract

Population growth, industrialization, and the need to ensure water quality have fostered the demand for analytical methods and tools to determine one of the important values of water quality standards. The oxygen demand of a given water matrix provides valuable information about the presence of organic compounds in a sample. The TiO2-based photoelectrocatalytic COD (PECOD) method offers a faster, more efficient, and more accurate alternative than conventional methods. Highly ordered TiO2 nanotube arrays (HOTNAs) were synthesized by anodizing titanium metal at 45V for 2 hours. HOTNAs/FTO photoanodes are used to oxidize organic compounds in water. HOTNAs/FTO photoanode has a bandgap of 3.4eV and a current density of 0.29 mA/cm2. Environmental samples were tested with the PeCOD sensor using glucose and mixed compound addition standards method. Water samples taken from local small ponds, namely Danau Kenanga, Danau Agathis, and typical wastewater of Laundry activity reveal COD values of 15,4659 to 15,9571 mg/L O2; 19,0500 to 19,6179 mg/LO2; 445,2336 to 449,7830 mg/L O2; respectively. The developed PECOD sensor performed well and provided analytical results that were not much different from conventional methods, with an error percentage below 10%.
Deteksi Mekanisme Efflux Pump Pada Resistensi Bakteri Staphylococcus haemolyticus, Sampel Pus Klinis Rumah Sakit Pekanbaru Wardana, Rexi Dwi; Savira, Maya; Anggraini, Dewi; Amalia, Aisyah Sabrina; Nurulita, Yuana
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.52038

Abstract

Infeksi adalah masalah kesehatan yang disebabkan oleh mikroorganisme patogen seperti bakteri. Salah satu jenis infeksi yaitu infeksi kulit dan jaringan lunak yang umumnya disebabkan oleh Staphylococcus aureus dan menyebabkan pembentukan pus. Saat ini, telah dilaporkan bahwa kasus spesies CoNS (Coagulase Negative Staphylococcus) seperti Staphylococcus haemolyticus sebagai penyebab infeksi, mengalami peningkatan. Selain itu, spesies ini juga diketahui telah mengalami resistensi terhadap beberapa golongan antibiotik. Dalam penelitian ini dilakukan karakterisasi isolat bakteri klinis dari sampel pus agar yang dilakukan dengan identifikasi mikrobiologi (kultur isolat, pewarnaan Gram dan uji biokimia) pada bakteri patogen (Isolat 3887), dan dilanjutkan dengan identifikasi molekuler, antara lain ekstraksi DNA kromoson dan plasmid, amplifikasi gen 16S rRNA, sekuensing dan analisis bioinformatik menggunakan BioEdit, BLAST dan filogenetika. Uji suseptibilitas terhadap 25 jenis antibiotik dan deteksi gen resisten clindamycin (ermA, ermB, ermC dan msrA) dan cefazolin (blaTEM-1, blaSHV dan blaOXA-1) dilakukan untuk mengidentifikasi kemungkinan mekanisme resistensi bakteri patogen. Berdasarkan hasil identifikasi mikrobiologi dan molekuler, isolat 3887 merupakan CoNS dengan strain Staphylococcus haemolyticus. Isolat 3887 resisten terhadap 12 dari 25 antibiotik yang diuji dan memiliki fenotipe resisten tertinggi terhadap clindamycin dan cefazolin. Hasil uji deteksi gen resisten clindamycin dan cefazolin menunjukkan hanya gen msrA yang terdeteksi baik pada kromosom dan plasmid isolat 3887 yang menunjukkan bahwa mekanisme resistensi melalui efflux pump.
In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes for The Early Detection of Nasopharyngeal Carcinoma Depamede, Brian Umbu Rezi; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Hafidhoh, Sanny; Nururrohmah, Siti; Tryawan, Ilham Ngongu; Yusuf, Muhammad
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.51749

Abstract

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, and hydrophilicity, then characteristic was analyzed and evaluated. The epitope candidates were compared with other saliva protein biomarkers to find if there were cross-reactions. CYFRA 21-1 consists of 57 amino acids, where two immunogenic epitopes (C3 and D2) were chosen. The Ramachandran Plot of both epitopes shows that 100% of the amino acids were in the favoured area. Epitopes C3 and D2 have no cross-reaction with other protein biomarkers. The predicted immunogenic epitopes have the potential as antigen to produce antibodies for developing saliva-based immunodiagnostics to early diagnose NPC patients.
Antioxidant Testing and Identification of Bioactive Compounds in Ethanol Extract of Propolis from Various Locations in Indonesia using LCMS-QTOF Mulyati, Ade Heri; Alawiyah, Hanis; Marom, Muhamad Fathul; Warnasih, Siti
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.53081

Abstract

Propolis produced by Trigona sp. stingless bees contains various bioactive substances including alkaloids, flavonoids, polyphenols, saponins, steroids, and terpenoids. The geographical origin of propolis production can influence its composition of secondary metabolites. This study aimed to qualitatively analyze ethanol extracts of propolis from Bintan, Lampung, and Makassar, and evaluate their phenolic and flavonoid contents, as well as antioxidant activities. The extraction method employed kinetic maceration with continuous stirring over 24 hours, using 70% ethanol as the solvent. Additionally, antioxidant activity was assessed using the DPPH method. The qualitative phytochemical analysis revealed that all three ethanol extracts contained alkaloids, flavonoids, and polyphenols. Saponin compounds were uniquely identified in the Makassar ethanol extract. Furthermore, antioxidant activity tests indicated significant potential in all three propolis extracts. These findings highlight the potential of Trigona sp. Stingless bee propolis as a valuable source of bioactive compounds beneficial for human health.
Formulasi Sediaan Hair Tonic dari Kombinasi Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Dan Ekstrak Lidah Buaya (Aloe vera) Sjamsiah, Sjamsiah; Andriani, Titik; Irmawati, Ekha; Ramadani, Kurnia
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.49604

Abstract

Sediaan penumbuh rambut alami telah menjadi pilihan paling populer karena diolah dari berbagai bahan alami dan mempunyai banyak manfaat dan efek samping yang relatif kecil. Tanaman obat seperti daun sirsak dan lidah buaya merupakan bahan-bahan alami yang dapat digunakan dalam pembuatan sediaan tonik rambut alami. Tujuan penelitian ini adalah untuk mengidentifikasi karakteristik tonik rambut dari berbagai ekstrak dan untuk mengetahui pengaruh ekstrak tonik rambut kombinasi ekstrak daun sirsak lidah buaya terhadap efektivitas pertumbuhan rambut pada hewan uji kelinci dengan menggunakan metode uji organoleptik, homogenitas, uji pH, uji berat jenis, uji viskositas dan uji ANOVA. Hasil penelitian menunjukkan bahwa karakteristik tonik rambut daun sirsak dan lidah buaya berwarna ‘dark olive’ dan bening, berbau khas ekstrak daun sirsak, cair, dan memiliki rasa sejuk pada kulit. Memiliki pH 5-6 dengan berat dosis berkisar antara 0,9519-0,9777 gr/cm3 dan viskositas 0,81-1,11 cPs. Tonik rambut juga memiliki efektivitas yang cukup pada pertumbuhan rambut pada kelinci, di mana persiapan terbaik ditemukan dalam persiapan F2, rasio kombinasi ekstrak adalah 2:1 dengan panjang pertumbuhan rambut rata-rata 0,93 cm.
24-Methylenecycloartanol Isolated from The Fruit Peel of Matoa (Pometia pinnata) and Its Activity as an Antibacterial against Staphylococcus aureus and Escherichia coli Anwar, Risyandi; Arnov, Steffi Triany; Putri, Ghesta Alifka; Sinaga, Siska Elisahbet; Naini, Al Arofatus; Supratman, Unang
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.55682

Abstract

Triterpenoids are compounds with highly diverse chemical structures and exhibit interesting biological activities such as antiviral, antibacterial, anti-inflammatory, and anticancer properties. The matoa plant (Pometia pinnata), belonging to the genus Pometia from the family Sapindaceae, has been used in traditional medicine and shows potential as an antibacterial agent. The purpose of this research was to isolate and determine the chemical structure of triterpenoids from the peel of the matoa fruit (P. pinnata) and to evaluate their antibacterial activity against Staphylococcus aureus and Escherichia coli. The ethyl acetate extract from the peel of P. pinnata demonstrated significant antibacterial activity. In this study, a triterpenoid compound was identified, and its chemical structure was determined using spectroscopic methods, including UV, IR, MS, 1H-NMR, 13C-NMR, and 2D-NMR, as well as by comparing data from the literature. The compound was identified as a cycloartane-type triterpenoid known as 24-methylenecycloartanol. The compound was then tested for antibacterial activity against S. aureus and E. coli. The test results showed a minimum inhibitory concentration (MIC) of 500 μg/mL for both bacteria, which was categorized as very weak
Sintesis Etil 2-(4-Formilfenoksi)asetat melalui Substitusi Gugus Hidroksil 4-Hidroksibenzaldehida Fadlan, Arif; Nurhasan, Moch.
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.50210

Abstract

Senyawa 4-hidroksibenzaldehida merupakan salah satu senyawa fenolat yang mengandung gugus aldehida dan dapat mengalami transformasi struktur melalui berbagai reaksi kimia menghasilkan produk dengan aktivitas biologis yang potensial. Pada penelitian ini struktur senyawa 4-hidroksibenzaldehida dimodifikasi melalui substitusi gugus hidroksil oleh etil kloroasetat dengan perbandingan mol 6:10 (metode A), 5:10 (metode B), dan 2,5:10 (metode C) menghasilkan etil 2-(4-formilfenoksi)asetat. Spektroskopi resonansi magnetik inti 1H dan 13C NMR, inframerah, dan massa digunakan untuk menetapkan struktur hasil sintesis. Hasil penelitian menunjukkan bahwa metode B memberikan produk berupa padatan berwarna putih dengan yield sebesar 70% yang lebih tinggi dibandingkan metode A (yield 23%) dan metode C (yield 47%). Pembentukan etil 2-(4-formilfenoksi)asetat diusulkan terjadi melalui substitusi nukleofilik bimolekular (SN2). 

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