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All Journal Jurnal Natur Indonesia Chimica et Natura Acta Asian Journal of Aquatic Sciences Unri Conference Series: Community Engagement Narra J Makara Journal of Science

Yuana Nurulita

Unknown Affiliation

Author-ID : 335890

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Articles

Potensi Metabolit Sekunder dari Trichoderma sp. LBKURCC22 Tanah Gambut Hutan Sekunder Sebagai Antibiotik Narasswati, Nungki; Oktavia, Rani; Nenci, Nuryani; Eryanti, Yum; Nugroho, Titania Tjandrawati; Nurulita, Yuana
Chimica et Natura Acta Vol 5, No 2 (2017)
Publisher : Departemen Kimia

Trichoderma sp. LBKURCC22 adalah isolat lokal yang diisolasi dari lahan hutan rawa gambut sekunder. Isolat ini berpotensi menghasilkan metabolit sekunder. Tujuan dari penelitian ini adalah untuk menggali potensi metabolit sekunder dari isolat Trichoderma sp. LBKURCC22 dalam fermentasi batch. Metabolit sekunder diekstraksi dengan etil asetat. Ekstrak diuapkan, kemudian diperoleh ekstrak kasar. Analisis dilakukan dengan uji fitokimia, KLT, dan KCKT. Selanjutnya, aktivitas antibiotik dilakukan terhadap Escherichia coli dan Staphylococcus aureus dengan metode dilusi. Uji fitokimia menunjukkan bahwa ekstrak mengandung alkaloid. Namun, aktivitas antibakteri, senyawa metabolit sekunder dari ekstrak tidak aktif terhadap bakteri-bakteri yang diuji. Hasil penelitian menunjukkan bahwa KLT dengan eluen etil asetat:n-heksana (6:4) setelah disemprot dengan 0,5% p-anisaldehid menunjukkan tidak adanya peptaibol pada noda P1 (Rf :0,78), P2 (Rf 0,65), dan P3 (Rf 0). Analisis KCKT menghasilkan ekstrak mengandung satu puncak pada waktu retensi (tR) 4,115 menit pada 214 nm dan 4,106 menit pada 227 nm. Penelitian ini menunjukkan bahwa isolat Trichoderma sp. LBKURCC22 tidak memproduksi metabolit sekunder yang berpotensi sebagai antibiotik. Perlu dilakukan analisis lebih lanjut untuk mengeksplorasi potensi isolat ini.

Penapisan Aktivitas dan Senyawa Antidiabetes Ekstrak Air Daun Dandang Gendis (Clinacanthus nutans) Nurulita, Yuana; Dhanutirto, Haryanto; Soemardji, Andreanus A.
Jurnal Natur Indonesia Vol 10, No 2 (2008)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

An investigation of the antidiabetic activity of Aqueous Extract and its fractions from a different polarity solvent:ethanol, ethyl acetate, and n-hexane of Dandang Gendis Leaves (Clinacanthus nutans Lindau) on Mile SwissWebster Mice has been carried out. The effect of aqueous extract of dose of 50, 100, and 150 mg/kg BW wastested on glucose serum level of alloxan induced that mice. Its fractions were tested by glucose tolerance method.Aqueous extract (150 mg/kg BW) significantly decreased blood glucose serum level (pd”0,05) that had the sameeffect as oral glibenclamide (0,65 mg/kg BW) administrated once a day for 9 days. Aqueous extract that wasfractionated has 5 fraction. Fraction of ethanol extract that was insoluble in ethyl acetate at a dose of 100 mg/kgBW was the most active fraction, that significantly (p<0,05) decreased blood glucose serum level of mice atglucose tolerance method of 18,4% in 3 hours after 2 g/kg BW of glucose administration. Thin layer chromatography(TLC) of that fraction ethanol 95%-chloroform 9:2 as eluent gave 5 spots under ultraviolet ray and showed spesificcompounds by qualitative test. Spot 1 (steroid) gave Rf 0,14; spot 2 and spot 3 that gave Rf 0,53 and 0, 67 wereflavonoid, spot 4 (triterpenoid) gave Rf 0,77; and spot 5 (chlorophyll) gave Rf 0,89. This research show that this plantcan used for hipoglicemic traditional medicine.

Sintesis dan Uji Antibakteri Senyawa Bromo Kalkon Piridin Jasril, Jasril; Teruna, Hilwan Yuda; Zamri, Adel; Alfatos, Darian; Yuslinda, Elka; Nurulita, Yuana
Jurnal Natur Indonesia Vol 14, No 3 (2012)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Three pyridine chalcones including (Z)-1-(4-bromophenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1), (Z)-1-(4-bromophenyl)-3- (pyridin- 3-yl)prop-2-en-1-one (2) and (Z)-1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (3) were synthesized by aldol condensation reactions from pyridinecarbaldehyde with 4-bromoacetophenone. In antibacterial assay, compound 3 exhibited strong activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli with the inhibition zone of 19.9; 19.5, and 17.5 mm, respectively.

Penerapan teknologi biopori dalam pencegahan banjir dan kekeringan yang sekaligus pembuatan biokompos di Kelurahan Delima Kecamatan Tampan Pekanbaru Andi Dahliaty; Yuana Nurulita; Titania Tjandrawati Nugroho; Sri Helianty
Unri Conference Series: Community Engagement Vol 1 (2019): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.1.255-261

Flooding is a problem that almost every year affects urban and rural areas. Generally, in urban areas, floods are caused more by the lack of smooth flow of water (sewage) due to waste dumped into the water stream and the reduction of water catchment areas. The Delima Subdistrict of Tampan Subdistrict has a simple housing area that has a limited home yard measuring around 7m x13m up to 10m x 15m per house unit. To meet clean water needs, this area uses bore wells which over time will reduce underground water reserves. The housing area is sometimes disemenised, which results in a lack of infiltration of rain water so that it is prone to flooding and drought. To overcome this, the community can apply biopore infiltration technology. This service activity aims to introduce biopore infiltration technology and invites the community to apply it and make biocompost from the infiltration hole. The method of service activities was carried out with material delivery techniques and discussions as well as demonstrations or practices in making biopori infiltration holes as an effort to overcome floods and droughts in settlements around the Delima Village, Tampan District, Pekanbaru. From the results of this activity it is known that the target community seemed enthusiastic about the material presented and there was an increase in the knowledge and insights of the participants about biopori absorption technology by around 80%.

Teknologi Biokompos dalam Biopori vertikal di Kelurahan Pematang Pudu Kecamatan Mandau Kabupaten Bengkalis Andi Dahliaty; Yuana Nurulita; Titania Tjandrawati Nugroho
Unri Conference Series: Community Engagement Vol 3 (2021): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.3.156-162

Pematang Pudu Village is one of the villages in Mandau District, Bengkalis Regency which is approximately 116 km from Pekanbaru city. Based on information from residents of RT 02 RW 10 Km 5 Jalan Rangau, Pematang Pudu Village often floods. Floods in this area can be caused by overflowing river water, reduced rainwater catchment areas due to construction and land clearing. This biopore infiltration hole is a simple technology that does not require expensive and effective rainwater absorption. In addition, through this technology, it can reduce organic waste and make biocompost to be used as organic fertilizer that can fertilize plants. The purpose of this service activity is to provide knowledge and skills to the community about the benefits of vertical biopore technology and increase public awareness to prevent flooding. The method used in this service activity is the delivery of material using powerpoint media and field practice and involving community members in RT 02 RW 10 Pematang Pudu Village. The results of this service activity show that 38% of socialization participants have a score range between 75-80, 13.66% of socialization participants have a range of values between 85-90, and 28% of socialization participants have a range of values between 95-100. It can be stated that the provision of training has an effect on increasing public knowledge about biopore infiltration holes.

SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES Eryanti, Yum; Nurulita, Yuana; Hendra, Rudi; Yuharmen, Yuharmen; Syahri, Jufrizal; Zamri, Adel
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.

Deteksi Mekanisme Efflux Pump Pada Resistensi Bakteri Staphylococcus haemolyticus, Sampel Pus Klinis Rumah Sakit Pekanbaru Wardana, Rexi Dwi; Savira, Maya; Anggraini, Dewi; Amalia, Aisyah Sabrina; Nurulita, Yuana
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.52038

Infeksi adalah masalah kesehatan yang disebabkan oleh mikroorganisme patogen seperti bakteri. Salah satu jenis infeksi yaitu infeksi kulit dan jaringan lunak yang umumnya disebabkan oleh Staphylococcus aureus dan menyebabkan pembentukan pus. Saat ini, telah dilaporkan bahwa kasus spesies CoNS (Coagulase Negative Staphylococcus) seperti Staphylococcus haemolyticus sebagai penyebab infeksi, mengalami peningkatan. Selain itu, spesies ini juga diketahui telah mengalami resistensi terhadap beberapa golongan antibiotik. Dalam penelitian ini dilakukan karakterisasi isolat bakteri klinis dari sampel pus agar yang dilakukan dengan identifikasi mikrobiologi (kultur isolat, pewarnaan Gram dan uji biokimia) pada bakteri patogen (Isolat 3887), dan dilanjutkan dengan identifikasi molekuler, antara lain ekstraksi DNA kromoson dan plasmid, amplifikasi gen 16S rRNA, sekuensing dan analisis bioinformatik menggunakan BioEdit, BLAST dan filogenetika. Uji suseptibilitas terhadap 25 jenis antibiotik dan deteksi gen resisten clindamycin (ermA, ermB, ermC dan msrA) dan cefazolin (blaTEM-1, blaSHV dan blaOXA-1) dilakukan untuk mengidentifikasi kemungkinan mekanisme resistensi bakteri patogen. Berdasarkan hasil identifikasi mikrobiologi dan molekuler, isolat 3887 merupakan CoNS dengan strain Staphylococcus haemolyticus. Isolat 3887 resisten terhadap 12 dari 25 antibiotik yang diuji dan memiliki fenotipe resisten tertinggi terhadap clindamycin dan cefazolin. Hasil uji deteksi gen resisten clindamycin dan cefazolin menunjukkan hanya gen msrA yang terdeteksi baik pada kromosom dan plasmid isolat 3887 yang menunjukkan bahwa mekanisme resistensi melalui efflux pump.

SECONDARY METABOLITE CHARACTERISTICS OF HETEROTROFIC BACTERIA PRODUCTION AS ANTIMICROBIAL AT DIFFERENT SALINITY Apriyola, Nadya; Feliatra, Feliatra; Nurulita, Yuana
Asian Journal of Aquatic Sciences Vol. 3 No. 2 (2020): August
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/

This research was conducted from March-June 2019. The purpose of this study was to determine the characteristics of secondary metabolites prduced by of heterotrophic bacterial from sea water Sungai Kayu Ara Village, Siak Regency as an antimicrobial and to determine the storage time of these bacteria by measuring at the optimal growth time. Five bacterial secondary metabolite extracts used were B, C, D, and H (B. cereus) and J (V. fluvialis) obtained from the collection of Marine Microbiology Laboratory, Department of Marine Sciences, Faculty of Fisheries and Marine sciences, University of Riau. phytochemical test showed that extracts of isolates B, D, and H contained saponin compounds, while isolate J contained flavonoid compounds, however, all extracts contained alkaloid compounds. Antimicrobial test indicated that J extract inhibited A. Hydrophila at concentration 500 µg/ml but the extract could not inhibit V. algynolyticus and Pseudomonas sp concentrations determined. In the bacterial storage time test, the optimal growth of each bacterial concentration at was 7th day incubation and decreased on the 14th day.

Metabolomic profiling and antimicrobial investigation of Aspergillus fumigatus LBKURCC269 and Bacillus paramycoides LBKURCC218 co-culture Octarya, Zona; Nugroho, Titania T.; Nurulita, Yuana; Suraya, Nabella; Saryono, Saryono
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1647

The increasing resistance of pathogenic microbes to antibiotics is a major public health concern, necessitating the discovery of effective antimicrobial compounds. The aim of this study was to assess the bioactive metabolites produced by Aspergillus fumigatus LBKURCC269 and Bacillus paramycoides LBKURCC218 under three fermentation conditions: monoculture of each microorganism and their co-culture. Metabolite analyses initiated with gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) followed with molecular networking–Global Natural Products Social Molecular Networking (GNPS) and molecular docking. Antimicrobial activity of the extracts was then conducted. Metabolite analysis using GC-MS identified key antimicrobial compounds, including 2,6-bis(1,1-dimethylethyl)-4-methylphenol, pentadecanoic acid, cyclopropane pentanoic acid, and 3-piperidinol. LC-HRMS, combined with multivariate analysis and GNPS molecular networking, revealed additional antimicrobial compounds, including novel pyrazine derivatives induced in co-culture fermentation. Molecular docking analysis of 3-(propan-2-yl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione demonstrated its potential as an antimicrobial agent by inhibiting topoisomerase IV and cytochrome monooxygenase with binding affinity of -5.34 kcal/mol and -5.6 kcal/mol, respectively. The antimicrobial assays showed that the co-culture fermentation extract had the strongest activity, with inhibition zones of 20.33±0.59 mm (Escherichia coli), 14.33±0.59 mm (Staphylococcus aureus), and 25.67±0.59 mm (Candida albicans). This study highlights the advantages of co-culture fermentation in enhancing the discovery of antimicrobial compounds. The findings underscore the potential of this approach to simplify chemical isolation and accelerate the identification of novel antimicrobial agents for pharmaceutical development.

Co-Authors Adel Zamri Amalia, Aisyah Sabrina Andi Dahliaty Andi Dahliaty Andreanus A. Soemardji Apriyola, Nadya Darian Alfatos Dewi Anggraini Elka Yuslinda Feliatra Haryanto Dhanutirto Hendra, Rudi Hilwan Yuda Teruna Jasril Jasril Jufrizal Syahri Maya Savira Narasswati, Nungki Nenci, Nuryani Oktavia, Rani Saryono Saryono Sri Helianty suraya, nabella Titania Tjandrawati Nugroho Wardana, Rexi Dwi Yuharmen, Yuharmen Yum Eryanti Zona Octarya

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