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Chimica et Natura Acta
ISSN : 23550864     EISSN : 25412574     DOI : -
Chimica et Natura Acta diterbitkan oleh Departemen Kimia, FMIPA, Universitas Padjadjaran tiga kali setiap tahun pada bulan April, Agustus dan Desember. Artikel yang dimuat mencakup Kimia Analisis dan Pemisahan, Kimia Material, Kimia Energi dan Lingkungan, Kimia Organik Bahan Alam dan Sintesis, Biomolekular Pangan dan Kesehatan serta topik-topik lain yang berhubungan dengan ilmu Kimia.
Arjuna Subject : -
Articles 382 Documents
Computational Study of Household Plants as Immunomodulators on Human Metapneumovirus Raizma, Elda Zaelita Nurul; Sopian, Devia Angelina; Alifianto, Handika Maulana; Yahya, Jasmine Rizkyta; Bimantoro, Tanaya Aryo Jalu; Eshananda, Yuriza
Chimica et Natura Acta Vol 14, No 1 (2026)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v14.n1.69624

Abstract

Human metapneumovirus (HMPV) is a causative agent of acute lower respiratory tract infections, especially in children. Until now, there are not many natural-based immunomodulatory therapies available. This study aims to explore the potential of household plants from the Syzygiumand zingiber Genus as immunomodulators against HMPV using computational studies. The target receptor used is RNA-dependent RNA polymerase (RdRp), a vital enzyme in HMPV genome replication. The methods used include molecular docking, validation of biological activity through Way2Drug and evaluation of pharmacokinetic feasibility using Lipinski’s Rule of Five. Based on the docking results, the compounds with the strongest binding affinity are myricetin (-8.3 kcal/mol) from the Syzygiumgenus and 10-gingerdione (-7.2 kcal/mol) from the Zingiber genus. Based on the Way2Drug assay results, myricetin compounds from the Syzygiumgenus showed the strongest antioxidant potential (Pa 0.924). In the Zingiber Genus, the compound 10- gingerdione showed the highest antiviral value (Pa 0.434). Based on the Lipinski’s Rule of Five analysis, quercetin from the Syzygiumgenus and 10-gingerol from the Zingiber genus fulfilled all five criteria. Both showed high potential as natural immunomodulatory agents against HMPV, confirming that secondary metabolites from household plants deserve further research as natural immunomodulators.
Influence of Polyvinyl Alcohol Content on Starch-Based Bioplastic Reinforced with Chitosan and Microcrystalline Cellulose Putra, Bagus Kharisma; Andoko, Andoko; Afandy, Mochamad Viky; Pasha, Muhammad Faizullah; Prasetya, Riduwan
Chimica et Natura Acta Vol 14, No 1 (2026)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v14.n1.70771

Abstract

Starch-based bioplastics are promising sustainable alternatives to petroleum-based plastics; however, their limited mechanical strength and stability restrict broader packaging applications. This study investigates the influence of polyvinyl alcohol (PVA) content on the structural and functional properties of starch-based bioplastic films reinforced with chitosan and microcrystalline cellulose (MCC). Films prepared by solution casting with varying PVA compositions were characterized in terms of density, mechanical properties, thermal stability, biodegradation behavior, antibacterial activity, and structural features. Increasing PVA content produced denser film structures with improved tensile strength and thermal stability, while elongation at break reached its maximum at the intermediate formulation, indicating a strength–ductility trade-off. The control film exhibited antibacterial inhibition zones of 12.6 mm against Staphylococcus aureus and 8.8 mm against Escherichia coli, with activity decreasing at higher PVA content. These findings demonstrate that adjusting PVA composition effectively tailors the multifunctional performance of starch-based bioplastic films for sustainable packaging applications.