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INDONESIA
Indonesian Journal of Rheumatology
ISSN : 20861435     EISSN : 25811142     DOI : -
Core Subject : Health,
Indonesian Journal of Rheumatology is a peer-reviewed open access journal on rheumatic diseases and connective tissue disorders. This is an official journal of Indonesian Rheumatology Associantion (IRA) and published twice a year since 2009. Our mission is to encourage the development of scientific and medical practice in rheumatic diseases and connective tissue disorders. This journal is self-focused on rheumatic disease and connective tissue disorders in the form of original article (extended and/or concise reports), review articles, editorial letters, leaders, lesson from memorable cases, book reviews, and matter arising. Both in clinical and laboratory including animal studies.
Arjuna Subject : -
Articles 307 Documents
Chronic Osteomyelitis of Wrist Joint in An Immunocompromised Host Utari, Amanda P; Oktavia, Dina; Sumaryono, Sumaryono; Setyohadi, Bambang
Indonesian Journal of Rheumatology Vol 5, No 1 (2014)
Publisher : Indonesian Rheumatology Association

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Abstract

Osteomyelitis is heterogenous in its pathophysiology, clinical presentation, and management. Osteomyelitis is generally categorized as acute or chronic based on histopathologic findings, rather than duration of the infection. Necrotic bone ispresent in chronic osteo-myelitis, and symptoms may not occur until six weeks after the onset of infection.1 Epidemiology of chronic osteomyelitis is less well characterized compared with acute osteomyelitis. Adult osteomyelitis most commonly arisesfrom open fractures, diabetic foot infections, or the surgical treatment of closed injuries. Hematogenous  osteomyelitis accounts for approximately 20% of cases of osteomyelitis in adults. It is more common in males regardless of age. Although rare in adults,it most frequently involves the vertebral bodies.2 S.aureus is the most common isolate in all types of bone infection and is implicated in 50-70% of cases of chronic osteomyelitis.3
Prevalence and factors associated with vitamin D deficiency in systemic lupus erythematosus patients Pangestu, Y; Setiati, S; Setiyohadi, Bambang; Sukmana, N
Indonesian Journal of Rheumatology Vol 4, No 1 (2013)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: In addition to the calcium-phosphorus metabolism, vitamin D might also play a role in the immune system. Studies have showed lower levels of vitamin D among SLE patients compared with controls. Researches regarding vitamin D in SLE patients have only been conducted in four seasons’ countries (Caucasians subjects in a large part) , but no data has been available in tropical countries, particularly Indonesia. The presence of VDR gene polymorphism in different populations will affect the role of vitamin D in the immune system. Objectives: To determine the prevalence of vitamin D deficiency and identify its risk factors such as lack of sunlight exposure, sunscreen usage, long-term corticosteroid therapy, disease activity, insufficient vitamin D supplementation, and obesity in SLE patientswith vitamin D deficiency.Methods: A cross-sectional study was conducted on SLE patients who were under treatment at Cipto Mangunkusumo General Hospital or members of Indonesian Lupus Foundation. Then those patients completed questionnaires and their 25(OH)D serum levels were measured. The cut-off value of 25(OH) D levels for vitamin D inadequacy is 75 nmol/L, which then grouped into vitamin D insufficiency (25(OH)D 25 - <75 nmol/L) and vitamin D deficiency (25(OH)D <25 nmol/L). SLE activity was assessed with MEX-SLEDAI.Results: During May-June 2008, 80 SLE patients were enrolled with 96.3% female subjects, median age of 26 years (range 17-56 years), 66.3% non-obese, 93.8% using steroid, 62.5% with active disease, and 63.8%have adequate sun exposure. In addition, 81.5% didnot use sunscreen and 83.8% did not take vitamin D supplementation. All patients had vitamin D inadequacy with 41.2% in insufficiency level and the other 58.8% in deficiency level. The median of 25 (OH)D levels were 21.85 nmol/L (range 11.5-57.7 nmol/L). It also has been found that vitamin D deficiency occurred more in subjects who were obese, used sunscreens, had lower exposure to sunlight, in a long-term high-dose steroid therapy, had active SLE disease, and had no vitamin D supplements.Conclusions: All SLE patients had vitamin D inadequacy. Vitamin D deficiency occurred more in subjects who were obese, used sunscreens, had lower exposure to sunlight, in a long-term high-dose steroid therapy, had active SLE disease, and had no vitamin Dsupplements.
Diagnostic criteria of knee osteoarthritis in rheumatology outpatient clinic, Dr. Sardjito Hospital, Yogyakarta Kertia, Nyoman; Wachid, Deddy Nur; Krishnan, P N
Indonesian Journal of Rheumatology Vol 3, No 1 (2011)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: Osteoarthritis (OA) is a chronic condition characterized by the breakdown of joints cartilage. Approximately 25% of persons 55 years of age or older have knee pain on most days and about half of them have radiographic OA in the knee. Prevalence of knee OA increases with age and it is more common in women than men. It is not easy to establish the diagnosis of knee OA since other knee disorders have similar clinicalsigns and symptoms.Objective: The purpose of this study was to observe the diagnosis pattern of knee OA in rheumatology outpatient clinic at Dr. Sardjito Hospital based on clinical and radiographic criteria of American College of Rheumatology (ACR). Method: The design of this study was cross-sectional. Data of the patients with knee OA were investigated from their medical records. Results: There were 212 subjects diagnosed with knee OA during the year 2000–2010. Most of the subjects (90.56%) were more than 50 years old. Women were more frequent affected by OA than men. All of the subjects (100%) had knee pain. Crepitus was found in98.11% subjects. Morning stiffness less than 30 minutes was found in 86.79% subjects. Osteophyte appearances were found in 79.72% subjects.Conclusion: Knee pain, crepitus, and age more than 50 years old were the most frequent criteria used to diagnose knee OA. Morning stiffness less than 30 minutes and osteophyte appearances were also frequent in knee OA.
Osteomalacia Induced by Renal Tubular Acidosis Type 1 Sihombing, Steven Sutanto; Ariane, Anna; Wibowo, RM Suryo Anggoro Kusumo; Setyohadi, Bambang
Indonesian Journal of Rheumatology Vol 9, No 2 (2017)
Publisher : Indonesian Rheumatology Association

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Abstract

Renal Tubular Acidosis, a group of disorders characterized by defective renal acid-base regulation, can impair mineralization of bone matrix in adults known as osteomalacia. RTA is classified into 3 major forms, such as proximal RTA or type 2; distal RTA or type 1; and hyperkalemic RTA or type 4. Among all type of RTA, proximal RTA or type 2 is known have association with Fanconi syndrome and bone involvement. However, distal RTA or type 1 can also cause osteomalacia. Hereby we report a case of 22 years old Asian woman who wasfirstly diagnosed with distal type RTA several years ago then started developing bone involvement recently. She was complaining with low back pain due to fracture on left medial side of inferior pubic ramus and endplate fracture on right side superior L4 and BMD examination showed low mineral density. She was diagnosed with osteomalacia induced by distal type RTA due to the loss of calcium salts from bone and hypophosphatemia.Keywords: Osteomalacia; Renal Tubular Acidosis; Hypokalemia; Hypophosphatemia
Correlation of Random Urine Protein Creatinine (P-C) Ratio with 24-Hour Protein Urine in Lupus Nephritis Patients Aini, Y H; Tjandrawati, A; Suraya, N; Hamijoyo, Laniyati
Indonesian Journal of Rheumatology Vol 8, No 1 (2016)
Publisher : Indonesian Rheumatology Association

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Abstract

Background : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs including kidney and known as lupus nephritis (LN). Lupus nephritis has a poor prognosis after a 10-years onset, more than 25% will be ended by end stage renal disease. There are glomerular and tubulointerstitial tissue damages due to immune complex deposits in LN which is activating inflamation cascade and causing disfunction of glomerular filtration and tubular reabsorption resulting proteinuria. In LN, proteinuria is used to diagnose, to assess the disease activity and to monitor the therapy. The gold standard of proteinuria is 24-hour urine protein examination, but the process ofcollecting in 24 hour urine is difficult, then the result is less accurate and reliable. Another alternative parameter is spot urine protein/creatinine ratio. Several studies have found a positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels, but in LN, the results are various.Objective: The aim of this study was analyzing the correlation between spot urine protein/creatinine ratio and 24-hour urine protein in lupus nephritis.Methods: The study was conducted at Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia in October 2014 to December 2014. The subjects were 45 patients with lupus nephritis based on the criteria of the American College of Rheumatology. The study analyzedcorrelation through cross-sectional model. Results: The results of Spearman correlation test analysis showed a significantly strong positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels in lupus nephritis (rs =0.96; p <0.001). Based on the degree of proteinuria there was a strong positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels in lupus nephritis significantly on the degree of protein <1 g/24-h (rs = 0.91; p <0.001) and at 1–3.5 g/24-h (rs = 0.73; p<0.05).Conclusion : There is a significant strong positive correlation between spot urine protein/creatinine ratio and the 24-hour urine protein levels in lupus nephritis, so it is recommended to use spot urine protein/creatinine ratio, as an alternative quantitative examination in lupus nephritis.Keywords: lupus nephritis, 24-hour urine protein, spot urine protein/creatinine ratio
Atherosclerosis prevalence and the correlation between atherosclerosis risk factors and carotid intima-media thickness in below 40-year-old women with systemic lupus erythematosus Sari, R M; Kasjmir, Yoga I; Antono, D; Setiati, S
Indonesian Journal of Rheumatology Vol 2, No 2 (2010)
Publisher : Indonesian Rheumatology Association

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Abstract

Objectives: To determine the prevalence of atherosclerosis in female systemic lupus erythematosus (SLE) patients aged below 40 years old and the factors correlated with carotid intima-media (CIM) thickening.Methods: A cross-sectional study was conducted on 80 female SLE respondents aged below 40 years old who were either in- or outpatient of Cipto Mangunkusumo General Hospital, Jakarta. History of disease and treatment was taken, and laboratory test and  ultrasonography of the carotid artery to evaluate CIM thickness were performed.Results: The prevalence of atherosclerosis was 40%, comprising of CIM thickening and/or presence of atherosclerotic plaque in the carotid artery. The median values of CIM thickness in the right common carotid artery, right carotid bulb, left common carotid artery, and left carotid bulb were 0.040 cm, 0.04535 cm, 0.0430 cm, and 0.047 cm, respectively. There was also a positive correlation reported of CIM thickness with increased age, the duration of SLE disease, and the duration of steroid treatment.Conclusions: We found a positive correlation of CIM thickness with age, the duration of SLE disease, and the duration of steroid treatment in female SLE patients aged below 40 years.
The Characteristic of Anti dsDNA and Organ System Involved in Systemic Lupus Erythematosus Patient at Hasan Sadikin General Hospital, Bandung Nadifa, Safira; Achadiyani, Achadiyani; Dharmadji, Hartati Purbo; Hamijoyo, Laniyati
Indonesian Journal of Rheumatology Vol 9, No 1 (2017)
Publisher : Indonesian Rheumatology Association

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Abstract

Background : Clinical manifestation of Systemic Lupus Erythematosus (SLE) may be varies in attacking various body tissue and organ system. Anti-dsDNA is the important antibody indetermining diagnosis and prognosis of SLE. This study was conducted to explain the characteristics of antidsDNA and organ system involved in SLE patients.Method:  We used quantitative descriptive analysis methods. Data were collected from medical records of SLE patients who came to Dr. Hasan Sadikin Bandung General Hospital Rheumatology Clinic from September to November 2016. Using categorical descriptive research equation, we found that total minimum samples were 67 subjects. Data observed included the level of anti-dsDNA antibody and clinical manifestation of organ systeminvolved.Result: From 67 samples, there were 65 females which accounted for 97% of the research subjects. Distribution of organ system involved in our subjects was musculoskeletal (29%), mucocutaneous (27%), hematologic (21%), kidney (15%), neuropsychiatry (4%),lung involvement (4%) and cardiovascular (0%). Organ system involved related with strong positive anti-dsDNA were mucocutaneous (21,6%), hematologic (25%), musculoskeletal (12,5%), kidney (14,3%) and lungs (20%).Conclusion:  The most frequent organ system involved in SLE patients at our setting was musculoskeletal. The common organ involvement related with strong positive antidsDNA were mucocutaneous, musculoskeletal, and hematologic. Keywords: anti-dsDNA, involvement of organ system, clinical manifestation, systemic lupus erythematosus
Diabetes insipidus in neuropsychiatric-systemic lupus erythematosus patient Pangestu, Y; Wardoyo, A; Wijaya, Linda K; SETIYOHADI, BAMBANG; Albar, Zuljasri; Sukmana, N; Budiman, Budiman; Djoerban, Z; Effendy, S; Aziza, L; Sitorus, F
Indonesian Journal of Rheumatology Vol 2, No 1 (2010)
Publisher : Indonesian Rheumatology Association

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Abstract

Systemic lupus erythematosus (SLE) is an idiopathic autoimmune chronic inflammatorydisease that is unique in its diversity of clinical manifestations, variability of disease’s progression, and prognosis. The disease is characterized by the remission and multiple flare-ups in between the chronic phase that may affect many organ systems.The prevalence of SLE in the US population is 1:1000 with a woman to man ratio of about 9-14:1. At Cipto Mangunkusumo Hospital, Jakarta in 2002, there was 1.4% cases of SLE of the total number of patients at the Rheumatology Clinic. Neuropsychiatric manifestations of SLE (NP-SLE) have a high mortality and morbidity rates. The incidence of NP-SLE ranges 18-61%. Diagnosis of NP-SLE is difficult because there is no specific laboratory examination. Accordingly, in all SLE patients with central nervous system (CNS) dysfunction, additional tests will be necessary to confirm an NP-SLE diagnosis and exclude other causes. Similar to diabetes insipidus, SLE is a systemic disease which affects many organ systems, one being the endocrine system. No data has specified the occurrence rate of diabetes insipidus in SLE patients. This disease arises from a number of factors able to interfere with the mechanism of neurohypophyseal renal reflex resulting in the body’s failure to convert water.3 There are three general forms of the disease, a polydipsicpolyuric syndrome caused by partial/complete vasopressin deficiency (central-diabetes-insipidus/CDI), vasopressin resistance of the kidney tubules (nephrogenic-diabetes-insipidus/NDI), and primary polydipsia. CDI occurs in about 1 in 25,000 persons
Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Pambudi, Joko Rilo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Systemic sclerosis and hyperthyroidism in pregnancy Awalia, Awalia; Yuliasih, Yuliasih; Soeroso, Joewono
Indonesian Journal of Rheumatology Vol 4, No 1 (2013)
Publisher : Indonesian Rheumatology Association

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Abstract

Systemic sclerosis (SSc) is a connective tissue disease affecting women of childbearing age at least five times more than men. For a long time, pregnant women with SSc have high morbidity and mortality based on case reports and case series. Therefore, the disease was a contraindication for pregnancy. However, current retrospective studiesshow that despite of an increased frequency of prematurity and small for gestational age infants, overall maternal and neonatal survival is good. With close monitoring and appropriate therapy, most scleroderma patients can sustain a successful pregnancy.

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