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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
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Articles 25 Documents
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Search results for , issue "Vol 22, No 6 (2022)" : 25 Documents clear
Carbon/Alginate/Chitosan Composite as a Sorbent for Solid-Phase Extraction and Preconcentration of Cu(II) Ahmad Akhib Ainul Yaqin; Suherman Suherman; Mudasir Mudasir; Dwi Siswanta
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70587

Abstract

Carbon/Alginate/Chitosan Composite (CAC) as a sorbent for solid-phase extraction of Cu(II) (pre-concentration) with atomic absorption spectrometry for analysis was successfully prepared. The sorbent was made with a mass ratio of chitosan:alginate:carbon = 1:1:1. CAC sorbents were characterized using FTIR for functional group analysis while SEM-EDX characterization was performed to determine surface morphology and percentage of elements. SPE parameters were optimized for adsorption-desorption efficiency under various conditions, i.e. of pH 5, Cu(II) concentration of 4 mg/L, the flow rate of Cu(II), and Na2EDTA eluent at 5 mL/min, the volume of Cu(II) sample and Na2EDTA eluent 25 mL and 1.0 M of Na2EDTA eluent concentration. Applying CAC-based SPE for Cu(II) analysis in water samples at optimum conditions gave 80.9–83.6% recovery. In bottled drinking water samples, a pre-concentration factor of 2.5–5 times was obtained, and the Cu(II) concentration of 0.017–0.020 mg/L was detected.
Adsorption of Pb(II) on Calix[4]arene Derivatives: Kinetics and Isotherm Studies Busroni Busroni; Dwi Siswanta; Jumina Jumina; Sri Juari Santosa; Chairil Anwar
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70665

Abstract

This study aims to investigate the application of two calix[4]arene derivatives named 5,11,17,23-tetra-(t-butyl)-25,26,27,28-tetrahydroxycalix[4]arene (TBCA) and 5,11,17,23-tetra-(t-butyl)-26,27,28-tribenzoyloxycalix[4]arene (TBMTCA) as adsorbents of Pb(II) from aqueous solution in a batch system. Adsorption was carried out by varying pH solution, exposure time, and concentration. The kinetics was evaluated based on the adsorption in various exposure times using the Lagergren and Ho equations, while the isotherms were analyzed based on the adsorption in various Pb(II) concentrations using the Langmuir and Freundlich equations. Furthermore, the isotherm model showed the Pb(II) adsorption of TBCA and TBMTCA followed Langmuir model with a capacity of 137.29 and 128.46 mg/g, respectively. Based on the adsorption capacity, both adsorbents are the potential for the removal of heavy metal cations from polluted water.
Synthesis of Vanillin-Azine as Colorimetric Chemosensor of Sulfide Anion Nevi Faizatu Rokhmah; Muhammad Idham Darussalam Mardjan; Bambang Purwono
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.71569

Abstract

Vanillin-azine (VA), (4,4'-((1E,1'E)-hydrazine-1,2-diylidenebis(methane-lylidene))bis(2-methoxyphenol) has been synthesized from vanillin and tested as anion colorimetric chemosensors for sulfide anion. The VA was obtained from a condensation reaction between vanillin and hydrazine hydrate with a mol ratio of 2:1 mol for 24 h at room temperature. The structure was elucidated using FTIR, GC-MS, 1H-NMR, and 13C-NMR spectrometers. The VA compound was examined as a colorimetric chemosensor for sulfide anion over several anions of CN−, F−, Cl−, Br−, I−, N3−, CH3COO−, and NO3−. The structure of the product showed agreement with all spectrometric data. The VA chemosensor tests indicated only selective to S2− anion followed by a color change from colorless to light blue in a DMF:HEPES buffer solution (DMF:HBS) medium (9:1, v/v, 10 mM, pH = 7.4). Filter paper strips can detect S2− anion with a color change from white to yellow. The VA chemosensor has a limit of detection (LOD) of 5.4 × 10−4 M, therefore, the VA chemosensor can be applied to detect S2− anion in tap water.
Characterization of α-Glucosidase Inhibitor Streptomyces sp. IPBCC.a.29.1556 Aqueous Extract: An Endophyte of Indonesian Ficus deltoidea Isra Janatiningrum; Yulin Lestari; Dedy Duryadi Solihin; Anja Meryandini
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72433

Abstract

Filamentous bacteria have been known as actinobacteria which could produce various secondary metabolites, including an α-glucosidase inhibitor. The α-glucosidase inhibitor has been identified to be potentially valuable for the treatment of diabetes mellitus. Endophytic actinobacteria are able to produce bioactive compounds that are similar to their hosts. Indonesian Ficus deltoidea is one of the medicinal plants which has the activity of the α-glucosidase inhibitor. The α-glucosidase inhibitor has been characterized by optimizing compound production, fractionation, analysis using TLC and LC-MS, and identifying inhibitor mechanisms. The α-glucosidase inhibitor substance is present in Streptomyces sp. IPBCC.a.29.1556 aqueous extract. The aqueous extract was separated and fraction 1 had an IC50 value of 58.8 μg/mL, which is better than acarbose (IC50 = 90.4 μg/mL). Kinetic studies revealed that this fraction inhibited the enzyme through a non-competitive mechanism. Chemical profile based on LC-MS, fraction 1 showed the presence of Phenylpropynal, Butyric acid, 2-(2-Ethoxyethoxy)ethanolate, 1,1-Diethoxyethane acetate, N,N-dimethyl-3-oxide-1H-Benzotriazole-1-propanamine, p-coumaric acid, and isoquinolinium which might contribute individually or synergistically to the observed α-glucosidase inhibitor activity. These results suggest that fraction 1 from the aqueous extract of Streptomyces sp. IPBCC.a.29.1556 is the potential source to produce an α-glucosidase inhibitor for the management of postprandial hyperglycemia.
Geochemistry and Potential Hydrocarbon Source Rocks of Rambatan Formation in Karangkobar Area, Central Java Praptisih Praptisih; Yoga Andriana Sendjaja; Vijaya Isnaniawardhani; Anggoro Tri Mursito; Purna Sulastya Putra; Septriono Hari Nugroho
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73162

Abstract

The purpose of the study in the Karangkobar area was to investigate the source rock potential of the fine-grained surface samples of clastic sediments. The use of surface samples for source rock potential study in Indonesia is still limited. We conducted geochemical laboratory analyses in this research, including Total Organic Carbon (TOC), Rock-Eval Pyrolysis (REP), and Gas chromatography–mass spectrometry (GCMS). Seventeen samples have been analyzed for their TOC content. The result shows that TOC values varied between 0.36–1.55%, indicating that the source rock potential level based on the surface samples is poor to fair organic richness. REP was conducted on 16 samples, and the results show that the hydrocarbon-generating characteristics (HI values) ranged from 15 to 163 mg HC/g TOC. The kerogens identified included type II and III kerogen, which indicated the oil and gas-generating potential. Pyrolysis temperature is at maximum (Tmax) in the 276–458 °C, indicating that the samples were thermally immature to mature. GCMS analysis of source rock indicated that the depositional environment of the organic material derived from an open marine and plankton environment. This study is essential to complete the understanding of the petroleum system in Central Java.
Strategies in Improving Sensitivity of Colorimetry Sensor Based on Silver Nanoparticles in Chemical and Biological Samples Hanim Istatik Badi'ah; Dinda Khoirul Ummah; Ni Nyoman Tri Puspaningsih; Ganden Supriyanto
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73194

Abstract

Colorimetric sensors-based silver nanoparticles (AgNPs) are very interesting to be studied and developed because of the simplicity and ease in the principle of detection. It does not require sophisticated and affordable tools but still has high sensitivity. The coefficient extinction of AgNPs is relatively higher than AuNPs of the same size, making the sensitivity of AgNPs higher than AuNPs. The principle of detection is based on the aggregation of nanoparticles with analytes that causes shifting in Localized Surface Plasmon Resonance (LSPR) to a larger wavelength, commonly called a bathochromic shift or redshift. It is a favorite phenomenon because it is more easily observed with naked eyes. This sensor shows a good analytic performance with high sensitivity due to strong LSPR and good strategies that selectively bring interaction between analytes and AgNPs. AgNPs are characterized using UV-Visible (Ultra Violet-Visible), TEM (Transmission Electron Microscope), FTIR (Fourier Transform Infrared), and DLS (Dynamic Light Scattering), and many analytes have been detected with this sensor successfully. This article discusses several important parameters in increasing the sensitivity of AgNPs colorimetric sensors. Finally, it can be used as guidelines in the development of methods in the future.
Low-Cost Yet High-Performance Hydrochar Derived from Hydrothermal Carbonization of Duku Peel (Lansium domesticum) for Cr(VI) Removal from Aqueous Solution Risfidian Mohadi; Novie Juleanti; Normah Normah; Patimah Mega Syah Bahar Nur Siregar; Alfan Wijaya; Neza Rahayu Palapa; Aldes Lesbani
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73353

Abstract

Carbon-based adsorbent as a hydrochar (Hc) material with Duku (Lansium domesticum) peel precursors has been successfully synthesized as evidenced by XRD, FT-IR, BET, and SEM analysis. XRD analysis showed the presence of diffraction peaks around 16° and 22° which indicated the presence of carbonaceous material. This is confirmed by FTIR analysis which shows the presence of vibration at 2931 cm−1 of cellulose. SEM data results showed that heterogeneous and has an irregular shape and surface area increased twice from Duku peel to Hc. Duku peel and Hc adsorbent materials were applied to adsorb heavy metal ions Cr(VI). Kinetic parameters of Cr(VI) using Duku peel and Hc showed that the optimum time reached was at 120 min. The adsorption kinetics model of Cr(VI) using Hc tends to follow the PFO model and Langmuir isotherm adsorption. Duku peel material used to adsorb Cr(VI) reached an adsorption capacity of 42.19 mg/g, while in Hc material there was an increase that reached 80.64 mg/g. The thermodynamic parameters of both materials show that the adsorption process is spontaneous.
Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes Rizal Irfandi; Indah Raya; Ahyar Ahmad; Ahmad Fudholi; Hasnah Natsir; Desy Kartina; Harningsih Karim; Santi Santi; Subakir Salnus
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73738

Abstract

The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.
Recent Advances and Future Prospects of Molecular Imprinting Polymers as a Recognition Sensing System for Food Analysis: A Review Almajed Asaad Abdullah Sfoog; Norlaili Abu Bakar; Nurulsaidah Abdul Rahim; Wan Rusmawati Wan Mahamod; Norhayati Hashim; Siti Kamilah Che Soh
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73879

Abstract

Molecular imprinting polymers (MIPs) have been widely used to produce stable polymeric materials due to their highly selective binding sites to determine the analyte (target molecule) in food products. MIPs begin with a complex compound between the template molecule and the functional monomers that can be polymerized when there is a closely crossed link. MIPs left specific cavities after the removal of templates during washing, which complements the size and shape of the templates. The use of MIPs has contributed to novel advances in materials science, polymer science, natural science, and other multi-disciplinary systems. Optical chemical sensor is an exciting field in MIPs today due to comprehend the unique affirmation limit of associated polymers giving stable polymers with high molecular recognition capabilities. MIPs display a wide extent of relevance, incredible flexibility, security, and high selectivity; their internal affirmation districts can be explicitly gotten together with design molecules to achieve specific affirmation. This review covers the various achievements of sensors used in laboratory analyses. The advancement in the development of MIPs is evaluated with an accentuation on the preparation principle, the discovery process, the molecular recognition mechanism and future perspectives and challenges for MIPs in building an optical chemical sensor.
Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies Gunasingham Parthiban; Ramachandren Dushanan; Samantha Weerasinghe; Dhammike Dissanayake; Rajendram Senthilnithy
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.74167

Abstract

The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, higher HDAC expression is frequent in various cancers, resulting in the dysregulation of several target genes involved in cell proliferation, differentiation, and survival. In this study, the inhibitory feasibility of several HDAC inhibitors was investigated, including vorinostat (SAHA), N-hydroxy-3-phenylprop-2-enamide (CPD1), N-hydroxy-3-(pyridine-4-yl)prop-2-enamide (CPD2), N-hydroxy-3-(pyridine-2-yl)prop-2-enamide (CPD3), 4-(diphenylamino)-N-(5-(hydroxyamino)-5-oxopentyl)benzamide (CPD4), 2-(6-(((6-fluoronaphthalen-2-yl)methyl)amino)-3-azabicyclo[3.1.0]hex-3-yl)-N-hydroxypirimidine-5-carboxamide (CPD5), and N-(3-aminopropyl)-N-hydroxy-2-((naphthalene-1-yloxy)methyl)oct-2-enediamide (CPD6). By examining the stability of the enzyme, positional stability of the individual amino acids, and binding energies of HDLP-inhibitor complexes, the inhibitory feasibility was assessed. The complexes of the HDLP enzyme with SAHA, CPD4, CPD5, and CPD6 had higher stability than the other studied complexes, according to the results of trajectory analysis and the Ramachandran plot. Based on the calculated MM-PBSA binding free energies, the stability of the HDLP enzyme followed this order CPD4 > CPD5 > SAHA > CPD6 > CPD2 > CPD3 > CPD1. The drugability values followed the same trend as the previous ones. Based on the obtained in silico results, CPD4, CPD5, and CPD6 were discovered to be possible lead compounds as reference inhibitors of SAHA.

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