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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 25 Documents
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Search results for , issue "Vol 26, No 1 (2026)" : 25 Documents clear
Antihypercholesterolemic Activity of Ethanol Extract from Manilkara kauki Leaves: In Vitro and In Silico Studies Meilasari, Renita; Tukiran, Tukiran
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110256

Abstract

Current food consumption patterns are a significant concern in the field of health. For example, the habit of consuming high-calorie, high-saturated-fat, and high-sugar junk food contributes to various health problems. Fat, as a molecule required by the body as a source of energy, has adverse effects if its levels exceed the amount needed by the body. One of these effects is an increase in cholesterol levels, a condition known as hypercholesterolemia. Manilkara kauki is a plant that has the potential as an antihypercholesterolemic agent. The objective of this study is to evaluate their antihypercholesterolemic activity both in vitro, using the Liebermann-Burchard method, and in silico, by assessing the inhibition of the HMG-CoA reductase enzyme (PDB ID: 1HW9), which plays a key role in cholesterol synthesis. The antihypercholesterolemic activity assessed via the Liebermann-Burchard assay revealed that the ethanol extract exhibited significant activity, with an IC50 value of 108.91 ppm. Furthermore, LC-MS analysis identified 117 compounds in the extract, which were subjected to molecular docking studies. Three flavonoid compounds, lanaroflavone (−8.69 kcal/mol), sequoiaflavone (−9.28 kcal/mol), and sumaflavone (−8.55 kcal/mol), demonstrated higher binding affinities to HMG-CoA reductase than the positive control, simvastatin (−8.53 kcal/mol).
Multifunctional Coumarin-Derived Metal Complexes: Synthesis, Bio-Screening, and In Silico Target Evaluation Shahid, Zulfiqar Ali; Tabassum, Rukhsana
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110413

Abstract

Antibiotic resistance and oxidative stress-related diseases are emerging as serious global health concerns. These challenges underscore the urgent need for novel, effective, and environmentally friendly therapeutic agents. Coumarin derivative (ZL) and its Mn(II) and Zn(II) metal complexes were synthesized. Structural characterization was performed using various analytical techniques, including FTIR, XRD, 1H-NMR, 13C-NMR, TGA, and MS. FTIR spectra confirmed the existence of the –N=N– functional group of the coumarin-derived ligand. The antioxidant potential of the coumarin-derived compounds (against DPPH and NO) was evaluated. The ZL exhibited the most potent activity, with IC50 values of 6.48 μg/mL for the DPPH assay and 6.91 μg/mL for the NO radical scavenging assay. Antibacterial activities were evaluated against both Gram-negative and Gram-positive bacteria. Molecular docking studies further supported the biological potential of Zn-ZL, which showed strong binding affinities to oligo-1,6-glucosidase (PDB ID: 3AJ7) and mannosyl-oligosaccharide glucosidase (PDB ID: 4J5T), with binding energies of −8.5 and −9.4 kcal/mol, respectively. These findings revealed the therapeutic potential of coumarin-derived compounds and their metal complexes, particularly in addressing oxidative stress and antibiotic resistance.
Synthesis and Biological Activity of Ni(II), La(III), and Ce(IV) Complexes with 8-Hydroxy-7-iodo-6-((4-sulfophenyl)diazinyl)quinoline-5-sulfonic Acid Ligand Muhi, Noora Qasem; Abbas, Alyaa Khider
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110573

Abstract

In this study, a new azo ligand, 8-hydroxy-7-iodo-6-((4-sulfophenyl)diazinyl)quinoline-5-sulfonic acid (HAQ), was synthesized from 8-hydroxy-7-iodo-quinoline-5-sulfonic acid using a diazotization-coupling procedure and then complexed with La(III), Ni(II), and Ce(IV) ions. The ligand and its metal complexes were analyzed using elemental analysis, FTIR, UV-vis, 1H-NMR, TGA, SEM, ICP, and XRD techniques. Spectral and analytical results indicated the effective coordination of oxygen and nitrogen donor atoms, resulting in stable 1:1 (metal:ligand) of [La(HAQ)Cl2(H2O)2]·5H2O, and (1:2) of [Ce(HAQ)2(SO4)]·H2O and [Ni(HAQ)2(H2O)2]·4H2O complexes. Thermal analysis has revealed that metal complexes are more thermally stable than their corresponding free ligands. SEM showed significant morphological modifications during complexation, whereas XRD patterns revealed an increase in crystallinity in the metal complexes. The antioxidant characteristics of the synthesized compounds were evaluated using the phosphomolybdate technique, with the Ce(IV) complex displaying the highest activity, most likely due to its redox capacity. Overall, the results highlight the potential of HAQ and its metal complexes as promising candidates for antioxidant and anticancer applications. These findings warrant further mechanistic studies and in vivo evaluations.
A Novel Multiepitope Vaccine for Jembrana Disease: Immunoinformatics, Structural Analysis, Molecular Docking, and Molecular Dynamics Fatimah, Fatimah; Wibowo, Syahputra; Sari, Dini Wahyu Kartika; Pratiwi, Rarastoeti; Kusumawati, Asmarani
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110759

Abstract

Jembrana disease, caused by the Jembrana virus, leads to high mortality (30%) and abortion (49%) in cattle, making vaccination essential. In this study, a multiepitope vaccine was designed using immunogenic TM and CA proteins. Predicted cytotoxic T lymphocyte, helper T lymphocyte, and linear B-cell epitopes were linked with flexible linkers, and the 50S L7/L12 ribosomal protein was added as a TLR4 agonist. In silico analysis confirmed the construct as non-allergenic, antigenic, and thermostable (aliphatic index 85.44), with 94.2% of residues in favored Ramachandran regions. Docking analysis revealed strong binding to TLR4 (−66 kcal/mol), and molecular dynamics simulations validated the structural stability. Immune simulations revealed increased antigen and antibody levels (IgM early, IgG1/IgG2 after day 15), progressive CD4+ T-helper expansion, transient CD8+ T-cell peaks, elevated IFN-γ and IL-2, and strong dendritic cell activation through MHC I and II pathways. These findings indicate the vaccine effectively stimulates humoral and cellular responses, supporting its potential as a promising candidate against the Jembrana virus.
Study of Bioactivity and Physicochemical Properties of New Metal Chelates of Schiff Base Derived from 4-Aminoantipyrine with Cysteine Hussein, Kawther Adeeb; Ali, Dina Naseer; Faeq, Marwa
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111223

Abstract

Transition metallic complexes Cr, Co, Ni, Mn, and Cu were designed and prepared using a new bidentate chelator ligand from 4-aminoantipyrine with cysteine. The products were characterized using various analytical, spectroscopic, and theoretical methods. According to the various analysis data, the azomethine-Schiff base chelator linked with metallic cations as a neutral bidentate chelator exhibited distorted octahedral and tetrahedral structures, with protonated and deprotonated carboxyl oxygen and azomethine nitrogen atoms in a molar ratio of 1:2 metal: ligand in a structure of [M(L)2Cl2]·nH2O and [M(L)2]·Cl2nH2O. According to mass spectroscopy, the molecular weights of the azomethine-Schiff base closely match those estimated by m/z. Additionally, Fourier-transform infrared (FTIR), ultraviolet-visible (UV-vis), 1H-NMR, and 13C-NMR spectra, LC-MS, magnetic moment, and molar conductance were used to study the structure of the azomethine-Schiff base ligand and metallic complexes. The antibacterial activity was tested against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Acinetobacter baumannii, while the antifungal activity was evaluated against Candida albicans, Candida parapsilosis, Candida lusitaniae, and Candida tropicalis. The free ligand showed negligible activity, whereas its metal complexes exhibited moderate to strong antimicrobial effects, confirming that metal coordination significantly enhances biological potency.

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