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INDONESIA
Jurnal Penelitian Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Indonesia Riau
ISSN : 2302187X     EISSN : 26563614     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penelitian Farmasi Indonesia adalah publikasi ilmiah berkala yang terbit dua kali dalam satu tahun (September dan Maret) dan menggunakan sistem peer-riview dalam seleksi makalah. Jurnal Penelitian Farmasi Indonesia menerima naskah publikasi tentang hasil penelitian, survei dan telaah pustaka yang erat kaitanya dengan bidang kefarmasian dan kesehatan.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol. 10 No. 2 (2021): JPFI" : 7 Documents clear
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN TUMBUHAN AKAR KAIK-KAIK (Uncaria cordata (Lour) Merr) TERHADAP MENCIT PUTIH JANTAN (Mus musculus L) Meiriza Djohari; Noveri Rahmawati; Nur Indah Melati
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1402

Abstract

Research on the acute toxicity test of the ethanol extract of kaik-kaik (Uncaria cordata (Lour) Merr) leaves has been carried out on male white mice (Mus musculus L.). This study aims to determine the effects of acute and delayed toxicity of the ethanol extract of kaik- kaik root (Uncaria cordata (Lour) Merr) leaves by determining the LD50 value. The experimental animals were divided into 4 groups, namely the negative control group (NaCMC), and the ethanol extract group of kaik-kaik root leaves with doses of 200, 1000, and 5000 mg / KgBB. The results showed that the LD50 value was> 5000 mg / kg BW and was included in the practical non-toxic category. In the observation, there were no tremors, seizures, salivation, diarrhea, lethargy, weakness, sleep, and coma in each experimental animal.
AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN DAN BATANG SIDAGURI (Sida rhombifolia) TERHADAP MODEL HEWAN DIABETES TIPE 2 Aulia Nurfazri Istiqomah; Widhya Aligita; Hendra Mahakam Putra; Denny Galang; Hapipah Nurjamilah
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1410

Abstract

Diabetes is a disease characterized by increased levels of glucose in the blood that occur due to a lack of insulin production or the cessation of insulin production in the body. Sidaguri herb (Sida Rhombifolia) is known to have antidiabetic activity. This study was conducted to evaluate the antidiabetic activity of the ethanolic extract of the leaves and stems of sidaguri (Sida rhombifolia) in animal of type 2 diabetes model and to find out which part is the most effective as antidiabetic. This research method is an in vivo experimental study. Mice were divided into 9 groups, that is negative control group, positive control group, Glibenclamide 0.65 mg/KgBW, sidaguri leaf extract at a dose of 3.5; 7; and 14 mg/KgBW, as well as sidaguri stem extract at a dose of 3.5; 7; and 14 mg/KgBW. The test was carried out curatively, the test animals except negative controls were given induction of alloxan monohydrate 80 mg/KgBW via the intravenous route, then after 3 days post-induction, fasting blood glucose levels were checked. The treatment was continued by giving therapy for 14 days via the oral route. The test parameters in this study were the measurement of blood glucose levels on days 0, 7, and 14, and pancreatic histopathology was also performed. The test results show that was found that the extract that gave the best antidiabetic effect was the ethanolic extract of sidaguri leaves at a dose of 14 mg/KgBW but had not been able to fully improve the condition of the pancreatic cells
PENGETAHUAN MASYARAKAT TENTANG APLIKASI CEK-KLIK BPOM PADA OBAT TRADISIONAL DI KUBANG JAYA KAMPAR RATNA SARI DEWI; Muhammad Dani Jabbar
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1411

Abstract

Public warning issued by BPOM in 2017 that 39 traditional medicines were found to contain BKO and in 2018 there were 7 traditional medicines containing BKO. One of BPOM's efforts in monitoring and protecting consumers against the circulation of unlicensed traditional medicines is by presenting the CEK Klik application on Android. This study aims to determine the level of public knowledge about the CEKklik application. This study is an observational study with a descriptive design with concurrent data collection methods through filling out online questionnaires. The research population, namely the Kubang Jaya Kampar community, amounted to 37031. The sampling technique was non-probability sampling with purposive sampling method. The number of samples was 160 respondents who met the inclusion criteria. The results showed that people who have good knowledge are 24.4%, sufficient knowledge is 47.5%, and less knowledge is 28.1%. It can be concluded that most people still do not know about the CEK CLICK application
Optimasi Formula Stick Balm Minyak Atsiri Daun Sereh (Cymbopogon citratus) I Komang Ary Werdhi Widnyana; Windah Anugrah Subaidah; Nisa Isneni Hanifa
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1417

Abstract

The content in lemongrass leaves essential oil (Cymbopogon citratus) has a neurobehavioral effect, so lemongrass leaves essential oil can be useful as aromatherapy. The stick balm form as an innovation of aromatherapy form is required to increase the user’s comfort and ease of application of the product. The aim of this study is to determine the optimum formula and physical properties of lemongrass essential oil stick balm form with additive variations of cera alba and lanolin. Eight stick balm formula designs were determined by using SLD (Simplex Lattice Design), method with Design Expert 11 software, and made by using melting method. The stick balm forms were tested for the physical properties such as pH test, melting point test, and adhesion test. The response to the physical properties test was processed by using Design Expert 11 software to obtain optimal formula. The optimal form of stick balm was tested for physical, organoleptic, and homogeneity properties. The results of the physical properties test of optimal formula were verified by using one sample t-test method with SPSS software. The results of the optimization of the formula were 5,310% of lanolin and 11,690% of cera alba. The stick balm forms were bright yellow in color, have a characteristic smell of lemongrass essential oil, semi-solid consistency, homogeneous mixed materials, pH level of 5,63±0,06, melting point of 44,5±0,5oC, and adhesion tests of 2,437±0,106 seconds, with the result that, the optimum formula of stick balm met requirements for the physical properties. The physical properties of the optimal formula are not significantly different from the predictions in the Design Expert 11 application.
KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook) Rahayu Utami Utami; Ginta Rio Maranti; Mustika Furi; Melzi Octaviani; Septi Muharni; Fina Aryani; Husnawati; Wira Noviana Suhery; Musyirna Rahmah Nst; Haiyul Fadhli; Emma Susanti; Emrizal
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1418

Abstract

Simpur air is one of plant that has been using as traditional medicine for treating several diseases. Some studies on its chemical constituents and biological activities of this species have been published. However, chemical constituents and antioxidant activity of this plant which is Riau origin has not been reported before. This study aims to determine the total of phenolic and flavonoid content as well as its antioxidant activity of methanol extracts of roots, leaves and flowers of simpur air. Determination of total of phenolic and flavonoid content was performed by spectrophotometric method using Folin Ciocalteu and AlCl3 as reagents, respectively. Whereas, its antioxidant activity was evaluated using DPPH method. The results showed that methanol extracts of its roots afforded the highest total of phenolic and flavonoid content and also its antioxidant activity. The total of phenolic content of methanol extracts of its roots of 428.131 GAE/mg extract; its total of flavonoid content of 766.164 QE/mg extract; as for its antioxidant activity gave IC50 value of 3.852 µg/ml.
A ANALISIS KETERKAITAN SIKAP DAN PENGETAHUAN PASIEN HIPERTENSI TERHADAP KEPATUHAN PENGGUNAAN OBAT ANTI HIPERTENSI DI RUMAH SAKIT ISLAM PURWODADI: Sikap dan pengetahuan pasien hipertensi terhadap obat anti hipertensi Ratna Wulandari Ratna; Delia Paramita; Eleonora Maryeta Toyo
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1416

Abstract

ABSTRAK Hipertensi merupakan penyakit yang memiliki angka prevalensi yang tinggi. Hipertensi dapat distabilkan dengan melakukan pola hidup yang sehat dan menggunakan obat anti hipertensi. Penggunaan obat antihipertensi diperlukan kepatuhan agar hipertensi dapat terkontrol. Kepatuhan pasien dalam melaksanakan pengobatan harus dipertahankan dalam jangka waktu yang lama, oleh sebab itu pasien harus memiliki pengetahuan yang baik dan sikap yang positif terhadap hipertensi. Tujuan penelitian ini adalah untuk mengetahui hubungan sikap dan pengetahuan pasien hipertensi terhadap kepatuhan peggunaan obat anti hipertensidi Rumah Sakit Islam Purwodadi. Penelitian ini menggunakan metode sensus dengan rancangan Cross Sectional. Desain ini digunakan untuk meneliti suatu kejadian dalam waktu yang bersamaan atau dalam sekali waktu. Teknik sampling dalam penelitian ini menggunakan metode sensus. Instrumen penelitian yang digunakan berupa kuesioner. Analisis data yang digunakan adalah analisis univariat dan bivariat. Dari analisis univariat didapatkan hasil 65% responden memiliki sikap yang baik, 70% responden memiliki tingkat pengetahuan yang baik, serta 55% responden memiliki kepatuhan minum obat antihipertesi yang tinggi. Pada analisis bivariat dengan uji statistik Chi Squareα < 0,05 didapatkan hasil bahwa ada hubungan antara sikap dan kepatuhan minum obat antihipertensi (p value= 0,005), dan terdapat hubungan antara tingkat pengetahuan dan kepatuhan minum obat antihipertensi di Rumah Sakit Islam Purwodadi (p value = 0,021). Kata kunci: hipertensi, pengetahuan, sikap, kepatuhan, antihipertensi
UJI AKTIVITAS ANTIBAKTERI INFUSA DAUN SIRIH (Piper betle L.) TERHADAP BAKTERI Escherichia coli Hasyrul Hamzah; Amrina Rossada Septilapani; Neni Frimayanti
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1434

Abstract

Research has been carried out on the antibacterial activity test of betel leaf infusion against Escherichia coli bacteria by solid dilution method. This study aims to determine the antibacterial activity of betel leaf infusion (Piper betle L.) against Escherichia coli bacteria. Bacterial control used a bacterial suspension dilution of 10-5 with a colony count of 212.33 colonies/mL and the control media showed that the media used was free from contamination. The results of the antibacterial research showed that the infusion of betel leaf had activity in inhibiting the growth of Escherichia coli bacteria at an infusion concentration of 25% with the number of colonies 188.33 colonies/mL, 50% with the number of colonies 160.66 colonies/mL, 75% with the number of colonies 137, 33 colonies/mL and 100% with the number of colonies 106.33 colonies/mL. The results of data analysis with the percentage decrease in the number of betel leaf infusion colonies against Escherichia coli bacteria that the higher the betel leaf infusion concentration, the less the number of bacterial colony growth, there was a difference marked by the difference in the number of bacterial colonies between control bacteria and the number of bacterial colonies at each concentration infusion.

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