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INDONESIA
Indonesian Journal of Pure and Applied Chemistry
Published by Universitas Tanjungpura
ISSN : 26208571     EISSN : 2620858X     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Chemistry
Indonesian Journal of Pure and Applied Chemistry (IJoPAC) was first established in 2018 as a scientific journal that accommodates researchers and education practitioners to publish scientific work and research results which are the results of experiments or literature studies in the field of chemistry. Publications are carried out periodically with three issues (January-April, May-August, September-December) in one volume per year. Published scientific work can be in the form of original articles, short communications and review results covering the fields of Physical chemistry, Organic chemistry, Analytical chemistry, Inorganic chemistry, Biochemistry / Biological Chemistry, Applied Chemistry. Focus and Scope of Indonesian Journal of Pure and Applied Chemistry covering the fields : Physical chemistry Organic chemistry Analytical chemistry Inorganic chemistry Biochemistry/Biological Chemistry Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 124 Documents
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AKTIVITAS ANTIINFLAMASI EKSTRAK BIJI PINANG (Areca catechu L.) MENGGUNAKAN METODE STABILITAS MEMBRAN RED BLOOD CELL (RBCs) (ANTI-INFLAMMATORY ACTIVITIES OF ARECA (Areca catechu L.) FRUIT SEED EXTRACTS USING RED BLOOD CELL (RBCs) MEMBRANE STABILITY METHOD) Banan Fitriani; Harlia Harlia; Andi Hairil Alimuddin
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 1 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i1.61936

Abstract

Areca catechu L. belongs to the Arecaceae which has been widely developed as a raw material for cosmetics industries. Areca nut contains many bioactive compounds, one of which is anti-inflammatory. In this study, the anti-inflammatory activity of betel nut extract was tested using the Red Blood Cell membrane stability method. The results of phytochemical screening showed that areca nut contains flavonoid compounds. Partitioning was carried out with n-hexane, dichloromethane solvents. Partition results obtained fraction of n-hexane 1.442 g with a yield of 5.546%; fraction of dichloromethane 5.831 g with a yield of 22.427%; fraction of ethyl acetate 0.470 g with a yield of 1.807%; and fraction of methanol was 3.432 g with a yield of 13.200%. The results of the anti-inflammatory activity test showed that the highest percent value of hemolysis inhibition was in the 100 g/mL concentration of methanol extract, which was 77.693% compared to the partitioned fractions such as the n-hexane fraction 10.215%; dichloromethane fraction 75.713%; ethyl acetate fraction 73.218% and methanol fraction 48.130%. This value can be said to be good if it approaches or exceeds the positive control of diclofenac sodium, which is 89.613%. The data from this study showed that methanol extract, fraction dichloromethane and fraction ethyl acetate had the best potential as an anti-inflammatory because the percentage of hemolysis was close to positive control
KARAKTERISASI DAN STUDI SINERGI ANALOG KURKUMIN DARI SENYAWA 4-METOKSIBENZALDEHIDA SEBAGAI ANTIDIABETES DENGAN METODE IODIN (CHARACTERIZATION AND SYNERGY STUDY OF CURCUMIN ANALOGS FROM 4-METHOXYBENZALDEHYDE COMPOUND AS AN ANTIDIABETIC USING IODINE METHOD) Khoirotun Nafillah; Chairil Anwar
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 3 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i3.67301

Abstract

Curcumin is the main component of turmeric with various biological activities, one of which is antidiabetic. However, curcumin has low bioavailability and fast metabolism, so repeated doses are required if used as a medicine. Curcumin analogs have better bioavailability than curcumin. This study aims to synthesize curcumin analog from 4-methoxybenzaldehyde and monoketone (cyclohexanone and cyclopentanone), and their synergism effect using iodine method. The compounds A and B have been synthesized using Claisen-Schmidt condensation from benzaldehyde derivatives using KOH 8% and ethanol as solvent. The results showed that the curcumin analogs A and B were yellow solids with yields of 31,13% and 31,87%, respectively. The structure of products was characterized by FTIR, DI-MS, 1H- and 13C-NMR, showed that curcumin analogs A is 2,6-bis(4-methoxybenzylidene)cyclohexanone and curcumin analogs B is 2,6-bis(4-methoxybenzylidene)cyclopentanone. α-amylase inhibition assay of curcumin analogs A and B were performed by formation of amylum-iodine complex with UV-vis spectrophotometer at wavelength of 600 nm, showed that 33,03% and 91,5% at concentration 1 mM. Synergy studies with ferulic acid indicated that compound A 99,23% at a concentration ratio (1:8) and B 99,14% (1:4). This indicates a synergy between curcumin analogs and ferulic acid as an inhibitor of the α-amylase.
POTENSI FRAKSI ETIL ASETAT KULIT BATANG KESAMBI SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli THE POTENTIAL OF ETHYL ACETATE FRACTION OF KESAMBI STEM AS ANTIBACTERIAL AGAINST Escherichia coli Afif Hidayatul Mustafid; Yeyen Maryani; Sri Agustina; Boima Situmeang
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.63497

Abstract

In our previous research, ethyl acetate extract of kesambi stem bark have the highest antibacterial activity against Escherichia coli compared with n-hexane and methanol extract. In our present study, we report the antibacterial activity of fractions from ethyl acetate extract against Escherichia coli. The method of fractionation used coloumn and thin lawyer chromatography. The Antibacterial activity uses Kirby Bauer methods. The characterization of active fractions used spectrometer infrared. The result showed fractions 6 and 7 have the highest antibacterial activity with inhibition zone 11.65 and 7.1 mm. The characterization of fractions 6 and 7 showed fungtional groups C=O, O-H, and C=C. The ethyl acetate fraction has the potential as antibacterial materials.
DAYA HAMBAT EKSTRAK DAUN MANGROVE (Rhizophora apiculata) ASAL PESISIR SUKADANA TERHADAP BAKTERI Escherichia coli (INHIBITION THE LEAF EXTRACT OF Rhizophora apiculata FROM THE SUKADANA COAST AGAINST Escherichia coli) Muhamad Agus Wibowo; Ninda Kumala Sari; Puji Ardiningsih; Afghani Jayuska
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 3 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i3.69965

Abstract

Rhizophora apiculata is a plant that is widely found in mangrove forests in Sukadana subdistrict, and has the potential to inhibit of Escherichia coli. This research aims to determine the activity of R. apiculata which grows in the Sukadana mangrove forest in inhibiting E. coli. The leaves of R. apiculata were macerated with methanol solvent, partitioned into three fractions (n-hexane fraction, dichloromethane fraction, and methanol fraction), and tested for phytochemical screening. The results of phytochemical screening of R. apiculata leaves were positive for flavonoids, alkaloids, phenolics, terpenoids, tannins, and saponins. The potential of R. apiculata leaf samples in inhibiting bacterial growth was measured by the size of the clear zone in the antibacterial test with the agar well diffusion method that uses variations in concentration, namely 250 mg/mL, 125 mg/mL, and 62.5 mg/mL. Based on the research results, it is known that R. apiculata leaves can inhibit the growth of the test bacteria with a minimum inhibitory concentration for methanol extract of 250 mg/mL. The methanol and dichloromethane fractions had minimum inhibitory concentrations of 125 mg/mL and 250 mg/mL respectively, while the n-hexane fraction did not inhibit at all test concentrations. So it can be concluded that the leaves of R. apiculata have the potential as an alternative for antibacterial active compounds
SINTESIS GEOPOLIMER DENGAN BAHAN DASAR KAOLIN CAPKALA SEBAGAI ADSORBEN ION Pb(II) DALAM LARUTAN (SYNTHESIS OF GEOPOLYMERS WITH BASE MATERIALS KAOLIN CAPKALA AS ADSORBENT ION Pb(II) IN SOLUTION) Nur Ridha An Nisa; Intan Syahbanu; Winda Rahmalia; Nurlina Nurlina
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.62731

Abstract

Geopolymer synthesis was carried out using kaolin, for the adsorption of Pb (II) ions in solutions. Kaolin is used by Kaolin Capkala from Bengkayang Regency, West Kalimantan. This kaolin was first modified into metakaolin. The scaling up of geopolymers is carried out by making an activating solution, namely by mixing NaOH and Na2SiO3. The activating solution is mixed into metakaolin. The mass composition of each component in the geopolymer: metakaolin of 94,5 grams, Na2SiO3 of 57 grams, NaOH of 12 grams, and H2O of 30 grams. The formed geopolymers are tested for their adsorption ability against Pb(II) ions. The research results show the success of geopolymer formation as indicated by FTIR and XRD characterization results. Based on the FTIR results, several indications of successful geopolymer formation are seen in the shift and widening of the Si-O absorption peak at wave number 1109 cm-1 for kaolin to 1058 cm-1 for metakaolin and 1016 cm-1 for geopolymer; the appearance of O-C-O bond absorption in CO32- at 1362 cm-1 in geopolymer; and a shift in absorption of Al-O (Al (VI), wherein kaolin it is indicated by a wave number of 536 cm-1 while in metakaolin it is characterized by a wave number of 544 cm-1 and for geopolymer a wave number of 553 cm-1 indicates it. XRD diffractogram of the formation hump's appearance shows the amorphous characteristics of metakaolin and geopolymer at around 2θ 26o-35o. The application of geopolymer for Pb adsorption shows that Pb(II) can be adsorbed well in geopolymers with the maximum adsorption capacity of 2.77 mg/ g obtained at various concentrations of 40 ppm.
SYNTHESIS OF MAGNETITE-MODIFIED NATURAL ZEOLITE USING COPRECIPITATION AND PHYSICAL MIXING TECHNIQUES Teguh Pambudi; Hilman Imadul Umam
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 3 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i3.66363

Abstract

The synthesis of magnetite-modified natural zeolite has been carried out using two techniques, namely coprecipitation and physical mixing. The characteristics (crystallinity, pore characteristics, and recovery capabilities) of the resulting composites are compared. In addition, the effect of the Fe3O4 fraction (25.0% w/w, 33.3% w/w, and 50.0% w/w) on the composite characteristics was also evaluated. The results showed that the natural zeolite/Fe3O4 prepared using the coprecipitation technique showed better distribution of Fe3O4 than the physical mixing technique. It was observed that the natural zeolite's XRD peak intensity decreased as the Fe3O4 content increased. In accordance with the N2 adsorption-desorption isotherm, the pore spaces of the natural zeolite have been found to be filled by suspended Fe3O4 particles. Therefore, both natural zeolite/Fe3O4 prepared by coprecipitation and physical mixing had smaller pore diameters than washed natural zeolite. Then, in terms of recovery ability, natural zeolite/Fe3O4 prepared using the coprecipitation technique has greater recovery ability than natural zeolite/Fe3O4 prepared by physical mixing, with an increase in the Fe3O4 percentage typically enhancing the composite's recovery ability.
AKTIVITAS ANTIRAYAP DARI EKSTRAK METANOL GUBAL KAYU GAHARU BUAYA (Aetoxylon sympetalum) TERHADAP RAYAP TANAH (Coptotermes sp.) (ANTITERMITE ACTIVITY OF METHANOL EXTRACT AGARWOOD BUAYA (Aetoxylon sympetalum) ON SUBTERRANEAN TERMITES (Coptotermes sp.)) Khairunnisa Asyari; Afghani Jayuska; Muhamad Agus Wibowo; Puji Ardiningsih
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.62269

Abstract

Agarwood buaya (Aetoxylon sympetalum) is a Kalimantan endemic plant whose utilization has not been optimal. This plant has potential as an anti-termite, one of which is sapwood. This study aims to determine the content of secondary metabolites from the results of phytochemical screening, components of agarwood buaya sapwood based on GC-MS analysis fraction n-hexane and anti-termite activity against subterranean termites (Coptotermes sp.). Research that has been done is divided into four steps, maceration and fractionation, phytochemical screening, GC-MS analysis, and testing the activity of termites using a forced feeding test method. Crude methanol extract from 1 kg of dried agarwood buaya sapwood was 240.787 g (24.0787%), consisting of 0.8339% n-hexane fraction, 86.3663% chloroform fraction, and 0.7571% methanol fraction. The results of phytochemical screening on agarwood buaya sapwood extract showed that it contained flavonoid, terpenoid, steroid, and phenolic compounds. Identification of the components of agarwood buaya sapwood fraction n-hexane through GC-MS yielded compounds a4-chloro-6-methoxy-2-methylquinolin-8-amine (10.33%), stigmasterol among other (5.94%), n-hexa-decanoic acid (3.2%), 6-octa-decenoic acid (2.99%), and 1,2-Benzene-diol, 3,5-bis(1,1-dimethyl-ethyl) (2.01%). Termite activity test was carried out for 3 days with variations in the concentration of 0% (negative control), 0.1%, 0.2%, 0.3%, 0.4% (w/v), and 0.25% (v/v) (fibronil as positive control). The results of anti-termite testing show the most active fraction was the methanol fraction (LC50 0.146%) followed by the chloroform fraction (LC50 0.167%), methanol crude extract (LC50 0.192%), and the n-hexane fraction (LC50 0.208%).
PENETAPAN KADAR FLAVONOID, FENOLIK DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BUAH Tabernaemontana Macrocarpa JACK ASAL KALIMANTAN BARAT (DETERMINATION OF FLAVONOID, PHENOLIC, AND ANTIOXIDANT ACTIVITY OF Tabernaemontana Macrocarpa JACK FRUIT EXTRACT FROM WEST KALIMANTAN) Andi Hairil Alimuddin; Rudiyansyah Rudiyansyah; Masriani Masriani
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 3 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i3.63749

Abstract

Tabernaemontana macrocarpa Jack is one of the plants from the Tabernaemontana genus in the Apocynaceae family. Some compounds from the genus Tabernaemontana have shown interesting biological activities. Unfortunately, information about secondary metabolites and the bioactivity of T. macrocarpa Jack is limited. This study was conducted to determine the total phenolics and flavonoids contents of seeds flesh and fruit of T. montana together with their antioxidant activity. The seeds flesh and fruit of T. macrocarpa were extracted by maceration using methanol. Phytochemical tests showed that methanol extracts of seeds flesh and fruit contain alkaloids, flavonoids, and polyphenols. Total phenols and flavonoids were determined quantitatively by spectrometry and it showed that the seeds flesh contained more polyphenolics and flavonoids than the fruit. The results of the antioxidant activity showed that the seeds flesh and fruit extracts did not have antioxidant activity since their IC50 values were > 500 mg/L.
REVIEW SENYAWA BIOAKTIF DAN KONSTITUEN KIMIA DARI TANAMAN COLEUS SEBAGAI KANDIDAT OBAT (REVIEW OF BIOACTIVE COMPOUNDS AND CHEMICAL CONSTITUENTS FROM COLEUS PLANTS AS DRUG CANDIDATES) Dian Natasya; Marsella Oktavioni; Yusnaidar Yusnaidar; Indra Lasmana Tarigan
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.65149

Abstract

Miana plants (Coleus) are plants with compound interest types. Miana leaves have various bioactive compounds and are widely used to treat various diseases such as fever, colds, coughs, headaches, asthma, constipation, and skin diseases. There are several types of miana plants, such as Coleus scutellarioides (L.) Benth., Coleus aromaticus Benth., Coleus atropurpureus (L.) Benth. and Coleus blumei benth. This review aims to review the content of bioactive compounds and chemical constituents of the plant and its potential as a drug candidate. The method applied to the review articles is in the form of literature studies from national and international journals. Based on the data used, the n-hexane extract of miana leaves found 11 chemical compounds. Then based on the phytochemical screening of miana plants, several bioactive compounds were produced such as sterols, terpenoids, alkaloids, phenols, flavonoids, amino acids, glycosides, lactones, catechols, and tannins. The function of the Coleus aromaticus plant is as an antioxidant, antiepileptic, antiurolytic, anticancer, antidiabetic, anthelmintic, antiviral, antiprotozoal activity, the inhibitory activity of microorganisms, against digestive diseases, respiratory disorders, and against cardiovascular disorders
METABOLIT SEKUNDER DARI FRAKSI AKTIF AKAR PANDAN (Pandanus amaryllifolius roxb.) YANG BERSIFAT ANTIFEEDANT TERHADAP Epilachna sparsa (SECONDARY METABOLITES OF THE ACTIVE FRACTION OF PANDAN ROOT (Pandanus amaryllifolius roxb.) AS ANTIFEEDANT AGAINST Epilachna sparsa) Ari Widiyantoro; Harlia Harlia; Annisa Dyah Astari Putri
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 3 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i3.71213

Abstract

Pandan wangi (Pandanus amaryllifolius Roxb.) contains flavonoids, terpenoids, steroids, saponins, alkaloids and tannins which can be used as antifeedant compounds. This study aims to determine the antifeedant activity and to identify of secondary metabolites from pandan roots extract against Epilachna sparsa. The antifeedant activity test was carried out on the methanol extract and the partition yeild fraction. The research was carried out by maceration of pandan root which had been mashed into powder with methanol solution to obtain a methanol extract of 86.51 g. The extract was then separated by partitioning to obtain methanol fraction, ethyl acetate fraction, dichloromethane fraction and n-hexane fraction. The methanol extract and fraction from partition results were then tested for antifeedant activity against Epilachna sparsa. The results showed that at a concentration of 6% the methanol extract had an antifeedant activity of 59.37 ± 2.11 % against Epilachna sparsa. The fractions resulting from the partition included methanol, ethyl acetate, dichloromethane and n-hexane fractions at a concentration of 6% respectively showing antifeedant activity of 81.25 ± 3.56 %; 75.00 ± 2.99 %; 37.50 ± 3.77 % and 21.18 ±1.23 %. Based on the antifeedant activity test results, the methanol fraction showed the best activity. Furthermore, the methanol fraction was separated and purified by chromatographic techniques. The isolate obtained was 53.11 mg in the form of white needle crystals and had a melting point of 135-138oC. The isolate based on the phytochemical test showed positive for flavonoid

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