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Ajuk Sapar
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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University Jl. Prof. Dr. Hadari Nawawi, Pontianak, Kalimantan Barat, Indonesia
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INDONESIA
Indonesian Journal of Pure and Applied Chemistry
Published by Universitas Tanjungpura
ISSN : 26208571     EISSN : 2620858X     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Chemistry
Indonesian Journal of Pure and Applied Chemistry (IJoPAC) was first established in 2018 as a scientific journal that accommodates researchers and education practitioners to publish scientific work and research results which are the results of experiments or literature studies in the field of chemistry. Publications are carried out periodically with three issues (January-April, May-August, September-December) in one volume per year. Published scientific work can be in the form of original articles, short communications and review results covering the fields of Physical chemistry, Organic chemistry, Analytical chemistry, Inorganic chemistry, Biochemistry / Biological Chemistry, Applied Chemistry. Focus and Scope of Indonesian Journal of Pure and Applied Chemistry covering the fields : Physical chemistry Organic chemistry Analytical chemistry Inorganic chemistry Biochemistry/Biological Chemistry Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 132 Documents
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UJI AKTIVITAS ANTIOKSIDAN CESSA STERA WEDANG HERBAL TANPA GULA (ANTIOXIDANT ACTIVITY TEST OF CESSA STERA AS HERBAL DRINK WITHOUT SUGAR) Marsandah, Marsandah; Musfira, Ainun; Agustina, Ayu Safitri; Karneng, Syahdam
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.82578

Abstract

This study aims to evaluate the antioxidant content and organoleptic properties of herbal tea using a mixture of secang wood and stevia leaves. The sample preparation method involves separation based on wetness level, washing, drying, and grinding to powder. Phytochemical tests showed the presence of flavonoids, saponins, alkaloids, tannins, terpenoids and steroids in both samples. The water content test shows the value is in accordance with the quality standards for packaged dry tea. Antioxidant activity was tested using the DPPH method, and the herbal wedang formulation with a proportion of 1:1 (FIII) showed the highest antioxidant activity of 76%. Organoleptic tests showed that the panelists really liked the color, aroma and taste of the FIII formulation. The overall results show that the FIII formulation is the best choice with high antioxidant content and good acceptance from consumers.
PROFIL GC-MS DAN BIOAKTIVITAS EKSTRAK MINYAK DAUN CENGKEH (Syzygium aromaticum) TERHADAP ULAT GRAYAK Spodoptera frugiperda (GC-MS PROFILING AND BIOACTIVITY OF EXTRACTS CLOVE LEAF OIL (Syzygium aromaticum) AGAINST FALL ARMYWORMS Spodoptera frugiperda) Sitohang, Mikael; Jayuska, Afghani; Hernowo, Kukuh; Alimuddin, Andi Hairil; Aritonang, Anthoni Batahan
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.77091

Abstract

Clove leaf essential oil can be used as a natural insecticide to control pests. Essential oil obtained by steam distillation produces essential oil with a yield of 1.03%. The essential oil obtained was then analyzed using a GC-MS tool where the aim was to separate the mixture of compounds and identify the compounds contained in clove leaf essential oil. The results of GC-MS analysis of clove leaf essential oil shoved 6 compounds whose similarity was above 84%, where the main compounds were eugenol (74.28%), β-Caryophellene (20.49%), α-Caryophellene (2.32%), Caryophellene oxide (2.26%). The essential oils were then tested for mortality and antifeedant activity against 3rd larva S. frugiperda. Concentrations of 0.1%, 0.3%, 0.5%, 0.7% and 0.9% v/v the essential oil caused 43.44%, 56.66%, 70%, 76.77%, and 86.66% mortality on to tested larva. The probit analysis data the mortality resulted LC50 value of 0.58%. Antifeedant concentrations of 0.37% and 0.58% v/v or equivalent to LC25 and LC50 can reduce 42.41-71.96% of the preferred method and 66.46-86.59% of the non-optioned method.
STUDI IN SILICO METABOLIT SEKUNDER DALAM TANAMAN TAHONGAI (Kleinhovia hospita L.) SEBAGAI KANDIDAT AGEN TERAPI KARSINOMA HEPATOSELULER TERTARGET RESEPTOR c-MET (IN SILICO STUDY OF SECONDARY METABOLITES IN TAHONGAI PLANT(Kleinhovia hospita L.) AS A CANDIDATEFOR HEPATOCELLULER CARCINOMA THERAPEUTIC AGENT TARGETING c-MET RECEPTOR) Cahyaningrum, Lydia; Rubianti, Retno; Mahira, Tsania; Gabriel, Kevin; Rusdin, Agus; Novitasari, Dhania
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.82567

Abstract

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality in the world, mainly caused by chronic disease or virus. Prior studies have documented that the upregulation of c-MET can trigger the cancer progression, hence c-MET has been widely explored as target therapy for HCC. Tahongai plant (Kleinhovia hospita L.) has known to possess several biological effects, including anticancer activity. However, the molecular mechanism in this plant has not been studied yet. In this study, the bioactive constituents from Tahongai were evaluated based on the physicochemical features and molecular interaction in c-MET through in silico approaches. The druglikeness of each compound was checked through SwissADME, while the pharmacokinetic profile was predicted through preADMET webtool. The pharmacophore screening and molecular docking against c-MET were assessed using LigandScout and Autodock, respectively. Out of 14 selected compounds, only one (astragalin) did not pass the Lipinski rule, and most of the compounds demonstrated good ADMET profile. Eleutherol was choosen as the hit compound based on pharmacophore studies, and stibostemin G was potential to inhibit c-MET based on similar molecular interaction compared to its native ligand through molecular docking analysis. Further confirmation is urged to prove its anticancer effect from Tahongai against HCC, particulary targeting on c-MET
COMPARATIVE OF INHIBITORY EFFICIENCY OF LIGNIN EXTRACT OF NIPAH (Nypa fruticans Wurmb) PEEL AND FROND ON MILD STEEL IN HCl MEDIUM Emriadi, Emriadi; Sartika, Hilda; Pradiwi, Nailatul Zahrah; Stiadi, Yeni
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 1 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i1.83186

Abstract

Lignin extract from nipah fruit skin and nipah frond (Nypa fruticans Wurmb) was effectively extracted and used as a corrosion inhibitor on mild steel samples. The corrosion inhibition efficiency of lignin extract in 1 N HCl solution was determined by the weight loss method and surface morphology analysis using an optical microscope. The measurement results showed that the highest efficiency was obtained at the concentration of lignin extract from fruit skin (ELBN) and nipah frond (ELPN) of 82.16 and 78.36%. The adsorption of lignin extract on the surface of mild steel follows the Langmuir isotherm adsorption and includes mixed adsorption leading to chemical adsorption.
KONVERSI KITIN MENJADI GLUKOSAMIN PADA PREPUPA MAGGOT (Hermetia illucens) SEBAGAI ALTERNATIF TERAPI SINDROM METABOLIK: NARRATIVE REVIEW Pamungkas, Pandu; Mubinan, Muhammad Fathan; Cahyadi, Achmad; Husnawati, Husnawati
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 1 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i1.90282

Abstract

Maggots or larvae of the Black Soldier Fly (BSF) are decomposer insects widely cultivated in Indonesia due to their efficient and environmentally friendly ability to degrade organic waste. One of the key components in BSF is chitin, which accounts for approximately 17.93% (w/w) of its total body weight. Chitin can be converted into chitosan through deacetylation and hydrolyzed into glucosamine. Glucosamine has been shown to possess potential in the prevention and management of metabolic syndrome-related diseases such as hypercholesterolemia, diabetes, and obesity. This study explores the potential of glucosamine derived from BSF chitin in reducing the risk of metabolic syndrome. The method used is a literature review of various scientific articles. The findings indicate that glucosamine can activate the AMP-activated protein kinase (AMPK) pathway, which regulates glucose and lipid metabolism. AMPK activation inhibits adipogenesis, fatty acid synthesis, cholesterol production, and adipose tissue formation, positively affecting metabolic syndrome management. Therefore, glucosamine derived from BSF chitin has the potential to serve as a natural bioactive agent for the prevention of metabolic syndrome through AMPK pathway regulation.
PEMURNIAN HEMATIT DARI RED MUD PT INDONESIA CHEMICAL ALUMINA (ICA) DENGAN VARIASI SUHU KALSINASI Adhitiyawarman, Adhitiyawarman; Septiriyani, Melia; Zaharah, Titin Anita
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 3 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i3.70617

Abstract

Red mud is an insoluble fraction of bauxite ore, and it is a waste from bauxite processing into alumina. Red mud contaminated with alkaline substances and therefore poses a danger to the environment and humans. One of the largest bauxite processing companies in West Kalimantan is PT Indonesia Chemical Alumina (ICA). PT ICA can produce red mud around 240.000-450.000 each year. Red mud contains some minerals that are useful for various industries. The largest mineral content in red mud is hematite. Hematite is an iron oxide mineral with the chemical formula Fe2O3. This study aims to determine the hematite content of the extraction results from Red mud PT ICA. This research also investigates how different calcination temperatures during synthesis impact material properties, with analysis using XRF and XRD. It is known that the extracted sample contains 49.74% Fe2O3. The results of XRF analysis show that at 900 °C, the hematite content produced is higher (90.20%) compared to 800 °C (87.84%). The results of XRD analysis show that the position of the typical 2θ peaks of hematite that appear in both temperature variations is not too different, namely: 33.04 °; 35.515; 54.01 ° at 800 °C and 33,06 °; 35,55 °; 54,04 ° at 900 °C. The calcination temperature variation is also known to affect the percentage of hematite crystallinity, which is 18.23% at 800 °C and 24.87% at 900 °C. The crystal structure of hematite is rhombohedral.
ISOLASI SENYAWA ALKALOID DARI EKSTRAK METANOL DAGING BUAH Tabernaemontana macrocarpa Jack Wulandari, Adisti Riska; Alimuddin, Andi Hairil; Rudiyansyah, Rudiyansyah
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 3 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i3.77779

Abstract

The community has used Tabernaemontana macrocarpa Jack for traditional medicinal purposes such as toothaches, herpes, scabies, and also as poison on arrowheads. This research aims to isolate and characterize the structure of alkaloid compounds in the methanol extract of Tabernaemontana macrocarpa Jack. Extraction was carried out through maceration using methanol as the solvent. The methanol extract was partitioned using n-hexane, dichloromethane, and ethyl acetate. Fractionation was performed using gravity column chromatography, where silica gel was employed as the stationary phase, and a mixture of n-hexane-dichloromethane and dichloromethane-methanol with increasing polarity was used as the mobile phase. At this stage, nine combined fractions were obtained. Fractions that tested positive for alkaloid compounds were further separated using the preparative TLC method. The resulting isolate was a light yellow powder weighing 4 mg. The isolated compound was further characterized using 1H-NMR spectroscopy. The analysis results from the 1H-NMR spectrum suggest that the isolate is an indole alkaloid compound. Based on the 1H-NMR data, the isolate from fraction seven exhibited chemical shift values consistent with those of taberniacin, an indole alkaloid previously reported from Tabernaemontana divaricata.
MOLECULAR DOCKING AND ADME STUDIES OF STIGMASTEROL COMPOUNDS AS ANTI-BREAST CANCER Amir, Nur Insani; Nurfadillah, Arafah; Miladiarsi, Miladiarsi; Irma, Ade; Wahdaniar, Wahdaniar
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 1 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i1.83224

Abstract

Molecular docking studies of stigmasterol (test ligand) and estradiol (control ligand) against the ER-α receptor were performed using PyRx software. This study aims to determine the interaction between stigmasterol ligands and ER-α receptors by the molecular docking method using PyRx. The study results show that stigmasterol and estradiol have the same binding energy value of -7.3 kcal/mol. The stigmasterol compound could therefore be used as a candidate for breast cancer drugs.
PELARUTAN SILIKA PADA FRAKSI KUARSA KAOLIN MENGGUNAKAN Burkholderia cenocepacia Azhar, Annisa Sylvania; Wahyuni, Nelly; Sayekti, Endah
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 3 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i3.91962

Abstract

Dissolution of silica (SiOâ‚‚) from its insoluble form to a soluble form is crucial for enhancing its availability as precursor material. This study aimed to compare the effectiveness of silica dissolution by the bacterium Burkholderia cenocepacia producing organic acids (citrate, oxalate, acetate) and potassium hydroxide (KOH). Variations in incubation times using Burkholderia cenocepacia at 24, 96, and 192 hours were applied to samples of quartz-kaolin fractions and silica sand. The concentration of dissolved silica was measured using ICP-OES. The results showed maximum dissolution by B. cenocepacia in quartz-kaolin at 0.8493 mg/L (96 hours) and silica sand at 0.8638 mg/L (24 h). The dissolved silica from this procedure can be further processed for applications in agriculture as a nutrient for plants to overcome biotic and abiotic stress.
ISOLASI DAN KARAKTERISASI SENYAWA STEROID FRAKSI n-HEKSANA TERIPANG HITAM (Holothuria atra) ASAL PERAIRAN LEMUKUTAN KALIMANTAN BARAT Abrori, Sayyidus Dzaki; Sapar, Ajuk; Gusrizal, Gusrizal; Harlia, Harlia; Prayitno, Dwi Imam
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 1 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i1.88526

Abstract

Black sea cucumber Holothuria atra is a marine organism from the family Holothuriidae, a source for developing raw pharmaceutical materials, and is abundant in the waters of Lemukutan Island. This study aims to identify steroid compounds from the n-hexane fraction of the black sea cucumber (H. atra) from Lemukutan waters using FTIR and ¹H-NMR instruments. The steps involved in this study include extraction (maceration and partition), phytochemical tests, fractionation (column chromatography), purification, and molecular structure identification. Phytochemical analysis of the n-hexane fraction of H. atra sea cucumber revealed the presence of secondary metabolites belonging to the groups of steroids, alkaloids, phenolics, terpenoids, and saponins. The result of the isolation was a relatively pure isolate with a weight of 0.0303 grams, yellowish white in color, and suspected to be a steroid compound. The results of the n-hexane fraction identification using FTIR showed the presence of several functional groups found in steroid compounds, such as aliphatic C-H bonds, olefinic =C-H bonds, C-O group, C=O group, C=C bond, and OH (hydroxyl) group. The results of the isolate identification using the ¹H-NMR instrument (500 MHz, CDCl₃) showed chemical shift similarities to the β-sitosterol compound from two different references.

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