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INDONESIA
Indonesian Journal of Cardiology
Published by Indonesian Heart Association
ISSN : 28303105     EISSN : 29647304     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies. Subjects suitable for publication include but are not limited to the following fields: Acute Cardiovascular Care Arrhythmia / Cardiac Electrophysiology Cardiovascular Imaging Cardiovascular Pharmacotherapy Cardiovascular Public Health Policy Cardiovascular Rehabilitation Cardiovascular Research General Cardiology Heart Failure Hypertension Interventional Cardiology Pediatric Cardiology Preventive Cardiology Vascular Medicine
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 712 Documents
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Original Research ASMIHA, ASMIHA
Jurnal Kardiologi Indonesia Vol 45 No Suppl_C (2024): Abstracts of the 33rd Annual Scientific Meeting of the Indonesian Heart As
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1780

Abstract

Abstracts of the 33rd Annual Scientific Meeting of the Indonesian Heart Association (ASMIHA) 2024
Faktor Risiko Pneumonia Paska Operasi Bedah Pintas Arteri Koroner Fadhilah, Vita Karima; Achmad, Chaerul; Afrianti, Rien; Santoso, Prayudi
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1789

Abstract

Background: Postoperative pneumonia (POP) is a common infectious complication of coronary artery bypass grafting (CABG), leading to significant morbidity, mortality, and increased healthcare costs. This study found that the prevalence of POP was nearly double that reported in previous studies, underscoring the urgent need to identify specific risk factors. These findings emphasize the importance of local data in refining preventive strategies and improving clinical outcomes in CABG patients. Material and Methods: This is a retrospective cohort study. The subjects comprised patients who underwent CABG procedures at a single institution between June 2020 and June 2024. A logistic regression analysis model for evaluating the risk of POP was established. Results: This study observed a POP rate of 41.7%, significantly exceeding the 2–24% range reported in previous studies. Key risk factors included elevated creatinine levels, eGFR <60 ml/min/1.73 m², and low early postoperative albumin. POP strongly correlated with prolonged hospitalization, with an odds ratio of 13.043 (95% CI: 6.130–27.751, p < 0.0001), underscoring its substantial impact on patient outcomes. Conclusions: The present study delineates renal impairment and hypoalbuminemia postoperative as pivotal risk factors for POP following CABG. It emphasizes the importance of tailored interventions, structured institutional practices, and continuous research to enhance preventive strategies and patient outcomes.
Novel Echocardiographic Parameter Assessing Pulmonary Vascular Resistance in Patient with Acyanotic Congenital Heart Disease Natadikarta, Muhammad Raihan Ramadhan; Cool, Charlotte Johanna; Khalid, Achmad Fitrah; Sukmadi, Norman; Martha, Januar Wibawa
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1790

Abstract

Background Pulmonary vascular resistance (PVR) is an important variable in management of acyanotic congenital heart disease. Right heart catheterization (RHC) using impedance catheter remains gold standard for pulmonary vascular resistance (PVR) measurement. The ratio of peak tricuspid regurgitant velocity to the right ventricular outflow tract time-velocity integral (TRVmax/RVOTVTI) was presented as a reliable non-invasive method of estimating PVR. Recently, right ventricular 2-dimensional speckle tracking strain (RVGLS) was proven as a new promising parameter to evaluate PVR. This study performed to examine whether this new non-invasive variable ratio (TRVmax/RVGLS) provides clinically reliable method to determine pulmonary vascular resistance (PVR) obtained by echocardiography. Methods Right-heart catheterization and echocardiographic examination were performed in 56 patients with congenital heart disease. The ratio of TRVmax/RVOTVTI and TRVmax/RVGLS analysis performed using receiver-operating characteristic curve analysis, a cutoff value for the ratio was generated to determine PVR more than 5 WU. Results A TRVmax/RVOTVTI cutoff value of 0.21 provided a sensitivity of 77.1% and a specificity of 81% (CI 81% to 97.5%) and TRVmax/RVGLS cutoff value of -23.16 provided sensitivity of 74.3% and a specificity of 90.5% to determine PVR > 5 WU (CI 79.6% to 98.2%). Conclusions The echocardiography parameter (TRVmax/RVGLS) could serve as a dependable noninvasive method to predict PVR greater than 5 WU in acyanotic congenital heart disease patients.
Non-traditional Lipid Profile and Obstructive Coronary Artery Disease Based On CAD-RADS Score Munita, Fatihatul Firdaus; Kusumawardhani, Nuraini Yasmin; Achmad, Chaerul; Astuti, Astri; Muthiah, Azizah
Jurnal Kardiologi Indonesia Vol 46 No 1 (2025): January - March, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1810

Abstract

Background: The association between dyslipidemia and coronary artery disease (CAD) is undisputable. Current evidence suggests that, in comparison to conventional lipid parameters, a comprehensive non-traditional lipid profile serves as a more robust predictor of CAD. The evidence regarding the correlation between nontraditional lipid profile and severity of coronary lesions, as measured by the coronary artery disease-reporting and data system (CAD-RADS) score by Coronary Computed Tomography Angiography (CCTA), is still scarce. This study aimed to elaborate on the association between those parameters. Understanding these associations may improve risk stratification and management in CAD patients. Methods: A cross-sectional single-center study was conducted in a large population of patients with suspected CAD. Data were obtained from medical records between January 2020 and February 2024. The CAD-RADS score was stratified into three groups: CAD-RADS 0 (no CAD), CAD-RADS 1-2 (stenosis <50%, classified as non-obstructive CAD), and CAD-RADS ≥3 (stenosis ≥50% in ≥1 coronary segment, classified as obstructive CAD). Logistic regression analysis analyzes the association between patients' lipid profiles and CAD-RADS scores. P-value <0.05 was considered statistically significant. Results: A total of 543 (274 female) patients were included in this study. In the univariate analysis, the LDL/HDL ratio was significantly associated with the severity of CAD based on CAD-RADS scores. The multivariate analysis revealed that the LDL/HDL ratio was the most significant lipid parameter across all models (Adj OR: 9.728, 95% CI: 2.078-45.649, P = 0.004), with the highest adjusted odds ratio observed after adjustments for age, gender, family history, history of hypertension, diabetes mellitus, and chronic kidney disease, and also smoking status. The LDL/HDL ratio cut-off value was 2.82 with a sensitivity of 83.95% and a specificity of 21.05%. Other non-traditional lipid profiles lost their significance in the multivariate models. Conclusions: The LDL/HDL ratio was significantly associated with obstructive CAD, as assessed by the CAD-RADS score, even after adjustment for other cardiovascular risk factors
Mexiletine in the treatment of LQT2, LQT3, and acquired LQTS: a meta-analysis Ihsan, Dhiya; Iqbal, Mohammad; Cool, Charlotte Johanna; Achmad, Chaerul; Pramudyo, Miftah; Prameswari, Hawani Sasmaya; Akbar, Mohammad Rizki
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1835

Abstract

Background: High mortality in patients with Long QT Syndrome (LQTS) can be reduced with proper treatment. Gene-specific therapy is crucial, as many treatments are not equally effective across different LQTS types. While mexiletine has been established in the treatment of LQT3, its use in other types of LQT need further evaluation. Methods: A meta-analysis was conducted using systematic electronic searches of PubMed, Embase, and Cochrane Library. We assessed QTc reduction and cardiac events after Mexiletine treatment. Inclusion criteria: any study with no language restriction that diagnoses any type of LQTS, uses mexiletine treatment, and provides QTc comparison before and after treatment. Animal studies were excluded. The NIH Study Quality Assessment Tools and Newcastle-Ottawa Scale were used to evaluate bias. Data were analyzed using Review Manager 5.4 and MedCalc software Results: Nine studies (n=281) were included. Mexiletine reduced QTc by -64ms (mean difference [MD], -64.22; 95% confidence interval [CI] -76.13 to -52.30; p<.001; I2 60%). Sensitivity and subanalyses showed consistent efficacy. In five studies (n=76), the number of patient with high-risk QTc (>500ms) significantly decreased (Risk Ratio [RR], 0.38; 95% CI 0.26-0.55; p<.001). Five studies (n=141) showed a significant reduction in cardiac events (RR, 0.25; 95% CI 0.14-0.44; p<.001). Two studies reported gastrointestinal (GI) problems and vertigo as side effects of mexiletine treatment. Conclusion: Mexiletine significantly reduces QTc and cardiac events in LQT2, LQT3, and aLQT patients. Mexiletine also significantly reduces the number of Long QT patients with high-risk QTc Funding: No external funding was received for this study Registration: CRD420250652574
Non-surgical intervention for palliative treatment in Late-presentation Tetralogy of Fallot (TOF): Is there any hope? Siregar, Indah Pratiwi
Jurnal Kardiologi Indonesia Vol 45 No 3 (2024): July - September, 2024
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1451

Abstract

Background: Late congenital heart disease (CHD) in patients with tetralogy of Fallot (TOF). Due to the variable severity of defects in patients with TOF, late presentation of CHD may only be discovered beyond the neonatal period. Chronic polycythemia from TOF may increase the risk of hemorrhaging during surgery and patients with untreated TOF risk developing CHD-related pulmonary hypertension. Non-surgical transcatheter palliation in patients with TOF may be applied; however, the efficacy and safety of the method remained very scarce. Therefore, we report two cases of late-presenting TOF treated with non-surgical transcatheter palliation due to high perioperative risks for surgical repair of the defects. Case Illustration: A 41-year-old (Case 1) and 19-year-old man (Case 2) were admitted to the emergency room due to chief complaint of dyspnea and severe headache with previous history of hypoxic spell, respectively. Both patients had presented with signs of right ventricular hypertrophy and cardiomegaly from physical examination. Echocardiography had confirmed TOF in both cases. Non-surgical palliation for both cases were performed with right ventricular outflow tract (RVOT) stenting and balloon pulmonary valvuloplasty (BPV), respectively. Both patients had shown clinical and systolic function improvement after both interventions. Conclusion: Late-presentation TOF may present with major comorbidities that contraindicates definitive repair of the defects due to high perioperative risk. Palliative interventions in late-presentation TOF may be considered as a bridging procedure prior to the definitive repair to minimize the risk of complications from untreated TOF beyond neonatal period.
Collagen-Based Hydrogel Encapsulated Cardiosphere-Derived Cell (CDC): Potential of Stem Cells as Tissue Repair Therapy Post-Acute Myocardial Infarction Evananda, Maria Pramesthi Sabrina; Salim, Albert; Surya, Stevanus Christian; Suastika, Luh Olivia Saraswati
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1281

Abstract

Acute myocardial infarction (AMI) is a global health issue that is the leading cause of morbidity and mortality. Post-AMI management currently has therapeutic and side effect limitations, and has not been able to repair damage to myocardial tissue caused by AMI. The development and discovery of therapeutic modalities with the potential for a more optimal therapeutic effect remains a challenge in this post-AMI treatment. The purpose of this literature review is to collect and analyze various sources related to collagen-based hydrogel encapsulated cardiosphere-derived cell (CDC). This literature review is written systematically by gathering library sources from various search engines, such as Google Scholar, PubMed, and Research Gate. According to the findings of the study, CDC has the potential to be used as a post-AMI therapy because it can promote regeneration of the heart, which has lost function as a result of the AMI. To achieve the greatest effect, this modality is administered intracoronary. This modality will be encapsulated with collagen hydrogel, which has a cardioprotective effect, in order to increase the survival and effectiveness of CDC. The use of collagen-based hydrogel encapsulated CDC can provide post-AMI cell regeneration effects comparable to existing modalities while having minimal side effects. Further investigation in larger and more definitive trials is needed to elucidate the potential use of CDC therapy in AMI.
Transient ST Elevation following Anaphylactic Shock: A Case Report of The Potential Kounis Syndrome Aryadi, I Putu Hendri; Eryana, I Made; Sumajaya, I Dewa Gde Dwi
Jurnal Kardiologi Indonesia Vol 46 No 1 (2025): January - March, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1292

Abstract

Background: Anaphylactic shock rarely can induce allergic-induced acute coronary syndrome known as Kounis Syndrome. It involves the release of inflammatory cytokines through mast cell activation, which leads to coronary artery vasospasm and ST elevations presentation on electrocardiography (ECG).Case Illustration: A 45-years-old woman with unknown past medical history presented with weakness all over the body, dizziness, pain on left hand and history of fainted, immediately after being stung by small wasps. She was in hypotension with wheezing and weak peripheral pulses. Her laboratory examination displayed leukocytosis, thrombocytosis, high level of blood sugar and triglyceride. Initial twelve-lead ECG demonstrated ST-segment elevation on the inferior leads (II, III, and aVF) and reciprocal ST-depression on the lateral lead. Diagnosis of anaphylactic shock caused by insect bite was made, with a potential of becoming Kounis Syndrome. Treatment for anaphylactic shock was initiated with fluid resuscitation, intramuscular epinephrine, intravenous methylprednisolone and ranitidine. Patient’s complaint vanished and the patient discharged in stable condition two days later.Discussion: Kounis Syndrome consists of three main types, including Type I Kounis Syndrome―manifested as coronary artery vasospasm with/without cardiac biomarker elevation among patient without predisposing factor of coronary artery disease. This type differs with the second and third type, which present plaque erosion or thrombosis, leading to myocardial infarction. The treatment for Type 1 Kounis Syndrome mostly in the form of aborting the anaphylactic reaction only, through medication administration until symptoms resolved. Based on this case, the patient was a non-smoker young Asian woman with a low risk (<1% of 10-years-risk) of fatal cardiovascular disease (CVD) in populations with high CVD risk. Clinically, the patient did not show any vascular thrombotic symptoms. In addition, administration of adrenaline, corticosteroid and antihistamine relieved patient's complaint, thus this case can be hypothesized as a potential Type I Kounis Syndrome. Emergency coronary angiography or echocardiography has to be done to clarify the diagnosis of this allergic-induced acute coronary syndrome.Conclusion: Transient ST elevation could happen in some rare cases following an anaphylactic shock. The swift recognition, accurate diagnosis, and prompt treatment are important for optimal outcomes in the probability of Kounis Syndrome.Keywords: anaphylactic shock, Kounis syndrome, ST elevation
Outcome Analysis and Determinants of Major Adverse Cardiac Events in Young Adults After Coronary Artery Bypass Graft Surgery Who Participated in Early Phase II Cardiac Rehabilitation Program: A single-centre study Radi, Basuni Radi; Intan, Ryan Enast; Dwiputra, Bambang; Desandri, Dwita R; Ambari, Ade Meidian
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1727

Abstract

Background: Cardiac rehabilitation (CR) program is proven to reduce mortality risk after coronary artery bypass surgery (CABG). Our study aimed to investigate the determinants of survival in young adult patients after CABG. Method: This was a single-centre, longitudinal study with a survival analysis method from MACE of consecutive patients under 55 years old who underwent CABG and participated in the early phase II CR program between January 2017 and December 2018. The major adverse cardiac events (MACE) rates were determined over a 2-year follow-up time. Cox regression and Kaplan-Meier analysis were used to determine the predictors of the events based on the data registry. Result: 279 patients who fulfilled the inclusion criteria were recruited in this study. MACE happened to 23 (8.45%) of them (3 patients died, 20 patients were hospitalised). Patients who dropped out (12%) from the CR program had a higher risk of developing events (HR 3.86, 95% CI 1.36-10.99). Of those who completed the CR program (245 patients), beta-blocker usage, chronotropic index, resting heart rate, and functional capacity after the CR program independently correlated with MACE. Six-minute walk distance (6-MWD) 376 meters was a significant predictor (p=0.001), with a shorter mean survival time of 6 months. Conclusion: The early phase II CR program after CABG in young adult patients reduced the risk for cardiovascular mortality, major adverse events, and related readmission. It also increased the survival rate and mean survival time for participants who completed the CR program compared to dropouts. Optimum beta blocker medication, chronotropic index, resting heart rate, and functional capacity after the CR program are essential predictors of survival after CABG in young adults.
Tatalaksana Farmakologi takiaritmia supraventrikel pada pasien dengan pembesaran jantung kanan: Serial kasus Hendiperdana, Mochamad Rizky
Jurnal Kardiologi Indonesia Vol 46 No 1 (2025): January - March, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1750

Abstract

Background Right atrial (RA) enlargement is a common finding in patients with pulmonary hypertension (PH). Supraventricular arrhythmia (SVA) is common in PH patients with RA enlargement. Treatment of SVA should be aggressive since it can cause hemodynamic worsening consequences because RA function plays an important role in right heart function. Case Illustration Three cases of SVA in underlying right heart enlargement with preserved ventricular function that successfully managed by pharmacological cardioversion according to the guidelines. The first case describes atrial flutter with right bundle branch block (RBBB) morphology which successfully converted to sinus rhythm by amiodarone (class III antiarrhythmic drug) administration, meanwhile the second and third cases demonstrate paroxysmal SVA that converted to sinus rhythm by diltiazem (class IV antiarrhythmic drug) administration. Conclusion Supraventricular arrhythmia is a frequent arrhythmia that occurs in pulmonary hypertensive and right heart dilation patients. The tachyarrhythmia in this patient population tolerated poorly and led to hemodynamic perturbation. Pharmacological cardioversion is one of the effective approaches to alleviate patient symptoms with significant clinical improvement.

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