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Contact Name
Raymond Pranata
Contact Email
raymond_pranata@hotmail.com
Phone
+6282112918892
Journal Mail Official
ijc@inaheart.org
Editorial Address
Editorial Office: Heart House, Jalan Katalia Raya No. 5, Kota Bambu Utara West Jakarta, 11430 - Indonesia Telephone: +62 21 5681149, Fax: +62 21 5684220 Email: ijc@inaheart.org
Location
Kota adm. jakarta barat,
Dki jakarta
INDONESIA
Indonesian Journal of Cardiology
ISSN : 28303105     EISSN : 29647304     DOI : -
Core Subject : Health,
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies. Subjects suitable for publication include but are not limited to the following fields: Acute Cardiovascular Care Arrhythmia / Cardiac Electrophysiology Cardiovascular Imaging Cardiovascular Pharmacotherapy Cardiovascular Public Health Policy Cardiovascular Rehabilitation Cardiovascular Research General Cardiology Heart Failure Hypertension Interventional Cardiology Pediatric Cardiology Preventive Cardiology Vascular Medicine
Articles 717 Documents
The Hypoxic Preconditioning Effect On Senescence Cell Process In Cultured Adipose-Derived Mesenchymal Stem Cells (AMSCs) Nadiar Dwi Nuarisa; I Gde Rurus Suryawan; Andrianto Andrianto
Jurnal Kardiologi Indonesia Vol 39 No 3 (2018): Indonesian Journal of Cardiology: July-September 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i3.802

Abstract

Introduction : Stem cell therapy for myocardial regeneration is expected to increase cardiomyocyte proliferation and trigger neovascularization to improve cardiomyocytes. Mesenchymal Stem Cells (MSCs) are ideal candidates for regenerative medicine and immunotherapy. But low viability of MSCs is a major challenge in this alternative therapy. Therefore, a cytoprotective strategy is needed, one of them is hypoxic preconditioning which can significantly increase survival stem cells after being transplanted. MSCs are known to have a limited life span, after experiencing several splits MSC will enter the senescence process. It is known that hypoxia can also increase cell proliferation and differentiation potential in vitro and in vivo through the role of Octamer-4 (Oct-4) as a regulator of the pluripotency gene. Methods : Experimental laboratory studies (in vitro studies) using human-AMSCs which were given hypoxic preconditioning, observed as a immunocytochemistry. Results : The results showed that hypoxic precondition (1% O2) inhibited the senescence process. It can be seen in the lower expression of senescence in hypoxic conditions at P6, P7, P8, P9, P10 compared to normoxic ((p=0,004, p=0,001, p=0,009, p=0,013, p=0,024. There is a significant difference in the senescence expression of each passage in hypoxic and normoxic conditions with the highest expression at P10. In addition, we also observed AMSCs differentiation through the Oct-4 expression. It is showed that Oct-4 expression were higher in hypoxia compared to normoxia on P7, P8, P9, P10 (p=0,009, p=0,009, p=0,030, p=0,0001). Conclusions : Hypoxic preconditioning have the effect of inhibiting the senescence process on Adipose-derived MSCs (AMSCs) or prolonging their life span. The longer life span of AMSCs is also seen by higher cell differentiation potential from increased expression of Oct-4. However, the mechanism of inhibiting the senescence process in hypoxia in stem cells is still remain unknown. Keywords: human-Adipose derived Mesenchymal Stem Cell Cultures (h-AMSCs), Hypoxic Preconditioning, Senescence cell, Oct-4.
Hemodynamic Congestion at Hospital Discharge Predicts Rehospitalization during Short Term Follow Up in Acute Heart Failure Patients Yoga Waranugraha; Mohammad Saifur Rohman; Setyasih Anjarwani
Jurnal Kardiologi Indonesia Vol 40 No 3 (2019): Indonesian Journal of Cardiology: July-September 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i3.805

Abstract

Background: Hemodynamic congestion is an increase in left ventricular diastolic pressure (LVEDP) without clinical symptoms and signs of congestion. Current acute heart failure (AHF) treatment goals only focused on improving clinical congestion. The purpose of this study was to investigate whether hemodynamic congestion measured by NT-proBNP level and ePCWP at hospital discharge could predict short term clinical outcomes in AHF patients. Method: This prospective cohort study was conducted at dr. Saiful Anwar General Hospital Malang from January to July 2018. All patients got AHF treatment according to the 2016 ESC guidelines for heart failure. All patients were discharged without symptoms and signs of clinical congestion. Hemodynamic congestion at hospital discharge was defined as failure of treatment during hospitalization to achieve a reduction in NT-proBNP level >30% and/or ePCWP at hospital discharge >16 mmHg. NT-proBNP level and ePCWP were measured at 0-12 hours after hospital admisssion and at hospital discharge. ePCWP was measured using echocardiography. The clinical outcomes assessed were AHF rehospitalization and cardiovascular mortality within 30 days after hospitral discharge. Subgroup analysis was performed to determine therapeutic regimens that are effective in improving hemodynamic congestion. Result: A total of 33 AHF patients were included in this study. 48% patients were discharged with hemodynamic congestion and 52% patients discharged without hemodynamic congestion. Patients with hemodynamic congestion at hospital discharge showed a higher rehospitalization within 30 days (8 [50%] vs 1 [5.9%]; P = 0.007). Mortality within 30 days in both groups did not show a significant difference (2 [12.5%] vs 0 [0%]; P = 0.277). Treatment regiment of optimal dose of ACEi/ARB, β-blockers, and diuretics was associated with improvement of hemodynamic congestion (P = 0.026; r = 0.454), a decrease in NT-proBNP> 66% (P = 0.02; r = 0,574), and achievement of ePCWP <16 (P = 0,013; r = 0,493) at hospital discharge in HFrEF patients. Conclusion: This study showed that hemodynamic congestion assessed with NT-proBNP level and ePCWP at hospital discharge increased 30 day rehospitalization in AHF patients. In HFrEF, improvements in hemodynamic congestion can be achieved by giving the treatment regiment of optimal dose of ACEi/ARB, β-blockers, and diuretics. Keyword: Acute heart failure, hemodynamic congestion, NT-proBNP, ePCWP
CORELATION OF GLOBAL LONGITUDINAL STRAIN (GLS) – LEFT VENTRICLE AND SOLUBLE SUPRESSION OF TUMORGENICITY 2 (sST2) IN ACUTE HEART FAILURE WITH SYSTOLIC DYSFUNCTION Herlina Yulidia; Muhammad Aminuddin; Budi S Pikir
Jurnal Kardiologi Indonesia Vol 39 No 4 (2018): Indonesian Journal of Cardiology: October-December 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i4.807

Abstract

Background : Assessment of left ventricular function in patients with acute heart failure is important for prognostication, determination of treatment plan, for decisions related to expensive device therapies and for assessing response to treatment. Echocardiography is the "gold standard" of assessing left ventricular function, and in establishing a diagnosis of heart failure. Left ventricular Global Longitudinal Strain (GLS) assessed through Speckle Tracking Echocardiography (STE) is currently considered sensitive in assessing left ventricular motion, by analyzing multidimensional myocardial deformation . s ST2 used to be correlated with stretch miocard and inhibid ligand of IL-33 wich also inhibit the cardioprotectve effect. Objective : To prove the positive correlation between GLS-left ventricle with soluble ST2. Methods : This is a correlational study with cosecutive sampling technique. Thirty subjects participate in this reseach and each subject underwent echocardiography and GLS-left ventricle and soluble ST2 blood examination. The correlation between GLS-left ventricle and soluble ST2 were evaluated using Spearman correlation test. Results : There is a strong, significant, positive correlation between the GLS-left ventricle with soluble ST2 (r = 0.99 and p = 0.0001). Conclusion : There is a strong, significant, positive correlation between the GLS- left ventricle with soluble ST2. Keywords : acute heart failure, systolic dysfunction, global longitudinal strain, soluble ST2.
Improvement of level MDA and SOD Using of Ganoderma Lucidum as Adjunctive Treatment for Statin Based Therapy in High Risk Patient Based on Framingham Score vitriyaturrida vitriyaturrida; M Saifur Rohman; Djanggan Sargowo; Dadang Hendrawan
Jurnal Kardiologi Indonesia Vol 39 No 3 (2018): Indonesian Journal of Cardiology: July-September 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i3.820

Abstract

It is well known from previous research on the importance of antioxidants to inhibit the progression of coronary heart disease in high-risk patients based on framingham scores. Statins are routinely administered in high-risk patients based on the Dyslipidemia 2016 ESC guidelines but the effects of adding Ganoderma are known to have antioxidant effects, in patients who have received statins. This study aims to assess the effect of antioxidants through measurement of SOD and MDA in patients given a combination of Ganoderma lucidum with statins.Method: A total of 24 patients with high-risk patients based on the Framingham score > 20% were selected as sample of study. Patients with respondents who had never received statin therapy or ACEi or ARB or CCB or beta blocker, or did not routinely consume the drug for 2 weeks were excluded from this study. The addition of Ganoderma lucidum dose of 3x250 mg was added to statins as the first group and Ganoderma lucidum dose of 3x250 mg was added to the Statin combination of Angiotensin Converting Enzym inhibitors (ACE inhibitors) or Angiotensin Receptor Blockers (ARB) and or Calcium Channel Blockers (CCB) and or Beta blockers as second group for 90 days. SOD and MDA levels were measured before and after the administration of Ganoderma Lucidum with the ELISA method.Result: After the administration of Ganoderma Lucidum with standard therapy, there was a decrease in MDA levels and an increase in SOD levels after 90 days in two groups. Conclusion: The addition of Ganoderma Lucidum to standard therapy can reduce oxidant levels in high-risk patients based on framingham scores. Keyword: Superoxyde-dismutase, Malondyaldehide, Oxidative Stress, Antioxidant, Ganoderma Lucidum, Statin
The Quantitative Measurement of ST-Segment Deviation and Pathological Q Wave for Predicting Hospitalization Mortality in Patient with ST-Elevation Myocardial Infarction Muhammad Surya Tiyantara; Yustye Yustye; Djoen Herdianto; Swandari Paramita
Jurnal Kardiologi Indonesia Vol 40 No 3 (2019): Indonesian Journal of Cardiology: July-September 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i3.822

Abstract

Background: The appearance of ST-segment elevation (STE) and pathological Q wave were signs of worse myocardial damage and function, the quantitative measurement of the waves have a potential prognosis role. This study assesses the performance of the quantitative measurement of the waves in predicting in-hospital mortality and compares it with the Global Registry of Acute Coronary Events (GRACE) score as the standard recommended risk score. Methods: This was a cross-sectional study included patients with ST-elevation myocardial infarction (STEMI) that hospitalized in Abdul Wahab Sjahranie General Hospital Samarinda during January to December 2016. Standard 12-lead electrocardiograms (ECG) were assessed at patient admission as well as other data for GRACE score. The subjects were grouped into non-survivor and survivor group based on hospitalization survival state, and six quantitative ECG characteristics performance will be assessed. The performances were assessed using receiver operating characteristics (ROC) curve and area under the curve (AUC). Results: There were 57 subjects consisting of 9 non-survivor subjects. The AUC of the four ECG characteristics highest STE amplitude, deepest Q amplitude, total Q amplitude, and total STE amplitude did not significantly different with GRACE score (p>0.05). Highest STE amplitude has the best performance than the other ECG characteristics (AUC=0.81, 95% CI:0.65 to 0.97), and cut off point 4.5mm provides 56% sensitivity and 94% specificity. Conclusion: The quantitative measurement of ST-segment deviation and pathological Q wave have the prognosis role for predicting in-hospital mortality.
PERANAN ACETAMINOPHEN (PARASETAMOL) DALAM PENUTUPAN DUCTUS ARTERIOSUS Herlina Dimiati; Rini Fasli
Jurnal Kardiologi Indonesia Vol 39 No 3 (2018): Indonesian Journal of Cardiology: July-September 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i3.823

Abstract

Abstrak Patent ductus arteriosus (PDA) adalah kelainan kongenital yang ditandai adanya kegagalan penutupan duktus arteriosus (DA) segera setelah lahir. Dampak tidak menutupnya DA akan terjadi gangguan hemodinamik ,memperberat masalah lain yang menyertai bayi prematur sehingga akan meningkatkan morbiditas dan mortalitas. Parasetamol merupakan obat yang relatif baru digunakan untuk menutup PDA jika dibandingkan dengan indometasin ataupun ibuprofen dengan tinkat keberhasilan yang tinggi. Kata kunci: Patent ductus arteriosus (PDA), gangguan hemodinamik, parasetamol Abstract Patent ductus arteriosus (PDA) is a congenital disorder characterized by a failure to close the ductus arteriosus (DA) immediately after birth. The impact of not closing the DA will occur hemodynamic disturbances, aggravating other problems that accompany premature babies so that it will increase morbidity and mortality. Paracetamol is a relatively new drug used to close PDAs when compared with indomethacin or ibuprofen with the high success rates. Keywords: Patent ductus arteriosus (PDA), hemodynamic problem, paracetamol
Clinical Research Indonesian Heart Rhythm
Jurnal Kardiologi Indonesia Vol 39 No Suppl_A (2018): Indonesian Journal of Cardiology Supplement_A
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v38isuppl_A.829

Abstract

Abstracts of the 6th Annual Scientific Meeting of the Indonesian Heart Rhythm Society Jakarta, 21-22 September 2018 Original Articles
Case Reports Indonesian Heart Rhythm
Jurnal Kardiologi Indonesia Vol 39 No Suppl_A (2018): Indonesian Journal of Cardiology Supplement_A
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v38isuppl_A.830

Abstract

Abstracts of the 6th Annual Scientific Meeting of the Indonesian Heart Rhythm Society Jakarta, 21-22 September 2018 Case Reports
Systematic Reviews and Meta-Analyses Indonesian Heart Rhythm
Jurnal Kardiologi Indonesia Vol 39 No Suppl_A (2018): Indonesian Journal of Cardiology Supplement_A
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v38isuppl_A.831

Abstract

Abstracts of the 6th Annual Scientific Meeting of the Indonesian Heart Rhythm Society Jakarta, 21-22 September 2018 Systematic Reviews and Meta-Analyses
Advantages of Exercise Training In Hypertrophic Cardiomyopathy: Considering risks and benefits Deddy Tedjasukmana
Jurnal Kardiologi Indonesia Vol 40 No 4 (2019): Indonesian Journal of Cardiology: October-December 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i4.839

Abstract

Background. Hypertrophic cardiomyopathy (HCM) is one of the most common cardiac genetic disorders. The prevalence of this disease is 1 in 500 live births. It is stated to be the most frequent cause of sudden death in young adults. Therefore, some guidelines recommend to restrict physical activity and exercise. On the contrary, latest data show that active lifestyle and exercise in HCM patient provide significant benefits in cardiovascular function with no significant adverse reactions. Following to that, some experts might be reveal that its benefits might be outweigh risks. Summary. There is a paucity of studies that examine the effectiveness of exercise for HCM. American Heart Association (AHA) and (European Society of Cardiology) ESC established exercise recommendations for HCM individuals based on discussion and consensus of experts. We found three studies that investigate the efficacy of exercise in HCM individuals. Outcomes of our interest were differences in cardiovascular function, quality of life and safety issues. All studies found positive significant differences in main outcomes measure in which the HCM subjects on exercise had better or improved outcomes. None reported adverse reaction such as fatal arrhythmia or sudden death related to exercise. Brief Conclusion. Old belief regarding exercise restrictions on HCM need to be reconsidered, given that at present exercise have been shown to provide significant benefits for reducing cardiovascular risk factors. Nevertheless, exercise in patients with HCM must be specifically considered regarding the risk and benefit. Practicing active lifestyle and exercise on HCM individual is an exciting possibility that need further study. Keywords: hypertrophic cardiomyopathy, exercise training, risks and benefit, physical activity

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