Garuda - Garba Rujukan Digital

Kejadian dan Faktor Resiko Akne Vulgaris R.M. Suryadi Tjekyan
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 1 Year 2008
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.002 KB)

ABSTRACTAcne vulgaris and its risk factors.Background: Acne vulgaris (AV) gives cosmetic as well as psychological problem among the young. There is no data on the community prevalence and risk factors on this problem. Objective of this study aimed to find the community prevalence and risk factors of AV.Methods: A cross sectional study was carried in the city of Palembang among 5024 subjects aged 14-21 years in March-July 2007. Data were collected using questionnaire distributed through hamlets (RT) and analyzed using SPSS 13Results: The prevalence of AV was 68.2% and specifically were 58.4% among women and 78.9% among men, who were mostly at the age of 15-16 years. Papulopustulair type was the highest (35.8%) followed by comedonal (30.1%) and nodulistic (2.2%) with the location mostly on the face (58.9%) with bilateral position (55.7%). Routine facial cleaning gave lower AV development. Using and changing cosmetics were associated with AV (p1=0.04, p2=0.000). Respondents with family history of AV has higher risk to developAV (OR=2.18).Conclusion: Acne vulgaris is common among 15-16 years old boys and girls.Key Words: Prevalence, acne vulgaris, risk factorsABSTRAKLatar belakang: Akne vulgaris menjadi masalah kosmetika dan psikologis umum yang terutama terjadi pada kalangan remaja. Belum ada data angka kejadian dan faktor resiko akne vulgaris di masyarakat. Penelitian ini bertujuan untuk meneliti angka prevalensi dan beberapa faktor resiko akne vulgaris penduduk kota Palembang.Metode: Studi potong lintang dilakukan pada 5204 sampel usia 14 sampai 21 tahun di Palembang, memakai kuesioner yang didistribusikan melalui rukun tetangga di setiap kecamatan di kota Palembang yang terpilih. Penelitian dilaksanakan pada bulan Maret sampai Juli tahun 2007. Data diolah dengan piranti lunak SPSS 13.Hasil: Prevalensi umum AV pada subjek penelitian 68,2% dan 58,4% pada wanita dan 78,9% pada laki-laki dengan umur terbanyak berusia 15-16. Tipe papulopustular adalah yang tertinggi (35,8%) diikuti dengan komedonaly (30,1%) dan noduler (2,2%) dengan lokasi terutama di wajah dan bilateral. Pembersihan wajah secara rutin memberikan kejadian AV yang rendah. Menggunakan kosmetik dan kebiasaan berganti-ganti kosmetik berhubungan dengan kejadian AV (p1=0,04, p2=0,000). Responden dengan riwayatkeluarga ber-AV memiliki resiko untuk mendapatkannya (0R=2,18).Simpulan: Akne vulgaris banyak menimpa laki-laki maupun perempuan usia 15-16 tahun.

Kadar Testosteron dan Apoptosis pada Sel Penis dan Prostat dengan Pemberian Buceng Taufiqurrachman Taufiqurrachman
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.668 KB)

Increase in testosterone levels and decrease in number of apoptosis in penis and prostate cells by buceng treatmentBackground: Apoptosis is an important biological mechanism in aging process, vitality, and declining of physiological function. Buceng has been traditionally used to delay aging and enhance male vitality. Administration of buceng to enhance Te concentration and decrease apoptosis in penis and prostate cells has not been elucidated. This study is to elucidate the effect of buceng on increase Te concentration and declining of apoptosis in penis and prostate cells of male Sprague Dawley rats.Method: Post test only control group design, 60 male of 90 days old Sprague Dawley rats and ± 300 gram body weight, has been assigned multistage randomly into four group. Group A, the castrated rats, treated with 50 mg buceng. Group B, the rats were not castrated, immediately sacrificed as a positive control. Group C, the castrated rats, got 2 mL of water, as a negative control. Group D, the castrated rats, treated with 6.75 mg mesterolon diluted in water. Manova statistical model was adopted to analyze the difference consentration of Te and apoptosis among groups. Analysis was perfomed by SPSS 13 with 95% confident interval.Result: Manova analysis by Wilk Lambda procedure in four groups indicated that Te concentration, apoptosis in penis and prostate cells among groups were significantly different (p=0.000).Conclusion: This study concludes that the administration of 50 mg buceng for 30 consecutive days could enhance Te concentration and decrease apoptosis in penis and prostate cells.Keywords: Buceng, apoptosis, vitality ABSTRAKLatar belakang: Apoptosis adalah mekanisme biologi penting dalam proses penuaan, penurunan vitalitas, dan penurunan fungsi fisiologis organ. Buceng telah dipakai secara tradisional untuk menghambat penuaan dan meningkatkan vitalitas pria. Efek buceng terhadap peningkatan kadar testosteron (Te) dan penurunan apoptosis sampai sekarang masih belum dibuktikan. Tujuan dari penelitian ini adalah untuk mengungkap efek buceng terhadap peningkatan kadar Te dan penurunan apoptosis sel penis dan prostatpada tikus jantan Sprague Dawley.Metode: Post test only control group design dengan sampel 60 tikus jantan galur Sprague Dawley umur 90 hari dengan berat badan (BB) ±300 gram, dibagi menjadi 4 kelompok secara multistage random masing-masing terdiri dari 15 ekor (ditentukan menurut formula Federer). Kelompok A, tikus dikastrasi, diberi buceng aa 50 mg. Kelompok B, tikus tanpa dikastrasi, langsung dimatikan, sebagai kontrol positif. Kelompok C, tikus dikastrasi, diberi akuades 2 mL, sebagai kontrol negatif. Kelompok D, tikus dikastrasi,diberi mesterolon 6,75 mg yang dilarutkan dalam air. Analisis statistik untuk menguji perbedaan kadar Te dan apoptosis adalah uji Manova. Semua analisis dilakukan dengan metode SPSS 13, dengan tingkat kepercayaan 95%.Hasil: Analisis Manova dengan prosedur Wilk lambda, pada empat kelompok menunjukkan bahwa kadar Te, apoptosis pada sel penis dan prostat di antara kelompok berbeda bermakna (p=0,000).Simpulan: Penelitian ini menyimpulkan bahwa pemberian buceng 50 mg selama 30 hari berturut-turut dapat meningkatkan kadarTe dan penurunan apoptosis pada sel penis dan prostat.

Antioksidan Vitamin dan Kerusakan Otot pada Aktivitas Fisik Studi Eksperimen pada Mahasiswa JPOK-FKIP UNS Surakarta Kiyatno Kiyatno
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.934 KB)

Vitamin antioxidants administration toward muscle damage on exercise. An experimental study in students of FKIP–JPOK Sebelas Maret UniversityBackground: Exercise has dual effects, which not only enhance health status and performance but also results in muscular damage. The aim of this study is to determine when the administration of vitamin antioxidants is more effective in reducing the muscular damage.Methods: An experimental quantitative study with a 2x2 factorial research design was used in this study. Forty of total students in third semester of JPOK-FKIP Sebelas Maret University were randomly selected to become the experimental subjects and divided equally into four groups. First and second groups performed exercise with strenuous sub maximal intensity (SSI, running 2x800 m) and took the vitamin antioxidants (30 mg vitamin A, 200 mg vitamin C, 50 mg vitamin E, 15 mg Zn and 25 mcg Se) before runningfor first group and after running for second group respectively. Prior to perform prolonged sub maximal intensity (PSI, running 1500 m) third group took the same antioxidants while fourth group took the antioxidant after doing PSI. 48 hours later, MDA plasma levels were determined by using TBARS in order to measure the muscular damage. T-test was use for analyzing all collected data.Results: There is different effect on muscle damage when vitamin antioxidants were taken before and after exercise (obs.T 3.70> tb.T 1.68), which vitamin antioxidants were taken after exercise has a better muscle damage (MDA 200.60><222.38).Conclusions: The administration of vitamin antioxidants after exercise has a better muscle damage.Keywords: Exercise, vitamin antioxidants, muscle damageABSTRAK Latar belakang: Aktivitas fisik selain membuat tubuh menjadi lebih sehat dan lebih bugar, juga dapat menimbulkan kerusakan otot. Tujuan penelitian untuk mengetahui waktu pemberian antioksidan vitamin yang paling efektif untuk mengurangi kerusakan otot.Metode: Jenis penelitian adalah kuantitatif–eksperimental menggunakan rancangan penelitian faktorial 2x2. Subyek penelitian diambil secara acak sederhana (n=40) mahasiswa JPOK-FKIP UNS semester III, dibagi menjadi 4 kelompok: (1) minum antioksidan vitamin lalu lari 2x800 m (2) lari 2x800 m lalu 20 jam kemudian minum antioksidan vitamin (3) minum antioksidan vitamin lalu lari 1500 m (4) lari 1500 m lalu 20 jam kemudian minum antioksidan vitamin. Kerusakan otot diukur berdasarkankadar MDA plasma dengan metode TBARS 48 jam setelah perlakuan. Antioksidan vitamin terdiri vitamin C 200 mg, vitamin E 50 mg, vitamin A 30 mg, Zn 15 mg, Se 25 mcg. Analisis data menggunakan t-test dengan tingkat kepercayaan 95%, dengan komputer minitab for Window release 13.Hasil: Terjadi perbedaan pengaruh yang bermakna terhadap kerusakan otot antara pemberian antioksidan vitamin sebelum dengan sesudah aktivitas fisik (thit 3,70>ttab 1,68). Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik. (MDA 200,60><222,38).Simpulan: Pemberian antioksidan vitamin sesudah aktivitas fisik kerusakan otot lebih kecil dibanding sebelum aktivitas fisik.

Kekuatan Genggam pada Lansia Wanita Aktif dan Tidak Aktif Berolahraga Gheby Soraya S; Etisa Adi Murbawani
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.889 KB)

Handgrip strength in active and inactive elderly womanBackgrounds: Exercise is one of the factors determining handgrip strength. Lower handgrip strength is an indicator for lower Body Mass Index (BMI). The aim of this study is to compared differences in handgrip strength between active and inactive elderly woman. Methods: This was a cross-sectional study of 26 elderly active woman (spent ≥30 minutes for five times or more a week for exercise) and 26 elderly inactive woman (spent <30 minutes and less than five times a week for exercise). Subject were chosen through purposive sampling. Handgrip strength was measured with handgrip dynamometer. Questionnaire was used for measuring exercise activity. BMI value were obtained from body weight was measurement with digital scale and height measurement with microtoise. Data on energy and protein intake were obtained from food frequency semi quantitative questionnaire (FFSQ). Data analysed were using Kolmogorov-Smirnov, independent t-test, and anacova. Result: Most of active elderly woman (69.2%) had handgrip strength in sufficient category. There were significant differences of handgrip strength between the active and inactive elderly woman (p=0.001) and after being controlled by BMI, energy and protein intake per day (p=0.005). Conclusion: Routine exercise should be recommended to elderly for better handgrip strength.. ABSTRAKLatar belakang: Lansia wanita mempunyai kekuatan genggam yang lebih rendah daripada pria. Kebiasaan olahraga merupakan salah satu faktor yang berpengaruh terhadap kekuatan genggam. Nilai kekuatan genggam merupakan indikator nilai Indeks Massa Tubuh (IMT). Tujuan dari penelitian ini adalah membandingkan kekuatan genggam pada lansia wanita yang aktif dan tidak aktif berolahraga. Metode: Studi cross-sectional pada 26 lansia wanita yang aktif (menghabiskan waktu ≥30 menit dan 5 kali atau lebih dalam seminggu untuk berolahraga) dan 26 lansia wanita yang tidak aktif (menghabiskan waktu <30 menit dan kurang dari 5 kali dalam seminggu untuk berolahraga). Sampel diperoleh dengan cara purposive sampling. Kekuatan genggam diukur menggunakan Handgrip Dynamometer. Kuesioner digunakan untuk mengetahui kebiasaan olahraga. IMT diperoleh dari data berat badan yang diukur dengan timbangan digital dan tinggi badan yang diukur dengan mikrotoa, sedangkan data asupan energi dan protein diperoleh dari Food Frequency Semi Quantitative Questionnaire (FFSQ). Analisis data dengan Kolmogorov-smirnov, Independent t-test dan Anacova. Hasil: Nilai kekuatan genggam sebagian besar lansia wanita yang aktif berolahraga (69,2%) dalam kategori cukup sedangkan sebagian lansia wanita yang tidak aktif berolahraga (53,8%) dalam kategori sangat kurang. Terdapat perbedaan kekuatan genggam sangat bermakna antara lansia wanita yang aktif dan tidak aktif berolahraga (p=0,001) dan setelah dikontrol dengan IMT, asupan energi dan protein (p=0,005).Simpulan: Latihan teratur perlu dilakukan para lansia agar memiliki kekuatan genggam yang baik.

Uji Diagnostik Pemeriksaan Osteosklerotik Tulang dengan Sistem Radiografi Digital Susilo Susilo; Maesadji Tjokro Nagoro; Kusminarto Kusminarto; Wahyu Setia Budi
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.329 KB)

ABSTRACTDiagnostic test of bone osteosclerotics examination using digital radiography systemBackground: The interpretation of a conventional röntgen images have a high degree of subjectivity due to the limitation of humansight. The computationally detection help establish the accuracy of diagnosis of the radiologist. According to our knowledge, there has not been previous research on this issue in Indonesia. The research was aimed to examine a Matlab based software to determine the diagnostic value in the diagnosis of osteosclerotic bone.Methods: This study was a diagnostic test which was conducted in Radiology Department of Dr. Kariadi Hospital Semarang, Dr.Sardjito Hospital Yogyakarta and Bethesda Hospital Yogyakarta, April to August 2009. The radiographs of bone osteosclerotic resulted from computed radiography (CR) test results were taken consecutively, interpreted by a radiologist which was supported by the Anatomical Pathology Laboratory examination as a gold standard. Afterwards these steps were done respectively: classify patients as a normal or osteosclerotic patients based on the cut off point that was determined, calculate the value of the diagnostic by analysis of 2x2 tables, determine the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), anddetermine the optimal of COP (cut off point) using ROC procedure.Results: From the results of diagnostic tests of bone radiographs these following parameter values was obtained: AUC value of 97.6% (95% CI: 94.4%-100%), the optimal cut off point for bone oseosclerotic COP ≥1.05 with a sensitivity value of 93.0% and a specificity of 89.1%. Suitability kappa value of 0.818 K (95% CI: 0.757 to 0.879).Conclusion: The radiographic examination of the results of CR using Matlab-based software can be used to diagnose boneosteosclerotic with high sensitivity and specificity.Keywords: Bone osteosclerotic, röntgen images, optimal of COP, Matlab softwareABSTRAKLatar belakang: Pembacaan foto röntgen secara konvensional memiliki tingkat subyektivitas tinggi karena keterbatasan indrapenglihatan manusia. Pendeteksian secara terkomputasi membantu menegakkan diagnosis para radiolog. Sebagaimana diketahui, belum ada penelitian sebelumnya mengenai masalah ini di Indonesia. Penelitian ini bertujuan menguji perangkat lunak berbasis Matlab untuk menentukan nilai diagnostik pada diagnosis tulang osteosklerotik.Metode: Penelitian ini adalah uji diagnostik yang dilakukan di Bagian Radiologi RSUP Dr. Kariadi Semarang, RSUP Dr. SardjitoYogyakarta dan Rumah Sakit Bethesda Yogyakarta, April-Agustus 2009. Radiograf osteosklerotik tulang hasil pemeriksaan CR (computed radiography) diambil untuk sampel secara konsekutif, kemudian diperiksa oleh radiolog yang didukung oleh pemeriksaan Laboratorium Patologi Anatomi sebagai baku emas. Tahapan yang dilakukan berturut-turut adalah: mengelompokkan pasien sebagai osteosklerotik dan normal berdasar titik potong yang ditentukan, menghitung nilai diagnostik dengan tabel analisis 2x2, menentukan AUC (area under the curve) dengan prosedur ROC (receiver operating characteristic), dan menentukan COP (cut off point) optimal dengan prosedur ROC.Hasil: Hasil uji diagnostik radiograf tulang diperoleh nilai-nilai parameter sebagai berikut: nilai AUC adalah sebesar 97,6% (IK 95%: 94,4%-100%), titik potong optimal untuk osteosklerotik tulang COP ≥1,05 dengan nilai sensitivitas sebesar 93,0% dan spesifisitas sebesar 89,1%. Nilai kesesuaian kappa K sebesar 0,818 (IK 95%: 0,757-0,879).Simpulan: Pemeriksaan radiografi hasil CR menggunakanperangkat lunak berbasis Matlab dapat digunakan untukmendiagnosis osteosklerotik tulang dengan sensitivitas danspesifisitas tinggi

Pengaruh Media Kontras Iopamidol Dosis Tinggi Intravaskuler Terhadap Kadar Kreatinin Serum dan Gambaran Histopatologi Tubulus Ginjal pada Tikus Sprague-Dawley: Upaya Proteksi dengan L-arginin Hermina Sukmaningtyas; Djoko Untung Trihadi
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7526.009 KB)

High dose intravascular iopamidol influence on serum creatinine level and histopatologic feature of kidney tubules in Sprague-Dawley rats: using L-arginine as protectionBackground: Iopamidol, a Low Osmolar Contrast Media (LOCM), has relatively less nephrotoxicity, but contrast media (CM) volume has role to develop acute renal failure even in healthy person. L-arginine as a natural precursor of nitric oxide might prevent contrast nephropathy. Objectives: To investigate effects of iopamidol on acute renal damage by observing serum creatinine level and acute renal necrosis and to assses the role of L-arginine to protect acute renal failure.Methods: This was a post test only control group design experimental study using 35 male, twelve weeks old Sprague-Dawley rats, weighing 200-350 g, allocated into seven groups. The control group (K), P1, P2, P3 were group given 1.8 ml iopamidol and P4, P5, P6 groups were given 8.4% (W/V) L-arginine personde twice a day, 5 ml each for 7 days before 1.8 ml iopamidol injection. Serum creatinine and histological examination were done to assess acute tubular necrosis with H&E staining observed on 24, 48, and 72 hour accordingly. Dose of iopamidol used was equal to 100 ml human dose. The difference of serum creatinine and acute tubular necrosis were analyzed by using ANOVA test.Results: There were no significant differences among groups on serum creatinine level (p=0.261). Acute tubular necrosis increased following iopamidol administration in 72 hour (P3) p=0.007, and pretreatment with L-arginin reduced necrosis in group P6 (p=0.008).Conclusions: Serum creatinine level was not different after administration of iopamidol and L-arginine. Iopamidol induce acute tubular necrosis, while L-arginine can prevent CM-induced nephropathy. Keywords: Iopamidol, serum creatinine, acute tubular necrosis, L-arginine ABSTRAK Latar belakang: Iopamidol, media kontras osmolalitas rendah mempunyai efek nefrotoksik relatif rendah, tetapi pemakaian dosis tinggi merupakan faktor resiko nekrosis tubuler akut. L-arginin, asam amino prekursor NO dan sebagai antioksidan dapat mencegah contrast-induced nephropaty.Tujuan: Mengetahui pengaruh iopamidol terhadap perubahan kadar kreatinin serum dan gambaran nekrosis tubuler akut, serta melihat pengaruh L-arginin terhadap penurunan kejadian contrast-induced nephropaty.Metode: Penelitian eksperimental sesungguhnya dengan rancangan post test only control group design pada tikus Sprague-Dawley jantan, sehat, umur 12 minggu, berat badan 200-350 g. Sebanyak 35 ekor tikus dibagi secara acak menjadi 7 kelompok. Kelompok K, tidak mendapatkan perlakuan, P1, P2, P3 diberi iopamidol 1,8 cc intravena. Kelompok P4, P5, P6 diberi L-arginin 8,4 w/v 2x sehari masing-masing 5 ml selama 7 hari, sebelum disuntik iopamidol 1,8 ml intravena. Kadar kreatinin serum dan pemeriksaan nekrosis tubuler akut diperiksa secara histopatologi dengan pengecatan H&E pada jam ke-24, jam ke-48, jam ke-72 sesuai dengan kelompok perlakuan. Dosis iopamidol setara dengan 100 ml pada dosis manusia. Perubahan kadar kreatinin serum dan nekrosis tubuler akut diuji dengan uji ANOVA.Hasil: Kadar kreatinin serum tidak berbeda di antara kelompok (p=0,261). Pemberian iopamidol menyebabkan nekrosis tubuler akut pada jam ke-72 (p=0,007), dan pemberian L-arginin menurunkan nekrosis tubuler akut pada jam ke-72 (p=0,008). Simpulan: Iopamidol dosis tinggi dapat menginduksi nekrosis tubuler akut pada keadaan tanpa resiko, dan pemberian L-arginin dapat mencegah contrast-induced nephropathy. Kadar kreatinin serum tidak berbeda setelah pemberian iopamidol maupun L-arginin.

Gambaran IgG dan IgM Anti Phenolic Glycolipid–1 Mycobacterium leprae pada Siswa Pesantren Desa Wringin Jajar Kecamatan Mranggen Kabupaten Demak ES Indrayanti; Yuanita Dian Utama
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.671 KB)

IgG and IgM anti phenolic glycolipid–I mycobacterium leprae in pesantren students of Wringin Jajar village, Mranggen, DemakBackground: Sub clinical leprosy can be detected by IgM sera of anti phenolic glycolipid–I (PGL-1) value more than 600 u/ml. The prevalence data study of IgG and IgM sera anti PGL-I value in Indonesia are limited. Two leprosy patients have been reported on pesantren students of Wringin Jajar village, Mranggen District, Demak Regency.Methods: Enzyme linked immunosorbent assay (ELISA) was done to examine the IgG and IgM anti PGL-1 sera of the 44 pesantren students which have been contact which leprosy patients on Wringin Jajar, Mranggen Distric, Demak Regency.Results: The IgM anti PGL-1 sera value more than 600 u/ml (positive results) were on 33 of 41 students (80.5%), and the IgG anti PGL-1 sera value more than 150 u/ml were positive on 15 students (31.7%).Conclusions: The prevalence of sub clinic leprosy in pesantren students which have been contact with leprosy patients were high. Further studies are needed to preacut clinical leprosy outbreak.Keywords: IgG, IgM Phenolic glycolipid, sub clinical of leprosyABSTRAKLatar belakang: Lepra sub klinik dapat dideteksi dengan nilai IgM serum anti PGL-1 >600 iu/ml. Studi prevalensi serum antiPGL-1 di Indonesia masih terbatas. Dua penderita lepra telah dilaporkan pada siswa pesantren di Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak.Metode: Pemeriksaan nilai serum IgG dan IgM anti PGL-I dengan teknik enzyme linked immunosorbent assay (ELISA) dilakukan terhadap 44 siswa yang telah mengalami kontak dengan penderita lepra di desa Wringin Jajar, Mranggen Kabupaten Demak.Hasil: Hasil nilai IgM serum anti PGL-1 >600 u/ml terdapat pada 33 dari 41 (80,5%) siswa pesantren Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak. Sebaliknya IgG positif >150 u/ml positif pada 15 siswa (31,7%).Simpulan: Prevalensi lepra sub klinik siswa kontak penderita lepra positif di Pesantren Desa Wringin Jajar, Kecamatan Mranggen, Kabupaten Demak cukup tinggi. Studi lebih lanjut amat diperlukan untuk mencegah munculnya lepra secara klinis.

Hipotiroidisme pada Wanita Usia Subur (WUS) di Daerah Pertanian: Penelitian di Kecamatan Kersana Kabupaten Brebes Suhartono Suhartono; Sri Djokomoeljanto; Suharyo Hadisaputro; Hertanto Wahyu Subagio; Apoina Kartini
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.499 KB)

Background: Hypothyroidism can cause infertility, spontaneous abortion, fetal growth-development disorders, placental abruption and prematurity. Exposure to pesticides, both of organochlorines and organophosphate, can cause hypothyroidism. The aim of the study was to examine the prevalence of hypothyroidism in WCA in agricultural areas.Methods: A cross-sectional study was conducted in two hundred and eight women of WCA who were randomly selected from four villages and TSH levels were examined. The TSH cut-off point for the diagnosis of hypothyroidism was 4.5 μIU/mL. In a sub-sample, fT4 levels, UEI and thiocyanate in urine, were also examined. Result: The mean level of TSH was 3.66 (±5.330) μIU/mL, the lowest value was 0.05, and the highest was 60 µIU/mL; the median was 2.38 μIU/mL; the mean FT 4 (n=89) was 16.207±3.0438 pmol/L; UEI median value (n=41) was 288.0 mcg/L; while the mean of urinary thiocyanate levels (n=41) was 1.468±1.25 mcg/mL. There were 47 WCA (22,6%) with hypothyroidism, 46 of which (97.9%) are sub-clinical hypothyroidism.Conclusion: The prevalence of hypothyroidism in WCA was 22.6% and almost all women had sub-clinical hypothyroidism. Pesticide exposure is suspected as a risk factor for hypothyroidism in this population.ABSTRAKLatar belakang: Hipotiroidisme merupakan keadaan, di mana kelenjar tiroid tidak dapat memproduksi hormon cukup untuk memenuhi kebutuhan tubuh. Pada WUS, hipotiroidisme dapat menyebabkan infertilitas, abortus spontan, gangguan tumbuh-kembang janin, placental abruption dan bayi lahir sebelum waktunya. Pajanan pestisida, baik dari golongan organoklorin maupun organofosfat, dapat menyebabkan hipotiroidisme. Penelitian ini bertujuan mengkaji berapa besar prevalensi hipotiroidisme pada WUS yang bertempat tinggal di daerah pertanian.Metode: Penelitian ini menggunakan desain cross-sectional. 208 WUS dipilih secara acak dari empat desa dan dilakukan pemeriksaan kadar TSH. Diagnosis hipotiroidisme ditegakkan berdasarkan kadar TSH 4,5 µIU/mL. Pada sebagian WUS (sub-sampel) dilakukan pemeriksaan kadar fT4, UEI dan kandungan tiosianat dalam urin. Hasil: Rerata kadar TSH adalah 3,66 (±5,330) µIU/mL, nilai terendah 0,05, nilai tertinggi 60 µIU/mL sedangkan median TSH 2,38 µIU/mL; rerata fT 4 (n=89) adalah 16,207±3,0438 pmol/L; nilai median UEI (n=41) adalah 288,0 µg/L; rerata kadar tiosianat urin (n=41) adalah 1,25±1,468 µg/mL. Didapatkan 47 WUS (22,6%) dengan hipotiroidisme, 46 di antaranya (97,9%) adalah hipotiroidisme sub-klinik.Simpulan: Prevalensi hipotiroidisme pada WUS sebesar 22,6%, hampir semuanya hipotiroidisme sub-klinik. Pajanan pestisida patut dicurigai sebagai faktor risiko pada WUS di daerah pertanian yang diteliti ini.

Risiko Konsumsi Western Fast Food dan Kebiasaan Tidak Makan Pagi Terhadap Obesitas Remaja Studi di SMAN 1 Cirebon Lilis Banowati; Nugraheni Nugraheni; Niken Puruhita
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 2 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.107 KB)

ABSTRACTRisks of western fast food consumption and skipping breakfast to adolescents’obesity: Study at SMAN 1 CirebonBackground: Obesity prevalence in adolescents remains high. Western fast food consumption and skipping breakfast were identified as sub-culture among adolescents.The objective of this study was aimed to determine the risk of western fast food consumption in term of frequency of consumption, energy intake and energy contribution to adolescents’ obesity. It was also aimed to determine therisk of skipping breakfast for adolescents’ obesity.Method: It was an observational study using a case-control approach. Stratified random sampling was used to select participants from population. Seventy six secondary students from SMA Negeri 1 Cirebon were involved, divided into two groups; 38 students as case (BMI>95 persentile) and the rest 38 as controls (BMI 5-85 persentile). Chi-square and multiple logistic regression were employed in data analysis.Results: This study found obese students consumed western fast food more than their counterparts (263 kkal versus 140 kkal) (p=0.001). They were less frequent breakfast having (4.5 times per week) than those who were not obese (5,8 times per week) (p=0.019). Energy intake gained from western fast food consumption ≥244 kkal per day was found as the risk factor for obesity among adolescents (p=0,004) whilst frequency of consumption >9.2 times per month, energy contribution to total calorie intake >7.3% and skipping breakfast were failed to predict adolescents’ obesity (p>0.05). The result of multiple logistic regression test showed that the variable which is the most influential to the incident of obesity is energy intake gained from western fast food consumption (OR=6.26).Conclusion: Western fast food consumption ≥244 kkal per day is a risk factor for obesity.Keywords: Western fast food consumption, skipping breakfast, obesity, adolescentABSTRAKLatar belakang: Prevalensi obesitas remaja cukup tinggi. Hal ini disebabkan oleh konsumsi western fast food dan kebiasaan tidak makan pagi yang sudah merupakan kecenderungan di kalangan remaja. Tujuan penelitian ini untuk mengetahui besar risiko frekuensi konsumsi western fast food, asupan energi konsumsi western fast food, kontribusi energi western fast food dan kebiasaantidak makan pagi terhadap kejadian obesitas remaja SMAN 1 Cirebon.Metode: Jenis penelitian observasional dengan rancangan kasus kontrol. Pengambilan sampel dengan teknik stratified random sampling. Besar sampel 76 orang, terdiri dari 38 orang kasus (IMT >95 persentil) dan 38 orang kontrol (IMT persentil ke-5 -85). Penelitian menggunakan analisis bivariat dengan uji chi square dan analisis multivariat dengan uji regresi logistik ganda.Hasil: Pada remaja obesitas asupan energi konsumsi western fast food (263 kkal) lebih tinggi daripada yang tidak obes (140 kkal) (p=0,001). Sedangkan frekuensi makan pagi lebih rendah (4,5 kali/minggu) daripada yang tidak obes (5,8 kali/minggu) (p=0,019). Hasil analisis menunjukkan asupan energi konsumsi western fast food ≥244 kkal per hari merupakan faktor risiko terjadinyaobesitas (p=0,004). Sedangkan frekuensi konsumsi western fast food >9,2 kali per bulan, kontribusi energi western fast food terhadap total kalori >7,3% dan kebiasaan tidak makan pagi bukan faktor risiko obesitas (p>0,05). Hasil uji regresi logistik ganda menunjukkan bahwa variabel yang paling berpengaruh terhadap obesitas remaja adalah asupan energi konsumsi western fast food(OR=6,26).Simpulan: Konsumsi western fast food ≥244 kkal per hari berisiko untuk terjadinya obesitas.

Kadar C-Reaktif Protein Anak Kandung Penderita Dengan dan Tanpa Penyakit Jantung Koroner Juwairiyah Juwairiyah; Lisyani BS; Indranila KS; Imam BW
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.398 KB)

C-reactive protein levels in children of patients with and without coronary heart diseaseBackground: Coronary heart disease (CHD) has become the main cause of death worldwide, with atherosclerosis which is a chronic inflammation as the hiden background. CRP (C-reactive protein), a serum inflammation marker, appear in coronary heart disease. So for, the studies about the relation of CRP and CHD had been conducted, but the condition of the CRP serum level in children of CHD patients still rarely be evaluated. The aims to analyse the means CRP levels in children of patients with or without CHD, and to find the influence of CHD patients to the children’s CRP level after controlled by body mass index and lipid profile.Methods: A cross sectional approach to 20 blood specimens from each group, children of patients with and without CHD. The serum CRP levels means were measured twice in range of 2 weeks, using hs-CRP PETIA technique and analysed with Mann-Whitney test and logistic regression.Results: Median CRP levels in children of CHD parents was 2.15 mg/L, which was different from children without CHD parent (1.48 mg/L which was p=0.001). The proportion of parents with CHD to high CRP level in their own children 87%. Logistic regression analysis shows that parents with CHD was not a determinant to high CRP level (p=0.172; 95% CI=0.487-55.821).Conclusions: The CRP of level of children whose parents have CHD is higher than those with parents without CHD.Keywords: Inflammation, CRP levels, parents with coronary heart disease, inheritedABSTRAKLatar belakang: Penyakit jantung koroner (PJK), penyebab kematian utama di dunia dengan aterosklerosis sebagai penyebab tersembunyi merupakan inflamasi kronik. CRP (C-reactive protein), suatu petanda inflamasi akut didapatkan pada PJK. Penelitian yang menghubungkan CRP dan PJK sudah banyak, tetapi penelitian CRP anak dengan riwayat orang tua PJK masih terbatas. Tujuan penelitian ini untuk menganalisis perbedaan rerata kadar CRP anak kandung penderita dengan dan tanpa PJK serta pengaruh orang tua PJK terhadap kadar CRP anak kandung setelah dikontrol dengan IMT (indeks masa tubuh) dan profil lipid.Metode: Pendekatan belah lintang, masing-masing 20 spesimen darah anak kandung penderita PJK dan tanpa PJK. Diukur rerata kadar CRP pada dua kali pemeriksaan dengan interval dua minggu, menggunakan metoda hs-CRP teknik PETIA dan analisis statistik uji beda Mann-Whitney serta regresi logistik.Hasil: Median kadar CRP anak kandung penderita PJK berbeda dengan anak tanpa orang tua PJK (p=0,001). Proporsi orang tua PJK dengan kadar CRP yang tinggi pada anak kandung 87%. Hasil analisis regresi logistik menunjukkan bahwa orang tua PJK tidak merupakan determinan terhadap kadar CRP yang tinggi pada anak (p=0,172; 95% CI=0,487-55,821) .Simpulan: Kadar CRP anak dengan orang tua PJK lebih tinggi daripada mereka yang orang tua bukan penderita PJK.

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA