cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota semarang,
Jawa tengah
INDONESIA
MEDIA MEDIKA INDONESIANA
Published by Universitas Diponegoro
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 134 Documents
 1   2   3   4   5 
Pneumonitis Radiasi pada Penderita Karsinoma Payudara yang Mendapat Terapi Kemoradiasi di RSUP Dr. Kariadi Fatchoerochman Fatchoerochman; Nasirun Zulqarnain; Eko Kuntjoro
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.384 KB)

Abstract

Radiation pneumonitis in breast cancer patients who recieved chemoradiation therapy at Dr. Kariadi hospitalBackground: The diagnosis of radiation pneumonitis relied on clinical symptoms and chest x-ray. Radiation pneumonitis will arise 6 to 12 week after external radiation therapy was completed, combination with chemotherapy will increase risk factor of radiation pneumonitis. The aim of this research is to find incidence of radiation pneumonitis among the breast cancer patient with chemoradiation therapy. Method: This study was an analitic descriptive, with subjects were patients with stage II-III breast carcinoma that have finished chemoradiation therapy at Dr. Kariadi hospital from January 1st 2007 to March 31st 2009. They were contacted by telephone or came for control. Radiation was given with dosage of 50 Gy and booster 10 Gy on chest wall. Incidence data of radiation pneumonitis was analyzed. Result: The mean age was 48.7 years. The incidence of radiation pneumonitis was 13 from 32 subjects (40.6%), with 69% was mild degree. As much as 31.3% used CAF regiment, 55.6% CAF-xeloda regiment, 20.0% CEF regiment, and xeloda + CEF-xeloda was 100%. There was no significant difference of radiation pneumonitis proportion based on age (p=0.09) and stadium (p=0.15). Most of the patients examined by chest x-ray with pulmonary symptoms, while no pulmonary symptom disapproved to be taken the chest x-ray. This caused the selection bias, thus the incidence of radiation pneumonitis tend to be high.Conclusion: There were high tendency (40.6%) of radiation pneumonitis incidence at stage II-III breast cancer patient who get chemoradiation therapy at Dr. Kariadi General Hospital, but the most degree of radiation pneumonitis is mild.ABSTRAKLatar belakang: Diagnosis pneumonitis radiasi didasarkan pada gejala klinis dan pemeriksaan x foto toraks. Pneumonitis radiasi akan timbul 6-12 minggu setelah terapi radiasi lengkap dan pemberian kemoterapi akan meningkatkan faktor risiko pneumonitis radiasi. Penelitian ini bertujuan mencari insidens pneumonitis radiasi pada penderita karsinoma payudara.Metode: Penelitian ini adalah deskriptif analitik dengan subjek penderita karsinoma payudara stadium II-III yang telah menyelesaikan terapi kemoradiasi di RSUP Dr. Kariadi pada periode 1 Januari 2007 sampai dengan 31 Maret 2009 yang bisa dihubungi lewat telepon atau datang kontrol. Radioterapi diberikan dengan dosis 50 Gy dan booster 10 Gy pada dinding dada. Data insidens pneumonitis dianalisis secara deskriptif analitik.Hasil: Rerata umur subjek 48,7 tahun. Insidens pneumonitis radiasi sebanyak 40,6%. Sebagian besar (69%) gambaran pnemonitis termasuk dalam kategori ringan. Sebanyak 31,3% menggunakan regimen CAF, 55,6% menggunakan CAF-xeloda, 20,0% menggunakan CEF. Xeloda dan CEF-xeloda masing-masing ditemukan 1 dari 1 subjek (100%). Tidak ada perbedaan bermakna proporsi kejadian pneumonitis radiasi berdasarkan kelompok umur (p=0,09) dan kelompok stadium (p=0,15). Sebagian besar pasien yang bersedia datang untuk dilakukan pemeriksaan x foto toraks PA adalah yang merasa ada kelainan pada paru-parunya, sedangkan yang merasa tidak ada kelainan pada paru-parunya tidak bersedia untuk diperiksa. Hal ini yang menyebabkan adanya selection bias pada subjek penelitian ini sehingga insiden pneumonitis radiasi cenderung tinggi.Simpulan: Insiden pneumonitis radiasi pada penderita karsinoma payudara stadium II-III yang mendapat terapi kemoradiasi di RSUD Dr. Kariadi cenderung tinggi yakni 40,6%, dengan derajat pneumonitis radiasi mild yang terbanyak.
Praktik Inisiasi Menyusu Dini dan Pemberian ASI Eksklusif Studi Kualitatif pada Dua Puskesmas, Kota Semarang Etika Ratna Noer; Siti Fatimah Muis; Roni Aruben
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.246 KB)

Abstract

ABSTRACTEarly initiation of breastfeeding and exclusive breastfeeding practice: qualitative study at public health centers, Semarang cityBackground: Early initiation of breastfeeding (EIB) and exclusive breastfeeding (EB) up to six months are two important breastfeeding practices for child’s survival. EIB plays an important role in reducing infant mortality and improve the success of exclusive breastfeeding. Determinants in EIB and EB practices are predisposing, enabling, reinforcing, and environment. This study aimed to investigate determinants in EIB and EB practice until 4 months.Method: This study used a qualitative approach. Data were collected through intensive observations, non-intervention and in-depth interviews to 12 mothers. Data were analyzed using content analysis including data collection, reduction, presentation, and conclusions.Result: All the mothers were successful in the EIB with the help of professional midwife. Exclusive breastfeeding were successful in 3 mothers, partial breastfeeding were practiced by 6 mothers and not breastfeeding or formula feeding were practiced by 3 mothers. Predisposing and reinforcing were two strongly factors that cause the unsucessfull EB practices. The former were lack of knowledge of EB and breastfeeding techniques. The latter were lack of commitment of health providers, family support, and the status ofworking mothers.Conclusion: EIB practice does not ensure the success of EB.Keywords: Early initiation of breastfeeding, exclusive breastfeeding, qualitativeABSTRAKLatar belakang: Inisiasi menyusu dini (IMD) dan ASI eksklusif sejak lahir hingga usia enam bulan merupakan dua praktik pemberian ASI yang penting untuk kelangsungan hidup dan pertumbuhan optimal bayi. IMD berperan penting dalam mengurangi angka kematian bayi dan meningkatkan keberhasilan pemberian ASI eksklusif. Beberapa faktor determinan dalam praktik IMD dan  ASI eksklusif yaitu faktor predisposisi (predisposing), pemungkin (enabling), penguat (reinforcing), dan lingkungan. Penelitian inibertujuan untuk mempelajari beberapa faktor determinan pada praktik IMD dan ASI eksklusif selama 4 bulan pada ibu yang melahirkan pada dua puskesmas di kota Semarang. Hasil penelitian ini akan diteruskan sebagai masukan terhadap program peningkatan cakupan pemberian ASI eksklusif.Metode: Penelitian ini menggunakan pendekatan kualitatif pada 12 ibu. Pengumpulan data dilakukan dengan observasi intensif, non intervensi dan menggunakan teknik wawancara mendalam. Data dianalisis dengan cara analisis isi yang bersifat terbuka. Hasil: Semua ibu dapat melakukan praktik IMD dengan bantuan profesionalisme bidan puskesmas. Praktik ASI eksklusif dilaksanakan oleh 3 ibu, ASI parsial pada 6 ibu dan pemberian susu formula oleh 3 ibu. Hambatan utama praktik pemberian ASI eksklusif adalah dari faktor ibu yaitu rendahnya pengetahuan tentang ASI eksklusif dan teknik menyusui. Faktor penghambat lainnya adalah kurangnya komitmen petugas kesehatan, dukungan suami, dan status ibu bekerja.Simpulan: Praktik IMD tidak menjamin keberhasilan pemberian ASI eksklusif.
Dislipidemia dan Oval Fat Bodies Dalam Urin Indranila Indranila
MEDIA MEDIKA INDONESIANA 2008:MMI Volume 43 Issue 3 Year 2008
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (810.325 KB)

Abstract

Dyslipidemia and oval fat bodies in urineBackground: Lipid profiles such as cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol screening are expensive. Oval fat bodies (OFB) an epithelial tubulus cell within lipid degenerated/macrophag contains fat granule, is a marker of lipiduria will be expected as a feature of serum lipids and may be performed as a simple non invasive, inexpensive laboratory test. The aim of the study was to analyze the correlation between dyslipidemia and OFB.Methods: This study was performed in 66 male and female subjects of hypercholesterolemia and hypertriglyceridemia of 20-83 years old, which come to a private laboratory in Semarang within 3 months. Sample were taken purposively. The method used in detecting lipids serum was enzymatics (CHOD-PAP for cholesterol and GPO enzymatic for triglyceride) and OFB examination in urine using Sternheimer–Malbin staining.Results: Triglyceride and cholesterol mean value were 210.8 mg/dl (±131.74) and 230.6 mg/dl (±36.4). OFB were found in the urine of on 15 subjects (75%) with hyperlipidemia, 26 subjects (72.2%) with hypercholesterolemia and 6 subjects (70%) with hypertriglyceridemia. There were corellations between hypercholesterolemia and hypertriglyceridemia and OFB (r1=0.82, p1=0.01; r2=0.84, p2=0.05; r3=0.75, p3=0.05).Conclusions: There are positive correlation between dyslipidemia and the presence of OFB in urine.Keywords: Dyslipidemia, oval fat bodies.ABSTRAKLatar belakang: Profil lipid sebagai uji saring umumnya adalah kolesterol, trigliserid, kolesterol-HDL, kolesterol-LDL dimana biaya pemeriksaan ini masih cukup mahal, sementara pola makan cenderung tinggi lemak. Oval fat bodies (OFB) merupakan salah satu petanda lipiduria diharapkan dapat menggambarkan keadaan lemak darah pada uji saring laboratorium secara sederhana, non invasif dan murah. Penelitian ini bertujuan untuk mengetahui hubungan antara dislipidemi dengan OFB.Metode: Pengamatan dilakukan pada 66 subyek usia dewasa baik laki-laki dan wanita dengan hiperkolesterolemia dan atau hipertrigliseridemia yang memeriksakan diri di laboratorium klinik swasta di Semarang selama kurun waktu 3 bulan secara purposivesampling. Metode pemeriksaan yang digunakan adalah ensimatik (CHOD–PAP untuk kolesterol dan GPO ensimatik untuk trigliserida) dan mikroskopik sedimen urin menggunakan pengecatan Sternheimer-Malbin untuk OFB.Hasil: Didapatkan rerata trigliserid dan kolesterol 210,8 mg/dl (±131,7) dan 230,6 mg/dl (±36,4) OFB ditemukan dalam urin 15 subyek (75%) dengan hiperlipidemia, 26 subyek (72,2%) dengan hiperkolesterolemia dan 6 subyek (70%) dengan hipertrigliseridemia. Ada korelasi antara hiperlipidemia, hiperkolesterolemia dan hipertrigliseridemia dengan keberadaan OFB di urin (r1=0,82, p1=0,01; r2=0,84, p2=0,05; r3=0,75, p3=0,05).Simpulan: Ada korelasi positif antara dislipidemia dengan ditemukannya OFB di urin.
Profil Kromatogram dan Aktivitas Antibakteri Ekstrak Etanol Rimpang Bengle (Zingiber cassumunar Roxb) Terhadap Bakteri Escherichia coli In Vitro Lanjar Raharjoyo; Gunardi Gunardi
MEDIA MEDIKA INDONESIANA 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.815 KB)

Abstract

Chromatogram profile and antibacterial activity of ethanol extract from bengle rhizome (Zingiber cassumunar Roxb.) to Escherichia coli in vitroBackground: Bengle (Zingiber cassumunar roxb.) was a plant which had been used by society since long time ago as a traditional medicine. It was predicted that there were anti-bacteria substances in bengle, so it might substitutes the utilization of conventional antibiotics. The aims of this research was to explore the chromatogram and antibacterial activity etanol extract of Bengle Rhizome against Escherichia coli.Methods: The method of these research were descriptive and experimental study using the post test only control group design. Ethanol extract of Bengle rhizome was made by maceration method with ethanol as solvent. Chromatogram profile was using thin layer chromatography and antibacterial activity against escherichia coli was done using dilution method and than cultured in Mac Conkey agar media.Results: The results showed thad, thin layer chromatography shown 4 spot under UV light 254 nm wave leng with colour, blue violet, blue violet, brown yellow, brown yellow and Rf value 0.21; 0.34; 0.45; 0.55. No bacterial growth at etanol extract of Bengle rhizome 12.5% on Mueller Hinton Broth media, nor at consentration of 25% on Mac Conkey media.Conclusions: The were 4 compounds predictly included of flavonoid, steroid, volatile oil and terpenoid group. Etanol extract of Bengle rhizome had minimum consentration inhibitory 12.5% and minimum bactericide consentration 25% against Escherichia coli.Keywords: Ethanol extract of Bengle rhizome, Escherichia coli, anti-bacteria activity in vitroABSTRAKLatar belakang: Bengle (Zingiber cassumunar Roxb.) adalah tanaman yang sudah lama digunakan di masyarakat sebagai obat tradisional. Dalam tanaman ini diduga terdapat zat anti bakteri sehingga dimungkinkan untuk digunakan sebagai pengganti antibiotika konvensional. Tujuan penelitian ini untuk mengetahui profil kromatogram ekstrak rimpang etanol rimpang Bengle dan aktivitasnya terhadap Escherichia coli.Metode: Metode penelitian yang dilakukan adalah penelitian deskriptif dan penelitian eksperimental dengan rancangan post test only control group design. Ekstraksi rimpang Bengle dilakukan dengan metode maserasi menggunakan pelarut etanol. Untuk mengetahui profil kromatogram dilakukan pemisahan secara kromatografi lapis tipis dan aktivitas terhadap Escherichia coli dilakukan dengan metode pengenceran yang dilanjutkan dengan metode penanaman pada media Mac Conkey.Hasil: Profil kromatogram di bawah UV 254 nm didapatkan 4 bercak berwarna ungu biru, ungu biru, kuning coklat, kuning coklat  dengan Rf 0,21; 0,34; 0,45; dan 0,55. Dalam media cair Mueller Hinton Broth pertumbuhan bakteri tidak terlihat pada kadar ekstrak rimpang Bengle 12,5% dan dalam media Mc Conkey pada kadar 25%.Simpulan: Terdapat 4 komponen senyawa dalam ekstrak rimpang bengle yang dapat teramati, diperkirakan golongan flavonoid, steroid, minyak atsiri dan terpenoid. Ekstrak rimpang Bengle mempunyai aktivitas terhadap Escherichia coli dengan kadar hambat minimum 12,5% dan kadar bunuh minimum 25%.
Pengaruh Polifenol Mahkota Dewa Terhadap Proliferasi Sel dan Apoptosis pada Mencit Strain Balb/C yang Diinduksi Benzo(a) Pyrene (BaP) Theopilus W. Watuguly; Indranila KS; Pamela Mercy Papilaya; Edi Dharmana
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.839 KB)

Abstract

ABSTRACT The effect of mahkota dewa polyphenol in the cell proliferation and apoptosis in BaP induced Balb/c ratsBackground: The polyphenol of mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl) has the potency as antioxidant and anticancer which can handle free radicals, but there has not been extensive research on this. This research is aimed to prove the role of mahkota dewa polyphenol in the cell proliferation inhibition and induct lung carcinogenesis apoptosis in strain Balb/c mice which inducted with benzo(a)pyrene (BaP).Methods: Posttest control group design was carried out among 40 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice condition. All mice were inducted with BaP and then randomized into 2 groups, as control group and the treatment group. The development of the lung tumor was observed by tissue surgery in the 8th, 17th and 26th week. The data collected were AgNORs, and IHC-TUNEL-apoptosis index dying. The data analysis was conducted using Kruskal-Wallis, Mann-Whitney, One-way ANOVA, and Post hoc test LSD with significance degree of p<α (0.05).Results: The oral administration of mahkota dewa polyphenol showed significantly decreasing cell proliferation, increasing apoptosis index in treatment group in week 8, 17 and 26 (p=0.000). Carcinogenesis incidence for the treatment group week 8 and 26 were 2.32±0.26 and 3.93±0.46, while for the treatment group were 1.88±0.38 and 0.88±0.22 (p=0.000). The cell proliferations for control group week 8 and 26 were 1.57±0.12 and 2.29±0.15, while for the treatment group were 1.53±0.11 and 1.60±0.04 (p=0.000). Apoptosis index for the control group for week 8 was 0.00±0.00 and 0.92±0.22 in week 26, while the treatment group was 1.12±0.71 and 2.02±1.05 (p=0.000).Conclusion: The administration of mahkota dewa polyphenol effectively inhibited the cell proliferation activity and increased apoptosis measured by apoptosis index. Therefore polyphenol has anticancer and antioxidant activities which can inhibit lung carcinogenesis in Balb/c mice.Keywords: Polyphenol, mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl), apoptosis index, strain Balb/c mice, benzo(a)pyrene (BaP).ABSTRAKLatar belakang: Polifenol mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl) berpotensi sebagai antioksidan dan antikanker yang mampu menangkap radikal bebas, namun belum banyak diteliti. Penelitian ini bertujuan membuktikan peran polifenol mahkota dewa dalam menginhibisi proliferasi sel dan menginduksi apoptosis pada mencit strain Balb/c hasil induksi Benzo(a)pyrene (BaP).Metode: Posttest control group design dengan sampel 40 mencit strain Balb/c, umur 1-2 minggu, berat 20-30 g, kondisi mencit sehat. Semua mencit diinduksi BaP kemudian hewan dirandomisasi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok perlakuan polifenol 50 mg. Perkembangan tumor paru diamati dengan pembedahan jaringan pada minggu ke-8, 17 dan 26. Data dikumpulkan meliputi AgNORs, pengecatan IHC-TUNEL-indeks apoptosis. Analisis data dengan Kruskal-Wallis, Mann-Whitney, One-way ANOVA, post hoc test LSD dengan derajat kemaknaan p<α (0,05).Hasil: Pemberian oral polifenol mahkota dewa sebesar 50 mg secara bermakna memperlihatkan penurunan insidens karsinogenesis paru, proliferasi sel, protein Bax dan peningkatan indeks apoptosis, protein p53, Bcl-2, ekspresi caspase 3, 8, 9 pada kelompok perlakuan pada minggu ke-8, 17 dan 26 (p=0,000). Insidens karsinogenesis untuk kelompok kontrol minggu ke-8, dan 26 sebesar 2,32±0,26 dan 3,93±0,46, sedangkan kelompok perlakuan sebesar 1,88±0,38 dan 0,88±0,22 (p=0,000). Proliferasi sel untuk kelompok kontrol minggu ke-8 dan 26 sebesar 1,57±0,12 dan 2,29±0,15, sedangkan kelompok perlakuan sebesar 1,53±0,11 dan 1,60±0,04 (p=0,000). Indeks apoptosis pada kelompok kontrol minggu ke-8 sebesar 0,00±0,00 dan 0,92±0,22 minggu ke-26, sedangkan kelompok perlakuan sebesar 1,12±0,71 dan 2,02±1,05 (p=0,000).Simpulan: Pemberian polifenol mahkota dewa efektif meng-inhibisi proliferasi sel dan menginduksi apoptosis melalui peningkatan indeks apoptosis. Jadi polifenol mahkota dewa memiliki aktivitas antikanker dan antioksidan mampu menghambat karsinogenesis paru mencit Balb/c.
Beberapa Faktor yang Berperan Terhadap Keaktifan Kunjungan Lansia ke Posyandu Studi Kasus di Desa Tamantirto Kecamatan Kasihan Kabupaten Bantul Propinsi DIY Puji Lestari; Soeharyo Hadisaputro; Kris Pranarka
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 2 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.966 KB)

Abstract

ABSTRACTFactors influencing elderly visit to elderly community health care (posyandu lansia): Case study in Tamantirto Village, Kasihan, Bantul, DIYBackground: Elderly community health care (ECHC) is the base of holistic-continuous care for the elderly. The number of elderly at Tamantirto Village is 11.3% of the total residents, which has not been accompanied by a high scope of ECHC visit, where 6 of 9 the ECHCs still have the coverage lower than 50%. Purpose of this study is to prove that age, education, occupation, socio economic status, knowledge, attitude, facilities, access, cadre and health workers services, social role and family role can affect elderly people’s visitations to the ECHC.Methods: Study design: observational analytic, case-control approach. The case: elderly as the ECHC members who actively visited, the control: elderly as ECHC members were who did not actively visit ECHC. The sample’s are 52 cases and 52 controls. The quantitative data were gathered by interviews, while the qualitative data by using focus group disscussion.Results: The factors influencing elderly people’s visitations to the ECHC are age of  71 years old (OR:4.6), not working (OR:8.1), good attitude (OR:3), good facilities (OR:5.4), good service of cadres and health workers (OR:6.5) and a good family role (OR:3.2). The factors that do not affect elderly people’s visitations are educational level, socio economic, knowledge, access, and social role ofthe elderly.Conclusion: Characteristics of elderly activity visit ECHC are age of 71 years old, not working, good attitude, good facilities, good service of cadres and health workers and a good family role.Keywords: Elderly community health care, actively visit, influencing factorsABSTRAKLatar belakang: Posyandu lansia merupakan dasar pelayanan yang holistik dan berkesinambungan pada lansia. Jumlah lansia yang cukup banyak di Desa Tamantirto yaitu sebanyak 11,3% dari jumlah penduduk, belum diiringi dengan cakupan kunjungan yang tinggi, dimana 6 dari 9 posyandu masih mempunyai cakupan di bawah 50%. Tujuan penelitian adalah membuktikan bahwa umur, pendidikan, pekerjaan, kondisi sosial ekonomi, pengetahuan, sikap, fasilitas posyandu, akses terhadap posyandu, pelayanan kader dan petugas kesehatan, peran sosial lansia, serta peran keluarga berpengaruh terhadap kunjungan lansia ke posyandu.Metode: Desain penelitian: analitik observasional, pendekatan kasus kontrol. Kasus adalah lansia anggota posyandu (umur 60 tahun) yang aktif melakukan kunjungan ke posyandu. Kontrol adalah lansia anggota posyandu (umur 60 tahun) yang tidak aktifmelakukan kunjungan ke posyandu. Sampel penelitian 52 kasus dan 52 kontrol. Data kuantitatif diperoleh dengan wawancara, data kualitatif dengan diskusi kelompok terarah.Hasil: Faktor yang berpengaruh terhadap keaktifan kunjungan lansia ke posyandu yaitu umur 71 tahun (OR:4,6), tidak bekerja (OR:8,1), sikap yang baik (OR:3), fasilitas yang baik (OR:5,4), pelayanan kader dan petugas kesehatan yang baik (OR:6,5), peran
Karakteristik Klinik dan Laboratorik Kolestasis Intrahepatal dan Ekstrahepatal di Bangsal Perawatan Anak RSU Dr. Saiful Anwar Malang Satrio Wibowo; Nurtjahjo Budi Santoso
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.216 KB)

Abstract

Clinical and laboratory characteristics of intrahepatic and extrahepatic cholestasis in pediatric ward of Dr. Saiful Anwar General Hospital MalangIntroduction: Clinical examination in determining intrahepatic and extrahepatic cholestasis in children and infant remains invasive and difficult. There is a need of simple and aplicative method on clinical practice. The objective of this review is to find the cause of cholestasis based on clinical and laboratory examination. Subject and Methode: Sixty nine medical records from pediatric patients who suffered from prolonged conjugated jaundice between January 2008 and March 2011 in the Department of Pediatrics of Dr. Saiful Anwar General Hospital, Malang, Indonesia were reviewed with regard to the clinical examinations, laboratory parameters and ultrasound. Liver ultrasound was used to classify patients into two groups: intra or extrahepatic cholestasis. Unpaired t-test was performed to compare numerical data. P value less than 0.05 were considered as to indicate statistical significant.Results: Leucocytes count (mean 2.649/mm3, 95%CI 1.556 to 12.141/mm3, p=0.012), ALT (mean 155 IU/L, 95%CI 66.9 to 245 IU/L, p=0.043), cholesterol (mean 243 mg/dl, 95%CI 31 to 455 mg/dl, p=0.026) and triglyseride (mean 219 mg/dl, 95%CI 40 to 398 mg/dl, p=0.018) were significantly higher in patients with extrahepatic cholestasis than intrahepatic group, but potassium level (mean 1.18 mEq/L, 95%CI 0.22 to 2.14 mEq/L, p=0.017) were significantly lower in intrahepatic group. Pale stool color had 75%sensitivity and 80% spesificity in determining extrahepatic cholestasis.Conclusion: Elevated leucocyte count, increased ALT serum level, cholesterol, triglyseride and decreased of potassium and acholic stool can be used as determinant factors in classifying intra or extrahepatic cholestasis in children.Keywords: Acholic stool, leucocyte, ALT, cholesterol, triglyseride, potassium, cholestasisABSTRAKLatar belakang: Diagnosis pasti kolestasis intrahepatal dan ekstrahepatal pada bayi dan anak membutuhkan pemeriksaan yang invasif dan sulit. Dibutuhkan metode yang sederhana dan aplikatif untuk praktek klinis. Penelitian ini bertujuan untuk menentukan jenis kolestasis intrahepatal berdasarkan pemeriksaan klinis dan laboratoris.Metode: Enam puluh sembilan rekam medis pasien yang pernah dirawat di bangsal anak RSU Dr. Saiful Anwar Malang dengan kolestasis selama periode Januari 2008 sampai Maret 2011 dianalisis. USG digunakan untuk menentukan ada tidaknya sumbatan ekstrahepatal dan menentukan kelompok kolestasis intrahepatal atau ekstrahepatal. Identitas, keluhan, riwayat penyakit dan hasilhasil pemeriksaan laboratorium dibandingkan antara dua kelompok penelitian. Unpaired t-test digunakan untuk membandingkandata numerik dari dua kelompok yang diteliti.Hasil: Leukosit (rerata 2,649/mm3, 95%CI 1.556-12,141/mm3, p=0,012), ALT (rerata 155 IU/L, 95%CI 66,9-245 IU/L, p=0,043), kolesterol (rerata 243 mg/dl, 95%CI 31-455 mg/dl, p=0,026) dan trigliserida (rerata 219 mg/dl, 95%CI 40-398 mg/dl, p=0,018) lebih tinggi pada pasien dengan kolestasis ekstrahepatal dibandingkan dengan intrahepatal, namun kadar kalium (rerata 1,18 mEq/L, 95% CI 0,22-2,14 mEq/L, p=0,017) lebih rendah. Warna tinja pada kedua jenis kolestasis juga berbeda. Warna tinja yang pucat memiliki sensitivitas 75% and spesifisitas 80% dalam menentukan kolestasis ekstrahepatal.Simpulan: Peningkatan jumlah leukosit, ALT, kolesterol, trigliserida dan penurunan kadar kalium darah serta warna
Pola Kuman Pasien Pneumonia di Instalasi Rawat Intensif Anak (IRIA) RSUP Dr. Sardjito Amalia Setyati; Indah Kartika Murni
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.437 KB)

Abstract

Bacterial pattern of pneumonia patient admitted in pediatric intensive care unit (PICU) Dr. Sardjito General HospitalBackground: Pneumonia is an inflammation of the lung parenchyma. The causative agent of pneumonia is difficult to determinate. This study was to attemp the pattern of bacteria and antibiotic sensitivity of pneumonia, and to see the risk of pneumonia mortality by age and bacteria obtained from cultures.Methods: Data of tracheal aspirate and blood cultures and its sensitivity to antibiotics of pneumonia patients who admitted to PICU of Sardjito General Hospital Yogyakarta in January-June 2011 were collected retrospectively from medical records. Analyzed by using chi-square test and the relative risk is expressed by odds ratio.Results: Ninety-four isolates of bacteria were obtained. There are 63 of tracheal aspirate and 32 of blood specimens. Gram (+) were 39.36% and gram (-) were 60.64%. The most cultures of tracheal aspirate was Pseudomonas, which the sensitivity of imipenem, amikacin, fosfomisin, netilmisin were 81.25%, 80.95%, 76.19%, 68.42%. The sensitivity of Klebsiella pneumoniae to fosfomisin, imipenem, amikacin were 92.31%, 84.62%, 76.92%. All isolates of coagulase negative Staphylococcus (CONS) were resistant to cephalosporin, likely 100% were sensitive to vancomisin. The sensitivity of Pseudomonas aeruginosa in the blood to ciprofloxacin, chloramphenicol, amikacin, cefepime and ceftazidim, gentamicin netilmisin and imipenem were 93.75%, 87.50%, 81.25%, 75%, 68.75%. The odds ratio (OR) of pneumonia death of age <1 year was 1.6, as well as the OR of pseudomonas was 2.5.Conclusion: The bacteria found were Pseudomonas aeruginosa, Klebsiella pneumoniae and CONS. The sensitivity of imipenem, amikacin, fosfomisin and ciprofloxacin were good to the three kind of bacteria. Patient under 1 year old and Pseudomonas aeruginosa are risk factors for death in pneumonia.Keywords: Pneumonia, culture, antibiotics ABSTRAKLatar belakang: Pneumonia adalah peradangan pada parenkim paru-paru. Penentuan penyebab pneumonia adalah sulit, Tujuan penelitian ini adalah melakukan pemetaan pola kuman dan kepekaan antibiotik pada pneumoni, melihat risiko kematian pneumonia berdasarkan umur dan kuman yang didapatkan dari kultur.Metode: Data kultur aspirat trakeal dan darah beserta kepekaan terhadap antibiotik pasien pneumonia yang dirawat di Instalasi Rawat Intensif Anak (IRIA) RSUP Dr. Sardjito Yogyakarta Januari- Juni 2011 diambil secara retrospektif dari catatan medik. Data dianalisis menggunakan uji x 2, risiko relatif dinyatakan dengan rasio odd.Hasil: Didapatkan 94 isolat kuman. Aspirat trakeal ada 63, isolat spesimen darah 32 isolat. Bakteri gram (+) 39,36% dan gram (-) 60,64%. Dari kultur aspirat trakeal terbanyak Pseudomonas, kepekaan terhadap Imipenem 81,25%, amikasin 80,95%, fosfomisin 76,19%, netilmisin 68,42%. Kepekaan Klebsiella pneumonia terhadap fosfomisin 92,31%, imipenem 84,62%, amikasin 76,92%. Semua isolat Staphylococcus coagulase negative (CONS) resisten terhadap sefalosporin, namun 100% peka dengan vancomisin. Kepekaan Pseudomonas aeruginosa dalam darah: ciprofloxacin 93,75%, kloramfenikol 87,50% amikasin, cefepime, ceftazidim 81,25%, gentamisin dan netilmisin 75%, imipenem 68,75%. Rasio odd (RO) kematian pasien pneumonia umur <1 tahun 1,6, RO kematian karena kultur pseudomonas 2,5.Simpulan: Kuman utama adalah Pseudomonas aeruginosa, Klebsiella pneumonia dan CONS. Kepekaan imipenem, amikasin, ciprofloksasin dan fosfomisin baik terhadap ketiga kuman tersebut. Umur <1 tahun dan pseudomonas merupakan faktor risiko kematian pada pneumoni
Pemberian Teh Rosela (Hibiscus sabdariffa Linn), Simvastatin dan Profil Lipid serta Serum ApoB pada Tikus Hiperkolesterolemi Enny Probosari; Hertanto WS; Niken Puruhita
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.145 KB)

Abstract

ABSTRACTConsumption of roselle tea and simvastatin, lipid profile and apoB serum in hypercholesterolemic ratsBackground: Roselle is commonly used as herbal beverages in Indonesian that is known have a hypocholesterolemic effect. The study was conducted to determine the efficacy of roselle tea compared to simvastatin on lipid profile and apo B of hypercholesterolemic rats.Methods: This study was an animal experimental with randomized pre test post test control design. Sixteen hypercholesterolemic male wistar rats of 15 week-aged were devided into 3 groups: control groups (K) received normal feeding and water adlibitum, group P1 received normal feeding, water adlibitum and roselle tea 4.5 ml twice a day, group P2 received normal feeding, water adlibitum and simvastatin 0.4 mg daily. Blood samples were collected at baseline and 30 days after administration of roselle tea or simvastatin for the measurement of serum lipids and apoB using ELISA.Results: Administration of roselle tea 1.37gram twice a day decreased trigliserid concentrations from 81.7mg/dl±43.13 to 26.5mg/dl±13.92 (p=0.038), but increased total cholesterol concentrations from 62.1mg/dl±4.25 to 91.9mg/dl±11.74 (p=0.001). Administration of 0.4mg simvastatin didn’t decreased triglicerid concentrations (50.9mg/dl±55.95 to 67.9mg/dl±3.07, p=0.207), total cholesterol concentrations (67.9mg/dl±3.07 to 74.2mg/dl±10.65, p=0.146), LDL cholesterol concentrations (156.8mg/dl±291.9 to 34.0mg/dl±30.06, p=0.686) nor increased HDL cholesterol concentration (58.1mg/dl±12.73 to 60.5mg/dl±8.61, p=0.674).Conclusion: Intake of 1.37 gram rosella tea twice a day decreases trigliserid more effective than simvastatin. Administration of roselle tea and simvastatin are not effective to reduce LDL cholesterol concentrations and apoB concentrations, nor increased HDL cholesterol concentrations.Keywords: Lipid profile, apoB, roselle, simvastatinABSTRAKLatar belakang: Teh rosela merupakan salah satu bahan minuman yang diketahui mempunyai efek menurunkan kadar kolesterol. Penelitian ini bertujuan untuk mengetahui efektifitas pemberian teh rosela dibandingkan simvastatin terhadap profil lipid dan apolipoprotein B pada tikus hiperkolesterolemi.Metode: Penelitian ini adalah penelitian eksperimental laboratorium dengan desain pre-post-test dengan kelompok kontrol. Enam belas tikus putih jantan galur wistar hiperkolesterolemi, usia 15 minggu, dibagi menjadi kelompok kontrol (K) hanya diberi pakan standar dan minum adlibitum, kelompok perlakuan 1 (P1) diberi pakan standar minum adlibitum, seduhan rosela 2x4,5ml per haridan kelompok perlakuan 2 (P2) diberi pakan standar minum adlibitum dan simvastatin 0,4mg per hari, selama 30 hari. Pada awal dan akhir perlakuan diambil serum darah untuk mengetahui kadar trigliserid, kolesterol total, kolesterol LDL, kolesterol HDL, sedangkan kadar apo B diukur pada akhir penelitian menggunakan metode ELISA.Hasil: Pemberian teh rosela (kelompok P1) menurunkan kadar trigliserid dari 81,7mg/dl±43,13 menjadi 26,5mg/dl±13,92 (p=0,038) setelah perlakuan, namun kadar kolesterol totalnya meningkat dari 62,1mg/dl±4,25 menjadi 91,9mg/dl±11,74 (p=0,001) setelah perlakuan. Pemberian 0,4mg simvastatin tidak menurunkan kadar trigliserid (50,9mg/dl±55,95 menjadi 67,9mg/dl±3,07, p=0,207), tidak menurunkan kadar kolesterol total (67,9mg/dl±3,07 menjadi 74,2mg/dl±10,65, p=0,146), tidak menurunkan kadar kolesterol LDL (156,8mg/dl±291,9 menjadi 34,0mg/dl±30,06, p=0,686) dan tidak meningkatkan kadar kolesterol HDL (58,1mg/dl±12,73 menjadi 60,5mg/dl±8,61, p=0,674).Simpulan: Pemberian teh rosela dengan berat rata-rata 1,37 gram yang dikonsumsi dua kali per hari lebih efektif dalam menurunkan kadar trigliserid serum tikus hiperkolesterolemi dibandingkan pemberian 0,4mg simvastatin. Pemberian teh rosela dosis lazim dan pemberian simvastatin dosis 0,4mg sama tidak efektifnya dalam menurunkan kadar kolesterol LDL, kadar apolipoprotein B dan meningkatkan kadar kolesterol HDL.
sTfR Sebagai Faktor Risiko Bangkitan Kejang Demam Abdul Khanis; Tjipta Bahtera; Noor Wijayahadi
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.316 KB)

Abstract

sTfR parameter as a risk factor of febrile seizuresBackground: Febrile seizures is the most often neurologic disorder in children and 2%-5% children under 5 years old have experienced febrile seizures. Prognosis of febrile seizures is good, however the seizure brings serious worries to the parents. Iron deficiency as a risk factor of febrile seizures is still controversial.Objective: To analyze iron deficiency with serum transferrin receptor (sTfR) parameter as a risk factor of febrile seizures in children.Method: Study design was case control with subjects 72 children aged 3 months – 5 years in Dr. Kariadi hospital on August 2009 – January 2010, 36 children with febrile seizures as case group and 36 children with febrile with no seizure as control group. Clinical data and blood sampling were recorded from study subjects for sTfR level measurement. Risk factors were analyzed with odds ratio (95% confidence interval) and multivariate logistic regression.Results: Mean sTfR level was 6.2 μg/mL (2.6-6.8) in case group and 2.0 μg/mL (1.8-2.3) in control group. Multivariate analysis showed iron deficiency with sTfR parameter was significantly as a risk factor for febrile seizures (p<0.001; OR=25.1; 95%CI 5.1-122.6). sTfR level could be used as febrile seizures indicator with sTfR level cut-off point was 2.55 μg/ml. Conclusion: sTfR parameter can be used is a risk factor for febrile seizures. ABSTRAKLatar belakang: Kejang demam merupakan kelainan saraf tersering pada anak dan 2%-5% anak di bawah umur 5 tahun pernah mengalami kejang demam. Prognosis kejang demam baik, namun cukup mengkhawatirkan bagi orang tuanya. Defisiensi besi sebagai faktor risiko bangkitan kejang demam masih kontroversial. Tujuan penelitian ini menganalisis defisiensi besi dengan parameter serum transferrin receptor (sTfR) sebagai faktor risiko bangkitan kejang demam pada anak.Metode: Penelitian kasus kontrol ini dengan subyek penelitian 72 anak berumur 3 bulan sampai 5 tahun di RSUP Dr. Kariadi pada Agustus 2009 – Januari 2010, 36 anak kelompok kasus dengan bangkitan kejang demam dan 36 anak kelompok kontrol dengan demam tanpa kejang. Subyek penelitian dicatat data klinis dan pengambilan darah untuk diperiksa kadar sTfR. Faktor risiko dianalisis dengan rasio odds (95% interval kepercayaan) dan multivariat regresi logistik.Hasil: Rerata kadar sTfR pada kelompok kasus 6,2 μg/mL (2,6-6,8) dan kelompok kontrol 2,0 μg/mL (1,8-2,3). Analisis multivariat menunjukkan defisiensi besi dengan parameter sTfR secara bermakna merupakan faktor risiko bangkitan kejang demam (p<0,001; OR=25,1; 95%CI 5,1-122,6). Kadar sTfR dapat dipergunakan sebagai indikator bangkitan kejang demam dengan cut-off point kadar sTfR adalah 2,55 μg/mL.Simpulan: Parameter sTfR merupakan faktor risiko bangkitan kejang demam.

Page 2 of 14 | Total Record : 134

 1   2   3   4   5 

Filter by Year

2008 2013


Reset
Filter By Issues
All Issue 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013 2012:MMI VOLUME 46 ISSUE 3 YEAR 2012 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012 2011:MMI Volume 45 Issue 3 Year 2011 2011:MMI Volume 45 Issue 2 Year 2011 2011:MMI Volume 45 Issue 1 Year 2011 2010:MMI VOLUME 44 ISSUE 3 YEAR 2010 2010:MMI VOLUME 44 ISSUE 2 YEAR 2010 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010 2009:MMI VOLUME 43 ISSUE 6 YEAR 2009 2009:MMI VOLUME 43 ISSUE 5 YEAR 2009 2009:MMI VOLUME 43 ISSUE 4 YEAR 2009 2008:MMI Volume 43 Issue 3 Year 2008 2008:MMI Volume 43 Issue 2 Year 2008 2008:MMI Volume 43 Issue 1 Year 2008 More Issue