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Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features
Homenta, Christian;
Wantania, John J;
Kaeng, Juneke J
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.433
Objective: To understand the relationship of heme oxygenase-1
(HO-1) level between normotensive pregnancy and preeclampsia
with severe features.
Method: The cross sectional study was conducted in the Department
of Obstetrics and Gynecology, Faculty of Medicine, Universitas
Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The
subjects consisted of 26 pregnant women with normal blood pressure
and 26 women with severe features of preeclampsia. We took
the patients’ history, general physical examination, and laboratory
assessment. The blood samples were taken from normotensive women
more than 20 weeks of pregnancy and preeclamptic women
with severe features more than 20 weeks of pregnancy. The data obtained
was processed using SPSS 20.0 software. We did the nonparametric
Mann-Whitney test to analyze the relationship between
heme oxygenase-1 (HO-1) level in normotensive pregnancy and
preeclampsia with severe features.
Result: The level of heme oxygenase-1 (HO-1) in normotensive
pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47),
and the level of heme oxygenase-1 (HO-1) of preeclamptic women
with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21).
The result of Mann-Whitney test showed p value of 0.001 which
meant that there was significant difference in the level of heme oxygenase-
1 (HO-1) between normotensive women and pre-eclamptic
women with severe features.
Conclusion: There was the relationship between the level of heme
oxygenase-1 (HO-1) and the incidence of preeclampsia with severe
features.
Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe features
The Prevalence and Risk Factors of Stress Urinary Incontinence in Postpartum
Pratiwi, Renny;
Suparman, Eddy;
Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To know the incidence of stress urinary incontinence in
postpartum and determine the relationship among age, parity, infant
birth weight, mode of delivery, episiotomy and perineum rupture.
Method: This study used cross sectional analytic design. Qualified
subjects from inclusion criteria were interviewed by researchers
using pre-defined MESA questioner. Subjects with stress urinary
incontinence were found from the questionnaire result. The acquired
data was measured and analyzed using SPSS v. 22.0 software and
discussed using available literature.
Result: From 162 subjects, 36 cases (22.22%) had stress urinary
incontinence, 47.22% aging ? 35 years old, 72.22% had multiple
pregnancies, 88.89% had per vaginal delivery. Using multivariate
logistic regression test, we found there was a relationship between
stress urinary incontinence with age and parity (p 35 years old and multiple parities.
Keywords: multiple parities, post-partum, stress urinary incontinence
Characteristics of Maternal Mortality Cases in a Tertiary Hospital
Indarti, Junita;
Irawan, Ferry Y
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.431
Objective: To identify the characteristics of maternal mortality cases in a tertiary hospital in Jakarta, including socio-demographic characteristics, previous medical and obstetric history, and patient’s clinical condition on arrival at the hospital.
Method: This was a survey to identify the descriptive data of maternal mortality cases through medical records during study period. Manual review of 51 medical records was conducted for 2 years from January 2013 to December 2014 in Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital (RSCM).
Result: Of 51 cases of maternal deaths, 46 subjects (90.19%) had nine years of minimum education background. There were two subjects less than 21 years old and another was 42 years old. None of these subjects were using intrauterine device (IUD) or implant as the contraceptive methods where 66.6% subjects with underlying disease never used contraception. Ninety-two percent of subjects did antenatal care (ANC) regularly and 80.4% (41 subjects) of them was done in midwives. There were 14 subjects (29.78%) who had ANC in the first trimester of pregnancy. Severe preeclampsia is the most prevalent complication in pregnancy (26 subjects, 65%), which all (100%) patients arrived at RSCM with HELLP Syndrome. Therefore, preeclampsia was the leading cause of death in RSCM.
Conclusion: The characteristics of maternal death in RSCM are prevalent in the group of 25-34 years old with the high school as the educational background. Most of them are multiparity and do not use the long-term contraceptive methods. Preeclampsia is the major cause of maternal death in RSCM.
Keywords: maternal mortality, risk factors, tertiary hospital
Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features
Homenta, Christian;
Wantania, John J;
Kaeng, Juneke J
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
Show Abstract
|
Download Original
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Original Source
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Check in Google Scholar
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Full PDF (96.884 KB)
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DOI: 10.32771/inajog.v4i3.433
Objective: To understand the relationship of heme oxygenase-1
(HO-1) level between normotensive pregnancy and preeclampsia
with severe features.
Method: The cross sectional study was conducted in the Department
of Obstetrics and Gynecology, Faculty of Medicine, Universitas
Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The
subjects consisted of 26 pregnant women with normal blood pressure
and 26 women with severe features of preeclampsia. We took
the patients’ history, general physical examination, and laboratory
assessment. The blood samples were taken from normotensive women
more than 20 weeks of pregnancy and preeclamptic women
with severe features more than 20 weeks of pregnancy. The data obtained
was processed using SPSS 20.0 software. We did the nonparametric
Mann-Whitney test to analyze the relationship between
heme oxygenase-1 (HO-1) level in normotensive pregnancy and
preeclampsia with severe features.
Result: The level of heme oxygenase-1 (HO-1) in normotensive
pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47),
and the level of heme oxygenase-1 (HO-1) of preeclamptic women
with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21).
The result of Mann-Whitney test showed p value of 0.001 which
meant that there was significant difference in the level of heme oxygenase-
1 (HO-1) between normotensive women and pre-eclamptic
women with severe features.
Conclusion: There was the relationship between the level of heme
oxygenase-1 (HO-1) and the incidence of preeclampsia with severe
features.
Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe features
Cystatin C Serum Level and the Severity of Preeclampsia
Winarto, Abraham;
Suparman, Eddy;
Wantania, John
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.434
Objective: Determining the cystatin C serum level among normotensive,
mild preeclamptic, severe preeclamptic pregnant women
and their relationship with the severity of preeclampsia.
Method: The study was held using cross sectional design in Prof. Dr.
RD Kandou Hospital in Manado and its network hospitals. We did on
51 samples at term pregnant women, consisting of 17 samples for
each group in normotensive, mild preeclampsia, and severe
preeclampsia. The data were analyzed using SPSS version 22.0 software
through ANOVA and Kruskal Wallis statistical test.
Result: The mean cystatin C serum concentration in normotensive
pregnant women, mild preeclampsia, and severe preeclampsia were
0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical
test showed the significant association between cystatin C level
and severity of preeclampsia (p
Classic Antiphospholipid and Antiphosphatidylserine Antibody Profile in Suspected Antiphospholipid Antibody Syndrome Patient
Suryadi, Angga J;
Sumapradja, Kanadi
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.435
Objective: To compare the classic examination results of antiphospholipid
(aPS) and antiphospatidylserine (aPL) antibody profile to
establish the diagnosis from suspected antiphospholipid antibody
syndrome (APS) patient in order to state the subsequent treatment
strategies.
Method: This descriptive cross-sectional study design was conducted
at outpatient clinics of Dr. Cipto Mangunkusumo Hospital
(RSCM) from January to December 2015. The laboratory test was
held in Clinical Pathology Laboratory RSCM/Faculty of Medicine
Universitas Indonesia (FKUI) and in corporation with Prodia laboratory.
Result: All of normal patients did not have positive result in any
laboratory examination (Lupus Anti-coagulant (LA), anticardiolipin
(aCL), anti-?2 glycoprotein I (anti-?2GPI), and aPS). In patient suspected
APS, 11 (37.1%) patients had positive aCL, 7 (25.9%) patients
had positive anti-?2GPI, and 11 (37.1%) patients had positive
aPS. The most positive cross laboratory examination was between
aCL and aPS (25.9%). In this study, we found the most positive test
result was aCL and aPS (62.9%). From this study, suspected APS patient
who had negative result in classic laboratory examination, but
showing the positive result in aPS was in 5 (18.5%) patients.
Conclusion: All normal pregnant patients do not have any positive
classic examination and aPS. Meanwhile, in patients with suspected
APS, less than 20% patients show positive result of aPS with negative
result in classic laboratory examination.
Keywords: antiphospatidylserine, antiphospolipid syndrome
Maternal and Fetal Outcome on Pregnancy in Advanced Maternal Age
Dewi, Sianty;
Ferry, Ferry;
Toynbee, Eddy;
Prayudhana, Sandhy
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.432
Objective: Pregnancy in advanced maternal age (AMA) was classified as high risk. The study aims to provide a better description of pregnancy outcome in AMA.
Method: The cross sectional study was to review the demography, medical and obstetrics problems, mode of delivery, maternal and fetal outcome in Tangerang General Hospital as a referral center in Banten. The data were taken from medical records of 35-year-old and above women age who delivered on the period of January to December 2014.
Result: The total number of delivery and live birth was 6,107 and 5,926 respectively, including 1,548 (25.36%) pregnancies in AMA. The prevalence of grandmultiparities was 11.4%. The average education level was mostly elementary. The prevalence of hypertension in pregnancy was 34.6%. There was increasing trend of miscarriages from 10.8% in 35-40-year-old group to 25% in above 45- year-old group. Pregnancy complications were higher consisting of 3.2% multifetal, 16.6% malpresentation, and 7.1% placenta previa. Cesarean section rate was 33.6%. Maternal near-missed cases were 56 of 1000 and the maternal mortality rate (MMR) was 932 of 100,000 live births. The prevalence of stillbirth and perinatal mortality were 5.3% and 12.9%; respectively.
Conclusion: Adverse maternal and fetal outcome were higher in AMA as it takes special attention and multidiscipline-approached care started from preconception, antenatal, preparation of delivery, and also postpartum care.
Keywords: advanced maternal age (AMA), fetal outcome, maternal outcome, pregnancy
The Level of Ca125 in Preand Postoperative of Endometriosis
Amsir, Asriyanti;
Tahir, Andi M;
Abdullah, Nusratuddin
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.436
Objective: To determine the Ca-125 level in pre- and post-operative
of endometriosis and its correlation to endometriosis stage and severity
of dysmenorrhea.
Method: This was a cross-sectional study design conducted at Dr.
Wahidin Sudirohusodo dan some affiliated hospitals. We took the
patients undergoing laparoscopy or laparotomy consecutively.
Result: The mean value of preoperative Ca-125 level in stage I-II
was 21.53 (SD 12.64) IU/ml vs 72.52 (SD 8.52) IU/ml in stage III-IV.
The mean value of postoperative Ca-125 level was 14.82 (SD 10.00)
IU/ml (stage I-II) vs 61.03 (SD 8.43) IU/ml (stage III-IV); they were
significantly different (p
Incidence of PostOperative Urinary Retention after Pelvic Organ Prolapse Reconstruction
Elisia, Elisia;
Priyatini, Tyas
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.437
Abstract
Objective: To determine the incidence of post-operative urinary retention
after pelvic organ prolapse reconstruction and associated
factors.
Method: This was a prospective cohort study conducted in Dr. Cipto
Mangunkusumo and another associate hospital. We recruited women
planned for pelvic organ prolapse reconstruction from April
2013 to April 2015. Inclusion and exclusion criteria were women
with pelvic organ prolapse (2nd, 3rd and 4th degree) without prior
urinary retention, drugs affecting bladder function, and history of
bladder injury. After surgery, urinary catheter was applied for 24
hours. Six hours apart from urinary catheter released, residual urine
was measured. Urinary retention was defined as residual urine more
than 100 ml.
Result: Of 200 subjects, 59 of them (29.5%) classified as having urinary
retention. No association found between age, body mass index
(BMI), degree of prolapse, degree of cystocele and urinary tract infection
toward urinary retention. Total vagina hysterectomy + anterior
colporaphy + colpoperineoraphy + sacrospinous fixation and reconstruction
duration more than 130 minutes were associated with
urinary retention (relative risk (RR) 3.66; 95% CI 2.91-4.60; p