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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,731 Documents
 160   161   162   163   164 
Mentzer and RDW Index in the Establishment of Iron Deficiency Anemia Diagnosis in the First Trimester of Pregnant Woman : Indeks Mentzer dan RDW dalam Diagnosis Anemia Defisiensi Besi pada Ibu Hamil Trimester Pertama Jane Belinda; Edihan Mardjuki; Sheella R. Bororing
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 1 January 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i1.1676

Abstract

Role of Platelet-Rich Plasma Application on Mesh-Tissue Integration: Peran Aplikasi Platelet-Rich Plasma pada Integrasi Mesh dengan Jaringan Alfa P. Meutia; Budi I. Santoso; Suskhan Djusad
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1721

Abstract

AbstractObjective: To review the advantage of PRP use on mesh-augmented surgery.Methods: Literature review of PRP application of mesh.Results: The application of PRP on mesh shows potential promising outcome.Conclusion: PRP may improve the mesh-tissue integration.Keywords: mesh-augmented surgery, pelvic organ prolapse, platelet-rich plasma, wound healing.AbstrakTujuan: Untuk menganalisa keuntungan penggunaan PRP pada pembedahan rekonstruktif dengan mesh.Metode: Kajian pustaka dari penggunaan PRP pada pembedahan rekonstruktif dengan mesh.Hasil: Aplikasi PRP pada mesh menunjukkan hasil yang positif.Kesimpulan: Aplikasi PRP dapat meningkatkan integrasi mesh dengan jaringanKata kunci: pembedahan rekonstruksi dengan mesh, penyembuhan luka, platelet-rich plasma, prolaps organ panggul.
Effect of Nanocurcumin in Combination with Methotrexate on Telomerase Activity, NF-kb Expression, and Proliferation Index of Bewo Choriocarcinoma Cells: Pengaruh Kombinasi Nanokurkumin dengan Methotrexate terhadap Aktivitas Telomerase, Ekspresi NF-kb, dan Indeks Proliferasi Sel Koriokarsinoma Bewo Subandi Subandi; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1733

Abstract

In Utero Ultrasonography Parameters as a Children Growth Prediction at Age 2 – 3 : Parameter Ultrasonografi in Utero sebagai Prediksi Pertumbuhan Anak Usia 2-3 Tahun Mazaya, Radiva H.; Dewantiningrum, Julian; Rahmadi, Farid A.; Anantyo, Dimas T.
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1791

Abstract

ltrasound parameters during pregnancy and the growth of children aged 2 – 3 years.Methods: This was an analytic observational study with a longitudinal approach using data from the first 1,000 days of life. Study conducted at the Faculty of Medicine, Diponegoro University. The research subjects were children aged 2 – 3 years old with good nutritional status and democratic parenting from 14 City Health Centers in Semarang. The ultrasound parameters obtained were Biparietal Diameter (BPD), Abdomen Circumference (AC), Head Circumference (HC), Femur Length (FL) at 20 – 24 weeks of gestation. Data were obtained during the second trimester. Data on the growth of children at the age of 2 years obtained are height, weight, and HC. Statistical test using Pearson correlation test, with p<0.1 is considered significant.Results: The level of confidence used in this study was 90% and obtained 45 research subjects with a female gender of 26 children (57.8%) and 19 male children (42.2%). The Pearson test showed that there was no significant relationship between BPD and height (p=0.18; r=-0.20), AC and height (p=0.12; r=-0.23), and FL and height (p=0.17; r=-0.20). There was a significant relationship between HC and height (p=0.04; r=-0.29), BPD and weight (p=0.06; r=-0.28), HC and weight (p=0.01; r=-0,.5), AC and weight (p=0.08; r=-0.26), FL and weight (p=0.05; r=-0.29) and prenatal HC and postnatal HC (p=0.03; r=-0.32).Conclusion: There is a significant relationship between ultrasound parameters during pregnancy and the growth of children aged 2 – 3 years.Keywords: abdominal circumference, biparietal diameter, child growth, femur length, head circumference, pregnancy.AbstrakTujuan: Untuk mengetahui hubungan antara parameter ultrasonografi saat kehamilan dengan pertumbuhan anak usia 2-3 tahun.Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan longitudinal menggunakan data penelitian 1.000 hari pertama kehidupan yang dilakukan di Fakultas Kedokteran Universitas Diponegoro. Subjek penelitian adalah anak usia 2 – 3 tahun dengan gizi baik dan pola asuh demokratis dari 14 Puskesmas Kota Semarang. Parameter USG yang diperoleh adalah diameter biparietal (BPD), lingkar abdomen (AC), lingkar kepala (HC), dan panjang femur (FL) pada usia kehamilan 20 – 24 minggu. Data diperoleh selama trimester kedua. Data tumbuh kembang anak usia 2 tahun yang diperoleh adalah tinggi badan, berat badan, dan lingkar kepala. Uji statistik menggunakan uji korelasi Pearson, dengan p<0,1 dianggap signifikan.Hasil: Tingkat kepercayaan yang digunakan dalam penelitian ini adalah 90% dan diperoleh 45 subjek penelitian dengan jenis kelamin perempuan 26 anak (57,8%) dan 19 anak laki-laki (42,2%). Uji Pearson menunjukkan bahwa tidak ada hubungan yang signifikan antara BPD dengan tinggi badan (p=0,18; r=-0,20), AC dan tinggi badan (p=0,12; r=-0,23), dan FL dan tinggi (p=0,17; r=-0,20). Terdapat hubungan yang signifikan antara HC dengan tinggi badan (p=0,04; r=-0,29), BPD dan berat badan (p=0,06; r=-0,28), HC dengan berat badan (p=0, 01; r=-0,35), AC dan berat badan (p=0,08; r=-0,26), FL dan berat badan (p=0,05; r=-0,29) dan HC prenatal dan postnatal HC (p=0,03; r=-0,32).Kesimpulan: Terdapat hubungan yang signifikan antara parameter ultrasonografi saat kehamilan dan pertumbuhan anak usia 2 – 3 tahun.Kata kunci: diameter biparietal, kehamilan, lingkar abdomen, lingkar kepala, panjang femur, pertumbuhan anak.
Mode of Delivery and Neonatal Outcomes in Preterm Pregnancy: Metode Persalinan dan Luaran Neonatus pada Kehamilan Prematur Gagah B. A. Nugraha; Nutria W. P. Anggraini
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1803

Abstract

Objectives: To explain that mode of delivery has a correlation with neonatal outcomes in preterm pregnancies.Methods: This study is a retrospective cohort conducted at Dr. Moewardi Surakarta Hospital, with total sampling of 484 cases divided into early preterm and late preterm from 2019 to 2021. Bivariate analysis was carried out to determine the correlation between Mode of Delivery (MOD) and neonatal outcomes.Results: In the early preterm group, mode of delivery had a significant correlation (p<0.05) with birth weight, APGAR score, and neonatal mortality, however a significant correlation (p<0.05) in the late preterm group was only found in the APGAR score and neonatal mortality outcomes. Cesarean delivery, in both early and late preterm births had a lower rate of asphyxia and neonatal death (p<0.05).Conclusion: There is a significant correlation between mode of delivery and neonatal outcomes in preterm birth. Caesarean delivery by indication can significantly reduce the risk of asphyxia, and neonatal mortality due to premature birth.Keywords: mode of delivery, neonatal outcome, preterm.AbstrakTujuan: Menjelaskan bahwa metode persalinan sangat berkorelasi dengan luaran neonatus pada kehamilan prematur, oleh karena itu penelitian ini dapat menjadi bahan pertimbangan untuk memilih metode persalinan.Metode: Penelitian ini merupakan penelitian kohort retrospektif yang dilakukan di RSUD Dr. Moewardi Surakarta, dengan total sampling sebanyak 484 kasus yang terbagi menjadi early preterm dan late preterm dari tahun 2019 hingga 2021. Analisis bivariat dilakukan dengan menggunakan analisis Chi-square dan Kruskal-Wallis untuk melihat korelasi antara metode persalinan (MOD) dan luaran neonatusHasil: Pada kelompok early preterm, metode persalinan memiliki hubungan yang signifikan (p<0,05) dengan luaran neonatus baik berat lahir, skor APGAR, dan kematian neonatus. Pada kelompok late preterm, hubungan yang signifikan (p<0,05) hanya didapatkan pada luaran skor APGAR dan kematian neonatus. Persalinan Caesar baik early maupun late preterm memiliki angka yang lebih rendah terhadap asfiksia dan kematian neonatus (p<0,05).Kata kunci: metode persalinan, luaran neonatus, preterm.
Ovarian Reservation in Women with Ovarian Endometriosis Cyst after Laparoscopic Cystectomy and Leuprorelin Acetate Administration: Cadangan Ovarium pada Perempuan dengan Kista Endometriosis Ovarium setelah Laparoskopi Kistektomi dan Leuprorelin Asetat Reza F. Akhmad; Yuli Trisetiyono; I Edward K. Setiawan; Besari A. Pramono; Soerjo Hadijono; Inu Mulyantoro; Ediwibowo Ambari
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1815

Abstract

Objective: To determine differences in ovarian reserve in women with ovarian endometrial cysts after laparoscopic cystectomy and leuprorelin acetate administrationMethods: Single cohort prospective pre and post-test design study with 25 research subjects. The independent variables were interventional laparoscopic cystectomy, and leuprorelin acetate administration. The dependent variable is ovarian reserve as measured by AMH levels.Results: The research subjects had a mean age of 31 years and a BMI of 23.55 kg/m2. There were 8 subjects with unilateral cysts and 17 subjects with bilateral cysts. Preoperative AMH levels had a median value of 1.32 ng/mL (0.88-5.13), postoperative AMH levels had a median value of 1.07 ng/mL (0.60-4.53), and postoperative AMH levels + Leuprorelin Acetate injection had a median value of 1.06 ng/mL (0.50-4.65). There was a significant difference between preoperative AMH and postoperative AMH (p<0.001). There was no significant difference between postoperative AMH and postoperative AMH + Leuprorelin Acetate injection (p=0.149). BMI has a relationship (p=0.048) with pre-operative AMH levels with a weak and opposite relationship (r= -0.399).Conclusion: There was a statistically significant 18.9% decrease between pre-operative post-operative AMH levels. Body Mass Index (BMI) and pre-operative AMH levels are associated with one another.Keywords: anti-müllerian hormone, leuprorelin acetate, ovarian cystectomy, ovarian reserve.AbstrakTujuan: Mengetahui perbedaan cadangan ovarium pada perempuan dengan kista endometrium ovarium setelah laparoskopi kistektomi dan injeksi leuprorelin asetat.Metode: Desain penelitian pre dan post-test prospektif kohort tunggal dengan 25 subjek penelitian. Variabel bebas adalah intervensi laparoskopi kistektomi, dan injeksi leuprorelin asetat. Variabel terikat adalah cadangan ovarium yang diukur dengan kadar AMH.Hasil: Subjek penelitian memiliki rerata usia 31 tahun dan IMT 23,55 kg/m2. Terdapat 8 subjek dengan kista unilateral, 17 subjek dengan kista bilateral. Kadar AMH praoperasi memiliki nilai median 1,32 ng/mL (0,88-5,13), kadar AMH pascaoperasi memiliki nilai median 1,07 ng/mL (0,60-4,53), dan kadar AMH pascaoperasi + injeksi Leuprorelin Asetat memiliki nilai median 1,06 ng/mL (0,50-4,65). Ada perbedaan yang signifikan antara AMH pra operasi dan AMH pascaoperasi (p<0,001). Tidak ada perbedaan bermakna antara AMH pascaoperasi dengan injeksi AMH + Leuprorelin Asetat pascaoperasi (p=0,149). IMT memiliki hubungan (p=0,048) dengan kadar AMH pra operasi dengan hubungan yang lemah dan berlawanan (r= -0,399).Kesimpulan: Terdapat penurunan 18,9% antara tingkat AMH pra-operasi dan tingkat AMH pasca-operasi yang signifikan secara statistik. Ada hubungan antara BMI dan tingkat AMH pra-operasiKata kunci: cadangan ovarium, hormon anti-müllerian, kistektomi ovarium, leuprorelin asetat.
Surgical Wound Dehiscence Treatment: Tata Laksana Dehisensi Luka Operasi Riyan H. Kurniawan; Ni Putu C. D. Atmantika; Achmad K. Harzif; Dewita Nilasari
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1847

Abstract

Objective: This article describes management of surgicalwound dehiscence. in a cesarean section.Method: Case report.Case: A 39 years-old woman, P4, presented with reddish puscoming out from open surgical wound on day 4 following acaesarean section. Laboratory fi ndings revealed a conditionof Hypoalbuminemia, leukocytosis, and a Staphylococcusaureus was detected on pus from the wound base. Upon theresuturing, the wound was dressed with antimicrobial wounddressings and pad and changed every 12 hours. After 3 days,the wound was dressed with modern antimicrobial wounddressings gel and pad, changed every 3 days and plannedfor necrotomy afterwards. A presence of dry, granulationtissue was observed before the resuturing.Conclusion: Selection of dressing regimen shouldbe individualized according to the wounds. Modernantimicrobial wound dressing can be a good therapy optionfor surgical wound dehiscence after caesarean section.Keywords: surgical site infection, surgical wound, wounddehiscence.Tujuan: Artikel ini melaporkan tata laksana dehisensi lukaoperasi seksio sesarea.Metode: Laporan kasus.Kasus: Seorang perempuan 39 tahun, P4, datang dengankeluhan nanah kemerahan keluar dari luka operasi terbukapostoperasi seksio sesarea hari ke-4. Temuan laboratorium:Hipoalbuminemia, leukositosis, dan Staphylococcusaureus dari kultur dasar luka. Sebelum operasi penjahitankembali, luka dibalut dengan pembalut dan bantalan lukaantimikroba modern yang diresapi dengan hidrogel, digantisetiap 12 jam. Setelah 3 hari, luka dibalut dengan gel danpembalut luka antimikroba modern yang diresapi denganhidrogel, diganti setiap 3 hari dan direncanakan untuknekrotomi. Sebelum operasi dilakukan kembali, luka tampakkering dengan dasar jaringan granulasi.Kesimpulan: Regimen pembalutan harus disesuaikandengan kebutuhan masing-masing luka. Pembalut lukaantimikroba modern dapat menjadi pilihan terapi yang baikuntuk dehisensi luka bedah setelah operasi seksio sesarea.Kata kunci: dehisensi luka, infeksi luka operasi, luka operasi.
RELA mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs11820062 Gene Variant: Ekspresi mRNA RELA pada Kanker Ovarium Epitelial : Korelasinya dengan Varian Gen rs11820062 Benedikta D. Saraswati; Dwi A. Suryandari; Ria Kodariah; Dewi Sukmawati; Luluk Yunaini; Primariadewi Rustamadji; Puji Sari
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1872

Abstract

and its correlation to i mRNA expression in low-grade and high-grade EOC’s patients from Dr. Cipto Mangunkusumo General hospital, Indonesia. Methods: This study is cross-sectional with a total of 65 healthy subjects and 80 ovarian biopsies (15 ovarian cysts as expression calibrators, 36 low-grade EOC, and 29 high-grade EOC) were used in this study. The distribution of genotypes and alleles was analyzed using ARMS PCR. The mRNA expressions of RELA were determined by real-time polymerase chain reaction (qPCR) analysis.Results: There was no significant difference between genotype and allele distributions for RELA rs11820062 in normal and case group. RELA relative mRNA expression was significantly higher in low-grade and high-grade EOC compared to in ovarian cysts (p<0.01). RELA rs11820062 CC genotype correlated to higher RELA mRNA relative expression and the TT genotype of RELA rs11820062 correlated with lower RELA mRNA relative expression in low-grade and high-grade EOC.Conclusion: C allele in rs11820062 caused an increased expression of RELA mRNA, which individuals with CC genotype correlated with higher RELA expression in low-grade and high-grade EOC. In contrast, individuals with the T allele of RELA rs11820062 had a protective effect against EOC risk because the RELA TT genotype tended to have a lower RELA mRNA expression in EOC.Keywords: epithelial ovarian cancer, NF-kB, RELA, rs11820062.AbstrakTujuan: Mengetahui distribusi RELA rs11820062 dan korelasinya dengan ekspresi mRNA RELA pada pasien EOC low-grade dan high-grade di Rumah Sakit Dr. Cipto Mangunkusumo, Indonesia.Metode: Penelitian ini merupakan peneliatan potong lintang terhadap 65 sampel darah perempuan normal dan total 80 biopsi kanker ovarium dengan rincian: 15 kista ovarium sebagai kalibrator ekspresi, 36 EOC low-grade, dan 29 EOC high-grade. Distribusi genotipe dan alel dianalisis menggunakan ARMS PCR dan ekspresi mRNA RELA dikuantifikasi menggunakan teknik qPCR. Hasil: Tidak terdapat perbedaan distribusi genotipe dan alel antara kelompok normal dengan kasus EOC. Ekspresi relatif mRNA RELA meningkat secara signifikan pada kelompok EOC low-grade dan high-grade. Individu dengan genotipe RELA rs11820062 homozigot CC memiliki ekspresi mRNA yang lebih tinggi dibandingkan genotipe lain. Sebaliknya individu dengan genotipe TT memiliki korelasi dengan ekspresi mRNA RELA yang lebih rendah pada tipe low-grade dan high-grade EOC. Kesimpulan: Alel C pada RELA rs11820062 menyebabkan peningkatan ekspresi mRNA RELA pada pasien EO yang dilihat dari individu dengan genotipe CC cenderung memiliki ekspresi mRNA RELA yang lebih tinggi pada tipe EOC low-grade dan high-grade. Sebaliknya, individu dengan alel T RELA rs11820062 diduga memiliki efek protektif terhadap risiko EOC karena adanya korelasi antara genotipe TT dengan ekspresi mRNA RELA yang lebih rendah pada EOC.Kata kunci: kanker ovarium epitelial, NF-kB, RELA, rs11820062.
Attitude towards COVID-19 Vaccine among Pregnant Women: Sikap terhadap Vaksinasi COVID-19 di kalangan Ibu Hamil Venkatesha K. Vasudevamurthy; Rashmi S Desai; Ashwini H. Rmaswamy; Kasturi V. Donimath; Divyashree Bhat
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1873

Abstract

Objective: To assess the perceptions and intentions of pregnant women regarding COVID-19 vaccination and to explore the reasons for vaccine hesitancy as well as acceptance. Methods: This prospective cross-sectional study was conducted in tertiary care hospital in Karnataka. Around 811 pregnant women attending the antenatal clinic were recruited into the study. Data were collected using a face-to-face, anonymous questionnaire written in local language.Results: Eighty six point two percent participants were aged 20 to 30 years and 64.6% had completed their schooling. 94.3% of them were homemakers and 58 % of the participants were in their third trimester. 65.5% of study group members lived in a COVID-supportive environment. Participants with COVID-19 vaccination awareness accounted for 87.4% and 65.4% were willing to receive the same whole heartedly. Our study found that 65.4% of participants were willing to receive covid-19 vaccine. The reasons for refusal were Lack of sufficient information regarding the vaccine, may be harmful to foetus and mother and lack of data proving its quality and efficiency.Conclusion: Pregnant women in the North Karnataka region were highly receptive to COVID-19 immunization. Although a high level of awareness was apparent, the lack of data and fear of side effects were two major concerns for refusal. Confidence in the government and the availability of free vaccines for all have demonstrated a massive impact on vaccination. Keywords: antenatal, covid-19, pregnancy, vaccination.AbstrakTujuan: Menilai persepsi dan keinginan perempuan hamil terkait vaksin COVID-19 dan alasan terkait penerimaan dan juga keraguan terhadap vaksin.Metode: Penelitian ini merupakan penelitian potong lintang dengan pendekatan prospektif yang dilakukan di Rumah Sakit Karnataka. Perempuan hamil sebanyak 811 menjadi subjek penelitian. Data dikumpulkan menggunakan kuesioner yang dituliskan dalam Bahasa lokal dan pengumpulan data dilakukan secara tatap muka. Hasil: Sebanyak 86,2 % sampel penelitian berusia 20 hingga 30 tahun dan 64,6% telah lulus sekolah. Sebanyak 94,3% sampel adalah ibu rumah tangga dan 58% dari sampel dengan usia kehamilan pada trimester ketiga. Sebanyak 65,5% grup tinggal pada kondisi. Sebanyak 87,4% sampel sadar akan keutamaan vaksin dan 65,4% bersedia mendapatkan vaksin. Alasan penolakan terhadap vaksin adalah kurangnya pengetahun mengenai vaksin dan ketakutan akan efek sampingnya.Kesimpulan: Perempuan hamil di Karnatakan Utara terbuka terhadap imunisasi COVID-19. Disamping tingginya angka kesadaran akan imunisasi COVID-19, penolakan umumnya didominasi akibat kurangnya pengetahuan dan ketakutan akan efek samping. Keyakinan pada pemerintah dan ketersediaan vaksin secara gratis sangat berpengaruh pada vaksinasi.Kata kunci: antenatal. covid-19, kehamilan, vaksinasi.
Depo Medroxyprogesterone Acetate (DMPA): Long-Term Effects on Menstrual Cycle Disorders: Depo Medroksiprogesteron Asetat (DMPA): Efek Penggunaan Jangka Panjang terhadap Gangguan Menstruasi Nurhayati Nurhayati; Suhermi Sudirman; Sitti H. Hamang
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1884

Abstract

Objective: To determine the effect of the duration ofusing Depo Medroxyprogesterone Acetate (DMPA) on theMenstrual CycleMethods: This research is an analytical study of 102 patientswho used DMPA for less than 1 year and more than 1year and then analyzed the types of menstrual disordersexperienced while using DMPA contraception at RSIAMasyita Makassar Tahun 2022. Data collection was carriedout by direct observation at RSIA. Masyita was then arrangedin a checklist that has been prepared.Data is processed usingSPSS version 25.0.Results: There is a signifi cant effect between the length ofuse of Depo Medroxyprogesterone Acetate (DMPA) and theMenstrual Cycle (p=0.000).Conclusion: There are long-term effects of using DMPAon menstrual cycle disorders, the most common beinghypermenorrhea. These results showed that the use ofDepo Medroxyprogesterone Acetate (DMPA) for > 1 yearhas shown many effects on Menstrual Disorders and can beused by midwives to providing knowledge and counselingto patients who wll to use DMPA regarding the side effectsand risks of using longer contraceptives.Keywords: Depo Medroxyprogesterone Acetate (DMPA),duration of use, menstrual cycle.AbstrakObjektif: Untuk mengetahui pengaruh lama penggunaanDepo Medroksiprogesteron Asetat (DMPA) terhadap siklusmenstruasi.Metode: Penelitian ini merupakan jenis penelitian analitikterhadap 102 pasien yang menggunakan DMPA kurang dari1 tahun dan lebih dari 1 tahun kemudian dianalisis jenisgangguan menstruasi yang dialami selama menggunakankontrasepsi DMPA di RSIA Masyita Makassar. Pengumpulandata dilakukan dengan metode observasi langsung di RSIATahun 2022. Masyita kemudian disusun dalam checklistyang telah disiapkan.Data diolah menggunakan SPSS versi25.0.Hasil: Ada pengaruh yang signifi kan antara lamapenggunaan Depo Medroksiprogesteron Asetat (DMPA)dengan siklus menstruasi (p=0,000).Kesimpulan: Adanya Efek dari Jangka Panjang PenggunaanDMPA terhadap gangguan siklus Mentsruasi yangterbanyak yaitu Hipermenore. Hasil ini menunjukkan bahwaPenggunaan Depo Medroksiprogesteron Asetat (DMPA)selama > 1 tahun telah menunjukkan banyak efek padagangguan menstruasi dan selanjutnya dapat digunakanoleh bidan dalam memberikan pengetahuan dan konselingkepada pasien yang akan menggunakan DMPA mengenaiefek samping dan resiko penggunaan kontrasepsi yanglebih lama.Kata kunci: Depo Medroksiprogesteron Asetat (DMPA),lama pemakaian, siklus menstruasi.

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