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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,731 Documents
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Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial: Granisetron Lebih Efektif Dibandingkan Ondansetron Sebagai Antiemetik Pada Pasien Kanker Ovarium: Penelitian Uji Acak Terkendali Hanif Reza; Shinta Prawitasari; Ardhanu Kusumanto
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1877

Abstract

Objective: To determine the effectiveness of intravenousinjection of granisetron compared to ondansetron inpreventing nausea and vomiting, we used the MASCCAntiemesis Tool (MAT) in ovarian cancer patients undergoingpaclitaxel-carboplatin chemotherapyMethods: This study was conducted as a double-blind,randomized controlled trial. The treatment group received1 mg of granisetron, whereas the control group received8 mg of ondansetron intravenously. Nausea and vomitingwere assessed using the MAT scale at 12 hours, 24 hours,and 48 hours after chemotherapy. The differences in MATscores between the groups were analyzed using the Mann-Whitney test.Results: A total of 60 participants were enrolled in thisstudy. The results indicated that the MAT score at the 12-hour mark significantly differed from the 24-hour and 48-hour MAT scores (p = 0.00, p = 0.00). The MAT scores in thegranisetron group at 12 hours, 24 hours, and 48 hours werestatistically lower compared to the ondansetron group (p =0.00, p = 0.00, p = 0.00).Conclusions: In conclusion, intravenous granisetron provedto be more effective than intravenous ondansetron inpreventing nausea and vomiting among patients with ovariancancer undergoing paclitaxel-carboplatin chemotherapy.Keywords: chemotherapy, granisetron, MAT score,ondansetron, ovarian cancer.AbstrakTujuan: Mengetahui efektivitas perbandingan pemberianinjeksi intravena antara granisetron dan ondansetrondalam mencegah mual dan muntah dengan menggunakanMAT pada pasien dengan kanker ovarium yang mendapatkemoterapi dengan regimen paclitaxel-carboplatin.Metode: Penelitian ini merupakan double blind randomizedcontrolled trial dengan kelompok perlakuan diberikangranisetron 1 mg dan kelompok kontrol yang diberikaninjeksi ondansetron 8mg. Kemudian dilakukan penilaianterhadap mual dan muntah dengan menggunakan skorMAT pada 12 jam, 24 jam, dan 48 jam setelah diberikankemoterapi dengan menggunakan Mann-Whitney testkarena distribusi data tidak normal.Hasil: Total sampel pada penelitian ini adalah 60 subjek.Hasil skor MAT pada 12 jam berbeda bermakna dengan skorMAT 24 jam dan skor MAT 48 jam (p= 0,00, p= 0,00. Terdapatperbedaan bermakna secara statistik pada pengaruh terapigranisetron dan ondansetron terhadap skor MAT 12 jam, 24jam, dan 48 jam (p= 0,00, p= 0,00, p= 0,00).Kesimpulan: Pemberian injeksi granisetron intravena lebihefektif mencegah mual dan muntah dengan menggunakanMAT dibandingkan dengan injeksi ondansetron intravenapada pasien dengan kanker ovarium yang mendapatkemoterapi paclitaxel-carboplatin.Kata kunci: kemoterapi, granisetron, kanker ovarium,ondansetron, skor MAT.
The Role of Probiotics in Urinary Tract Infections in Women: Peran Probiotik dalam Infeksi Saluran Kemih pada Perempuan Kurniawati, Eighty Mardiyan; Gatut Hardianto; Setyo Hadi, Tri Hastono; Paraton, Hari; Widyasari, Anis; Rahmawati, Nur Anisah
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1881

Abstract

Objective: To review the role of probiotics in urinary tractinfections in womenMethods: Systematic review was conducted by searchingfi ve databases with several keywords, namely “urinary tractinfection”, “cystitis”, “women” and “probiotics”. Articles thathave gone through peer review are included in the studyif they meet the inclusion and exclusion criteria. Reportingfollows the PRISMA rules.Results: The women included in this study varied from earlyadulthood to postmenopausal, most of whom were sexuallyactive, used birth control methods, and had recurrenturinary tract infections. The results showed that the use ofprobiotics in varied outcomes, either positive or not showedsignifi cant results. This is also due to the differences in theoutcomes studied and the additional materials used. Thisalso contributed to the emergence of adverse effects.Conclusion: The use of probiotics in the treatment ofcystitis and urinary tract infections has hope, although notall studies show signifi cant results. The side effects foundare still tolerable although they need to be considered.Keywords: cystitis, probiotic, urinary tract infection, women.AbstrakTujuan: Meninjau peran probiotik dalam infeksi salurankemih pada perempuan.Metode: Tinjauan sistematis dilakukan dengan mencari limadatabase dengan beberapa kata kunci, yaitu “infeksi salurankemih”, “sistitis”, “perempuan” dan “probiotik”. Artikel yangtelah melalui peer review diikutsertakan dalam penelitianjika memenuhi kriteria inklusi dan eksklusi. Pelaporanmengikuti aturan PRISMA.Hasil: Perempuan yang diikutsertakan dalam penelitian inibervariasi mulai dari dewasa awal hingga pascamenopause,sebagian besar aktif secara seksual, menggunakan metodekontrasepsi, dan mengalami infeksi saluran kemih berulang.Hasil penelitian menunjukkan bahwa penggunaan probiotikpada infeksi saluran kemih menunjukkan hasil yang positifmaupun tidak menunjukkan hasil yang signifi kan. Hal inijuga disebabkan perbedaan outcome dan bahan tambahanyang digunakan. Penggunaan bahan juga berkontribusipada munculnya efek samping.Kesimpulan: Penggunaan probiotik dalam pengobatansistitis dan infeksi saluran kemih memiliki harapan, walaupuntidak semua penelitian menunjukkan hasil yang signifi kan.Efek samping yang ditemukan masih dapat ditoleransimeskipun perlu diperhatikan.Kata kunci: infeksi saluran kemih, perempuan, probiotik,sistitis.
Management of Spontaneous Cornual Heterotopic Pregnancy in Low-Resources Setting: Tata Laksana Kehamilan Heterotopik Kornual Spontan pada Keadaan Sumber Daya Terbatas Jacklyn Yosefin Gracia Lubis; Yosep Sutandar; Lidya F. Nembo
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1883

Abstract

Objective: To report management of spontaneous cornualheterotopic pregnancy in low-resources setting in EndeDistrict, Flores, East Nusa Tenggara.Methods: Case report.Case: A 34 year old primigravida with history of 8-9 weeksamenorrhea came to Obstetrics ER with chief complaintof vaginal bleeding and lower abdominal pain. Ultrasoundshows intrauterine pregnancy (IUP), an ectopic pregnancy(EP) in right uterine cornu, and free fl uid in hepatorenalspace, splenorenal space, and pouch of douglas suggestingthe occurrence of hemoperitoneum and heterotopicpregnancy. We performed cornual resection by laparotomyand administered progesterone orally before and after thesurgery. Successful outcome was achieved.Discussion: Heterotopic pregnancy (HP) rarely occurs,especially in natural conception. Thus, early diagnosis andtreatment of HP are quite a challenge for physicians especiallyin rural area. Due to the condition of our patient and limitedresources, laparotomy was conducted to remove the EP,rather than laparoscopy despite its advantage to lower riskof IUP abortion. Progesterone was then administered orallyto prevent threatened abortion of the IUP.Conclusion: Despite its challenge in diagnosing andtreating HP, it is a life-threatening condition that requiresaccurate and prompt treatment. The treatment goal is toremove the EP and preserve the IUP. Treatment of choiceshould be decided by takeing the patient’s condition andavailability of resources into account. Surgical along withadministration of progesterone before and after the surgerywould likely improve the outcome of the patient and theintrauterine pregnancy.Keywords: cornual resection, heterotopic pregnancy,laparotomy, low-resources setting, progesterone.AbstrakTujuan: Untuk membahas tentang penatalaksanaankehamilan heterotopik kornu spontan di daerah dengansumber daya rendah khususnya di Kabupaten Ende, Flores,Nusa Tenggara Timur.Metode: Laporan KasusKasus: Seorang perempuan primigravida usia 34 tahundengan riwayat amenore minggu ke-8 dan 9 datang keIGD Obgyn dengan perdarahan pervaginam dan nyeriperut bagian bawah. Temuan USG menunjukkan kehamilanintrauterin (KIU), kehamilan ektopik (KE) di tanduk rahimkanan, dan cairan bebas di ruang hepato-renal, splenorenal,dan cavum douglas. Hal ini menunjukkan terjadinyahemoperitoneum dan kehamilan heterotopik. Reseksikornu dengan laparotomi dilakukan dan pasien diberikanprogesteron secara oral sebelum dan setelah operasi.Luaran baik berhasil dicapai.Diskusi: Kehamilan heterotopik jarang terjadi, terutamapada konsepsi alami. Sehingga diagnosis dan tata laksanaKH sejak dini menjadi tantangan bagi para dokter, terutamadi daerah terpencil Karena kondisi pasien dan sumber daya,laparotomi dilakukan untuk mengangkat KE, daripadalaparoskopi meskipun keuntungannya dalam menurunkanrisiko keguguran KIU. Progesteron kemudian diberikansecara oral untuk mencegah terjadinya keguguran terancamdari KIU.Kesimpulan: Terlepas dari tantangan untuk diagnosisdan tatalaksananya, KH adalah kondisi yang mengancamjiwa yang membutuhkan penanganan yang akurat dansegera. Tujuan tatalaksananya adalah untuk mengangkatKE dan mempertahankan KIU. Pilihan tata laksana harusdiputuskan dengan mempertimbangkan kondisi pasien danketersediaan sumber daya. Pendekatan bedah dan obatdengan progesteron yang diberikan sebelum dan sesudahoperasi akan meningkatkan kemungkinan luaran pasien dankehamilan intrauterine yang baik.Kata kunci: kehamilan, heterotopik, laparotomi,progesteron,reseksi kornual, sumber daya rendah.
The Role of Vitamin D in Pregnant Women in Birth Weight of Neonates: Peran Vitamin D pada Ibu Hamil terhadap Berat Badan Lahir Neonatus Rajuddin Rajuddin; Derevie Hendryan Moulina; Munawar; Cut Meurah Yeni; Hilwah Nora
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1896

Abstract

Objective: To determine the relationship between serumvitamin D levels in third trimester mothers and newbornbirthttweight.Method: The study was conducted at the maternity wardof Dr. Zainoel Abidin General Hospital in Banda Aceh,Indonesia. Maternal and infant serum vitamin D levelswere measured using the Automatic ChemiluminescenceImmunoassay Analyzer (CLIA) method. Blood samples werecollected from mothers in the third trimester and frominfants after delivery. Spearman's correlation rank test wasemployed with a confi dence level of 95%. Vitamin D levelswere categorized as suffi cient, insuffi cient, and defi cient.Results: A total of 39 pregnant women with an averageage of 30.38 ± 6.21 years participated in the study, with apredominance of 38-39 weeks of gestation (35.9%). Themean vitamin D levels in mothers and neonates were 17.4ng/mL and 17.6 ng/mL, respectively (p = 0.003, R = 0.462).The average birth weight of the babies was 3,100 grams,ranging from 2,100 grams to 4,200 grams (p = 0.185, R =0.217). Both variables showed a positive correlation withvarying strength of the relationship.Conclusion: Maternal serum vitamin D levels in the thirdtrimester exhibited a positive correlation with serum vitaminD levels in neonates with moderate strength, but therewas no correlation with birth weight. The evaluation ofmaternal third-trimester serum vitamin D levels can serve asa predictor of neonatal vitamin D levels.Keywords: birth weight, neonates, pregnancy, vitamin D. AbstrakTujuan: Untuk menilai pengaruh hubungan kadar vitaminD serum ibu trimester ketiga terhadap kadar vitamin D danberat badan neonatus yang dilahirkan.Metode: Penelitian ini studi observasional korelatif dengandesain potong lintang yang dilakukan pada kamar bersalinRSUD dr. Zainoel Abidin Banda Aceh. Pengukuran kadarvitamin D serum ibu dan bayi dilakukan dengan metodeAutomatic Chemiluminescence Immunoassay Analyzer(CLIA). Analisis data dengan melakukan Uji Spearman’scorrelation rank test untuk menilai kekuatan hubungan duavariabel.Hasil: Sebanyak 39 ibu hamil usia 30,38 ± 6,21 tahun terlibatdalam penelitian ini dengan dominasi usia kehamilan 38–39minggu (35,9%). Rerata kadar vitamin D ibu dan bayi secaraberurutan adalah 17,4 ng/mL dan 17,6 ng/mL (p = 0,003,R = 0,462). Rerata berat badan bayi yang dilahirkan adalahsebesar 3.100 gram dengan rentang 2.100 gram hingga4.200 gram (p = 0,185, R = 0,217). Kedua variabel didapatkankorelasi positif dengan kekuatan hubungan bervariasi.Kesimpulan: Kadar vitamin D serum ibu trimester ketigaberkorelasi positif terhadap kadar vitamin D serum neonatusyang dilahirkan dengan kekuatan sedang namun tidakberkorelasi terhadap berat badan lahir bayi. Kadar vitaminD serum ibu pada trimester ketiga dapat dijadikan prediktorkadar vitamin D neonatus saat dilahirkan.Kata kunci: berat badan lahir, kehamilan, neonatus,vitamin D.
Neuroendocrine Cervical Carcinoma: Karsinoma Serviks Neuroendokrin Yulian Prastisia; Adrian Djatikusumo; Wina Kanya Wasystha; Iwan Kurnia Effendi
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1898

Abstract

Objective: To present a series of neuroendocrine cervical carcinoma, a rare malignancy of the cervix with different stages, treatment approach and outcome. It is included in this article review about diagnostic approach, treatment and prognosis in dealing with neuroendocrine cervical carcinoma. Methods: Case report Cases: We reported three cases of neuroendocrine cervical carcinoma. First is a 40-year old woman para 2, with stage IIIB neuroendocrine cervical carcinoma and chose palliative care only. Second, a 54-year old woman, para 5 with stage IIB neuroendocrine cervical carcinoma which underwent radiotherapy, with a 4 months disease free period. And lastly, a 36-year old woman, para 2 with stage IB1 neuroendocrine cervical carcinoma, underwent a radical abdominal hysterectomy procedure with pelvic lymphadenectomy and external pelvic radiotherapy. The disease is well controlled and had no recurrence in 15 years. Conclusion: It is important to differentiate neuroendocrine cervical carcinoma with other malignancies that could be found in the cervix. Immunohistochemistry (IHC) tests could be used to achieve that purpose. It is also important to arrange a treatment plan to treat these malignancies and multimodality treatment is preferable for better outcomes. Keywords: Neuroendocrine cervical carcinoma, cervical carcinoma, multimodality treatment.AbstrakTujuan: Melaporkan serangkaian kasus neuroendocrinecervical carcinoma, salah satu jenis keganasan langka padaarea serviks dengan stadium, tata laksana, dan hasil yangberbeda. Dalam artikel ini juga terdapat ulasan mengenaiprosedur diagnosis, manajemen, dan prognosis darineuroendocrine cervical carcinoma.Metode: Laporan kasusKasus: Artikel ini melaporkan tiga kasus. Pertama perempuan40 tahun riwayat partus dua kali dengan karsinoma serviksneuroendokrin stadium IIIB dan hanya memilih perawatanpaliatif. Kasus kedua, perempuan 54 tahun, riwayat partuslima kali dengan karsinoma serviks neuroendokrin stadiumIIB. Pada pasien dilakukan terapi radiasi dan didapatkankondisi bebas penyakit selama 4 bulan. Terakhir, pasienperempuan 36 tahun riwayat partus dua kali dengankarsinoma serviks neuroendokrin stadium 1B1. Dilakukanhisterektomi radikal dan limfadenektomi kelenjar limfepelvis serta terapi radiasi. Kondisi pasien terkontrol dantidak terdapat kekambuhan setelah 15 tahun.Kesimpulan: Karsinoma serviks dengan jenis neuroendokrinharus dibedakan dengan keganasan lain pada daerah serviks.Uji imunohistokimia dapat digunakan untuk membedakanhal tersebut. Selain itu, penyusunan rencana tatalaksanauntuk mengatasi keganasan pada serviks juga harusmenjadi perhatian penting bagi klinisi. Direkomendasikanuntuk menerapkan tata laksana multimodal untuk mencapaihasil terapi yang optimal.Kata kunci: karsinoma serviks, karsinoma serviksneuroendokrin, tata laksana multimodal.
The Effect of Water Intake during Pregnancy on Birth Weight: Pengaruh Asupan Air selama Kehamilan pada Berat Lahir Bayi Tria Rosemiarti; Hardinsyah Hardinsyah; Budi I. Santoso; Sudung O. Pardede; Parlindungan Siregar; Netta M. Putri; Ratu S. Hanifah
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1963

Abstract

AbstractObjective: This systematic review aimed to investigate theeffect of water intake during pregnancy on infant birthweight.Methods: A comprehensive search was conducted usingthe keywords "water intake," "dehydration," "pregnancy,""outcome," "hydration," "birth weight," and "birth outcome"in databases such as "SCOPUS," "EBSCO," "PUBMED,""COCHRANE," and through "Google Search." MeSH headings"pregnancy" and "hydration" were used for the search.Inclusion criteria encompassed pregnant women withoutpathological disorders, birth weight as a studied outcome,prospective cohorts, clinical trial study designs, and Englishlanguagepapers. Out of the 254 articles retrieved, six metthe specifi ed requirements and were included in this review.Results: The fi ndings from the six studies consistentlydemonstrated a positive correlation between higher waterintake, improved hydration, and increased birth weight.All studies measured water consumption or hydrationstatus between 8-37 weeks of gestation. Regardless of theduration of the studies, underhydration or low water intakewas consistently associated with lower birth weight.Conclusion: This review highlights that increasing waterintake among pregnant women positively affects infantbirth weight. Adequate water intake during pregnancy isrecommended to be in the range of 2180 – 3000 mL daily,considering hydration status and the stage of pregnancy.Keywords: birth weight, hydration, pregnancy, water intake.AbstrakTujuan: Untuk mengungkap pengaruh asupan air selamakehamilan terhadap berat lahir bayi.Metode: Menggunakan kata kunci “water intake,""dehydration," "pregnancy," "outcome," "hydration," "birthweight," dan "birth outcome,", artikel dicari. Data diambil daridatabase "SCOPUS," "EBSCO," "PUBMED," "COCHRANE,"dan "Google Search". Kami menggunakan MeSH headingskehamilan dan hidrasi untuk istilah pencarian. Kriteria inklusiadalah perempuan hamil tanpa kelainan patologis, beratbadan lahir adalah salah satu luaran penelitian, desain studiberupa kohort prospektif dan uji klinis, serta artikel dalambahasa Inggris. Dari 254 artikel yang diperoleh, enam artikelmemenuhi persyaratan dan digunakan untuk review ini.Hasil: Dari keenam penelitian menunjukkan bahwa semakintinggi asupan air, semakin baik hidrasi atau asupan airmeningkatkan berat bayi lahir. Semua penelitian mengukurkonsumsi air atau status hidrasi antara 8-37 minggu. Studistudiini secara konsisten memberikan bukti bahwa asupanair yang rendah atau kondisi kekurangan cairan dikaitkandengan berat badan lahir rendah, terlepas dari durasi studi.Kesimpulan: Kajian ini menunjukkan bahwa peningkatanasupan air ibu hamil berpengaruh positif terhadap beratlahir bayi. Asupan air yang cukup pada ibu hamil adalah2180 – 3000 mL setiap hari bergantung pada status hidrasidan usia kehamilan.Kata kunci: asupan air, berat lahir, hidrasi, kehamilan.
Diagnostic Performance of Urine-based HPV-DNA Test (CerviScan, Bio Farma) as Cervical Cancer Screening Tool in Adult Women: Performa Tes Diagnostik DNA-HPV berbasis Urine (CerviScan, Bio Farma) sebagai Alat Skrining Kanker Serviks pada Perempuan Dewasa Andrijono Andrijono; Dewi Wulandari; Indah Suci Widyahening; Dicky Mahardhika; Neni Nurainy; Rini Mulia Sari; Indriastuti Soetomo; Revata Utama
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1968

Abstract

Objective: Detection of high-risk human papillomavirus (hr-HPV) in urine specimens has been introduced recently and a new local PCR kit has been developed in Indonesia (CerviScan, Bio Farma). The objective of this study was to obtain the accuracy of hr-HPV DNA testing using the new kit (CerviScan, Bio Farma) on urine specimens against the gold standard on cervical swabs.Method: Adult women (aged 20–50 years) underwent routine general check-up or Pap test were enrolled between July and September 2022. Pairs of urine and cervical swab specimens were obtained from all subjects. HPV-DNA tests were performed using the new local PCR kit (CerviScan, Bio Farma) and the standard procedure (COBAS® 6800 HPV, Roche Molecular System). Direct sequencing was added whenever there were dispute results between the two methods. Agreement between both methods was tested using Kappa statistics. Diagnostic performance test was done on CerviScan. Results: A total of 876 women completed the examination. Agreement between CerviScan and COBAS® 6800 was substantial (K=0.662; p<0.001) and was almost perfect against COBAS® 6800 plus sequencing (K=0.828; p<0.001). The accuracy of CerviScan on urine samples was 95.8% against COBAS® 6800 and increased to 97.8% after additional sequencing. The sensitivity and specificity of CerviScan on urine samples compared to cervical swabs are 73.1% and 97.3%, respectively.Conclusion: Urine-based HPV-DNA testing with CerviScan is a reliable tool to detect high-risk HPV subtypes. It could become an alternative method for HPV-DNA testing to improve the coverage of cervical cancer screening program.
Neurodevelopment and Fetal Growth in Fetuses with Congenital Heart Disease: Perkembangan Saraf dan Pertumbuhan Janin dengan Penyakit Jantung Bawaan Adhi Pribadi
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 4 October 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i4.1751

Abstract

Objective: To determine mechanisms underlying fetal growth abnormalities, particularly intrauterine neurodevelopment, in congenital heart defects. Method: Literature Review Results: Since intrauterine, smart mechanisms have ensured that blood flow to the central nervous system remains smooth to maintain Neurodevelopment. The mechanism fluctuates to keep oxygen flowing to the brain. Blood with the highest oxygen content should always be pumped to upper body and the head via the heart and the aorta. Aortic arch region contains three major blood vessels, a.Brachiocephalic, a.Carotid communis, and a.Subclavia that bleed the upper body and head, including the brain. So, blood flow from the left heart through the aortic arch is critical for fetal brain growth. If the heart cannot drain blood to the head, brain growth will be jeopardized because hypoxia will interfere with brain growth so will be influence to Neurodevelopment. Impaired blood flow can occur as early as intrauterine, particularly if the fetus has congenital heart disease. Blood flow in the Middle Cerebral Artery (MCA) can be used to measure blood flow in the fetus head. The pulsatility index value can be used to measure blood flow in the MCA, and another parameter is the cardioplacental ratio. There is a decrease in flow to the head in congenital heart disease, which results in a decrease in the Pulsatily index of the MCA and a decrease in the cardioplacental ratio. Conclusions: Prolonged reduction in cardiac-derived blood flow leads to compromised neurodevelopment. Consequently, timely correction of postpartum heart defects becomes paramount to prevent protracted impairments in brain growth. Failing to address this promptly could also diminish the overall quality of life for children afflicted by congenital heart disease. Keyword: cardioplacental ratio, middle cerebral artery, congenital heart disease, fetal neurodevelopment. Keyword: cardioplacental ratio, cerebral media artery, congenital heart disease, fetal neurodevelopment. Abstrak Tujuan: Untuk menentukan mekanisme kelainan pertumbuhan janin terutama perkembangan saraf intrauterin pada cacat jantung bawaan. Metode: Kajian Pustaka Hasil: Pada kehidupan intrauterin, mekanisme yang baik telah memastikan bahwa aliran darah ke sistem saraf pusat tetap lancar untuk mempertahankan perkembangan saraf. Mekanisme ini berfluktuasi untuk menjaga oksigen tetap mengalir ke otak. Darah dengan kandungan oksigen tertinggi harus selalu dipompa ke otak melalui jantung dan arteri utama ke kepala melalui a.Brachiocephalic, a.Carotid communis, dan a.Subclavia. Pada daerah arkus aorta terdapat tiga pembuluh darah utama yang memperdarahi tubuh bagian atas dan kepala, termasuk otak. Aliran darah ini dipompa melalui jantung kiri melalui arkus aorta. Bila jantung tidak dapat mengalirkan darah ke kepala, maka akan menyebabkan pertumbuhan otak terancam karena hipoksia akan mengganggu pertumbuhan otak, sehingga secara jangka panjang akan berpengaruh terhadap perkembangan saraf fetus. Gangguan aliran darah dapat terjadi sejak dini terutama jika janin memiliki penyakit jantung bawaan. Aliran darah di Arteri Serebri Media (MCA) dapat digunakan untuk mengukur aliran darah pada bagian kepala. Nilai indeks pulsatilitas dapat digunakan untuk mengukur aliran darah di MCA, dan parameter lain adalah rasio kardioplasental. Terdapat penurunan aliran ke kepala pada penyakit jantung bawaan, yang mengakibatkan penurunan indeks Pulsatily pada MCA serta terdapat penurunan rasio kardioplasental. Kesimpulan: Penurunan perkembangan saraf terjadi ketika aliran darah dari jantung berkurang secara kronis ke daerah kepala janin, sehingga bila terdapat kelainan jantung bawaan pasca persalinan harus diperbaiki segera agar penurunan pertumbuhan otak pada periode pascasalin tidak berlangsung terlalu lama. Bila hal ini terjadi akan menurunkan pula kualitas hidup anak dengan penyakit jantung bawaan. Kata kunci: arteri serebri media, penyakit jantung bawaan, perkembangan saraf janin, rasio kardioplasenta.
COVID-19 Infection and the Preeclampsia in Pregnant Women : Infeksi COVID-19 dengan Preeklamsia pada Ibu Hamil Cindy M. Pradana; Dita D. Parti; Elly N. Sakinah
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 4 October 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i4.1796

Abstract

Objective: To determine the relationship between COVID-19 infection and preeclampsia in pregnant women at RSD dr. Soebandi Jember. Methods: This study used cross-sctional study with simple random sampling. The data is secondary data from medical records of 118 pregnant women who checked their pregnancies from March 2020 to December 2021 at RSD dr. Soebandi Jember and analyzed with chi-square test and logistic regression test. Results: Multivariate analysis showed that there were a relationship between COVID-19 infection with preeclampsia. COVID-19 is the most risky variable with an OR of 4.045 (95% CI 1.595 – 10.259). This condition happens because COVID-19 infection triggers down-regulation of RAS which make the failure of spiral artery remodelling and preeclampsia. Conclusion: There is a relationship between COVID-19 infection and the incidence of preeclampsia in RSD dr. Soebandi Jember. Keywords: COVID-19, preeclampsia, renin-angiotensin system (RAS), SARS-CoV-2 Abstrak Tujuan: Untuk mengetahui hubungan antara infeksi COVID-19 dengan kejadian preeklamsia pada ibu hamil di RSD dr. Soebandi Jember. Metode: Penelitian ini merupakan studi potong lintang dengan pengambilan sampel menggunakan simple random sampling. Penelitian ini menggunakan data sekunder rekam medis 118 ibu hamil yang memeriksakan kehamilannya mulai Maret 2020 hingga Desember 2021 di RSD dr. Soebandi Jember dan dianalisa dengan uji statistik Chi-square dan uji regresi logistik. Hasil: Analisis statistik menunjukkan terdapat hubungan antara infeksi COVID-19, usia, dan obesitas dengan kejadian preeklamsia di RSD dr. Soebandi Jember. Variabel COVID-19 merupakan variabel yang paling berisiko terhadap terjadinya preeklampsia dengan OR 4,045 (95% CI 1,595 – 10,259). Hal ini terjadi karena infeksi COVID-19 memicu down-regulasi pada RAS yang mengakibatkan kegagalan remodelling arteri spiralis dan preeklamsia Kesimpulan: Terdapat hubungan antara infeksi COVID-19 dengan kejadian preeklamsia di RSD dr. Soebandi Jember. Kata kunci: COVID-19, preeklamsia, renin-angiotensin system (RAS), SARS-CoV-2
Partum Mothers' Experience Regarding Support during the COVID-19 Pandemic: Pengalaman Ibu Bersalin Mengenai Dukungan selama Pandemi COVID-19 Ria H. Sari; Farida Kartini; Menik S. Daryanti
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 4 October 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i4.1876

Abstract

Objective: This study aims to investigate the experiences of mothers giving birth with regard to family support and the assistance of health workers during the COVID-19 pandemic. Methods: A descriptive phenomenological approach was employed for this research, following the framework standards for reporting qualitative research (SRQR). Thirteen individuals participated in the study, comprising seven mothers giving birth, three husbands, two midwives, and one parent. The research was conducted at the Mlati II Health Center in Sleman Regency, specifically in Cabakan Hamlet, Sumberadi, Kec. Mlati, Kab. Sleman, Special Region of Yogyakarta, during January-February 2022. The choice of location was based on specific criteria set by the researchers. Data collection took place online due to practical reasons, with informants being contacted to choose between online or offline interviews. Purposive sampling was used for informant selection, and in-depth interviews lasting approximately one hour each were conducted via WhatsApp, Zoom, or phone calls, with prior agreement from the informants. The interviews followed a semi-structured format. Results: Two main themes emerged from the data analysis: the emotional experiences of mothers during labor and their various needs. The COVID-19 pandemic had a significant impact, leading to feelings of anxiety, fear, tension, and the need for comfort and confidence. These psychological needs were categorized into verbal support, including encouragement, communication, and reassurance, as well as tactile support, involving gestures such as stroking, holding, and back rubs. Mothers also expressed spiritual needs, such as prayer and maintaining positive thoughts for a smooth delivery and the health of the baby. Nutritional needs, encompassing healthy and balanced eating, were identified as essential during childbirth. Support from husbands, family members, and health workers played a crucial role in reassuring mothers and educating them about COVID-19 prevention, contributing to a positive birthing experience. Conclusion: The provision of positive support during childbirth can facilitate a normal delivery and instill confidence in mothers. Keywords: childbirth, covid-19 pandemic, experience, maternity, support. Abstrak Tujuan: Untuk mengetahui pengalaman ibu bersalin mengenai dukungan keluarga dan tenaga kesehatan selama pandemi covid-19. Metode: Desain penelitian ini menggunakan pendekatan fenomenologi deskriptif sehingga untuk melengkapi pelaporan menggunakan framework standards for reporting qualitative research a synthesis of recommendations (SRQR). Jumlah informan yang digunakan dalam penelitian ini yaitu 13 orang, yang terdiri dari 7 ibu bersalin, 3 suami, 2 bidan dan 1 orang tua. Penelitian ini dilakukan di Puskesmas Mlati II di Kabupaten Sleman, di Dusun Cabakan, Sumberadi, Kec. Mlati, Kab. Sleman Daerah Istimewa Yogyakarta. Penelitian ini dilakukan pada bulan Januari-Februari 2022, alasan pemilihan tempat ini adalah berdasarkan kriteria peneliti. Metode dalam penelitian dilakukan secara online. Peneliti memiliki beberapa alasan praktis untuk mengumpulkan data secara online. Peneliti menghubungi informan untuk menanyakan apakah bersedia di wawanacara secara online atau offline. Rekruitmen informan pada penelitian ini menggunakan purposive sampling. Peneliti melakukan indepth interview dengan informan secara online melalui media whatsapp, zoom dan telepon seluler kurang lebih satu jam tiap individu dengan perjanjian terlebih dahulu dengan informan.Wawancara yang digunakan dalam penelitian ini semi structure. Hasil: Didapatkan 2 tema yaitu tanda-tanda persalinan dan kebutuhan ibu bersalin. Dampak pandemi covid-19 membuat ibu merasa was-was atau kekhawatiran, takut dan cemas, tegang, berusaha nyaman, berusaha tenang dan rasa percaya diri. Kebutuhan psikologis ini terbagi menjadi dua bagian yaitu dukungan secara verbal dan dukungan secara sentuhan. Dukungan secara verbal seperti menyemangati, di ajak ngobrol, memberikan dukungan, mendampingi, ramah, komunasi, percaya diri, siaga, pelayanan bagus, harus kuat, menyayangi dan perhatian. Dukungan secara sentuhan seperti di elus-elus, mengusap keringat, pegang kepala, menggosok-gosok punggung dan menggosok perut.Kebutuhan spiritual yang didapatkan ibu selama proses persalinan yaitu zikir, berdoa, dan selali berpikir positif agar persalinan lancar dan bayi sehat. Kebutuhan nutrisi ibu bersalin seperti makan-makanan yang sehat, makanan bergizi seimbang, minum air putih untuk tenaga mengejan. Dukungan yang diberikan oleh suami, keluarga dan tenaga kesehatan membuat ibu merasa tenang dan mendapatkan edukasi terhadap penyebaran covid-19 agar mendapatkan persalinan yang positif. Kesimpulan: Dukungan yang positif akan memberikan persalinan normal dan ibu percaya diri. Kata kunci: dukungan, ibu bersalin, pandemi covid-19, pengalaman, persalinan.

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