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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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Pengaruh suntikan depo medroxy progesteron asetat terhadap profil lipid SANGER, O. G.; LOHO, M F; WIRASTI, C. R.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 3, July 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.01 KB)

Abstract

Tujuan: Mengetahui pengaruh pemberian DMPA terhadap profil lipid akseptor. Rancangan/rumusan data: Pre test - post test. Bahan dan cara kerja: Penelitian dilakukan mulai Januari 2006 sampai Maret 2007 di Kota Tomohon. Pada penelitian ini direkrut 250 orang akseptor DMPA yang memenuhi kriteria inklusi. Sebagai subjek dalam penelitian ini adalah wanita usia 20 - 35 tahun berstatus menikah, masih mengalami menstruasi, tidak menggunakan kontrasepsi hormonal selama 3 bulan terakhir. Sampel dipilih secara simple random sampling, ditentukan 26 orang subjek yang akan dilakukan pemeriksaan laboratorium bertahap pada 1, 3, 6, 9, dan 12 bulan. Selanjutnya dilakukan pengumpulan data, ditabulasi, dan disajikan dalam bentuk tabel untuk karakteristik subjek, perubahan profil lipid sebelum dan sesudah penyuntikan DMPA dilakukan analisis dengan uji T - Berpasangan. Hasil: Pada penelitian ini sebagian besar akseptor berusia 31 - 35 tahun 40,8 %, pendidikan SLTA 45,2 %, dan tidak bekerja (IRT) 83,6 %, paritas 2 40,8 %, dan IMT rata-rata 24,6. Kadar kolesterol total baseline, 1, 3, 6, 9, 12 bulan (188,31; 174,42; 182,35; 184,08; 182,50; 184,30; p>0,05). Kadar HDL baseline, 1, 3, 6, 9, 12 bulan (57,00; 51,35; 51,19; 49,92; 51,31; 48,38; p0,05). Kadar Trigliserida baseline, 1, 3, 6, 9, 12 bulan (97,31; 88,92; 81,81; 94,60; 99,50; 111,04; p>0,05). Kesimpulan: Terjadi penurunan kadar kolesterol total selama pemakaian DMPA 12 bulan, namun secara statistik tidak bermakna. Tidak terjadi perubahan kadar LDL, trigliserida secara bermakna, namun terjadi penurunan kadar HDL secara bermakna setelah pemberian DMPA selama 12 bulan, bila diukur dari baseline. Penggunaan kontrasepsi DMPA pada calon akseptor yang memiliki risiko tinggi PJK harus dihindari. Perlu dilakukan pemeriksaan profil lipid secara rutin terhadap semua akseptor kontrasepsi DMPA jangka panjang > 1 tahun. [Maj Obstet Ginekol Indones 2008; 32-3: 153-60] Kata kunci: DMPA, kolesterol total, HDL, LDL, trigliserida.
Contraception in Malignancies Anggraeni, Tricia D
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.893 KB) | DOI: 10.32771/inajog.v2i3.401

Abstract

Along with the development of cancer diagnosis and treatment, the life expectancy of women in reproductive age who suffer from cancer are also higher. Women with cancer still have the possibility to be pregnant and have a child during or after completion of therapy. Taking this into consideration, the guideline for contraception in special circumstances like this is needed. After reviewing the safety and effectiveness of contraceptive methods available for women with cancer, The Society of Family Planning urged not to use combination hormonal contraceptives (estrogen and progestin). Hormonal contraceptive use in cancer patients may increase the risk of venous thromboembolism (Level A). T380A IUD, which has a high effectiveness, reversible, long-term, and hormone-free contraception should be considered as the primary choice in patients with breast cancer (Level A). In women who received tamoxifen therapy, the use of IUD containing Levonorgestrel can be considered as a second choice (Level B) because it can decrease the proliferation endometrium. Women with anemia due to chemotherapy may be given contraceptive containing progestin (Level A). Women with osteopenia or osteoporosis after chemotherapy should avoid progestin contraceptive injection (Level A). Currently, there are no data to evaluate the risk of venous thromboembolism in progestin contraceptive use. Further information is also needed to determine the effect of the use of IUD that contains Levonorgestrel against breast cancer recurrence and the effect of hormonal contraceptives on breast cancer in women who received chest wall radiotherapy. [Indones J Obstet Gynecol 2014; 3: 166-170] Keywords: cancer, contraception, malignancy
Hypoxia Inducible Factor1α in Correlation with Preeclampsia Juarsa, Hendrik; Tendean, Hermie M M; Wantania, John E
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (54.485 KB) | DOI: 10.32771/inajog.v4i1.67

Abstract

Objective: To know the correlation between Hypoxia Inducible Factor (HIF)-1α level with preeclampsia. Method: The study was conducted at the Obstetrics and Gynecology Department of Prof. Dr. R. D. Kandou Hospital. This research was carried out from April to June 2014. This study is a cross-sectional analytic approach in preeclampsia and normotensive pregnancy. We perform cubital venous blood sampling for inspection by 5 ml of serum and stored it in a refrigerator (-20°C). The level of HIF-1α serum was done by quantitative ELISA method in Prodia Lab Jakarta. Result: Seventy six pregnant women with 38 normotensive pregnancies and 38 preeclampsia, showed a significant association between the average levels of HIF-1α in the serum of pregnant women with preeclampsia compared to normotensive pregnancies (p = 0.000). Conclusion: There is a positive relationship between the levels of HIF-1α in serum of preeclampsia, in which HIF-1α levels in preeclampsia was higher than normotensive pregnancies. [Indones J Obstet Gynecol 2016; 1: 19-22] Keywords: hypoxia inducible factor-1α, preeclampsia
Lselectin Levels in Patients with Endometriosis Fanggidae, Melkiandri; Loho, Maria F.T.; Mewengkang, Maya E.
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v6i1.758

Abstract

Objective: To investigate the L-selectin profile in endometrioticpatients.Methods: This was a cross-sectional study. Subjects were patientsdiagnosed endometriosis based on clinical examination, transvaginalultrasound, MRI and CT scan at the Department of Obstetricsand Gynecology of Prof. Dr. R.D. Kandou Hospital Manado, SiloamHospital and Network Hospital starting from January 2017 to May2017. The blood samples in patients prior to surgery were taken ona vein and then separated to obtain serum. Further more, serumlevels of L-selectin were measured using enzyme-linked immunosorbentassay (ELISA). Data were analyzed with SPSS version 22.0to see significance level.Results: Of the 18 samples, based on age, endometriosis highest inthe group > 26 years ie 17 patients (94.44%), followed by the agegroup of 21-25 years in 1 patient (5:56%), and none of thepatients in the age group <20 years (0%). Based on parity, themost established on a parity group 0 for 11 patients (61.11%),followed by the 1-3 parity group of 7 patients (38.99%), and nopatients in the parity > 4 (0%). Based on the highest stage is thethird stage as many as 11 people (61.11%), followed by stage 4 of7 patients (38.99%), and none of the patients in stage 1 or stage 2(0%). From a statistical test used to stage endometriosis age, theT test, p value 0.286. From a statistical test according to the levelsof L-selectin on endometriosis stadium used, the T test, p value0.090. Results of correlation tests were used, namely statingPearson test p value of 0.921.Conclusion: L-selectin levels in women with endometriosisincreased according to clinical stage, but not significant in statisticaltests. There is no significant relationship between age withstages or levels of L-selectin in women with endometriosis.Keywords: adhesion, age, endometriosis, L-selectin, stage
Adhesion Prevention in Operative Laparoscopy Hadisaputra, Wachyu
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.729 KB)

Abstract

Objective: To know the modalities used for prevention of adhesion formation in operative laparoscopy. Method: Literature study. Results: Methods of prevention of adhesion in laparoscopy include: modification of surgical technique, anti-inflammatory agents, peritoneal instillates and barrier adjuvants. Modification of surgical techniques such as adherence to basic principles of microsurgery, the use of electrothermal bipolar vessel sealer, liberal irigation of the abdominal cavity and instillation of a large amount of Ringer’s lactate at the completion of the procedure. This technique alone, eventhough seems effective, is insufficient. The anti-inflammatory agents used are the NSAIDs, corticosteroids, antihistamines, progestogens, GnRH agonists and calcium channel blocker. But none of them demonstrated to be significantly effective. Barrier adjuvants consist of: oxidized regenerated cellulose (ORC) and expanded polytetrafluoroethylene (ePTFE) and peritoneal instillates are the crystalloids, icodextrin, hyaluronic acid (HA), solution of HA, viscoelastic gel, hydrogel, and fibrin sealent. There is insufficient evidence data regarding the methods above for the prevention of adhesiogenesis in laparoscopy. But one study evaluating the use of viscoelastic gel did significantly reduce adnexal adhesion in laparoscopy. Conclusion: Laparoscopy does not trully eliminate the adhesiogenesis problem. No single therapy is effective for prevention of adhesion formation. The multimodal methods shall be used to increase the successful rate in adhesion prevention. [Indones J Obstet Gynecol 2010; 34-4: 204-7] Keywords: laparoscopy, adhesion, microsurgery, anti-inflammatory, peritoneal instillates, barrier adjuvants
Perbandingan ekspresi p53, Bcl-2, dan indeks apoptosis trofoblas pada preeklampsia/eklampsia dan kehamilan normal KEMAN, K.
Indonesian Journal of Obstetrics and Gynecology Volume. 33, No. 3, July 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Membuktikan bahwa, jumlah sel trofoblas yang mengalami apoptosis pada sampel jaringan trofoblas yang berasal dari kehamilan dengan preeklampsia/eklampsia lebih tinggi apabila dibandingkan dengan kehamilan normal. Tempat: Bagian Obstetri dan Ginekologi RSU Dr. Saiful Anwar Malang, dan Lab Biomedik FKUB Malang. Bahan dan cara kerja: Penelitian ini merupakan studi laboratorium secara potong lintang; dengan teknik imunohistokimia untuk pengamatan ekspresi protein Bcl-2 dan p53, dan teknik DNA-terfragmentasi (TUNEL) untuk menghitung indeks apoptosis. Sampel jaringan trofoblas berasal dari biopsi jaringan plasenta preeklampsia/eklampsia, dibandingkan dengan persalinan normal (n = 20). Variabel bebas: p53, Bcl-2, apoptosis. Variabel tergantung: preeklampsia/eklampsia. Analisa statistik menggunakan Independent t test (p ≤ 0,05). Hasil: Terdapat perbedaan yang signifikan jumlah sel-sel trofoblas yang mengalami apoptosis pada kelompok kehamilan normal (4,70± 1,829), dibandingkan dengan kelompok preeklampsia/eklampsia (4,70± 1,829), (t test; p≤0,000). Terdapat perbedaan yang signifikan ekspresi protein Bcl-2 pada jaringan trofoblas kelompok kehamilan normal (20,30±5,774), dibandingkan kelompok preeklampsia/eklampsia (9,90± 1,912) (t test; p≤0,000). Terdapat perbedaan yang bermakna ekspresi protein p53 pada jaringan trofoblas kelompok kehamilan normal (8,20 ±2,898), dibandingkan dengan kelompok preeklampsia/preeklampsia (22,70±4,990) (t test; p≤0,000). Kesimpulan: Jumlah sel trofoblas yang mengalami apoptosis pada jaringan trofoblas preeklampsia/eklampsia lebih tinggi daripada kehamilan normal. [Maj Obstet Ginekol Indones 2009; 33-3: 151-9] Kata kunci: trofoblas, indeks apoptosis, p53, Bcl-2, preeklampsia, eklampsia
Korelasi antara Hormon Reproduksi dengan Tampilan Integrin Endometrium pada Wanita dengan Infertilitas SURJANA, E.; SANTY, D.; HESTIANTORO, A.; INDARTI, J.; KUSUMAH, F.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 2, April 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Untuk mengetahui apakah terdapat hubungan antara hormon reproduksi terhadap tampilan integrin endometrium. Tempat: Klinik Yasmin bagian Obstetri dan Ginekologi RSCMFKUI. Rancangan/rumusan data: Penelitian ini bersifat klinis retrospektif. Bahan dan cara kerja: 53 orang wanita usia antara 20-40 tahun. Pada semua pasien dilakukan biopsi endometrium pada fase sekresi dan pemeriksaan hormon FSH, LH, Prolaktin, estradiol dan progesteron, dan tampilan integrin dari biopsi endometrium dianalisa dengan pemeriksaan imunohistokimia. Hasil: Nilai rerata tampilan integrin pada penelitian ini 1,3. Dan didapatkan angka korelasi progesteron terhadap tampilan integrin endometrium 0,285 dengan nilai probabilitas 0,04 dan koefisien determinasi 0,081. Kadar hormon FSH, LH, Prolaktin dan estradiol tidak bermakna terhadap tampilan integrin. Kesimpulan: Terdapat hubungan positif antara kadar hormon progesteron terhadap tampilan integrin endometrium di fase luteal madya. Diperlukan adanya faktor-faktor lain untuk memperkuat nilai prediktor hormon progesteron. [Maj Obstet Ginekol Indones 2006; 30-2: 112-5] Kata kunci: integrin, FSH, LH, Estradiol, Progesteron, Infertilitas, Jendela implantasi.
Changes in Cortisol Levels before and after Supportive Psychotherapy in Patients with Comorbid Cervical Cancer Distress with Depression Type Nuranna, Laila; Nuryanto, Kartiwa H; Andriansyah, Andriansyah; Elvira, Sylvia D; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.702 KB) | DOI: 10.32771/inajog.v6i3.784

Abstract

Objective: To prove the success of supportive psychotherapy thatwas provided as a distress therapy on advanced cervical cancer.Knowing the prevalence of distress type of depression in patientwith epithelial cervical cancer, proving the benefits of psychotherapysupportive for distress can decreasing cortisol level in cervicalcancer patient, can assess distress thermometer score, HAM-D17score and scoring incident predictors of distress with depressiontype.Methods: There were 32 subjects from 71 advanced cervical cancerpatients had mild-moderate depression. Then randomizationblocking was performed to determine a subject who entered thetreatment group (n = 16) who got supportive psychotherapy orcontrol group who got common psychotherapy (n = 16). All ofparticipants assessed the distress level with cortisol value, distressthermometer score, and HAM-D17 score before and after they gotsupportive psychotherapy.Results: After the intervention of psychotherapy in the treatmentgroup decreased HAM-D17 score, the average decline 7.53 (SB 3.34).The mean decreasing in the control group was 3.98 (SB 2.85). Thereis a significant difference in mean reduction in HAM-D17 scores ontreatment and control groups with p = 0.003 (p <0.005). There wasdecreasing blood cortisol level in the treatment group amounted to39.43, while the control group there was a drop of 1.59. The reductionof cortisol level in the treatment group and the control has a pvalue0.302. After got supportive psychotherapy, found a decreasingthe average value of the thermometer distress in the treatmentgroup 3.02 and the control group 2.51, with a p value more than0.492.Conclusion: There were 45% of cervical cancer patients in the clinicexperiencing distress disorder with depressive type. The bloodcortisol level could be decreased by giving supportive psychotherapywith a mean decrease of 39.43 nmol/l. There was a significantreduction in the level of depression (HAM-D17 score) of 7.53 pointsand distress thermometer impairment by 3 points after givensupportive psychotherapy. Obtained scoring predictors for theoccurrence of distress type of depression in patients with advancedcervical cancer with a sensitivity of 46.15% and a specificity of89.47%.[Indones J Obstet Gynecol 2018; 6-3: 179-187]Keywords: cervical cancer, cortisol, distress, distress thermometer,HAM-D17 score
Morbidity Occurs to a Fifth of Referred Post Partum Hemorrhage Cases Rahardja, Fitri
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 1, January 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To assess maternal morbidity (five scoring system) and mortality of referred post partum hemorrhage (PPH) in Dr. CiptoMangunkusumo Hospital period 2008-2010 and to identify its related factors. Method: Retrospective study with cross sectional design for referred obstetric cases in RSCM period 2008-2010. Analysis of relation was conducted to these data using Chi-square or Fisher test with SPSS 17.0. Result: There were 10,752 referred obstetrics cases in RSCM from 2008-2010, the three most common cases were severe preeclampsia, premature rupture of membrane, and preterm labour. The rate of referred cases of PPH in RSCM from 2008-2010 was 2%. There were 44 cases (20.5%) suffering morbidity (five scoring system) and 3 cases ending in mortality (1.4%) from all PPH referral cases. Mortality to morbidity rate for referred PPH cases in RSCM was 6.81% (3/44) with case/fatality ratio 14.7: 1. Variables that related to morbidity were age and referral factors (midwife). There were no relation between parity, education background, pay of services, occupation, type and etiology of PPH with morbidity due to PPH. Mortality assesment for 3 PPH referred cases would be descriptive. Conclusion: The proportion of referred PPH cases in RSCM 2008-2010 was 2%, of which 20.5% classified as morbid and 1.4% was classified as mortal cases. Variables related significantly to morbidity were age and referral factors. [Indones J Obstet Gynecol 2013; 37-1: 3-7] Keywords: five scoring system, maternal morbidity, maternal mortality, referred cases of PPH
The effect of 17β Estradiol Exposure on Mutant p53 Expression in Hydatidiform Mole Trophoblast Cell Culture Nurseta, Tatit
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (69.252 KB)

Abstract

Objectives: To compare the mutant p53 expression in normal trophoblast (N) cell culture with hydatidiform mole trophoblast (HM) cell culture which was exposed to 17β estradiol. Methods: An experimental study conducted at the Laboratory of Physiology Faculty of Medicine, Brawijaya University Malang using N cell culture and HM cell culture with 17β estradiol exposure. Trophoblast cell culture of normal and hydatidiform mole was divided in 6 groups, such as: 1. Without added 17β estradiol; 2. Added 5 nm 17β estradiol; 3. Added 10 nm 17β estradiol; 4. Added 20 nm 17β estradiol; 5. Added 40 nm 17β estradiol; 6. Added 80 nm 17β estradiol. Then performed immunocytochemistry staining using p53 mutant primary antibody and observed the expression of p53 mutant. Data from observations analized with the ANOVA test and correlation test. Results: Mutant p53 expression in N cell culture showed no significant differences in each treatment dose of 17β estradiol (p = 0086 > 0.05). The dose at 80nm 17β estradiol showed an average of highest mutant p53 expression on N cell culture rather than giving the dose of 17β estradiol on 40 nm, 20 nm, 10nm and 5 nm. While the control group showed a lowest average of mutant p53 expression in N cell culture when compared to the treatment group which was exposed to 17β estradiol. Mutant p53 expression in HM cell culture showed a significant difference at each treatment dose of 17β estradiol (p = 0.000 < 0.05). The existence of the effect of 17β estradiol begins when the expression of mutant p53 in HM cell culture becomes higher after being given treatment in the form of 17β estradiol on the dose of 5 nm compared with the expression of 17β estradiol in the control group. Then the expression of mutant p53 in HM cell culture is increasing when given doses of 17β estradiol at 20 nm and 40 nm. At a dose of 40 nm it shows the highest expression of mutant p53. Expression of mutant p53 in HM cell culture decreased when given at doses 80 nm. Conclusion: Mutant p53 expression in N cell culture exposed to 17β estradiol showed no significant difference. Expression of mutant p53 in HM cell culture which was exposed to 17β estradiol showed a significant difference. Mutant p53 expression in N and HM cell culture which was exposed to 17β estradiol showed significantly different, in which mutant p53 expression in N cell culture is lower than the expression of mutant p53 in HM tissue culture. [Indones J Obstet Gynecol 2011; 35-1: 30-5] Keyword: p53 mutant, 17β-estradiol, hydatidiform mole

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