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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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The Estrogen Receptor Concentration and Col3A1 Gene Immunoexpression in Uterosacral Ligament is Correlated with Postmenopausal Uterine Prolapse Asmara, Erick C.
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To analyze correlation between concentration of estrogen receptor and imunoexpression of Col3A1 gene on uterosacral ligament of postmenopausal uterine prolapse patient. Methods: This is a cross-sectional analytic observational study involving 32 subjects who met inclusion criteria. Samples are taken consecutively in Dr. Hasan Sadikin Hospital in January 1st - December 31st 2012. Statistical analysis was performed with non-parametric Mann-Whitney test and Spearman’s rho non-parametric correlation test. Result: There is no significant difference of estrogen receptor concentration between postmenopausal women with and without uterine prolapse (p = 0.377), while there is no significant difference of Col3A1 gene immunoexpression between postmenopausal women with and without uterine prolapse (p = 0.119) either. There is a significant positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients (p = 0.002, r= 0.711). Conclusion: There is a positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients. [Indones J Obstet Gynecol 2013; 37-2: 103-6] Keywords: Col3A1 gene, estrogen receptor, menopause, uterine prolapse, uterosacral ligamen
Gambaran Kadar Interleukin-6 Serum dan Sekret Serviks pada Wanita Infertilitas yang Dicurigai Menderita Penyakit Radang Panggul Subklinik SURJANA, E.; DHANASARI, N.K.Y.; HESTIANTORO, A.; ENDARDJO, S.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 1, January 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Mendapatkan gambaran kadar IL-6 serum dan sekret serviks pada kasus infertilitas yang terbukti mengalami Penyakit Radang Panggul dan bukan Penyakit Radang Panggul. Rancangan penelitian: Penelitian ini bersifat deskriptif dan dilakukan secara potong lintang. Sebanyak 20 wanita infertilitas tersangka PRP subklinik dilakukan pengambilan darah dan sekret servikal untuk diperiksa kadar IL-6 serum maupun sekret serviks serta dilakukan biopsiendometrium untuk menegakkan ada tidaknya PRP sesuai dengan kriteria Kiviat. Hasil: Rerata kadar IL-6 serum pada wanita yang terbukti PRP tidak menunjukkan perbedaan dengan yang tidak terbukti PRP (Rerata 2,56 vs 2,47 pg/ml; median 1,90 vs 1,95 pg/ml; minimum 0,80 vs 0,73 pg/ml;maksimum 10,65 vs 4,87 pg/ml dengan p=0,74) Sedangkan rerata kadar IL-6 sekret serviks pada wanita yagn terbukti PRP lebih tinggi dibandingkan dengan yang tidak terbukti PRP (Rerata (SD) 1275,8 (1073,9) vs 330,7 (178,2) pg/ml; kisaran 85,86 - 3928,86 vs 120,28 - 520,82 pg/ml dengan p= 0,016). Kesimpulan: Rerata kadar IL-6 sekret serviks pada wanita dengan PRP lebih tinggi dibandingkan pada wanita tanpa PRP. Sedangkan rerata kadar IL-6 serum pada wanita dengan PRP dan tanpa PRP tidak menunjukkan perbedaan. [Maj Obstet Ginekol Indones 2006; 30-1: 30-5] Kata kunci: IL-6, Penyakit Radang Panggul Subklinik, endometritis, sekret serviks. Objective: To obtain profile of IL-6 serum level and cervical secretes in infertility proved to have experienced pelvic inflammatory disease and not pelvic inflammatory disease. Design: This study was a descriptive, cross-sectional trial. As many as 20 infertile women suspected of subclinical PID (pelvic inflammatory disease) were submitted to blood taking and cervical secretes for the examination of IL-6 serum level and cervical secretes, and endometrial biopsy to confirm the presence or absence of PID in accordance with Kiviat criteria. Results: Mean IL-6 serum level in women with confirmed PID did not show any difference from that in women without confirmed PID (mean 2.56 vs 2.47 pg/ml; median 1.90 vs 1.95 pg/ml; minimum 0.80 vs 0.73 pg/ml; maximum 10.65 vs 4.87 pg/ml with p = 0.74. On the other hand, mean IL-6 level of cervical secretes in women with confirmed PID was higher than that in women without confirmed PID (mean (SD) 1275.8 (1073.9) vs 330.7 (178.2) pg/ml; range 85.86 - 3928.86 vs 120.28 - 520.82 pg/ml, with p = 0.016). Conclusion: Mean IL-6 level of cervical secretes in women with PID was higher than that in women without PID. On the other hand, means IL-6 serum level in women with PID and without PID did not show any difference. [Indones J Obstet Gynecol 2006; 30-1: 30-5] Keywords: IL-6, subclinical pelvic inflammatory disease, endometriosis, cervical secretes.
Low Class Ib (HLA-G/Qa-2) MHC Protein Expression against Hsp-70 and VCAM-1 Profile on Preeclampsia. An observation on experimental animal Mus Musculus with Endothelial Dysfunction model Sulistyowati, Sri
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 3, July 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To analyze the expression of MHC class Ib Qa-2 protein (homologue to HLA-G in human), Hsp-70, and VCAM-1 in trophoblast cells of preeclampsia and control using endothelial dysfunction model on Mus Musculus. Method: Design of study is experimental study. Pregnant mice was treated with anti-Qa-2. Hsp-70 and VCAM-1 expressions of trophoblast cells was assessed on week I, II, and III. Result: Negative Qa-2 expression was achieved after administration of 40ng anti Qa-2 on the fifth day of pregnancy. The Hsp-70 and VCAM-1 expressions in negative Qa-2 mice (preeclampsia) was higher compared with those of positive Qa-2 mice (normal pregnancy) on week I, II and III. Conclusion: Low Qa-2 and high of HSP-70 and VCAM-1 expression might be useful for prediction of preeclampsia or endothelial dysfunction. [Indones J Obstet Gynecol 2010; 34-3: 103-7] Keywords: preeclampsia, HLA-G/Qa-2, Hsp-70, VCAM-1, endothelial dysfunction
Perubahan Densitas Mineral Tulang Lumbal Perempuan Pengguna Kontrasepsi Suntik Depo Medroksi Progesteron Asetat (DMPA) selama 6 Bulan di Puskesmas Tebet, Jakarta Selatan KASMARA, E.; SUMAPRAJA, K.; SANTOSO, S. S.I.; WIDYAHENING, I. S.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 4, October 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Untuk mengetahui densitas mineral tulang (DMT) lumbal perempuan Indonesia berusia 20 - 35 tahun sebelum dan setelah pemberian kontrasepsi suntik DMPA selama 6 bulan, dan mengetahui hubungan antara faktor asupan kalsium dan aktivitas fisik perempuanperempuan tersebut dengan DMT lumbal. Tempat: Puskeskmas Kecamatan Tebet, Jakarta Timur, Departemen Obstetri dan Ginekologi RSUPN Dr. Cipto Mangunkusumo dan Klinik Imunoendokrinologi Yasmin, Jakarta Pusat. Rancangan/rumusan data: Penelitian ini bersifat eksperimental self-controlled dengan rancangan pra-intervensi dan pasca-intervensi pada kelompok subyek. Bahan dan cara kerja: Sembilan-belas responden perempuan paritas satu berusia antara 20-35 tahun menjalani pemeriksaan densitas mineral tulang (DMT) lumbal 1-4 dengan menggunakan densitometri DEXA (dual energy x-ray absorptiometry). Para responden adalah akseptor KB suntik depo medroksi progesteron asetat (DMPA) pertama kali, dengan jadual pemberian sebesar 150 mg DMPA intramuskular tiap tiga bulan. Selain itu, didapatkan data mengenai berat badan, tinggi badan, indeks massa tubuh (IMT), asupan kalsium per hari dan aktivitas fisik responden. Kemudian dilakukan pemeriksaan DMT lumbal 1-4 yang kedua setelah 6 bulan penggunaan kontrasepsi DMPA. Hasil: Didapatkan rata-rata usia subyek (n = 11) adalah 25,0 ± 4,2 tahun (rentang 20 - 33 tahun). Rata-rata berat badan, tinggi badan dan indeks massa tubuh berturut-turut adalah sebesar 49,7 ± 6,2 kg (41 - 60 kg); 151,8 ± 6,2 cm (142 - 163 cm) dan 21,61 ± 2,74 kg/m2 (17,69 - 26,67 kg/m2). Densitas mineral tulang (DMT) L1-L4 awal menunjukkan rata-rata 0,958 ± 0,023 g/cm2 (0,876 - 1,080 g/cm2), rata-rata nilai T awal sebesar -1,26 ± 0,61 (-1,85 sampai dengan -0,25). Nilai rata-rata asupan kalsium per hari sebesar 329,01 ± 228,22 mg (78,25 - 784,55 mg). Rata-rata DMT L1-L4 akhir adalah sebesar 0,969 ± 0,078 g/cm2 (0,844 - 1,084 g/cm2), rata-rata nilai T akhir sebesar -1,17 ± 0,65 (-2,21 sampai dengan -0,22). Rata-rata pengeluaran energi total (Total Energy Expenditure [TEE]), laju metabolik basal (Basal Metabolic Rate [BMR]) dan faktor aktivitas (Activity Factor [AF]) berturut-turut adalah sebesar 2157,51 ± 342,55 kkal (1679,58 - 2753,49 kkal); 1288,05 ± 69,64 kkal (1189,20 - 1411,30 kkal) dan 1,68 ± 0,24 (1,4 - 2,1). Rata-rata persentase perubahan DMT adalah sebesar 1,13 ± 2,86% (-3,76 sampai dengan 6,74%). Terdapat korelasi yang sangat lemah dan tidak bermakna statistik antara faktor aktivitas dengan persentase perubahan DMT (r = 0,066, p = 0,846), antara IMT dengan persentase perubahan DMT (r = 0,098, p = 0,774). Sedangkan korelasi antara asupan kalsium per hari dengan persentase perubahan DMT adalah lemah (r = 0,457) dengan tingkat kemaknaan 0,158 (tidak bermakna). Analisis multivariat menunjukkan tidak ada perubahan yang bermakna secara statistik antara persentase perubahan DMT dengan IMT, asupan kalsium dan faktor aktivitas (p = 0,515). Kesimpulan: Pada sebelas responden yang diteliti, tidak terdapat perubahan bermakna DMT lumbal 1-4 setelah pemberian DMPA selama 6 bulan pertama dan tidak terdapat korelasi yang bermakna antara penggunaan DMPA selama 6 bulan pertama dengan indeks massa tubuh, asupan kalsium dan aktivitas fisik. [Maj Obstet Ginekol Indones 2007; 31-4: 243-50] Kata kunci: densitas mineral tulang (DMT), depo medroksi progesteron asetat (DMPA), indeks massa tubuh (IMT), asupan kalsium, faktor aktivitas.
Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%. [Indones J Obstet Gynecol 2014; 2-1: 40-45] Keywords: cervical cancer, SCC, therapeutic response, VEGF
Endometrial Histology in Abnormal Uterine Bleeding with Risk Factors Hasan, Rudy; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.86 KB) | DOI: 10.32771/inajog.v3i3.44

Abstract

Objective: To determine the endometrial histology in abnormal uterine bleeding (AUB) patients with risk factors. Method: This study involved 30 patients with complaints of AUB, aged over 35 years with associated risk factors of parity, obesity and fasting blood glucose in the outpatient clinic at Prof. Dr. R. D. Kandou General Hospital Manado, from July 2013 until October 2013. Patients who agreed to be involved in this study, underwent dilatation and curettage (D&C) to assess the endometrial histology that was grouped as the hyperplasia and non-hyperplasia groups. Result: From the results of the study, 7 patients were in the 35-40 years age group (23.3%) and in the 41-50 years age group were 23 patients (76.7%). Based on parity, 11 patients (36.7%) were nulliparous and 19 patients (63.3%) were multiparous. Based on the BMI, 16 patients (53.5%) were obese and 14 patients (46.7%) were non-obese. And based on the results of fasting blood sugar, similar results was obtained in normal and abnormal fasting blood glucose with the results of 15 patients in each groups (50%). And from all of patients who underwent D&C, endometrial hyperplasia was shown in 21 patients (70%) and non-hyperplasia endometrium in 9 patients (30%). From the results of Fischer exact test, a significantly high association was obtained between BMI and fasting blood glucose with the occurrence of endometrial hyperplasia. Conclusion: There is a significant relationship between BMI and high fasting blood glucose with endometrial hyperplasia. [Indones J Obstet Gynecol 2015; 3: 146-150] Keywords: age, AUB, BMI, endometrial hyperplasia, fasting blood sugar, parity
A Case of BeckwithWiedemann Syndrome with Polyhydramnios Yusrawati, Yusrawati; Muhatiah, Reno
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.101 KB) | DOI: 10.32771/inajog.v5i3.549

Abstract

Objective: To report a rare case of Beckwith-Wiedemann Syndrome with polyhydramnios. Methods: Reporting a case of Beckwith-Wiedemann syndrome with polyhydramnios. Results: Case of Mrs. Y, 27 years old woman, G2P1A0L1 preterm pregnancy (30-31 weeks) with polyhidramnios. From ultrasound found renomegaly, bilateral hyperechogenic polycystic kidney, and the karyotype result was 46,XX. Caesarean section was performed due to fetal distress. A female baby was born by caesarean section with birth weight of 1300 grams, 37 centimeters of body length, and APGAR score of 6/8. The congenital anomalies found were hepatomegaly, renomegaly, bilateral hyperechogenic renal polycystic, low set ears. The baby was died in NICU on day care 5th, with suspected of sepsis. Conclusion: Prenatal diagnosis of Beckwith-Wiedemann syndrome on fetus with polyhydramnios. [Indones J Obstet Gynecol 2017; 5-3: 185-188] Keywords: amniocentesis, beckwith-wiedemann syndrome, polyhydramnios, prenatal diagnostic, USG
Comparison between Vacuum and Forceps Extraction to Neonatal outcome on Prolonged Second Stage of Labor Syamsuri, Kurdi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To assess the effectiveness of vacuum and forceps extraction in prolonged second stage in Dr. Mohammad Hoesin Hospital Palembang. Methods: A retrospective study for 5 years (2005-2009) by doing a prognostic test on prolonged second stage of labor. Results: The subject age most commonly ranges from 20 to 35 years (84.8% in the forceps extraction group and 86% in the vacuum group). The common parity was nulliparity (58.1% in the forceps extraction group and 61.58% in the vacuum extraction). In the forceps extraction group, 76.7% scores >7 in the 1 minute APGAR score with the mean score of 7.14±1.62, whilst in the vacuum extraction group, 79.1% scores >7 in the 1 minute APGAR score, with the mean score of 7.16±1.78. And in the forceps extraction group, 94.2 scores >7 in the 5 minute APGAR score with mean score of 8.62±1.11, whilst in the vacuum extraction group, 93% scores >7 in the 5 minute APGAR score with the mean score of 8.65±1.08. It is concluded that there is no significant differences on both 1 and 5 minute APGAR scores (p value is 0.713 and 0.755, respectively). Maternal complication of extended episiotomy and perineal rupture were found more often in forceps extraction, but with no statistically significant difference (p=0.324). Conclusion: There is no difference of effectiveness between forceps extraction and vacuum extraction in the case of prolonged second stage. Physicians are free whether to use the vacuum or foceps according to their own desirability and skill. [Indones J Obstet Gynecol 2012; 36-1:28-31] Keywords: forceps extraction, prolonged second stage, vacuum extraction
Profil siklus menstruasi dan kejadian ovulasi perempuan usia reproduksi pecandu heroin WIRIAWAN, W.; HESTIANTORO, A.; PRIHARTONO, J.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 4, October 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Mengetahui pola siklus menstruasi dan angka kejadian ovulasi perempuan usia reproduksi pecandu heroin dan diketahuinya sebaran angka kejadian ovulasi perempuan usia reproduksi pecandu heroin menurut pola siklus menstruasinya. Rancangan/rumusan data: Studi deskriptif dengan rancangan potong lintang. Bahan dan cara kerja: Selama kurun waktu Januari sampai Juni 2007 dilakukan pengumpulan data terhadap 40 responden yang diambil secara consecutive sampling di RSKO Fatmawati dan beberapa puskesmas di Jakarta. Semua responden dilakukan wawancara mengenai pola siklus menstruasi tiga bulan sebelumnya dan dilakukan pemeriksaan kadar progesteron pada fase luteal madya. Hasil: Subjek yang diteliti berjumlah 40 perempuan usia reproduksi pecandu heroin yang berusia antara 20 sampai 40 tahun dengan rata-rata usia responden 26 (20 - 37) tahun. Rata-rata lamanya menggunakan heroin 7,1±3,1 tahun, sedangkan rerata usia responden pertama kali menggunakan heroin adalah 18 (13 - 31) tahun. Pola menstruasi yang didapatkan yaitu oligomenorea sebesar 67,5 %, siklus normal 22,5 %, dan amenorea sebesar 10 %. Pada penilaian kadar progesteron fase luteal madya didapatkan siklus menstruasi yang tidak berovulasi sebesar 77,5 % dan siklus yang berovulasi sebesar 22,5 %. Tidak ada perbedaan yang bermakna secara statistik (p > 0,005) di antara kelompok faktor risiko umur, lama pemakaian heroin, jumlah paritas, dan indeks massa tubuh mengenai gangguan ovulasi pada perempuan pecandu heroin. Kesimpulan: Pola menstruasi perempuan usia reproduksi pecandu heroin yang terbanyak adalah oligomenorea (67,5 %) dengan siklus yang berovulasi sebesar 26 %. [Maj Obstet Ginekol Indones 2008; 32-4: 223-8] Kata kunci: heroin, usia reproduksi, siklus menstruasi, ovulasi.
Profile of Maternal Referral Cases Indarti, Junita; Ocviyanti, Dwiyana; Aditya, Reyhan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.153 KB) | DOI: 10.32771/inajog.v4i2.76

Abstract

Objective: To explore the demography of maternal referral cases in Dr. Cipto Mangunkusumo Hospital (RSCM) along with the accuracy of referral. We also aim to evaluate the types of referral, origin of referral, referring healthcare facility and quality of referring healthcare facility. Method: The design of this study was a cross sectional design which described the accuracy of obstetrics referred cases in Emergency Unit Dr. Cipto Mangunkusumo Hospital from 2013 to 2014. Result: The total referred obstetric cases in 2013 was 1,645 patients. It was consisted of 1,307 appropriate (79.5%) and 338 inappropriate (20.5%) referred cases. Primary healthcare and general hospital were the most often referring cases to RSCM during two consecutive years. The top three cases referred to RSCM in both 2013 and 2014 were preterm premature rupture of membrane (PPROM), continued by severe preeclampsia and preterm labor. Conclusion: The number of referral cases in Indonesia is considered high, particularly in RSCM as the tertiary healthcare facility. There are still a high number of inappropriate referrals originating from primary healthcare facilities, pointing to the fact that the referral system is not running according to design or plan. To improve the quality of referral system, proper monitoring and evaluation of referral should be performed by local health department. [Indones J Obstet Gynecol 2016; 4-2: 64-66] Keywords: maternal case, referral system

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