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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
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Articles 11 Documents
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Search results for , issue "Vol. 13 No. 2 (2024): February" : 11 Documents clear
Comparison of 2009 and 2011 WHO Guidelines, and Scoring Models for Adult Hospitalized Dengue Infection: A Single Observation in Tangerang, Indonesia Wiwing, Veronica; Japutri, Josephine; Suryadinata, Neneng
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8104

Abstract

Background: World Health Organization (WHO) published a dengue guideline in 2009 and in 2011 by WHO-SEARO. However, many of dengue cases in early phase do not meet all the criteria by WHO classification. Because of this condition there is a scoring model that was published in 2015, that might help in primary health care. Therefore, a study to compare those diagnostic tools especially in adult dengue patients in Banten is needed.Aims: This study is to know the comparison between 2009 version and 2011 version of dengue diagnostic guidelines by WHO and scoring model version.Methods and Material: This study used a descriptive method with a cross-sectional design at 60 adult dengue patients. Each patient is grouped according to diagnostic tools’ classification and will be analyzed using Chi-square.Results: Results are grouped according to the WHO diagnosis from 2009 and 2011, presumptive model and probable models where there are 46 (77%), 48 (78%), 31(52%), and 15 (25%) of patients diagnosed with dengue infection. Overall, the diagnosis made by the 2009 WHO and the probable models has the most superior sensitivity and specificity values of 84,6% and 25%, and 82,4% and 97,7% respectively compared to other diagnostic tools. However, from the results of positive predictive values, probable models have a higher percentage than the 2009 WHO diagnosis.Conclusions: The probable model is more sensitive and specific than other diagnostic results. These conclude that probable model is best tool for dengue infection screening in early phase of infection.
Difference Disease Knowledge Level in Type 2 Diabetes Mellitus Patients at Siloam Lippo Village General Hospital Moningkey, Shirley Ivonne; Aprilyanri, Iegreat; Atmodjo, Wahyuni Lukita
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8105

Abstract

Background: In Indonesia, Diabetes Mellitus (DM) with complications is the third leading cause of death. Risk of complication increases tremendously in uncontrolled diabetes. The level of knowledge is one of the factors affect glycaemic control. However, little study has been done regarding the difference in disease knowledge level in type 2 DM patients. This study aims to find out the difference between the level of DM knowledge and glycaemic control in type 2 diabetes mellitus patients at Siloam Lippo Village General Hospital.Methods: Analytical observational with a cross-sectional study was conducted. 46 type 2 diabetes mellitus patients qualified for the inclusion criteria and were given the self-administered Michigan Diabetes Knowledge Test (MDKT) for General Knowledge Part (GKP) questionnaire and HbA1c test results taken in the past six months to evaluate glycaemic control. Purposive sampling method was used in this study for data collection. Student T-test was done to measure the difference with 95% significancy.Result: In 46 samples were shown that 60.90% women, a majority in the 50-59 age group, and 65.20% with more than 5 years of DM history. Among 46 samples, 26 have uncontrolled glycaemic with a mean score of 6.65 ± 1.83 in knowledge, and 20 have controlled glycaemic with a mean score 7.80 ± 1.61. Student T-test showed significant difference in level of knowledge between controlled and uncontrolled glycaemic levels with p = 0.032.Conclusions: It is concluded that there is a difference in disease knowledge level in type 2 DM patients at Siloam Lippo Village General Hospital. 
Association Between Breakfast and Dysmenorrhea in Female College Students at Faculty of Medicine, Pelita Harapan University Agnes, Agnes; Rivami, Dwi Savitri
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8106

Abstract

Background: Breakfast is an activity of eating and drinking that usually takes place after waking up until 9 A.M. and can fulfill 20-25% of daily nutritional needs. Unsupervised skipping breakfast can affect women's ovarian and uterus dysfunction. Dysmenorrhea is one of the diseases that can reduce productivity and quality of life in women. Previous studies have found a high incidence of dysmenorrhea in female college students who didn't have breakfast. Currently, there isn't much data regarding the association between breakfast and dysmenorrhea in female college students in Indonesia.Aim: The aim of this study is to discover the association between breakfast and dysmenorrhea in female college students of Faculty of Medicine at Pelita Harapan University.Methodology: This study is an unpaired analytical comparative categoric design study with a cross-sectional method. Data was collected from 60 college students of Faculty of Medicine at Pelita Harapan University using breakfast questionnaire, WaLLID score for dysmenorrhea, IPAQ-SF and PSS-10 were used to control the confounding variables. The data was analyzed using SPSS 23.Results: Among 60 samples were collected, the majority of female college students didn't have breakfast habit by 55%. There are 76.7% of female students who suffer dysmenorrhea, 91.7% have moderate and severe stress levels, 85% have high physical activity, and 70% of female college students have normal nutritional status. The results of the analysis showed that the p value > 0.05 for the association between breakfast with dysmenorrhea.Conclusion: There is no significant association between breakfast and dysmenorrhea.
Hydrodilatation and Intra-articular Steroid Injection are Both Effective in Management of Frozen Shoulder: A Case Series Butarbutar, John Christian Parsaoran; Riantho, Albert; Fidiasrianto, Kevin; Rizky, Dio Asgira
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8107

Abstract

Background: Frozen shoulder is a common problem in general orthopaedic practice, affecting about 2% of the population. Intra-articular corticosteroids (IA) and hydrodilatation have been reported as more effective among other conservative treatments. However, it is unclear which treatment is superior for frozen shoulder, and the hydrodilatation procedure leads to more discomfort in patients since it involves stretching of joint capsule. In this case series, we present 10 cases of frozen shoulder that were treated with hydrodilatation or IA steroid injection. The purpose of this study is to show the effectiveness of hydrodilatation and IA steroid injection in managing patient with frozen shoulder.Methods: This study was a retrospective case series of patients who received IA steroid injection or hydrodilatation. Five patients underwent IA steroid injection, and another five patients underwent hydrodilatation. The American Shoulder and Elbow Score (ASES) was used to evaluate each patient before and six months after treatment.Result: Hydrodilatation and IA steroid injection showed significant improvement in ASES score assessed at 6-month follow-up.Conclusions: Hydrodilatation and IA steroid injection are both effective to treat frozen shoulder in long term follow up.
Isolated Abducens Nerve Palsy: A Case Report of Cerebral Pseudocyst of Dorello’s Canal Puspitasari, Vivien; Japutri, Josephine; Solansa, Tracy; Cenweikiawan, Anderson
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8108

Abstract

Background: Abducens nerve is the second longest intracranial path out of all of the cranial nerves. Abducens nerve pasly had a prevalence 11.3/100.000 and mostly seen in adults. Isolated abducens nerve palsy due to neoplastic lesion are rare and mostly related to skull base tumor.Case Presentation: We present a case of 57 years old woman with complaints of red right eye and worsening headache associates with diplopia on the right lateral gaze for three days prior admission. She was later diagnosed with isolated abducens nerve palsy associated to neoplasm cause in Dorello’s canal. Patient was then discharged with symptomatic therapy and educated for head posturing and avoid triggers.Conclusions: Abducens nerve palsy is the most common isolated ocular nerve palsy. The incidence of mass formation such as neoplastic lesion or cyst are rare.
A Systematic Review of Efficacy and Safety of Difelikefalin in Treating Pruritus in Hemodialysis Patients with Chronic Kidney Disease Enggalhardjo, Muljani; Tumiwa, Gabriella Hilary; Khosasih, Yeshiza
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8109

Abstract

Background: Chronic Kidney Disease (CKD) is a type of kidney disease that gradual loss of kidney function over a period of months or years, usually more than 3 months. Uremic pruritus or chronic kidney disease-associated with CKD (CKD-aP) is a common complication that experienced by CKD patients especially for patients undergoing haemodialysis and it will negatively impact quality of life, for example depression, poor sleep quality, and miss dialysis sessions.Methods: Three online databases were used for the literature search: Science Direct, Embase, and PubMed. obtaining the information in January 2024. Using specific keywords, a comprehensive analysis of research articles was carried out. We examined the safety and effectiveness of difelikefalin in the management of pruritus in patients receiving hemodialysis who have chronic kidney disease.Result: Six studies were evaluated that met the criteria for inclusion. The efficacy of difelikefalin in all studies was examined by using WI-NRS as assessment tools for the primary outcome, and for the secondary outcome, skindex-10 or skindex-16 scoring, the 5-D itch scale, and the itch MOS (Medical Outcome Study) sleep disturbance scale were used. From all studies, difelikefalin in various dosages and routes (oral and intravenous) improved pruritus reduction in hemodialysis patients with CKD over placebo. However, in the majority of cases, difelikefalin caused a higher chance of experiencing adverse events than in the placebo group.Conclusions: All studies show a greater pruritus reduction in hemodialysis patients receiving therapy over placebo, with the optimal benefit-risk at 0.5 μg/kg of difelikefalin, despite unclear efficacy-dosage connections.
RNAi-Based Therapy: Prospect as Cancer Treatment Soentoro, Samuel E; Timothy, Michael; Jo, Juandy
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8110

Abstract

Cancer is one of the deadliest form of diseases in humans, with the annual deaths ranging in the millions. Conventional treatments including chemotherapy, radiotherapy, or surgery has their limitations, including common off-target and non-specific effects. Ribonucleic acid interference (RNAi) offers a new strategy for treating cancer by silencing specific genes to prevent gene expression. This review highlights the application of RNAi-based approach in targeting cancer, discusses its potential advantages and limitations, summarizes the existing clinical trials and provides a greater understanding of RNAi-based therapy in cancer.
Diagnosis and Surgical Management of Annular Pancreas in an 18-Day-Old Neonate: A Case Report Alim, Tasya Fabiola; Alim, Linawati; Alim, Kenny Dion
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10182

Abstract

Background: This case report presents a rare and challenging condition—annular pancreas—in an 18-day-old neonate. Annular pancreas is a congenital anomaly where a ring of pancreatic tissue encircles the duodenum, leading to gastrointestinal obstruction. Early diagnosis and intervention are crucial for optimal patient outcomes. The rarity of this condition in neonates underscores its clinical significance. Case Description: The patient presented with a history of persistent vomiting since birth, which initially appeared green but later turned yellow. The infant had been fed various types of milk sequentially, with vomiting occurring after each feeding. Additionally, the infant developed jaundice a week prior to presentation, which was treated without improvement in symptoms. Diagnostic modalities included abdominal X-ray, ultrasound, and upper gastrointestinal contrast study, which collectively confirmed a partial obstruction at the gastroduodenal junction due to annular pancreas. The definitive treatment involved a laparotomy for exploratory surgery, followed by a duodenoduodenostomy using the Kimura technique to address the anatomical abnormality. Postoperative management included prophylactic antibiotics, anti-emetic therapy, acid suppression, and probiotics to support recovery. The outcome of the case was favorable, with successful resolution of the gastrointestinal obstruction following the surgical intervention. Conclusions: This case underscores the importance of early recognition, precise diagnosis, and multidisciplinary intervention in managing congenital anomalies like annular pancreas, ultimately leading to favorable outcomes and improved quality of life for neonatal patients..
Diagnosis and Surgical Management of Annular Pancreas in an 18-Day-Old Neonate: A Case Report Alim, Tasya Fabiola; Alim, Linawati; Alim, Kenny Dion
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10182

Abstract

Background: This case report presents a rare and challenging condition—annular pancreas—in an 18-day-old neonate. Annular pancreas is a congenital anomaly where a ring of pancreatic tissue encircles the duodenum, leading to gastrointestinal obstruction. Early diagnosis and intervention are crucial for optimal patient outcomes. The rarity of this condition in neonates underscores its clinical significance. Case Description: The patient presented with a history of persistent vomiting since birth, which initially appeared green but later turned yellow. The infant had been fed various types of milk sequentially, with vomiting occurring after each feeding. Additionally, the infant developed jaundice a week prior to presentation, which was treated without improvement in symptoms. Diagnostic modalities included abdominal X-ray, ultrasound, and upper gastrointestinal contrast study, which collectively confirmed a partial obstruction at the gastroduodenal junction due to annular pancreas. The definitive treatment involved a laparotomy for exploratory surgery, followed by a duodenoduodenostomy using the Kimura technique to address the anatomical abnormality. Postoperative management included prophylactic antibiotics, anti-emetic therapy, acid suppression, and probiotics to support recovery. The outcome of the case was favorable, with successful resolution of the gastrointestinal obstruction following the surgical intervention. Conclusions: This case underscores the importance of early recognition, precise diagnosis, and multidisciplinary intervention in managing congenital anomalies like annular pancreas, ultimately leading to favorable outcomes and improved quality of life for neonatal patients..
Procedural Success and Safety of Cryoablation Versus Radiofrequency Ablation in Atrioventricular Nodal Reentrant Tachycardia: A Systematic Review and Meta-Analysis Putri, Evira Agustina; Tunisa, Izza; Suciati, Putri Ayu
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10775

Abstract

Background: This meta-analysis compares cryoablation and radiofrequency ablation efficacy, safety, and procedural outcomes in atrioventricular nodal reentrant tachycardia (AVNRT). This meta-analysis aims to compare procedural success, long-term recurrence, and complication rates of cryoablation versus radiofrequency ablation in the treatment of AVNRT. Methods: Following PRISMA 2020, PubMed, EMBASE, and Scopus were searched (25 September 2025). Eligible randomized or observational studies directly compared CRYO versus RFA for AVNRT and reported procedural success, recurrence, and/or complications. Risk of bias was assessed (ROBINS-I for non-randomized studies). Pooled effects were calculated in RevMan 5.4 using random-effects models; risk ratios (RR) were used for dichotomous outcomes and standardized mean differences (SMD) for continuous outcomes. Estimates used the Wald-type method with REML; heterogeneity was summarized with I². Result: Sixteen studies were included. Acute procedural success was equivalent between CRYO and RFA (RR 1.00, 95% CI 0.99–1.02; p=0.47; I²=0%). CRYO showed higher recurrence during follow-up (RR 2.29, 95% CI 1.49–3.53; p=0.0002; I²=39%). Complications favored CRYO (RR 0.51, 95% CI 0.28–0.92; p=0.03; I²=0%). Fluoroscopy time was shorter with CRYO (SMD −0.42, 95% CI −0.66 to −0.19; p=0.0004; I²=87%), while overall procedure duration was similar (SMD 0.12, 95% CI −0.06 to 0.31; p=0.19; I²=79%). Overall risk of bias was predominantly low. Conclusions: CRYO and RFA achieve comparable acute success in AVNRT. CRYO confers fewer complications and lower fluoroscopy exposure but a higher recurrence risk, highlighting a safety–durability trade-off.

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