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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 10 Documents
 1 
Search results for , issue "Vol 2, No 2" : 10 Documents clear
Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients Dinge, Fonny; Alfian, Sofa D.; Abdulah, Rizky; Sumiwi, Sri A.
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.442 KB) | DOI: 10.15416/pcpr.v2i2.15244

Abstract

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption.Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this studywas to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patientsreceiving paracetamol. This study was a cross-sectional study which was conducted duringApril-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnairesand medical records. Alcohol status was determined by Short Michigan Alcoholics ScreeningTest (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and afterreceiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels ofalcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcoholstatus did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise,logistic regression analysis showed that age gave a significant effect on AST level (P=0.067).Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol,malaria
Prediction of Binding Mode of Secondary Metabolites in Apium graveolens to Bcl-2 Shan, Kee P.; Saptarini, Nyi M.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.792 KB) | DOI: 10.15416/pcpr.v2i2.15209

Abstract

Developing new cytotoxic agent which has minimal effect against normal cell is requiredto reduce the side effects obtained from the existing chemotherapy agents. Celery (Apiumgraveolens) showed several pharmacology activities, including anti-cancer. This study wasconducted to predict and visualize the binding mode of ten secondary metabolites in A. graveolens,i.e., apigenin, caffeic acid, kaempferol, limonene, shikimic acid, chlorogenic acid,ascorbic acid, quercetin, eugenol and ferulic acid against Bcl-2. Navitoclax was employed asreference. Molecular dokcing simulation was performed using AutoDoc Vina v.1.5.6. Theresults showed that the interaction enery (Ei) ranged from -4.20 to -6.01 kcal/mol, whereasinhibition constant (Ki) were 40.15 to 842.29 μM. Kaempferol showed the best affinity toBcl-2 (Ei=-6.01 kcal/mol; Ki=24,21 μM). Hydrogen bonds were bond between kampferoland Lys20, Ser102, and Arg103, amino acid residues in Bcl-2.In conclusion,Keywords: anti-cancer, Apium graveolens, Bcl-2, navitoclax
Effectiveness of Erythropoietin in Hypertensive Hemodialysis Patients Ibrahim, Susannia; Diantini, Ajeng; Prihartanto, Budhi; Supriyadi, Rudi
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.204 KB) | DOI: 10.15416/pcpr.v2i2.15245

Abstract

Chronic renal failure (CRF) is one the most prevalent health problems among the elderly. Onthe fifth stage of CRF, the patient becomes eligible to hemodialysis. CRF-induced anemiais commonly treated with Erythropoietin (Epo). Information regarding the effectiveness ofEpo in hypertensive hemodialysis patients was limited. Therefore, this study was conductedto evaluate the effectiveness of Epo in hypertensive hemodialysis patients. This study usedan observational case-control analytic method. Data were retrieved from the medical recordsof hemodialysis patients during March-May 2014. A total of 54 participants were included.The increase of haemoglobin (Hb) in controlled hypertension was 0.6257 g/dl, while the inuncontrolled hypertension group, there was a decrease in Hb (-0.1590 g/dl). The use of Epowas more effective in hemodialysis patients with controlled hypertension.Keywords: chronic kidney disease, erythropoietin, hypertension
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.058 KB) | DOI: 10.15416/pcpr.v2i2.15210

Abstract

The potential toxicity effect presents in the medicinal plants is important to be identified forthe safety assurance. Accute toxicity study is an initial step in the drug safety assurance test.Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves,and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). Thisstudy used brine shrimp lethality test (BSLT) method. The total number of larvae used ineach concentrations in three times replications was 330 larvae. Each group was given consecutivelyroots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants withvariation concentrations 12.5 μg/ml, 25 μg/ml, 50 μg/ml, 100 μg/ml, 125 μg/ml, 250 μg/ml, 500 μg/ml, 1000 μg/ml, 2000 μg/ml, and 4000 μg/ml. The number of dead larvae after24 hours treatment were calculated to obtain the mortality percentages and to determine theLC50 value, which were determined by probit analysis using MiniTab application version17.1.0. Ethanol extract of P. pulchrum roots and stems resulted LC50 values of 933.08 μg/mland 919.58 μg/ml, respectively. While the LC50 values of leaves and flowers extracts were2207.06 μg/ml and 1081.90 μg/ml, respectively. In conclusion, P. pulchrum Blume roots andstems were classified as toxic according to BLST method, while leaves and flowers were not.Keywords: acute toxicity, brine shrimp lethality test, Polygonum pulchrum Blume
Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population Dewi, Annisa F.; Dwipa, Lazuardhi; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.994 KB) | DOI: 10.15416/pcpr.v2i2.15247

Abstract

Geriatric physiologically undergoes aging process that can cause decreasing cell functionand increasing risk of degenerative diseases caused by the accumulation of reactive oxygenspecies (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintainingthe balance of ROS. The aim of this study was to observe the selenium-binding protein(SELENBP1) level in relation with the geriatric patients charcateristics including sex, age,body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living(IADL), cognitive function, nutrition, depression, and insomnia status. The study usedcross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric OutpatientsClinics, at a hospital in Bandung. The data was obtained by interviewing the patientsand then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit.The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69)ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followedby male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patientsaged 70-79 years.Keywords: elderly, SELENBP1, selenium.
Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients Fonny Dinge; Sofa D. Alfian; Rizky Abdulah; Sri A. Sumiwi
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.442 KB) | DOI: 10.15416/pcpr.v2i2.15244

Abstract

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption.Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this studywas to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patientsreceiving paracetamol. This study was a cross-sectional study which was conducted duringApril-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnairesand medical records. Alcohol status was determined by Short Michigan Alcoholics ScreeningTest (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and afterreceiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels ofalcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcoholstatus did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise,logistic regression analysis showed that age gave a significant effect on AST level (P=0.067).Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol,malaria
Prediction of Binding Mode of Secondary Metabolites in Apium graveolens to Bcl-2 Kee P. Shan; Nyi M. Saptarini; Jutti Levita
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.792 KB) | DOI: 10.15416/pcpr.v2i2.15209

Abstract

Developing new cytotoxic agent which has minimal effect against normal cell is requiredto reduce the side effects obtained from the existing chemotherapy agents. Celery (Apiumgraveolens) showed several pharmacology activities, including anti-cancer. This study wasconducted to predict and visualize the binding mode of ten secondary metabolites in A. graveolens,i.e., apigenin, caffeic acid, kaempferol, limonene, shikimic acid, chlorogenic acid,ascorbic acid, quercetin, eugenol and ferulic acid against Bcl-2. Navitoclax was employed asreference. Molecular dokcing simulation was performed using AutoDoc Vina v.1.5.6. Theresults showed that the interaction enery (Ei) ranged from -4.20 to -6.01 kcal/mol, whereasinhibition constant (Ki) were 40.15 to 842.29 μM. Kaempferol showed the best affinity toBcl-2 (Ei=-6.01 kcal/mol; Ki=24,21 μM). Hydrogen bonds were bond between kampferoland Lys20, Ser102, and Arg103, amino acid residues in Bcl-2.In conclusion,Keywords: anti-cancer, Apium graveolens, Bcl-2, navitoclax
Effectiveness of Erythropoietin in Hypertensive Hemodialysis Patients Susannia Ibrahim; Ajeng Diantini; Budhi Prihartanto; Rudi Supriyadi
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.204 KB) | DOI: 10.15416/pcpr.v2i2.15245

Abstract

Chronic renal failure (CRF) is one the most prevalent health problems among the elderly. Onthe fifth stage of CRF, the patient becomes eligible to hemodialysis. CRF-induced anemiais commonly treated with Erythropoietin (Epo). Information regarding the effectiveness ofEpo in hypertensive hemodialysis patients was limited. Therefore, this study was conductedto evaluate the effectiveness of Epo in hypertensive hemodialysis patients. This study usedan observational case-control analytic method. Data were retrieved from the medical recordsof hemodialysis patients during March-May 2014. A total of 54 participants were included.The increase of haemoglobin (Hb) in controlled hypertension was 0.6257 g/dl, while the inuncontrolled hypertension group, there was a decrease in Hb (-0.1590 g/dl). The use of Epowas more effective in hemodialysis patients with controlled hypertension.Keywords: chronic kidney disease, erythropoietin, hypertension
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method Asman Sadino; Idin Sahidin; Wahyuni Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.058 KB) | DOI: 10.15416/pcpr.v2i2.15210

Abstract

The potential toxicity effect presents in the medicinal plants is important to be identified forthe safety assurance. Accute toxicity study is an initial step in the drug safety assurance test.Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves,and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). Thisstudy used brine shrimp lethality test (BSLT) method. The total number of larvae used ineach concentrations in three times replications was 330 larvae. Each group was given consecutivelyroots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants withvariation concentrations 12.5 μg/ml, 25 μg/ml, 50 μg/ml, 100 μg/ml, 125 μg/ml, 250 μg/ml, 500 μg/ml, 1000 μg/ml, 2000 μg/ml, and 4000 μg/ml. The number of dead larvae after24 hours treatment were calculated to obtain the mortality percentages and to determine theLC50 value, which were determined by probit analysis using MiniTab application version17.1.0. Ethanol extract of P. pulchrum roots and stems resulted LC50 values of 933.08 μg/mland 919.58 μg/ml, respectively. While the LC50 values of leaves and flowers extracts were2207.06 μg/ml and 1081.90 μg/ml, respectively. In conclusion, P. pulchrum Blume roots andstems were classified as toxic according to BLST method, while leaves and flowers were not.Keywords: acute toxicity, brine shrimp lethality test, Polygonum pulchrum Blume
Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population Annisa F. Dewi; Lazuardhi Dwipa; Ronny Lesmana
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.994 KB) | DOI: 10.15416/pcpr.v2i2.15247

Abstract

Geriatric physiologically undergoes aging process that can cause decreasing cell functionand increasing risk of degenerative diseases caused by the accumulation of reactive oxygenspecies (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintainingthe balance of ROS. The aim of this study was to observe the selenium-binding protein(SELENBP1) level in relation with the geriatric patients charcateristics including sex, age,body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living(IADL), cognitive function, nutrition, depression, and insomnia status. The study usedcross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric OutpatientsClinics, at a hospital in Bandung. The data was obtained by interviewing the patientsand then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit.The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69)ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followedby male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patientsaged 70-79 years.Keywords: elderly, SELENBP1, selenium.

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