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JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
Arjuna Subject : -
Articles 812 Documents
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The Effect of Fe Pillaring and Mg Intercalating into Bentonite Structure Widjonarko, Dian Maruto; Pramono, Edi; Rahardjo, Sentot Budi; Wahyuningsih, Sayekti; Saraswati, Teguh Endah
Jurnal Kimia Sains dan Aplikasi Vol 29, No 2 (2026): Volume 29 Issue 2 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.2.101-110

Abstract

Bentonite clay particles, measuring less than 2 μm, comprise stacked layers of tetrahedral and octahedral units in a 2:1 configuration (T-O-T). These negatively charged layers were subsequently neutralized with cations. However, the exchange or modification of the cation affects its structure and properties. This study investigates the effect of Fe-ion pillaring on the bentonite layer and the intercalation of Mg ions into Fe-pillared bentonite via ion exchange. The materials were characterized using Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy (SEM–EDX) to observe surface morphology and elemental composition, Particle Size Analyzer (PSA) to observe average size and size distribution of particle, Fourier-Transform Infrared Spectroscopy (FTIR) to identify the active site and layer structure, and X-ray Diffraction (XRD) to determine their structural and compositional changes. The results confirm the pillaring treatment effect on a higher average particle size of 469.3 nm, with a polydispersity index (PDI) of 0.495, compared to natural bentonite (414.8 nm and 0.586 nm, respectively). Meanwhile, the intercalating treatment showed a lower average particle size of 433.4 nm and a PDI value of 0.613. FTIR identified the silanol and siloxane functional groups, as well as the aluminosilicate layer. Pillaring by Fe2O3 increased the basal spacing of bentonite from 13.6 Å to 17.35 Å, as indicated by the shift of characteristic bentonite peaks to lower 2θ angles. However, intercalation by MgO into Fe-pillared bentonite actually slightly decreased the basal spacing to 15.16 Å. Meanwhile, Mg intercalation occurred within the interlayer of the aluminosilicate layer, resulting in a peak shift toward higher 2θ angles and an increase in crystallinity to 58.924%, compared with Fe-pillared bentonite (45.376%). This phenomenon is likely related to the presence of the Mg metal intercalant, which has basic properties and can attract the aluminosilicate sheets.
Mechanisms of Action, Resistance, Toxicity, and Recent Developments of Cisplatin as Anticancer Agent: A Comprehensive Review Pabisa, Lisdawati; Ahmad, Ahyar; Karim, Harnaningsih
Jurnal Kimia Sains dan Aplikasi Vol 29, No 3 (2026): Volume 29 Issue 3 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.3.227-244

Abstract

Cisplatin is among the most potent chemotherapy agents used to treat a range of cancers, including those affecting the ovaries, testes, lungs, and bladder. Its primary mode of operation involves creating cross-links in DNA, which blocks cell division and gene expression, ultimately leading to programmed cell death. Unfortunately, its therapeutic benefits are frequently undermined by harmful side effects and the development of resistance in cancer cells. This research seeks to delve deeply into cisplatin’s mechanisms, covering how it enters cells, gets activated internally, and interacts with DNA and key proteins. Additionally, it explores advancements in nanoparticle-based cisplatin delivery systems and platinum (Pt[IV]) compounds designed to enhance systemic absorption and reduce overall toxicity. Drawing on a review of 166 studies across five key databases, modifications to drug-delivery methods have shown notable improvements in cisplatin’s performance across different cancer types. As a result, innovative formulations and tactics to tackle resistance could broaden cisplatin’s role as a more targeted and safer cancer-fighting drug. This review was conducted using a structured literature search without a formal risk-of-bias assessment.

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