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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 12 Documents
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Search results for , issue "Vol. 5 No. 2 (2020)" : 12 Documents clear
Risk Factors of Behavioral Problems in Pediatric Epilepsy Nur, Fadhilah Tia; Azmi, Nurul; Hermasari, Bulan Kakanita
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Epilepsy is the most common neurological disorders in children and the number of case for epilepsy still incre­asing. Epilepsy can affect children and their growth physically, psy­cho­logi­cally, and socially, yet the treatment of behavioral problems in pediatric epilepsy is still lacking. This stu­dy aimed to investigate the association of frequency of seizure, type of seizure, duration of illness, and use of antiepileptic drug with behavioral dis­order in children with epilepsy.Subjects and Method: This was an analytical observational study with a cross sectional design. The study was conducted at Pediatric Neurology Unit of Dr. Moewardi hospital, Sura­karta, from September to October 2016. A sample of 50 pediatric patients with epilepsy was selected for this study. Parents or care­givers completed behavioral problems screen­ing tool Pediatric Symptom Checklist-17 (PSC-17) and were interviewed about frequency of seizure, type of seizure, duration of illness, and use of antiepileptic drug. The data were ana­lyzed by a multiple logistic regres­sion.Results: Frequent seizure (OR= 3.09; 95% CI= 0.89 to 10.59; p= 0.068) increased beha­vioral problem. Being treated with ≥1 anti-epileptic drugs (OR= 1.58; 95% CI= 0.44 to 5.71; p= 0.521) increased beha­vioral problem, but it was statistically non-significant. Type of seizure (OR= 1.01; 95% CI= 0.32 to 3.20; p= 0.991) and duration of illness ≥1 year (OR= 1.03; 95% CI= 0.22 to 4.89; p= 1.000) were not associated with behavioural problem. Conclusion: Frequent seizure increase beha­vioral problemKeywords: epilepsy, behavioral problems, pediatricsCorrespondence: Fadhilah Tia Nur. Department of Child Health, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: fadhilah.harris@gmail.comIndonesian Journal of Medicine (2020), 05(02): 162-169https://doi.org/10.26911/theijmed.2020.05.02.11
Plasma Zinc Difference in Children with Thalassemia β Major Received Deferiprone or Deferasirox Zinc Kusumawardhani, Wahyu; Salimo, Harsono; Riza, Muhamad
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Thalassemia is a blood disease charac­­terized by the most frequently found auto­somal recessive hereditary hemolytic anemia. It requires repeated blood trans­fusions for life. Routine blood transfusion can cause complica­tions in the form of accumu­lation of ferritin in the tissue. Iron chelation therapy is considered effective for treating body iron deposits. How­ever, iron chelation therapy has the side effect of decreasing levels of other im­­­­portant minerals such as zinc (Zn). This study aimed to examine plasma zinc difference in children with Thalasse­mia β major received deferiprone or deferasirox zinc.Subjects and Method: This was a cross sec­tional study conducted at Dr. Moewardi Hospital, Surakarta, from February to April 2017. A sample of 40 children with thalassemia β major aged 3 to 18 years who received deferiprone iron chelation and defe­rasirox at least 6 months was selected by consecutive sampling. The dependent variable was serum zinc levels. The independent vari­ables were iron ­deferip­rone and deferasirox. Plasma zinc levels were measured by atomic absorption spectroscope. The data were analyzed by t test.Results: Zinc levels in patients with deferiprone therapy (Mean= 54.50; SD= 11.02) were lower than defera­sirox therapy (Mean= 60.95; SD= 20.71), but statistically not significant (p= 0.229).Conclusion:Zinc levels in patients with deferi­prone therapy are lower than deferasirox therapy, but not statistically significant.Keywords: zinc, deferiprone, deferasirox, children with thalassemia β majorCorrespondence: Wahyu Kusumawardhani. Department of Pedi­a­trics, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Cen­tral Java. Phone/ Fax: 0271-633348. Email: dha­nisurya­diraja­@gmail.comIndonesian Journal of Medicine (2020), 05(02): 102-108https://doi.org/10.26911/theijmed.2020.05.02.02
The Relationship between Ferritin and Calcium Levels in Patients with Thalassemia β Major Iskandar, Nurdin Aji; Salimo, Harsono; Moelyo, Annang Giri
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Thalassemia is a hereditary disea­se in which the sufferer is unable to produce suf­fi­cient amounts of hemoglobin, causing impaired function of red blood cells and shortened red blood cell age. Thalassemia sufferers are spread all over the world, and thalassemia is one of the health problems in the world. Therapy in patients with thalassemia is with routine blood trans­fusions. One side effect of repeated transfusions is iron overload which causes deposits of iron in the endocrine glands. This study aimed to deter­mine the relationship between ferritin levels with blood calcium levels in patients with β major thalas­semia.Subjects and Method: This was a cross-sec­tional study conducted at Dr. Moewardi, Sura­karta, from June to November 2017. Samples of 49 patients with thalassemia β major aged 5-10 years were selected using consecutive sampling. The dependent variable is blood calcium levels. The independent variable is ferritin level. Data were analyzed with Chi Square test.Results: High ferritin levels reduce calcium level in pediatric thalassemia β major patients, but not statistically significant (OR = 0.27; 95% CI = 0.04 to 1.64; p = 0.134).Conclusion: High ferritin levels decrease with calcium levels in pediatric thalassemia β major patients, but not statistically significant.Keywords: ferritin, calcium, thalassemia β majorCorrespondence: Andhika Trisna Putra. Department of Pediatrics, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta. Telpon­/Fax.­0271-633348, Email: andhika.pedia­tric@gmail.­comIndonesian Journal of Medicine (2020), 05(02): 137-141https://doi.org/10.26911/theijmed.2020.05.02.07
The Optimum Dose of Beta-Glucan for Stimulating Peripheral Blood Mononuclear Cells (PBMCs) to Produce Cytokines: In Vitro Study Erawati, Meira
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Beta-glucan has been frequently used in laboratory trials as an immunomodulator in both in vivo and in vitro studies, but the ef­fective dose for measuring its performance has not been established. Like other immunomodula­tors, researchers must establish the right dose of beta-glucan in their laboratory experiments for the purpose of testing substances as immuno­modulators without achieving false-positive or –negative results. This study aimed to determine the optimum dose of beta-glucan to induce cyto­kine production by peripheral blood mononu­clear cells (PBMCs) in vitro.Subjects and Method: This was a laboratory experimental study. This study measur­ed the production of two cytokines, including in­terferon gamma (IFN-γ) and interleukin 12 (IL-12), from the isolated PBMCs of healthy subjects. The doses of beta-glucan used as immunomodu­lator in­clu­ded 1, 5, 10, 20, and 50 μg/ml. Beta-glucan was add­ed to the PBMC culture medium, and the PBMCs were cultured for 6 days. On the sixth day, the supernatant was harvested and the cytokine production was analyzed using sandwich enzyme-linked immunosorbent assay (ELISA). Cytokines were also analyzed using the human IFN-γ ELISA kit and the human IL-12 ELISA kit, and data analysis was performed by one-way ANOVA.Results: IFN-γ levels were found to be increased in the group treated with 5 μg/ml beta-glucan. The highest IFN-γ levels (70.0 pg/ml) were observed in the group treated with 10 μg/ml beta-glucan. The production of IL-12 increased sharply in the group treated with5 μg/ml beta-glucan but decreased in the group treated with 10 μg/ml beta-glucan. The mean cytokine levels of the beta-glucan group were found to be significantly different from those of the control group (p=0.001). One-way ANOVA revealed that the highest IL-12 production (77.2 pg/ml) occurred at a dose of 5 μg/ml beta-glucan. This average value was significantly different from the average production of IL-12 in the control group (p=0.001).Conclusion: The optimum dose of beta-glucan for stimulating PBMCs to produce IFN-γ in vitro was 10 μg/ml, while for the production of IL-12, the dose was 5 μg/ml. Both cytokines can be mea­sured within 6 days of cell culture.Keywords: beta-glucan, immunomodulator, cy­to­kinesCorrespondence: Meira Erawati. Faculty of Medicine, Diponegoro University. Jl. Prof. Soedarto, S.H, Tembalang, Semarang, Indonesia. Email: meira­e­rawati­@­gmail.com. Mobile: +62-81915339685Indonesian Journal of Medicine (2020), 5(2): 170-177https://doi.org/10.26911/theijmed.2020.05.02.12
Relationship between Anxiety Score and Erythrocyte Sedimentation Rate (ESR) in Hemodialysis Patient Setyaningrum, Rohmaningtyas Hidayah; Septiawan, Debree; Batong, Jhonny Prambudi
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anxiety in hemodialysis pati­ents often impaired quality of life. Complex interaction between Chronic Kidney Disease (CKD) and anxiety are dynamic and multifac­torial, including socio-economic, lifestyle and biological factors. Biological factors are close­ly related to anxiety in CKD including the im­mune system, inflammatory pathways of dis­orders of Hypothalamic-Pituitary-Adrenal Axis (HPA). Erythrocyte sedimentation rate (ESR) is one of the non-specific inflammatory marker that show the degree of inflammatory reaction, Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) also found as an easy and inexpensive mea­sureable marker to show the degree of inflam­mation. This study aimed to examine rela­ti­onship between anxiety and hematology in­flammation markers in hemodialysis patient.Subjects and Method: This was an obser­vational study with a cross-sectional design. The study was conducted at Dr. Moewardi general hospital, Surakarta, Central Java. A sample of 30 hemodialysis patients was selec­ted for this study. The dependent variables were ESR, NLR, and PLR. The independent variable was anxiety. Anxiety was measured by Taylor Manifest Anxiety Scale (TMAS). Data on ESR, NLR, and PLR, were measured using an assessment from RAND Corpora­tion. The data were analyzed by a multiple linear regression.Results:  Anxiety increased NLR and it was marginally significant (b= 0.37; 95% CI= -0.01 to 0.22; p= 0.080). Anxiety decreased ESR and it was statistically significant (b= -0.57; 95% CI= -0.02 to 0.01; p<0.001). An­xiety decreased PLR (b= -0.16; 95% CI= -0.02 to 0.01; p= 0.440) and duration of hemo­dia­lysis (b= -0.27; 95% CI= -0.03 to 0.01; p= 0.167), but they were statistically non-signi­ficant.Conclusion: Anxiety increases NLR. Anxi­ety decreases ESR, PLR, and duration of hemo­dialysis.Keywords: chronic kidney disease, hemo­dialysis, hematology markers, inflammationCorrespondence: Rohmaningtyas Hidayah Setyaningrum. De­partment of Psychiatry, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi General Hospital, Surakarta, Central Java. Email: astitdr@gmail.comIndonesian Journal of Medicine (2020), 05(02): 109-115https://doi.org/10.¬26911/theijmed.2020.05.02.03
The Effect of Bima Traditional Baby Massage on Sleep Pattern among Infants aged 5-12 Months Kurniadi, Kurniadi
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Massage was a tactile stimulation that has physiological and biochemical effects in the body. Baby massage was a fun way to relieve tension and anxiety, especially in infants. Gentle massage will help relax the muscles so that the baby becomes calm and sleeps soundly. Good qua­lity sleep can achieve optimal growth and development. The purpose of this study was to de­termine the effect of pe'e culture (baby mass­age) on the sleep needs of babies aged 5-12 months.Subjects and Method: This research was a quasi-experimental study with a pre and post test design in the same group. The number of samples in this study were 30 respondents using pur­po­sive sampling technique. The dependent vari­able of this study was sleep resting children aged 5-12 months. The independent variable was Bima traditional massage (pe'e). Data analysis was per­form­ed using the Wilcoxon test.Results: Average sleep quality of children aged 5-12 months after treatment (Mean= 2.73; SD= 6.­40) is higher than before treatment (Mean= 1.47; SD= 5.07), and statistically significant (p= <0.001).Conclusion: Culture Baby massage (pee) can imp­rove sleep rest patterns in infants aged 5-12 months.Keywords: baby massage, sleep patterns, sleep quality, age 5-12 monthsCorrespondence: Kurniadi. Health Polytechnics, Ministry of Health, Mataram, Lombok, West Nusa Tenggara. Email: kurniadi.poltekkes@gmail.comIndonesian Journal of Medicine (2020), 05(02): 142-147https://doi.org/10.26911/theijmed.2020.05.02.08
Two-Stage Reconstruction Surgery on Cervical Deformity Caused by Spondylitis TB Ermawan, Rieva; Utomo, Pamudji; Pradhana, Adhitya Indra; Islami, Umar Kharisma
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Of all form of spinal tuberculo­sis (TB), cervical involvement is immensely rare and merely found in 3-5% of all cases. Kyphotic deformity in spondylitis TB was caused by ver­tebral destruction in the anterior segment due to infection that lead to hyperemia, bone marrow edema, and osteoporosis. Treatment of spinal TB was divided into two sections which run simultaneously, medicament and surgery. The use of cage for spinal surgery has shown its effectivity in supporting the anterior segment of vertebrae and providing long term stability. The purpose of this study was to compare functional out­come of two patients with cervical deformity caused by spondylitis TB that underwent two-stage reconstruction surgery with expandable and non-expandable cage. Case Presentation: Two patients were re­ported with cervical deformity caused by spon­dylitis TB in Orthopedic Hospital Prof. Dr. R. Soeharso, Surakarta. Both patients had their neurological status, Cobb angle, decompres­s­ion effects and post-operative fusion rate assessed. The patients were diagnosed with cervical deformity due to spondylitis TB showing the involvement of C4-5 in the first patient and C3-5 in the second one. Both underwent two-stage reconstruction surgery and were evaluated right after. There was no decadence in their post-operative neurological function. In the first patient, pre-operative Cobb angle was 44oand becoming 18o post-operatively. The pre-operative Cobb angle of the second patient was 14o and becoming 3o post-operatively.Results: Assessment of post-operative decom­pression effects and fusion rate were carried out by CT scan and both patients showed a favorable result even when they both were given a different cage. Although both cages had their own advantages based on surgical consi­deration, we prefer to used expandable cage due to minimal dissection needed.Conclusion: Two-stage reconstruction surge­ry using whether expandable or non-expand­able cage to treat cervical deformity caused by Spondylitis TB gave equally satisfactory out­come.Keywords: Spondylitis, tuberculosis, cervical deformityCorrespondence: Adhitya Indra Pradhana. Prof. Dr. R. Soeharso Orthopaedic Hospital. Jl. Jenderal Ahmad Yani, Surakarta 57162, Central Java, Indonesia. Email: adhityaindrapradhana@gmail.comIndonesian Journal of Medicine (2020), 05(02): 116-124https://doi.org/10.26911/theijmed.2020.05.02.04
The Effect of Combination Avocado Juice Administration and Storytelling Therapy on Body Weight in Children with HIV/AIDS Warsini, Warsini; Ariasti, Dinar
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The incidence of HIV/AIDS is in­­­­creasing. In 2015 there were 30,935 new cases, 41,250 in 2016 and 33,660 in 2017, where new case findings were also found in children aged less than 4 years and caused child deaths world­wide in 2011 to reach 230,000. At present there is no treatment that can cure the disease, so vari­ous efforts are made to support the health and qua­lity of life of sufferers. The purpose of this study was to analyze the effect of providing a com­­bination of avocado juice and storytelling therapy on the weight of a child with HIV / AIDS.Subjects and Method: This was a quasy-experimental with pre-post test design. A sample of 15 children with HIV/AIDS was selec­ted for this study. The dependent variable was body weight. The independent variable was a combina­tion of avocado juice and storytelling therapy. Weight data was measured using weight scales. Data were analyzed using the Wilcoxon test.Results: Body weight (kg) after intervention (Mean= 26.17; SD= 9.30) was slightly greater than before intervention (Mean= 25.30; SD= 9.16), with p= 0.002.Conclusion: Combination of avocado juice and storytelling therapy increased body weight in children with HIV/AIDS.Keywords: storytelling therapy, avocado juice, children with HIV/AIDSCorrespondence: Warsini. Nursing Academy of Panti Kosala, Surakarta, Central Java. Alamat Instansi Jl. Raya Solo-Baki KM. 4 Gedangan, Grogol, Sukoharjo, Jawa Tengah. Email: warsinimulyono@­gmail.­com. Mobile: 0816418071Indonesian Journal of Medicine (2020), 05(02): 148-152https://doi.org/10.26911/theijmed.2020.05.02.09
Fusi In Situ Posterior for Congenital Scoliosis with Wedge Hemivertebrae Using Single Rod and Pedicle Screw Instrumentation in Girl 2 Years Old: A Case Report Utomo, Pamudji; Dharma, Adi Surya; Ermawan, Rieva
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Many spinal vertebral anoma­lies often occur, both scoliosis and kyfosis. In scoliosis, congenital abnormalities caused by hemivertebrae are the most common cause of abnormalities. The choice of treatment used can be either non-operative or operative. How­ever, non-operative treatment does not show satisfactory results to prevent the development of deformity. Operative treatment is an option that is considered to indicate more satisfying results. A variety of procedures such as in-situ posterior or with or without instrumentation anteroposterior fusions, combined anterior and poste­rior convex hemiepiphysiodesis and hemi­arthrodesis, and hemivertebral excision with fusion. Fusi In-situ posterior is a procedure option that is considered more beneficial for both surgeons and patients. This study aimed to evaluate the fusi in situ posterior for conge­nital scoliosis with wedge hemivertebrae using single rod and pedicle screw instrumentation in girl 2 year old.Case Presentation: Girl 2 year old with wedge hemivertebrae operated with fusion in situ posterior using single rod and pedicle screw instrumentation.Results: The operative treatment was per­formed on 2 hours operation time with amount of bleeding produced is 80 cc. There were no cranckshaft phenomena and no clinical and radological features suggestive of spinal ste­nosis. There were no major vascular or neuro­gical complications related to the pedicle screws. Then patient wore body jacket for limitation movement before fusion.Conclusion: Posterior situ fusion is perform­ed as convex fusion to avoid curve progression. Fusion in situ posterior using single rod and pedicle screw instrumentation. In congenital scoliosis is minimal blood loss, less traumatic, simple, safe and effective procedure. This study showed the early fusi in situ posterior of conge­nital scoliosis structural changes occur above or below can reduce fusion length, prevent curve progression and effectively achieve a more satisfactory correction without hazardous iatro­genic spinal stenosis, crankshaft phenomena, or neurological complications. Further research is needed to assess the progress of the outcome of surgeryKeywords: congenital scoliosis, wedge hemi­vertebrae, convex, fusi in situ posteriorCorrespondence: Pamudji Utomo. Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Sebelas Maret/ Prof. Dr. R. Soeharso Ortho­pae­dic Hospital, SurakartaIndonesian Journal of Medicine (2020), 05(02): 125-130https://doi.org/10.26911/theijmed.2020.05.02.05
Age-Related Sensory Impairment and Cognitive Decline in Geriatric Pratiwi, Dewi; Anggraini, Aulia Hervi; Bayu, Febri Arianto
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Incidence of sensory impair­ment and cognitive decline were increase with aging, each would give a considerable impact on public health and quality of life especially in geriatric population. Several mechanisms have been proposed to account for the correlation between sensory impairment and cognitive decline and the common mechanisms were sensory deprivation, information degradation, cognitive load, resource allocation and or social isolation. Prolonged reductions in the quality or quantity of sensory input lead to cognitive deterioration due to neuronal atrophy. This study aimed to determine whether age related sensory impairment with cognitive decline.Subjects and Method: This was a cross-sectional study design conducted at geriatric clinic, Dr. Moewardi General Hospital, Sura­karta, from May 31 to July 1, 2018. A sample of 54 elderly aged ≥60 years old was selected by consecutive sampling. The dependent variable was cognitive decline. The independent varia­bles were presbyacusis, presbyastasis, olfactory impairment, diabetes, and hypertension. Pres­bycusis was measured by Pure Tone Audio­metry. Presbyastasis was measured by Dynamic Visual Acuity (DVA) test. Olfactory dysfunction was measured by sniffing test. Cognitive decline was assessed by MoCA-Ina questionnaire. The data were analyzed by Chi-square test.Results: The mean age of subjects was 70.5 years old ranging from 61-81 years old and most of the subjects were females (72.2%). Pure tone audiometry test revealed that 44.4% pati­ents had presbycusis. Dynamic Visual Acuity test showed that 25.9% patients had pres­byas­tasis. Sniffing test revealed that 29.6% patients had olfactory dysfunction. Presbyacusis (OR= 11.9; 95% CI= 1.3 to 105.5; p= 0.008) and olfac­tory dysfunction (OR= 10.8; 95% CI= 1.8 to 61.9; p= 0.002) increased cognitive decline, and they were statistically significant. Presbyas­tasis decreased cognitive decline (or= 0.9; 95% CI= 0.1 to 5.3; p= 0.948), but it was statis­tically non-significantConclusion: Sensorineural health may serve as a marker of brain aging therefore sensory measures can be used as screening tools for cognitive decline risk.Keywords: sensory impairment, presbycusis, presbyastasis, olfactory dysfunction, cognitive declineCorrespondence: Dewi Pratiwi. Department of Otorhinolaryngo­logy Head and Neck Surgery, Dr. Moewardi Hospital/ Faculty of Medicine, Universitas Sebelas Maret Surakarta, Central Java. Email: pratiwi­dewi81@gmail.comIndonesian Journal of Medicine (2020), 05(02): 153-161https://doi.org/10.26911/theijmed.2020.05.02.10

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