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ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Sanjeev Bijukchhe; Ronny Isnuwardana; Sasivimol Rattanasiri; Kunlawat Thadanipon; Ammarin Thakkinstian
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs. Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs.Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2.Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70).Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs.

FACTORS AFFECTING GRADE 11 STUDENTS’ ACHIEVEMENT IN LEARNING POPULATION EDUCATION IN SCHOOL POPULATION AWARENESS, INDONESIA Andi Pancanugraha; Arisara Leksansern
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: School population awareness program (SSK) is a school program of teaching and learning strategies of population education developed at school level with the pilot project in Sukabumi, Indonesia. Prior this study, there was no research had been conducted to see the effectiveness of the program from the perspective of the students, on how the students perceived, their learning achievement, and whether the teaching and learning population under the SSK program contribute as the factor affecting learning achievement, which all of this could draw a conclusion whether the SSK program effective for students. Further, it would also give a valuable input for teacher and school sectors on how to improve the students’ learning achievement. This study has a purpose to investigate the attitude of student toward five aspect of learning situation of population education, which are the subject, method of teaching, activity of teaching, media of instruction, and class environment. Students’ learning achievement was also assessed in this study including the factors that affecting the students’ learning achievement in population education Methods: A descriptive cross-sectional study was applied using a quantitative research method. The sample size was 188 of eleventh grade students studying at three pilot projects of School Population Awareness in Sukabumi, Indonesia. Data were collected through a survey using close-ended questionnaire which distributed purposively.Results: Students’ attitudes were at high level, and their learning achievements were also high. Three predictive factors of learning achievement in population education were found: the attitude towards subject, activity of teaching, and method of teaching.Conclusion: From the result it was reveal that all of the predictive factors found were associated with the teaching and learning strategies of population education under the SSK program which draw a conclusion that the program is effective for the students. For BKKBN as the government institution who developed the SSK program it is recommends to advocate the Ministry of Education and Culture of Indonesia and other senior high schools to implement the SSK program based on the model of SSK implemented in Sukabumi. For the respective teachers and school sectors it is suggested to emphasize the students with the importance of learning population education, adding more real-life activities, and provide more group work in the learning process in order to improve the students’ learning achievement in population education.

FAMILY PLANNING FIELD WORKERS’ EXPECTATIONS AND PERCEPTIONS ON SERVICE QUALITY OF TRAINING AND EDUCATION AT NATIONAL POPULATION AND FAMILY PLANNING BOARD IN PROVINCE OF CENTRAL SULAWESI, INDONESIA Fatimah Fatimah; Arisara Leksansern
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Training and education for employees are the important thing to develop their knowledge, skill, performance as well as career. It is important to improve the quality of training and education service in National Population and Family Planning Board (BKKBN), specially training and education for field workers. Performance achievement of family planning field workers in province of Central Sulawesi until November 2018 was low, it was only 57,8% from 95% as a target for a year even though BKKBN province of Central Sulawesi implemented 10 training and education to them for improve the performance. This study aims to compare between trainees expectations and perceptions of service quality and then set up the guidelines to improve the trainig and education for family planning field workes at National Population and Family Planning Board, Province of Central Sulawesi, Indonesia.Method: This research method uses quantitative and qualitative with desciriptive design. 169 respondents filled the questionnaire with 22 statements which was pertaining with five dimensions of service quality (tangible, reliable, responsive, assurance and empathy). Moreover, focus group discussion has been used as one of qualitative methods with the management of BKKBN as participants who conduct the training and education.Conclussions: Level of expectation is in the highest level and level of perception in the highest level. Trainees expectation beyond their perceptions means that trainees did not satisfy with training and education, because perception was related with satisfaction. There was a significant differences between expectations and perceptions for tangible, reliability, responsive and assurance (p<0.05). All dimension had negative gap between expectations and perceptions (SQ= P-E). According to this gap, organiser who conduct training and education may be able to find the problem solving to improve the quality and reduce the gap between trainees expectations and perceptions and make the guidelines.

ADDRESSING GENDER INEQUALITY TO IMPROVE MATERNAL HEALTH IN INDONESIA: A NARRATIVE LITERATURE REVIEW I Gusti Ngurah Edi Putra
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Introduction: High maternal mortality ratio (MMR) remains a pressing public health issue in Indonesia. Despite many studies have been conducted to identify the associated factors from medical and socio-cultural perspectives, fewer studies and discussion appeared to focus on another social dimension such as gender norms, which is not explored deeply in the context of Indonesia. Aims: This paper aimed to discuss how gender inequality affects maternal health in Indonesia and practical strategies needed to address gender inequality in improving maternal health outcomes in Indonesia. Methods: This was a narrative literature review, based on several types of documents: research article, literature review, systematic review, books, and reports from institutions. Those would be reviewed and adjusted with the context of Indonesia in terms of how gender inequality affects maternal health, followed by the synthesis of argumentative ideas related to the practical strategies needed to address this issue.Results: The well-maintained patriarchal system and gender norms in Indonesia leads to gender inequality as one of the social factors contributing to maternal health outcomes. Gender inequality works to influence maternal health outcomes through structural and individual level factors, in which, influence women’s power and ability in the decision-making process and impact on women’s demand for maternal health service utilization. In addition, implemented maternal health programmes have not fully addressed gender inequality in Indonesia so far.Conclusion: To address gender inequality in order to improve maternal health, some strategies are suggested, such as women empowerment, men engagement to be supportive, and strengthening the protection of women’s reproductive rights.

THE EFFECTIVENESS OF LEMON JUICE (Citrus limon) TOWARD PYRAMIDAL NEURON CELLS OF MALE WHITE MICE’SCEREBRAL CORTEX THAT EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Pepi Arifiyani; Hikmah Fitriani; Rachmanda Haryo Wibisono
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The consumption rate of Monosodium Glutamate (MSG) in Indonesia remains high. Lemon is an antioxidant and neutralizer of free radicals which contains vitamin C and phytochemicals to prevent the long-term effects of MSG to pyramida cells. This study aims to test the effect of oral administration of lemon juice (Citrus limon) to the number of pyramidal neuron cells. Methodology: This experimental study employed 30 male white mice aged 2.5 to 3 months. Those mice were randomly divided into five control-groups: Normal Control (KN), Negative Control (K-) was treated with 4 mg/grBB MSG, Dose Group 1 (KD1) was treated with 3.33 ml/kgBB lemon juice, Dose Group 2 (KD2) was treated with 6.67 ml/kgBB lemon juice, and Dose Group 3 (KD3) was treated with 13.33 ml/kgBB lemon juice. Kruskal Wallis test was used to determine the difference in distribution between groups, followed with Post hoc Mann Whitney test.Results: After 28 days of treatment, the average number of pyramidal neuron cells in dose group 1 (637 cells) was higher than in negative control (589.5 cells) (p=0.078). The average number of pyramidal neuron cells in dose group 3 (482,5 cells) was lower than in the negative control (589.5 cells) (p=0.016). The statistical result shown that there were groups with a significant difference in pyramidal cells number. Mann-Whitney analysis of pyramidal cells number had shown that there was a significant difference between group KD3 and KD1, KD3 and K (-), KD3 and KD2.Conclusion: Lemon juice (Citrus limon) in precise dose has a beneficial effect to reduce the excitotoxic effect of MSG. Further studies is needed to validate the active compound and toxicity effect of lemon juice.

THE RELATIONSHIP BETWEEN KNOWLEDGE, ATTITUDE AND BEHAVIOR OF BREASTFEEDING AND INTAKE OF COMPLEMENTARY FEEDING WITH NUTRITIONAL STATUS OF CHILDREN AGED 6-24 MONTHS AT KESUNEAN HEALTH CENTER CIREBON Mauli Ardhiya; Ignatius Hapsoro; Shofa Nur Fauzah
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The insufficient nutrient intake in the certain time may affect physical growth and development of children. The percentage of babies with exclusive breast feeding are only 37.3%. It is still under the national target. This research aims to examine the correlation of knowledge, attitude, and behavior of breastfeeding and intake of complementary feeding with nutritional status in 6-24 months old children at kesunean health center in Cirebon.Methodology: This study was a cross-sectional research conducted in Kesunean Health Center Cirebon City. Totaling 100 mothers of children aged 6 to 24 months was selected by consecutive sampling. The nutritional status was calculated based on weight of age whereas the predictors (knowledge, attitude, behavior) was asked by 31 questions. The statistical analysis used Spearman test.Results: The univariate result showed that more than a half of children’s mothers was in aged 26 to 35 years and 48% graduated from senior high school. Additionally, 63% of the children had a good nutritional status. The bivariate analysis found that knowledge (p=0.001 and r=0.561), attitude (p=0.001 and r=0.498), and behavior (p=0.001 and r=0.606) had a correlation with nutritional status.Conclusions: Knowledge, attitude, and behavior of mother had correlation with nutritional status. Public health center should promote the importance of breastmilk and provide the counseling to the mother. Keywords: Breastfeeding, intake of complementary feeding, nutritional status of children.

ANTIDIABETIC EFFECT OF COMBINED Muntingia calabura L. LEAF EXTRACT AND METFORMIN ON RATS Adhy Nugroho; Risnandya Primanagara; Pahmi Budiman Sahputra Basyir
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a disease that causes blood glucose levels to increase. There are several therapies that can be done to reduce blood glucose levels in diabetes such as metformin, biguanides medicine and kersen (Muntingia calabura L.) leaves as an alternative. Treatment with combination of both is expected to further reduce blood glucose levels. This study aims to measure the effectiveness of the combination of metformin and Muntingia calabura L. leaf extract on blood glucose levels. Methods: This was an experimental research with pretest-posttest control group. The samples were 24 Sprague-Dawley rats divided into 4 groups, first group (K1) negative control was given only aquadest, second group (K2) positive control (+) was given 45 mg/kgBW metformin, third group (K3) was treated with 300 mg/kgBW Muntingia calabura leaf extract, and the fourth group (K4) was given the combination of 300 mg/kgBW Muntingia calabura leaf extract and 45 mg/kgBW metformin. Blood glucose levels were measured and analyzed using paired t-test and one-way ANOVA. Results: The combination of 300 mg/kgBW of Muntingia calabura extract and 45 mg/kgBB of metformin reduces 131.77 ± 3.57 mg/dl of blood glucose levels (p<0.05). This result is better than only metformin (92.68 ± 3.10 mg/dl) or only Muntingia calabura leaf extract (91.70 ± 4.40 mg/dl). There is a possibility that the synergistic effect of Muntingia calabura leaf extract and metformin caused the increased effectivity in reducing blood sugar level.Conclusion: The combination of Muntingia calabura and metformin is more effective in reducing blood glucose levels compared to a single dose of metformin or Muntingia calabura L. extract alone.

THE CORRELATION BETWEEN ANTENATAL CARE, PARITY AND MATERNAL AGE AMONG PREGNANT WOMEN WITH ANTEPARTUM HEMORRHAGE INCIDENCE AT GONDOSARI COMMUNITY HEALTH CENTER, KUDUS Akbar Dito Erlangga; Tissa Octavira Permatasari; Ouve Rahadiani Permana
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Antepartum hemorrhage is one of the main cause of maternal mortality. The Maternal Mortality Rate (MMR) in Indonesia currently reaches 305 every 100,000 live births which is still quite high from the MDGs target. Risk factors for antepartum hemorrhage will increase with increasing age and maternal parity, while, the cause of maternal death can be prevented via regular Antenatal Care (ANC). This present study aimed to determine the correlation between the frequency of antenatal care, parity, and age of pregnant women with the incidence of antepartum hemorrhage in the Community Health Center, Kudus City.Method: This was an observational analytic study with cross-sectional design. This study used secondary data obtained from maternal cohort books and Local Area Monitoring of Mother and Child Health (PWS-KIA) databooks. Using simple random sampling technique, a total of 323 individuals were recruited. Univariate analysis, bivariate analysis and multivariate analysis were performed on the data obtained.Results: The Spearman’s correlation test showed that there was significant correlation between frequency of Antenatal Care (ANC) (p=0.001), parity (p= 0.001) and age (p=0.001) with antepartum hemorrhage. The correlation coefficient showed that antenatal care (ANC) has a strong negative correlation with antepartum hemorrhage (r= -0.541), parity has a medium correlation with antepartum hemorrhage (r= 0.418) and age has a medium correlation with antepartum hemorrhage (r= 0.465). Multivariate analysis showed that age had the strongest influence on the incidence of antepartum hemorrhage (PR= 274.573), while other variables had the weakest influence smaller effect on the incidence of antepartum hemorrhage (ANC, PR= 0.001 and parity, PR= 0.041)Conclusion: The frequency of antenatal care (ANC), parity and age have correlation with antepartum hemorrhage in the working area in Gondosari Community Health Center, Kudus. Age is the most influential factor in the incidence of antepartum hemorrhage.

THE CORRELATION OF ADOLESCENT’S KNOWLEDGE AND ATTITUDE TO DRUGS WITH ADOLESCENT’S DRUG ABUSE BEHAVIOR IN THE COMMUNITY HEALTH CENTER OF KESUNEAN, CIREBON Ayatullah Ouve Rahadiani Permana; Uswatun Khasanah
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The reports on the number of drug abuse in Indonesia by the National Narcotic Agency (NNA) showed 3.3 million drug users in 2008 and 3.8 million drug users in 2014 in which its number keeps increasing year after year. The number of teenagers who become drug users in Cirebon is quite high, i.e. 25% compared to unemployed people of 19%, and followed by private employees and government employees of 56%. Data from community health center show that drug users who underwent treatment and were sent to rehabilitation center in 2017 were 32 people; it was higher than in 2016, i.e. 10 people. Adolescence is a transition period between childhood and adulthood. There are several factors influencing mental abilities, knowledge, and attitudes. It makes adolescents may consume narcotics, psychotropic abuse and other drug addictive substances. The community health center of Kesunean has an Integrated service post (ISP) program called REMPONG PISAN (an ISP who cares for HIV/AIDS and Narcotics) aiming to make adolescent understand about HIV/AIDS and drugs and to make them healthy. This ISP program is conducted once a month with one of the activities is education about HIV/AIDS and drugs.Aim: To observe the correlation of adolescent’s knowledge and attitudes to drugs with drug abuse behavior among adolescents at the ISP.Method: This research was an observational analytic study with a cross-sectional design. The sample was determined using consecutive sampling technique during the implementation of the ISP at the 2 neighborhood in the community health center of Kesunean. The data were analyzed using Pearson correlation to determine the correlation of adolescent’s knowledge and attitudes to drugs with drug abuse behavior among adolescents.Results: Statistical analysis shows that there was no significant correlation between knowledge and drug abuse behavior (p = 0.180 and; r = -0,201), there was no significant correlation between attitudes with drug abuse behavior (p = 0.264; r= -0,168), however, there was a significant correlation between knowledge and attitudes towards drug abuse (p = 0.000; r = 0,710**). Conclusion: The better the adolescent’s knowledge about drugs, the better their attitude will be. In this case, good teen behavior is influenced by good knowledge and attitude.

THE EFFECT OF LEMON JUICE (Citrus limon) IN LIVER HISTOPATHOLOGIC APPEARANCE OF MALE MICE (Mus musculus L.) EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Dela Destiani Aji; Ruri Eka Maryam Mulyaningsih; Ahmad Fariz MZZ
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Excessive consumption of MSG can cause the formation of free radicals in the body. Continuous use of MSG will cause free radical accumulation and oxidative stress in the liver. An antioxidant is one of the substances that has an ability to eliminate free radicals and protect the liver from oxidative stress. Lemon is a fruit that has benefits as a natural antioxidant. This study aims to determine the effect of administering lemon juice on the histopathological appearance of the liver exposed by MSG.Methodology: This post-test only control group design experimental study used 30 male white mice which were randomly divided into five groups: NC group, C(-) group, D1 group, D2 group, and D3 group. After 7 days of adaptation and randomized grouping, the mice were treated differently based on their group. All groups, except the NC group, were exposed to 4mg/gBW dose of MSG orally for 14 days. On the 15th day, MSG exposure was stopped and after that D1 group, D2 group, and D3 group were given lemon juice with a dose of each group 3.33ml/kgBW, 6.67 ml/kgBW, 13.33 ml/kgBW. The lemon juice was given once a day for 14 days using the gastric sonde. Histopathology examination was analyzed by pathologist in Gunung Jati Hospital, Cirebon, IndonesiaResults: Significant differences of liver histopathology were obtained between the normal control group with the dose 3 group (p = 0.005), the normal control group with the dose 2 group (p = 0.019), the normal control group with the dose group (p = 0.019) and between the negative control groups with dose 3 group (p = 0.027). Dose 3 group has higher liver damage compared to a normal control group and negative control group characterized by the form of parenchymatous degeneration. Conclusion: Lemon juice has a negative effect on the histopathology appearance of male white mice’s (Mus musculus L.) liver exposed by monosodium glutamate (MSG). Further studies are needed to validate the effect of the active compound and toxicity of lemon juice and to reveal the precise mechanisms on how lemon juice affects the hepatocytes.

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Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

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Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

Contact Email info@inschool.id

Phone -

Journal Mail Official icash@inschool.id

Editorial Address -

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Dyah Anantalia Widyastari, BSPH., MPH., Ph.D (Cand.)

Contact Email
info@inschool.id

Phone
-

Journal Mail Official
icash@inschool.id

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA