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All Journal Jurnal Kesehatan Andalas Proceedings of the International Conference on Applied Science and Health Interdental Jurnal Kedokteran Gigi (IJKG) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Kedokteran Mulawarman Jurnal Medika: Karya Ilmiah Kesehatan Jurnal Sains dan Kesehatan Proceeding Mulawarman International Conference on Tropical Public Health
Ronny Isnuwardana
Laboratorium Ilmu Kesehatan Masyarakat Dan Kedokteran Komunitas, Fakultas Kedokteran, Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Bijukchhe, Sanjeev; Isnuwardana, Ronny; Rattanasiri, Sasivimol; Thadanipon, Kunlawat; Thakkinstian, Ammarin
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (893.337 KB)

Abstract

Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs.  Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs.Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2.Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70).Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs.
ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Sanjeev Bijukchhe; Ronny Isnuwardana; Sasivimol Rattanasiri; Kunlawat Thadanipon; Ammarin Thakkinstian
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs.  Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs.Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2.Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70).Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs.
ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Sanjeev Bijukchhe; Ronny Isnuwardana; Sasivimol Rattanasiri; Kunlawat Thadanipon; Ammarin Thakkinstian
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs. Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs. Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2. Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70). Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs. Keywords: Telomere, Telomerase, Statin, Cardiovascular diseases
Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda Wenda Safitri; Sjarif Ismail; Ronny Isnuwardana
Jurnal Kesehatan Andalas Vol 12, No 1 (2023): Online March 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2167

Abstract

It is crucial for patients with hypertension to always control their blood pressure by consuming medicines for hypertension, the morbidity and mortality rates will be hopefully reduced. Medication adherence is necessary in order to reach the target of controlling blood pressure. There are a lot of causes affecting medication adherence, one of which is the consumption of herbal remedies. Objective: To investigated the correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda. Methods: The research design was analytical observational with a cross-sectional approach. The statistical analysis used Chi-Square test. The data were collected through interviews with 94 respondents. They were selected using convenience sampling and also asked to fulfill the identity form and MMAS-8 questionnaire. Results: Most respondents at Lempake Public Health Centre in Samarinda consumed herbal remedies (42.6%), but their medication adherence was low (82.9%). The significant p-value was 0.008 based on the statistical analysis. Conclusion: There is a significant correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda.Keywords:  herbal, hypertension, medication adherence, MMAS-8
THE RELATIONSHIP OF ORAL HEALTH AND QUALITY OF LIFE FOR ELDERLY AT THE TRESNA WERDHA NIRWANA SOCIAL ORGANIZATION PURI SAMARINDA Alifia Auralia; Nuryanni Dihin Utami; Endang Sawitri; Ellina Martalina; Ronny Isnuwardana; Cicih Bhakti Purnamasari
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 20 No. 1 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i2.7661

Abstract

Introduction: Elderly is the final stage of the aging process, usually followed by cumulative changes in human that create changes in the oral cavity as well. Oral Health plays a crucial role in general health and quality of life. Material and Methods: : This research used analytical observational study with cross-sectional design, using purposive sampling as its sampling method. The respondents were 81 elderly people. This research used oral health Levin questionnaire and Oral Health Impact Profile (OHIP-14). The data from this research were analyzed using Spearman correlation test. Results and Discussions: The correlation between dental and oral health and quality of life showed significant with the p value <0.001 and correlation coefficient R= 0.657. Conclusion: There was a significant correlation between dental and oral health and the quality of life of elderly people in Tresna Werdha Nirwana Puri Samarinda Nursing home.
HUBUNGAN ADIKSI INTERNET DENGAN MASALAH PERILAKU PADA SISWA SMP DI KOTA SAMARINDA Muslimin, Nurhakiki; Isnuwardana, Ronny; Sitinjak, Mariati Herlina
Jurnal Kedokteran Mulawarman Vol 10, No 1 (2023): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v10i1.9626

Abstract

Adiksi internet merupakan Perilaku individu yang berlebihan atau tidak terkontrol dalam menggunakan Internet yang mengarah pada gangguan. Adiksi internet memiliki dampak negatif berupa gangguan psikologis dan fisik. Pada remaja adiksi ini dapat menimbulkan masalah emosional dan perilaku. Penelitian ini bertujuan untuk mengetahui hubungan adiksi internet dengan masalah perilaku pada siswa SMP di Kota Samarinda. Desain penelitian ini adalah observasional analitik dengan metode cross sectional. Data yang diperoleh dari kuesioner Internet Addiction Test (IAT) dan kuesioner Difficulties Questionnaire (SDQ) dengan teknik consecutive sampling. Sampel pada penelitian ini berjumlah 135 orang responden. Hasil penelitian ini menunjukkan bahwa 56 orang responden (41,5%) mengalami adiksi internet ringan dan 15 orang responden (11,1%) mengalami adiksi internet sedang, sedangkan untuk masalah perilaku sebanyak 56 orang responden (41,5%) mengalami masalah perilaku kategori abnormal dan 40 orang responden mengalami masalah perilaku kategori borderline. Uji analisis bivariat dengan uji Spearman menghasilkan nilai p-value < 0,001 dengan r = 0,370. Hal ini menunjukkan bahwa terdapat hubungan positif yang signifikan antara adiksi internet dengan masalah perilaku, artinya semakin tinggi tingkat adiksi internet maka semakin tinggi pula tingkat masalah perilaku. Kata kunci: Adiksi internet, Masalah perilaku remaja, IAT, SDQ
Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas Swandari Paramita; Ronny Isnuwardana; Muhammad Khairul Nuryanto; Ruth Djalung; Dewi Guntar Rachmawatiningtyas; Prilandy Jayastri
Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i7.56

Abstract

Hypertension is a major health problem throughout the world, including Indonesia. The use of traditional medicine as part of the treatment of hypertension is increasing in the last decade. This is due to several factors, especially traditional medicine is a cheaper alternative with fewer undesirable side effects. This study tried to look at the pattern of use of natural medicine as a complementary therapy in hypertensive patients at the health center. The study is a descriptive study conducted in Puskesmas Sempaja Samarinda in the period September 2016, interviewing 62 hypertension patients with the use of natural medicine. The results showed 70.9% of patients with hypertension in the health center also uses natural medicines. All patients using herbal medicine which in theory is proven to lower blood pressure. However, there is no natural medicines used include standardized herbal medicine or phytopharmacy. Only 15.2% of patients using herbal medicine in accordance with the criteria BPOM regulation on herbal medicine. For conclusions, this study shows the patients still need to be educated for the use of natural medicine in the management of hypertension.
Gambaran Pasien Ulkus Kornea di Klinik Spesialis Mata SMEC Samarinda Tahun 2019-2022: Overview of Corneal Ulcer Patients at the Eye Clinic SMEC Samarinda from 2019-2022 Danang Biyan Permana; Nur Khoma Fatmawati; Ronny Isnuwardana
Jurnal Sains dan Kesehatan Vol. 6 No. 4 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i4.2333

Abstract

Corneal ulcers are partial loss of corneal surface tissue from the epithelium to the stroma. This study aims to determine the description of corneal ulcer patients at the Eye Clinic SMEC Samarinda. This study used a descriptive observational with a cross sectional method. Total of 214 samples were obtained using total sampling technique with medical records as the instrument. This study found that the majority of corneal ulcer patients occurred at the age of 30-60 years (65.4%). Most of them were male (71.03%). Most worked as labourers or farmers (32.7%). Most occurred unilaterally (97.2%). Most experienced visual acuity in category 4 (<1/60) (35.5%) with no improvement in visual acuity (50%). The average length of treatment was 61 days ±168.19. Most of them did not perform surgery (78.97%). The most common surgery performed was Amniotic Membrane Transplant (62.7%). Most of the patients had complications (65.9%) with corneal scar being the most common complication (30.4%). Keywords:          Corneal Ulcer, Visual Acuity Improvement, Amniotic Membrane Transplant   Abstrak Ulkus kornea adalah hilangnya sebagian jaringan permukaan kornea dari epitel sampai stroma. Penelitian ini bertujuan untuk mengetahui gambaran pasien ulkus kornea di Klinik Spesialis Mata SMEC Samarinda. Penelitian ini menggunakan desain penelitian observasional deskriptif dengan metode cross sectional. Sebanyak 214 sampel yang diperoleh menggunakan teknik total sampling dengan rekam medik sebagai instrumen penelitian. Penelitian ini mendapatkan mayoritas pasien ulkus kornea terjadi di usia 30-60 tahun (65.4%). Sebagian besar berjenis kelamin laki-laki (71.03%). Sebagian besar bekerja sebagai buruh atau petani (32.7%). Paling banyak terjadi secara unilateral (97.2%). Paling banyak mengalami penurunan visus kategori 4 (<1/60) (35.5%) didominasi tidak mengalami perbaikan ketajaman penglihatan (50%). Rata-rata lama perawatan adalah 61 hari ±168.19. Sebagian besar tidak dilakukan operasi (78,97%). Tindakan operasi yang paling sering dilakukan adalah Amniotic Membrane Transplant (62.7%). Sebagian besar pasien mengalami komplikasi (65.9%) dengan sikatrik kornea menjadi komplikasi terbanyak (30.4%).   Kata Kunci:         Ulkus Kornea, Perbaikan Ketajaman Penglihatan, Amniotic Membrane Transplant
Hubungan Frekuensi Merokok dengan Kejadian Kanker Rongga Mulut di RSUD Abdoel Wahab Sjahranie Samarinda Tahun 2019-2023: Correlation between Frequency of Smoking and the Incidence of Oral Cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023 Amila, Dalila Nur Azmi; Cahya, Wahyuni Dwi; Utami, Nuryanni Dihin; Isnuwardana, Ronny
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2365

Abstract

People who smoke will have an 8.4 times higher risk of developing oral cancer, and the number of cigarettes consumed per day increases the risk of developing head and neck cancer. This study aims to determine the correlation between frequency of smoking and the incidence of oral cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023. This research is an analytical observational study with a case-control approach using secondary data from medical records at Abdoel Wahab Sjahranie Samarinda Hospital in 2019-2023 with a purposive sampling technique and primary data from interviews with patients or patients' families. Case samples were patients with oral cancer, and control samples were patients with benign oral tumors at Abdoel Wahab Sjahranie Samarinda Hospital in 2019-2023. Research data from 60 patients with the Chi-square test obtained a p-value of age (p=0.005), gender (p=0.038), and smoking frequency (p=0.024) with an OR value of 3.824 (95% CI 1.150-12.713). There is a correlation between age, gender, and the frequency of smoking with the incidence of oral cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023. Keywords:          Oral cancer, Smoking, Frequency   Abstrak Orang yang merokok akan berisiko 8,4 kali lebih tinggi terkena kanker rongga mulut dan banyaknya jumlah rokok yang dikonsumsi per hari meningkatkan risiko terkena kanker kepala dan leher. Penelitian ini bertujuan untuk mengetahui hubungan frekuensi merokok dengan kejadian kanker rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan case control yang menggunakan data sekunder dari rekam medik di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023 dengan teknik purposive sampling dan data primer dari wawancara dengan pasien atau keluarga pasien. Sampel kasus yang diambil adalah pasien yang kanker rongga mulut dan sampel kontrol adalah pasien tumor jinak rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Data penelitian dari 60 pasien dengan uji Chi-square didapatkan p-value usia (p=0,005), jenis kelamin (p=0,038), dan frekuensi merokok sebesar (p=0,024) dengan nilai OR 3,824 (95% CI 1,150-12,713). Terdapat hubungan antara usia, jenis kelamin dan frekuensi merokok dengan kejadian kanker rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Kata Kunci:         Kanker rongga mulut, Merokok, Frekuensi
Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda Safitri, Wenda; Ismail, Sjarif; Isnuwardana, Ronny
Andalas Journal of Health Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2167

Abstract

It is crucial for patients with hypertension to always control their blood pressure by consuming medicines for hypertension, the morbidity and mortality rates will be hopefully reduced. Medication adherence is necessary in order to reach the target of controlling blood pressure. There are a lot of causes affecting medication adherence, one of which is the consumption of herbal remedies. Objective: To investigated the correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda. Methods: The research design was analytical observational with a cross-sectional approach. The statistical analysis used Chi-Square test. The data were collected through interviews with 94 respondents. They were selected using convenience sampling and also asked to fulfill the identity form and MMAS-8 questionnaire. Results: Most respondents at Lempake Public Health Centre in Samarinda consumed herbal remedies (42.6%), but their medication adherence was low (82.9%). The significant p-value was 0.008 based on the statistical analysis. Conclusion: There is a significant correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda.Keywords:  herbal, hypertension, medication adherence, MMAS-8
Co-Authors Alifia Auralia Amila, Dalila Nur Azmi Ammarin Thakkinstian Ammarin Thakkinstian Bakhtiar, Rahmat Bijukchhe, Sanjeev Billa, Azizah Salsa Cahya, Wahyuni Dwi Cicih Bhakti Purnamasari Danang Biyan Permana Dewi Guntar Rachmawatiningtyas Dyaksa, Hadyan Marta Ellina Martalina Endang Sawitri Evi Fitriany Fadhilah, Jihan Hanan, Nydia Kaban, Luly Kartika Dewi Br. Kunlawat Thadanipon Kunlawat Thadanipon Lu'Lu', Alvianita Ziinat Marta Dyaksa, Hadyan Muhammad Khairul Nuryanto Munir, Musnar Muslimin, Nurhakiki Nur Khoma Fatmawati Nuryanni Dihin Utami Nuryanni Dihin Utami, Nuryanni Dihin Nuryanto, Muhammad Khairul Pertiwi, Alda Puspa Prilandy Jayastri Puspa Pertiwi, Alda Puspa, Devi Renita Ramadhany, Candra Rattanasiri, Sasivimol Rita Yuliana Ruth Djalung Safitri, Wenda Salsa Billa, Azizah Sanjeev Bijukchhe Sanjeev Bijukchhe Saputra, Rudi Sasivimol Rattanasiri Sasivimol Rattanasiri Sitinjak, Mariati Herlina Sjarif Ismail Swandari Paramita Thadanipon, Kunlawat Thakkinstian, Ammarin Wenda Safitri Yadi Yasir Ziinat Lu'lu', Alvianita