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ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Bijukchhe, Sanjeev; Isnuwardana, Ronny; Rattanasiri, Sasivimol; Thadanipon, Kunlawat; Thakkinstian, Ammarin
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs. Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs.Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2.Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70).Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs.

ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Sanjeev Bijukchhe; Ronny Isnuwardana; Sasivimol Rattanasiri; Kunlawat Thadanipon; Ammarin Thakkinstian
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs. Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs.Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2.Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70).Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs.

ASSOCIATION AMONG STATIN, TELOMERE LENGTH AND CARDIOVASCULAR DISEASES Sanjeev Bijukchhe; Ronny Isnuwardana; Sasivimol Rattanasiri; Kunlawat Thadanipon; Ammarin Thakkinstian
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Recent evidence has shown associations between cardiovascular diseases (CVDs) and telomere length (TL). Many factors affect telomerase activity (TA) and TL, and statin was recently found to be associated with TA and TL. This systematic review and meta-analysis was conducted to summarize the evidence on the effect of statin on TA and TL, and update the knowledge of association between TL and CVDs. Primary objective is to determine the effect of statin on TA and TL; Secondary objective, to assess the associations between TL and CVDs. Methods: The MEDLINE and Scopus databases were searched to identify eligible studies and extracted data. Meta-analysis was done to see effects of statin on TA/TL [i.e., standardized/unstandardized mean difference (SMD/USMD)] and TL on CVDs using random-effects and fixed-effects model according to heterogeneity assessed by Q test and I2. Results: Five and 18 studies were selected for the primary and secondary objectives, respectively. Pooled TA showed effect of statin on TA with SMD [95% confidence interval (CI)] of 1.90 (1.16, 2.64) TA. However, no significant effect on TL was seen. Increased risk of CHD among participants with shorter TL was estimated by a pooled risk ratio of 1.58 (1.19, 2.09). However, pooled hazard ratios (HRs) for CHD and stroke were non-significant; but shorter TL was significantly increased risk for unspecified CVDs with pooled HR of 1.33 (1.04, 1.70). Conclusions: Our study showed association between statin and TA, but not for TL. In addition, shorter TL is more likely to be higher risk for CHD and unspecified CVDs. However, results were still inconclusive based on different pooled parameters. More studies are required to confirm the association of statin with TL, possibly to elucidate its protective effect on CVDs. Keywords: Telomere, Telomerase, Statin, Cardiovascular diseases

Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda Wenda Safitri; Sjarif Ismail; Ronny Isnuwardana
Jurnal Kesehatan Andalas Vol 12, No 1 (2023): Online March 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2167

It is crucial for patients with hypertension to always control their blood pressure by consuming medicines for hypertension, the morbidity and mortality rates will be hopefully reduced. Medication adherence is necessary in order to reach the target of controlling blood pressure. There are a lot of causes affecting medication adherence, one of which is the consumption of herbal remedies. Objective: To investigated the correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda. Methods: The research design was analytical observational with a cross-sectional approach. The statistical analysis used Chi-Square test. The data were collected through interviews with 94 respondents. They were selected using convenience sampling and also asked to fulfill the identity form and MMAS-8 questionnaire. Results: Most respondents at Lempake Public Health Centre in Samarinda consumed herbal remedies (42.6%), but their medication adherence was low (82.9%). The significant p-value was 0.008 based on the statistical analysis. Conclusion: There is a significant correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda.Keywords: herbal, hypertension, medication adherence, MMAS-8

THE RELATIONSHIP OF ORAL HEALTH AND QUALITY OF LIFE FOR ELDERLY AT THE TRESNA WERDHA NIRWANA SOCIAL ORGANIZATION PURI SAMARINDA Alifia Auralia; Nuryanni Dihin Utami; Endang Sawitri; Ellina Martalina; Ronny Isnuwardana; Cicih Bhakti Purnamasari
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 20 No. 1 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i2.7661

Introduction: Elderly is the final stage of the aging process, usually followed by cumulative changes in human that create changes in the oral cavity as well. Oral Health plays a crucial role in general health and quality of life. Material and Methods: : This research used analytical observational study with cross-sectional design, using purposive sampling as its sampling method. The respondents were 81 elderly people. This research used oral health Levin questionnaire and Oral Health Impact Profile (OHIP-14). The data from this research were analyzed using Spearman correlation test. Results and Discussions: The correlation between dental and oral health and quality of life showed significant with the p value <0.001 and correlation coefficient R= 0.657. Conclusion: There was a significant correlation between dental and oral health and the quality of life of elderly people in Tresna Werdha Nirwana Puri Samarinda Nursing home.

HUBUNGAN ADIKSI INTERNET DENGAN MASALAH PERILAKU PADA SISWA SMP DI KOTA SAMARINDA Muslimin, Nurhakiki; Isnuwardana, Ronny; Sitinjak, Mariati Herlina
Jurnal Kedokteran Mulawarman Vol 10, No 1 (2023): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v10i1.9626

Adiksi internet merupakan Perilaku individu yang berlebihan atau tidak terkontrol dalam menggunakan Internet yang mengarah pada gangguan. Adiksi internet memiliki dampak negatif berupa gangguan psikologis dan fisik. Pada remaja adiksi ini dapat menimbulkan masalah emosional dan perilaku. Penelitian ini bertujuan untuk mengetahui hubungan adiksi internet dengan masalah perilaku pada siswa SMP di Kota Samarinda. Desain penelitian ini adalah observasional analitik dengan metode cross sectional. Data yang diperoleh dari kuesioner Internet Addiction Test (IAT) dan kuesioner Difficulties Questionnaire (SDQ) dengan teknik consecutive sampling. Sampel pada penelitian ini berjumlah 135 orang responden. Hasil penelitian ini menunjukkan bahwa 56 orang responden (41,5%) mengalami adiksi internet ringan dan 15 orang responden (11,1%) mengalami adiksi internet sedang, sedangkan untuk masalah perilaku sebanyak 56 orang responden (41,5%) mengalami masalah perilaku kategori abnormal dan 40 orang responden mengalami masalah perilaku kategori borderline. Uji analisis bivariat dengan uji Spearman menghasilkan nilai p-value < 0,001 dengan r = 0,370. Hal ini menunjukkan bahwa terdapat hubungan positif yang signifikan antara adiksi internet dengan masalah perilaku, artinya semakin tinggi tingkat adiksi internet maka semakin tinggi pula tingkat masalah perilaku. Kata kunci: Adiksi internet, Masalah perilaku remaja, IAT, SDQ

Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas Swandari Paramita; Ronny Isnuwardana; Muhammad Khairul Nuryanto; Ruth Djalung; Dewi Guntar Rachmawatiningtyas; Prilandy Jayastri
Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i7.56

Hypertension is a major health problem throughout the world, including Indonesia. The use of traditional medicine as part of the treatment of hypertension is increasing in the last decade. This is due to several factors, especially traditional medicine is a cheaper alternative with fewer undesirable side effects. This study tried to look at the pattern of use of natural medicine as a complementary therapy in hypertensive patients at the health center. The study is a descriptive study conducted in Puskesmas Sempaja Samarinda in the period September 2016, interviewing 62 hypertension patients with the use of natural medicine. The results showed 70.9% of patients with hypertension in the health center also uses natural medicines. All patients using herbal medicine which in theory is proven to lower blood pressure. However, there is no natural medicines used include standardized herbal medicine or phytopharmacy. Only 15.2% of patients using herbal medicine in accordance with the criteria BPOM regulation on herbal medicine. For conclusions, this study shows the patients still need to be educated for the use of natural medicine in the management of hypertension.

Hubungan Frekuensi Merokok dengan Kejadian Kanker Rongga Mulut di RSUD Abdoel Wahab Sjahranie Samarinda Tahun 2019-2023: Correlation between Frequency of Smoking and the Incidence of Oral Cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023 Amila, Dalila Nur Azmi; Cahya, Wahyuni Dwi; Utami, Nuryanni Dihin; Isnuwardana, Ronny
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2365

People who smoke will have an 8.4 times higher risk of developing oral cancer, and the number of cigarettes consumed per day increases the risk of developing head and neck cancer. This study aims to determine the correlation between frequency of smoking and the incidence of oral cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023. This research is an analytical observational study with a case-control approach using secondary data from medical records at Abdoel Wahab Sjahranie Samarinda Hospital in 2019-2023 with a purposive sampling technique and primary data from interviews with patients or patients' families. Case samples were patients with oral cancer, and control samples were patients with benign oral tumors at Abdoel Wahab Sjahranie Samarinda Hospital in 2019-2023. Research data from 60 patients with the Chi-square test obtained a p-value of age (p=0.005), gender (p=0.038), and smoking frequency (p=0.024) with an OR value of 3.824 (95% CI 1.150-12.713). There is a correlation between age, gender, and the frequency of smoking with the incidence of oral cancer at Abdoel Wahab Sjahranie Regional General Hospital Samarinda from 2019 to 2023. Keywords: Oral cancer, Smoking, Frequency Abstrak Orang yang merokok akan berisiko 8,4 kali lebih tinggi terkena kanker rongga mulut dan banyaknya jumlah rokok yang dikonsumsi per hari meningkatkan risiko terkena kanker kepala dan leher. Penelitian ini bertujuan untuk mengetahui hubungan frekuensi merokok dengan kejadian kanker rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan case control yang menggunakan data sekunder dari rekam medik di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023 dengan teknik purposive sampling dan data primer dari wawancara dengan pasien atau keluarga pasien. Sampel kasus yang diambil adalah pasien yang kanker rongga mulut dan sampel kontrol adalah pasien tumor jinak rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Data penelitian dari 60 pasien dengan uji Chi-square didapatkan p-value usia (p=0,005), jenis kelamin (p=0,038), dan frekuensi merokok sebesar (p=0,024) dengan nilai OR 3,824 (95% CI 1,150-12,713). Terdapat hubungan antara usia, jenis kelamin dan frekuensi merokok dengan kejadian kanker rongga mulut di RSUD Abdoel Wahab Sjahranie Samarinda tahun 2019-2023. Kata Kunci: Kanker rongga mulut, Merokok, Frekuensi

Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda Safitri, Wenda; Ismail, Sjarif; Isnuwardana, Ronny
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2167

It is crucial for patients with hypertension to always control their blood pressure by consuming medicines for hypertension, the morbidity and mortality rates will be hopefully reduced. Medication adherence is necessary in order to reach the target of controlling blood pressure. There are a lot of causes affecting medication adherence, one of which is the consumption of herbal remedies. Objective: To investigated the correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda. Methods: The research design was analytical observational with a cross-sectional approach. The statistical analysis used Chi-Square test. The data were collected through interviews with 94 respondents. They were selected using convenience sampling and also asked to fulfill the identity form and MMAS-8 questionnaire. Results: Most respondents at Lempake Public Health Centre in Samarinda consumed herbal remedies (42.6%), but their medication adherence was low (82.9%). The significant p-value was 0.008 based on the statistical analysis. Conclusion: There is a significant correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda.Keywords: Â herbal, hypertension, medication adherence, MMAS-8

Korelasi Tingkat Pengetahuan Hoaks Vaksin COVID-19 dengan Sikap Masyarakat pada Program Vaksinasi di Samarinda Saputra, Rudi; Nuryanto, Muhammad Khairul; Bakhtiar, Rahmat; Yasir, Yadi; Isnuwardana, Ronny
Majalah Kedokteran Indonesia Vol 73 No 2 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.2-2023-932

Introduction: The COVID-19 pandemic problem was followed by the development of an infodemic supported by advance technologies. This development has an impact on how quickly information spreads throughout society. Different types of COVID-19 information are very accessible to the public. However, some of the information received by the public contained hoaxes. The purpose of this research is to know the correlation between the level of knowledge COVID-19 vaccine hoax and people’s attitudes toward the vaccination program.Methods: This research was conducted online in Samarinda using a cross-sectional research design with voluntary response sampling. The minimal sample was 147 respondents, which was distributed through social media. This research using Spearman Rank correlation test, Mann-Whitney test, and Kruskal-Wallis test with 95% level of confidence.Result: The results showed there was a significant correlation between people’s attitudes about the vaccination program and their level of knowledge COVID-19 vaccine hoax (p less than 0,001). Furthermore, it was discovered that people who were greater than 35 years old (p = 0.011), had a recent education history at college (p less than 0.001), and were married (p = 0.001) were disagree with the COVID-19 vaccination program. There was no significant differences on gender (p = 0.076) and a positive history of COVID-19 (p = 0.702).Conclusion: There is a significant correlation between the level of knowledge COVID-19 vaccine hoax and people’s attitudes toward the vaccination program.

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