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Uji efek Hipnotik sedatif ekstrak etanol Batang Jaka Tua (Scoparia dulcis Linn) terhadap Mencit Jantan Galur Swiss Gilbert Lister
SCIENTIA JOURNAL Vol. 13 No. 1 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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This study aims to evaluate the hypnotic and sedative effects of ethanol extract from the stem of Jaka Tua (Scoparia dulcis Linn) on male Swiss strain mice. The sleep time method with sodium pentobarbital induction was used to assess the extract’s potential to enhance sleep duration. The experiment was conducted at the laboratory of Universitas Adiwangsa Jambi. Mice were divided into five treatment groups: a negative control group (distilled water), a positive control group (diazepam 1 mg/kgBW), and three groups receiving the ethanol extract of Scoparia dulcis stems at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW. Observed parameters included sleep onset time and total sleep duration. Results showed that administration of the extract at 200 mg/kgBW and 400 mg/kgBW significantly increased sleep duration and decreased sleep onset time compared to the negative control. The sedative effect at the highest dose approached that of diazepam. These findings suggest that the stem extract of Scoparia dulcis Linn possesses potential as a natural sedative agent.

Perbedaan Cardiothorax’s Ratio Foto Rontgen Polos Usia di Atas 50 dan di Bawah 50 Tahun pada Pasien Diabetes Melitus di RS Royal Prima Jambi Leo Nardi
SCIENTIA JOURNAL Vol. 13 No. 2 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Background: The cardiothoracic ratio (CTR) is a crucial radiological indicator used to assess cardiac size and detect cardiomegaly, particularly in patients with chronic diseases such as diabetes mellitus. Cardiovascular complications are common in diabetic patients and may progress with age. Evaluating CTR differences between age groups in diabetic populations can aid in early risk detection. Objective: To determine the differences in cardiothoracic ratio on chest X-rays between diabetic patients aged above 50 years and those aged 50 years and below at Royal Prima Hospital Jambi. Methods: This retrospective descriptive-comparative study utilized secondary data from chest X-rays of diabetic patients at Royal Prima Hospital Jambi. Subjects were divided into two age categories: ≤50 years and >50 years. The CTR was measured using the standard posteroanterior radiographic method and analyzed statistically to evaluate differences between groups. Results: The study found a statistically significant difference in CTR between the two age groups. Patients over 50 years old had a higher average CTR than those 50 years and below, suggesting an increased risk of cardiomegaly in older diabetic patients. Conclusion: There is a significant difference in cardiothoracic ratio between diabetic patients aged over 50 years and those aged 50 years and below. These findings indicate that age is a contributing factor in cardiac enlargement among diabetic patients, supporting the need for age-specific cardiovascular monitoring strategies.

Pengaruh Penggunaan APD dan Formula Emulsi terhadap Dermatitis Kontak Akibat Kerja pada Pekerja Batik di Muaro Jambi Nadya Nazimuddin Putri
SCIENTIA JOURNAL Vol. 13 No. 2 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Occupational contact dermatitis remains a prevalent health issue among batik workers due to repeated exposure to irritants and allergens, particularly from dyes and chemical fixatives. This study aimed to evaluate the effect of personal protective equipment (PPE) usage and the application of an emulsion-based formula in preventing occupational contact dermatitis among batik artisans in Muaro Jambi. A quasi-experimental pretest-posttest control group design was employed involving 60 batik workers divided into four groups: control, PPE only, emulsion only, and PPE with emulsion. The incidence and severity of contact dermatitis were assessed using the Hand Eczema Severity Index (HECSI) and patch testing over a 4-week period. Results demonstrated a statistically significant reduction in dermatitis symptoms in the PPE and emulsion combination group compared to the other groups (p<0.05). The use of both PPE and emulsion provided synergistic protection against irritant exposure and improved skin barrier function. This study underscores the importance of integrated preventive strategies combining physical barriers and topical protectants to reduce occupational dermatoses in traditional industries.

Peran Ekstrak Curcuma Zedoaria terhadap Faktor Pertumbuhan Plasenta pada Retinopati Diabetik Zaimah Hilal
SCIENTIA JOURNAL Vol. 13 No. 2 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Diabetic retinopathy (DR) is a common and serious complication of diabetes that can lead to significant vision impairment and blindness. Placental growth factor (PlGF) has been identified as a key factor in the pathogenesis of DR, contributing to retinal angiogenesis and inflammation. This study aims to explore the role of Curcuma zedoaria extract in modulating PlGF levels and its potential therapeutic effects in diabetic retinopathy. An experimental design was used with diabetic rat models, divided into three groups: a control group (no treatment), a diabetic group, and a diabetic group treated with Curcuma zedoaria extract. The extract was administered for 30 days, and PlGF levels were measured using immunohistochemistry and Western blot. The results showed that Curcuma zedoaria extract significantly reduced PlGF levels in the treated group compared to the untreated diabetic group, indicating its potential to inhibit retinal angiogenesis and inflammation. Furthermore, histological analysis revealed improvements in retinal structure and reduced vascular leakage in the Curcuma zedoaria-treated group, supporting its protective effect in DR. This study concludes that Curcuma zedoaria extract plays a role in reducing PlGF levels, offering a promising therapeutic approach for managing diabetic retinopathy. These findings provide a solid foundation for further research into its clinical applications in DR treatment, particularly in diabetic patients.

Histologi Kardiovaskular pada Wistar Diabetes Melitus Tipe 2 dengan Curcuma Zedoria Antonius Fransiskus Putra Meliala; Christopher Lawrence; Andreas Xaverio Bangun; Sondang Silitonga
SCIENTIA JOURNAL Vol. 13 No. 1 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Type 2 Diabetes Mellitus (T2DM) can cause significant cardiovascular damage, including diabetic cardiomyopathy and diabetic vasculopathy, associated with increased oxidative stress and inflammation. This study aimed to evaluate the effect of Curcuma zedoaria extract on the improvement of heart and aorta histopathology in Wistar rats with T2DM. C. zedoaria extract was administered orally at doses of 100, 200, and 400 mg/kgBW for 6 weeks. The results showed that administration of C. zedoaria extract significantly reduced heart fibrosis and aortic elastin fragmentation, particularly at the 400 mg/kgBW dose. These findings suggest that C. zedoaria has potential as an adjunctive therapy to prevent cardiovascular damage in T2DM, with mechanisms involving the inhibition of oxidative stress and inflammation.

Hubungan Antara Body Mass Index (Bmi) dan First Degree Dengan Fenotipe Molekul Her-2 pada Pasien Breast Cancer of No Special Type (NST) di RSUD Raden Mattaher Jambi Ismail Usman
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Breast cancer of No Special Type (NST) is the most common histological subtype of breast malignancy and demonstrates diverse molecular phenotypes, including the expression of Human Epidermal Growth Factor Receptor-2 (HER-2), a key marker associated with tumor aggressiveness and therapeutic response. Risk factors such as nutritional status measured through Body Mass Index (BMI) and the presence of a first-degree family history of breast cancer are suspected to be associated with molecular phenotypes; however, local evidence remains limited. This study aimed to analyze the association between BMI and first-degree family history with HER-2 molecular phenotype among patients diagnosed with breast cancer NST at RSUD Raden Mattaher Jambi.This analytic observational research employed a cross-sectional design. Data were collected from medical records, including BMI values, first-degree family history, and HER-2 expression determined through immunohistochemistry (IHC). Statistical analysis using the Chi-Square test was conducted to assess the relationship between the independent variables and the HER-2 phenotype. The results indicated that most patients were categorized as overweight or obese. There was a tendency for patients with higher BMI to show a greater proportion of HER-2–positive expression compared with those with normal BMI. Additionally, patients with a first-degree family history of breast cancer exhibited a higher proportion of HER-2–positive cases than those without such a history. Overall, this study found a significant association between BMI and first-degree family history with HER-2 molecular phenotype in patients with breast cancer NST. These findings underscore the importance of early detection, enhanced risk factor education, and close monitoring among individuals with elevated BMI and positive family history. The results are expected to support the development of clinical and preventive strategies for breast cancer management at RSUD Raden Mattaher Jambi.

Hubungan Antara Usia dan Tempat Tinggal dengan Fenotipe Molekular ER pada Pasien Invasive Carcinoma Mammae of No Special Type (Nst) di RSUD Raden Mattaher Melly Miranda
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Breast cancer of No Special Type (NST) is the most common histological subtype of breast malignancy and demonstrates diverse molecular phenotypes, including the expression of Human Epidermal Growth Factor Receptor-2 (HER-2), a key marker associated with tumor aggressiveness and therapeutic response. Risk factors such as nutritional status measured through Body Mass Index (BMI) and the presence of a first-degree family history of breast cancer are suspected to be associated with molecular phenotypes; however, local evidence remains limited. This study aimed to analyze the association between BMI and first-degree family history with HER-2 molecular phenotype among patients diagnosed with breast cancer NST at RSUD Raden Mattaher Jambi.This analytic observational research employed a cross-sectional design. Data were collected from medical records, including BMI values, first-degree family history, and HER-2 expression determined through immunohistochemistry (IHC). Statistical analysis using the Chi-Square test was conducted to assess the relationship between the independent variables and the HER-2 phenotype. The results indicated that most patients were categorized as overweight or obese. There was a tendency for patients with higher BMI to show a greater proportion of HER-2–positive expression compared with those with normal BMI. Additionally, patients with a first-degree family history of breast cancer exhibited a higher proportion of HER-2–positive cases than those without such a history. Overall, this study found a significant association between BMI and first-degree family history with HER-2 molecular phenotype in patients with breast cancer NST. These findings underscore the importance of early detection, enhanced risk factor education, and close monitoring among individuals with elevated BMI and positive family history. The results are expected to support the development of clinical and preventive strategies for breast cancer management at RSUD Raden Mattaher Jambi.

Hubungan Kadar Trombosit dan Hematokrit Terhadap Mortalitas Pasien Stroke Iskemik Fase Akut Pela Meyadsa
SCIENTIA JOURNAL Vol. 14 No. 1 (2025): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Ischemic stroke is a major medical condition with a high mortality rate, particularly during the acute phase. Various factors influence the prognosis and mortality of ischemic stroke patients, including hematological factors such as platelet count and hematocrit levels. This study aims to analyze the relationship between platelet count and hematocrit levels with mortality in acute ischemic stroke patients in the hospital. This study used an observational analytic design with a cross-sectional approach. Data were collected from medical records of patients admitted to the intensive care unit (ICU) and inpatient ward with a diagnosis of acute ischemic stroke between January and December 2025. Platelet count and hematocrit levels were measured on the first day of hospital admission and correlated with 30-day mortality. Statistical analysis was performed using the Chi-Square test to assess the relationship between the independent variables (platelet count and hematocrit levels) and the dependent variable (mortality). The results of the study showed that patients with higher platelet counts and lower hematocrit levels had a significantly higher risk of mortality compared to other groups. These findings suggest that elevated platelet count and low hematocrit levels may serve as important prognostic indicators in predicting mortality in acute ischemic stroke patients. This study provides additional insights into the importance of monitoring hematological factors in the management of acute ischemic stroke patients and could serve as a foundation for developing more targeted therapeutic strategies.

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Hafiz Muchti Kurniawan

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lppm.unaja@gmail.com

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Location
Kota jambi,

Jambi

INDONESIA

Abstract

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Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Hafiz Muchti Kurniawan

Contact Email hafezkurniawan84@gmail.com

Phone -

Journal Mail Official lppm.unaja@gmail.com

Editorial Address -

Location Kota jambi, Jambi INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Hafiz Muchti Kurniawan

Contact Email
hafezkurniawan84@gmail.com

Phone
-

Journal Mail Official
lppm.unaja@gmail.com

Editorial Address
-

Location
Kota jambi,

Jambi

INDONESIA