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Eksakta : Berkala Ilmiah Bidang MIPA
Published by Universitas Negeri Padang
ISSN : -     EISSN : 25497464     DOI : https://doi.org/10.24036/eksakta/
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering
Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) is an open access journal and peer-reviewed that publishes either original article or reviews. The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine & public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. This Journal Is Published at 3 Month intervals on January-Marc, April-June, July-September and October-December
Arjuna Subject : Umum - Umum
Articles 415 Documents
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Risk Assessment of Household Water Facilities Based on Physicochemical Water Quality and Sanitary Inspection in Urban Bengkulu, Indonesia Riang Adeko; Moh.Gazali; Aplina Kartika Sari; Zainal Arifin
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/704

Abstract

Safe household water should be acceptable, chemically stable, and protected from sanitary hazards to support urban public health. However, facilities in dense settlements remain vulnerable to contamination from wastewater, limited sanitation, groundwater dependence, and inadequate protection. This condition is evident in Bengkulu, where residents use piped water, dug wells, and bore wells with different vulnerability levels. Integrated assessment combining physicochemical measurement, sanitary inspection, and spatial mapping is needed to identify priorities. This study aimed to assess water-facility risk based on physicochemical water quality and sanitary inspection in Bengkulu. Sanitary risk was assessed using a standardized sanitary inspection checklist adapted from WHO-based household water facility inspection principles, and risk categories were determined from the cumulative sanitary hazard score. A quantitative cross-sectional study was conducted on 2,772 facilities. Data were analyzed using descriptive statistics, Kruskal–Wallis, Chi-square, Cramer’s V, Spearman correlation, ordinal logistic regression, and spatial mapping. Results showed that 60.89% were low risk, 31.64% medium risk, and 7.47% high risk. Dug wells showed higher risk, while odor, turbidity, facility type, and septic-tank distance were key determinants. Spatial mapping indicated that high-risk urban villages should be prioritized for sanitation improvement, monitoring, and interventions.
Integrative Transcriptomic and Docking Analysis of Coffee Bioactives Targeting CCNA2, AKT1, and CDK2 in TNBC Ida Neni Haryanti; Linda Erlina; Ade Arsianti; Aryo Tedjo
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/707

Abstract

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by high proliferation rates, poor prognosis, and limited therapeutic options. Coffee-derived bioactive compounds have demonstrated potential anticancer properties, but their interactions with key TNBC-associated targets remain insufficiently understood. Therefore, this study aimed to identify molecular biomarkers and therapeutic targets in TNBC and evaluate the potential of major coffee bioactive compounds using an integrative in silico approach. Five Gene Expression Omnibus (GEO) datasets (GSE38959, GSE186102, GSE65194, GSE45827, and GSE7904) were analyzed to identify differentially expressed genes (DEGs) using |log2FC| ≥ 1 and adjusted p-value < 0.05. Protein–protein interaction analysis, machine-learning validation, Kaplan–Meier survival analysis, chemogenomic mapping, molecular docking, and ADMET prediction were subsequently performed. A total of 917 overlapping DEGs were identified, with CCNA2 emerging as a key hub gene associated with poor prognosis. Machine-learning validation achieved 97.7% accuracy and an AUC of 0.964. Chemogenomic analysis prioritized AKT1, CDK2, and CCNA2 as therapeutic targets. Molecular docking revealed favorable interactions of caffeic acid and chlorogenic acid, with caffeic acid showing the most consistent multitarget affinity (−5.94 to −6.96 kcal/mol). These findings suggest that caffeic acid is a promising multitarget candidate for TNBC therapy and warrants further experimental validation.
Evaluation of Horizontal Geometric Accuracy and Area Differences of the Indonesian Topographic Base Map (RBI) Using GNSS RTK Measurements Yastin David Batara; Muhammad Ikhsan
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/709

Abstract

This study evaluates the horizontal geometric accuracy and area representation of the 1:50,000 Indonesian Topographic Base Map (RBI) using Global Navigation Satellite System Real-Time Kinematic (GNSS RTK) measurements as reference data. The study was conducted within a 29.937 ha area in Raden Village, Tanah Laut Regency, South Kalimantan Province, Indonesia. Horizontal accuracy assessment was performed using 12 boundary vertices identified from corresponding features in both the RBI map and field observations. Positional differences were quantified using the Root Mean Square Error (RMSE) and Circular Error at the 90% confidence level (CE90), while area differences were evaluated by comparing RBI-derived and GNSS RTK-derived boundaries. The results indicate RMSEx and RMSEy values of 11.638 m and 21.766 m, respectively, resulting in a CE90 value of 44.848 m. Although the evaluated RBI map satisfies the horizontal accuracy requirement for a Class 3 map according to BIG Regulation No. 6 of 2018, the CE90 value is close to the maximum allowable threshold of 45 m. In addition, the RBI-derived area underestimated the GNSS RTK-derived area by 9,332 m² (0.933 ha) or 3.12%. 
Identification of Fault Structures Using First Horizontal Derivative and Second Vertical Derivative Analysis of Gravity Data in the Sumedang Area, West Java Laudrien Natarissa; Noor Muhammad Indragiri; Mochamad Ervan; Hesty Sampeliling; Budy Santoso
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/698

Abstract

Sumedang is a region with complex tectonic activity, making the identification of subsurface fault structures essential for understanding geological conditions and potential geohazards. This study aims to identify subsurface fault structures in Sumedang, West Java, using gravity data through First Horizontal Derivative (FHD) and Second Vertical Derivative (SVD) analysis. A total of 271 Bouguer anomaly data points were analyzed through regional–residual anomaly separation, spectral analysis, derivative analysis, and 2D forward modeling. Spectral analysis estimated average regional and residual depths of 9188.13 m and 2564.5 m, respectively. Fault interpretation was conducted based on the relationship between the SVD zero points and the extreme values of the FHD, supported by residual anomaly contrasts. The results indicate reverse faults, normal faults, and strike-slip faults with reverse components. The identified structures include the Baribis Fault on lines 5 and 7, the Rajamandala Fault on line 1, and the Cimanuk Fault on line 5, consistent with the Java–Bali–NTB active fault database. The 2D modeling results reveal the presence of younger sediment, older sediment, and basement. The study demonstrates that the combination of FHD and SVD analysis is effective for identifying subsurface fault structures in tectonically complex regions such as Sumedang.
Universal Health Coverage Achieves Equitable Maternal Healthcare Quality Among JKN Participants Romhana Alifah; Asri Hidayat; Wantonoro
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/711

Abstract

Universal Health Coverage (UHC) aims to ensure equitable access to quality healthcare services regardless of socioeconomic status. Maternal healthcare quality is a key indicator of UHC implementation because it directly influences maternal and neonatal outcomes. Although Indonesia has expanded healthcare coverage through the National Health Insurance (JKN) program, evidence regarding equity in maternal healthcare quality between Penerima Bantuan Iuran (PBI) and non-PBI participants remains limited. This study aimed to analyze differences in maternal healthcare service quality between PBI and non-PBI JKN participants at RSUD Dr. H. Moh. Anwar Sumenep. A quantitative cross-sectional study was conducted among 94 respondents, consisting of 47 PBI and 47 non-PBI participants selected using a non-probability quota sampling technique. Data were collected using a SERVQUAL-based questionnaire and analyzed using the Mann–Whitney U test. Significant differences were found in responsiveness (p = 0.029) and assurance (p = 0.045). However, no significant differences were observed in tangible (p = 0.197), reliability (p = 0.154), empathy (p = 0.111), or overall service quality (p = 0.063). These findings suggest generally comparable maternal healthcare quality between financing categories, although improvements in responsiveness, communication, and service assurance remain necessary to support UHC objectives.
VES-GIS Application for Groundwater Potential and Aquifer Identification in Talang Kelapa District, Banyuasin, South Sumatra Arif Muhammad; Andjarila Nurryska; Rizka
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/713

Abstract

Talang Kelapa District faces serious challenges regarding a high risk of groundwater drilling failure due to extreme lithological heterogeneity in the Gumai Formation. This study aims to identify aquifer geometry characteristics and accurately map groundwater potential zones to support sustainable water resource management. The method integrates Geographic Information System-Analytical Hierarchy Process (GIS-AHP) spatial analysis using six parameters: regional geology, slope, rainfall, drainage density, land use/land cover (LULC), and soil type. Subsurface validation was conducted using Vertical Electrical Sounding (VES) geophysical surveys with the Schlumberger configuration at six observation points to determine vertical resistivity profiles. The results show that the primary hydrogeological target is an unconfined aquifer system within sandstone layers, characterized by depths of 2.4–16.8 m and thicknesses reaching 21.9 m. The integration of these two methods produced a significant positive correlation between the Groundwater Potential Index (GPI) score and the actual aquifer thickness from VES, yielding a coefficient of determination (R2) value of 0.76. This study concludes that an integrative multi-criteria approach is an effective exploration instrument for recommending optimal drilling depths and minimizing technical exploration risks.
Antihyperglycemic Activity of Methanolic Annona muricata L. Leaf Extract Nanoemulsion in Alloxan Induced Mice Desfira Syahrani; Ratih Dyah Puspitasari; Dina Erliana; Munifilia Ekasari
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/690

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and oxidative stress-related organ damage, including liver injury. This study evaluated the antihyperglycemic activity and liver histopathological effects of a nanoemulsion containing methanolic extract of Annona muricata L. leaves in alloxan-induced rats. The nanoemulsion exhibited an average droplet size of 13.96 nm and a polydispersity index of 0.216. Thirty-five male rats were divided into seven groups: normal control, negative control, positive control (glibenclamide), nanoemulsion-treated groups (140 and 280 mg/kg body weight), and conventional extract-treated groups at the same dose. Blood glucose levels were measured on days 0, 3, and 17, while liver histopathology was evaluated using hematoxylin-eosin staining. Alloxan induction caused severe hyperglycemia and liver damage characterized by congestion, inflammatory cell infiltration, vacuolization, fatty degeneration, and necrosis. Both nanoemulsion and conventional extract treatments significantly reduced blood glucose levels compared with the negative control. Nanoemulsion at 280 mg/kg body weight produced the greatest antihyperglycemic effect, reducing blood glucose levels by 79.8%, whereas the conventional extract reduced them by 77.1% at the same dose. Histopathological findings also demonstrated improved liver structure and reduced tissue damage, particularly in nanoemulsion-treated animals. These results suggest enhanced biological performance and therapeutic potential.
Clinical Efficacy and Safety of Topical Microbiome Modulation for Acne Vulgaris: A Systematic Review of Clinical Studies Published Between 2020 and 2025 Gandhi Innas Salsabil; Nieke Andina Wijaya
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/714

Abstract

Acne vulgaris is common chronic inflammatory disorder in which effective treatment should control lesions while preserving skin barrier function and microbial homeostasis. In clinical practice, standard topical therapies may cause irritation, while prolonged antibiotic exposure raises antimicrobial resistance concerns. Topical microbiome modulation has therefore emerged as a targeted strategy using postbiotics, probiotic-derived products, and bacteriophages. This systematic review evaluated the clinical efficacy and safety of these interventions. Following PRISMA 2020, PubMed, ScienceDirect, and Google Scholar were searched for primary human studies published from 2020 to 2025. Five studies met the eligibility criteria. LactoSporin reduced sebum from 106.74 ± 9.78 to 61.41 ± 7.91 µg/cm² after 21 days, a 42.4% reduction. A Lactiplantibacillus plantarum ferment lysate improved acne lesions in 59.1% of participants and reduced sebum in 72.7% by week 4. A Lactobacillus paracasei-derived lotion produced inflammatory-lesion improvement comparable with 2.5% benzoyl peroxide and fewer treatment-associated adverse effects,7.69% versus 26.92%. Bacteriophage BX001 reduced facial Cutibacterium acnes burden, although standardized clinical lesion endpoints were limited. Overall risk of bias was low to moderate, mainly because of small samples, open-label designs, and incomplete blinding. Topical microbiome modulation is promising as adjunct or alternative, but current evidence does not establish superiority over standard therapy.
A Decision-Making Framework for Supplier Selection in High Tech Industry Based on Analytical Hierarchy Process Vera Methalina Afma; Rika Ampuh Hadiguna; Alexie Herryandie Bronto Adi; Tzong-Ru (Jiun-Shen) Lee; Nikorn Sirivongpaisal
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/718

Abstract

In the high-tech industry, effective supply chain management is essential to ensure product quality, innovation, competitiveness, and sustainability. Ideally, supplier selection should be conducted using  comprehensive framework that balances economic, quality, environmental, governance, and social considerations. This situation highlights the urgency of developing a structured and reliable approach for sustainable supplier evaluation. Therefore, this study aims to identify and prioritize the criteria and subcriteria required for sustainable supplier selection in the high-tech industry using the Analytical Hierarchy Process (AHP). Through literature reviews and expert interviews, five main criteria and 25 subcriteria were established. Pairwise comparisons were conducted by three experts with extensive supplier management experience, and the results were analyzed using geometric mean calculations, normalization, and consistency ratio testing. The findings show that economic criteria have the highest priority (0.490), followed by quality (0.253), environment (0.109), governance (0.083), and social factors (0.064). Key subcriteria include long-term price consistency, technical troubleshooting support, RoHS compliance, ISO 9001 certification, and material purity. The proposed framework provides a practical solution for decision-makers to select sustainable suppliers, enhance competitiveness, and support long-term collaboration. Although the consistency ratios indicate reliable results, future studies should involve a larger and more diverse group of experts to improve generalizability.
Mapping Research on BPJS Claims Management and Hospital Reimbursement: A Bibliometric Analysis Sofara Rezanti; Ekorini Listiowati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/721

Abstract

 In Indonesia, however, the near-universal coverage achieved by BPJS Kesehatan has not been matched by efficient claims governance: reimbursement deficits and administrative bottlenecks persist, while evidence remains fragmented across separate epidemiological, economic, and administrative research streams that rarely intersect. This fragmentation is especially consequential during 2020-2025, the post-pandemic transition when claim volumes surged and digital verification expanded, yet no synthesis has mapped how research responded. Consolidating this evidence is therefore essential for guiding hospital management and BPJS Kesehatan policy. This study applied bibliometric analysis to Scopus-indexed, Indonesia-affiliated publications from 2020 to 2025, narrowing 25,270 initial records to 50 documents analysed in VOSviewer through keyword co-occurrence mapping. Unlike earlier Indonesian bibliometric studies on health policy or bibliometrics broadly, this study is the first to chart specifically the intellectual structure of BPJS claims and hospital reimbursement research. Five thematic clusters emerged: health outcomes and disease burden (32%), economic evaluation and cost analysis (21%), hospital reimbursement systems and financial management (19%), health policy and UHC (15%), and healthcare access and service delivery (13%), with annual publications rising from seven-eight to thirteen by 2025. Operational aspects, including digital claims verification and reimbursement governance, remain underexplored and should guide future research and hospital practice.

Page 41 of 42 | Total Record : 415

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