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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
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Articles 12 Documents
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Search results for , issue "Vol 42, No 3 (2022)" : 12 Documents clear
Factors Affecting the Outcomes of COVID-19 Patients Treated at Dr. M. Djamil Padang General Hospital Yessy Susanty Sabri; Dewi Wahyu Fitrina; M. Hari Nandi Pinto; Lusi Agustini Arda; Nova Indriyani; Kornelis Aribowo; Ilham Ilham; Dimas Bayu Firdaus
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.273

Abstract

Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality. This study aimed to determine the factors that influenced the outcomes of COVID-19 patients treated at RSUP. Dr. M. Djamil Padang.Methods: This was an observational analytic study conducted with a retrospective cohort design on COVID-19 patients at RSUP Dr. M. Djamil Padang. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients were analyzed using Chi- Square/Fisher Exact Test.Results: Majority of the patients were female (56.4%) and aged above 50 years (64.3%). Hypertension was the most common comorbidity (41.1%). Diabetes mellitus affected the final outcome of treatment. The number of comorbidities the patients had was associated with a worse outcome for COVID-19.Conclusion: Most of COVID-19 patients at RSUP Dr. M. Djamil Padang were male and more than 50 years old. There was a correlation between age, gender, and comorbidities in COVID-19 patients with the outcomes.
Correlation of Antibiotic Resistance with Sepsis Incidence, Hospital Mortality, and Time of Sepsis Onset in Community Acquired Bacterial Pneumonia Kresentia Anita Raniputri; Harsini Harsini; Reviono Reviono; Leli Saptawati
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.359

Abstract

Background: Community acquired pneumonia is associated with high morbidity and mortality. Treatment of multidrug-resistant organisms (MDRO) infection in pneumonia is a challenge. Antibiotic resistance is a major factor determining clinical treatment unresponsiveness and rapid progression to sepsis. Septic patients with MDRO have a higher hospital mortality. The correlation of antibiotic resistance with the incidence of sepsis and hospital mortality is yet to be known. This study analyzed the correlation of antibiotic resistance with sepsis incidence, hospital mortality, and time of sepsis onset.Methods: Retrospective cohort study of patients with community acquired bacterial pneumonia from July-December 2019 at RSUD Dr. Moewardi. The correlation between antibiotic resistance and incidence of sepsis, hospital mortality was tested by using Chi Square and Fisher's exact test correction. Association between two variables with relative risk. Survival analysis and log rank test were used to examine the time differences of sepsis onset.Results: There was a correlation between antibiotic resistance and incidence of sepsis in community acquired bacterial pneumonia (r = 0.417, p = 0.000) with RR = 4,294 (95% CI 2,886-6,390). The median time of sepsis onset was day 0 in the MDRO group and day 4 in non-MDRO group (p = 0.000).Conclusion: There is a correlation between antibiotic resistance and incidence of sepsis in community acquired bacterial pneumonia with a fairly strong and significant correlation value. The presence of antibiotic resistance increases the incidence of sepsis fourfold. Antibiotic resistance also affects the time of sepsis onset.
Surfactant Protein D Level in Cement Workers Nurlinah Jalil; Sita Laksmi Andarini; Muhammad Ilyas; Feni Fitriani Taufik
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.280

Abstract

Background: Pneumoconiosis occurs almost all over the world. Pneumoconiosis is a threat to cement workers. Serological abnormalities are observed in pneumoconiosis. Surfactant protein D (SP-D) levels were increased in workers exposed to silica. SP-D may be useful as a biomarker for the early diagnosis of pneumoconiosis but it has not been studied in Indonesia.Methods: This cross-sectional study was conducted with consecutive sampling technique. The number of subjects was 61 people, consisting of 44 workers exposed to cement and 17 controls from September 2017 to March 2018. Serum level of SP-D was measured using ELISA method. Cement exposed workers were workers in the production area and workers in quarry areas.Results: All of the study subjects were male (100%) with mean age of 42.5 years old. The youngest and oldest subjects were 21 and 55 years old, respectively. Majority of the subjects was in the normal weight group (47.7%). Based on smoking history, there were 26 subjects (59.1%) had never smoked, 12 subjects (27.3%) as smokers, and 6 subjects (13.6%) as former smokers. Duration of exposure <10 years was found in 9 subjects (20.5%) while exposure ≥10 years was observed in 35 subjects (79.5%). Good category of using self-respiratory safety instrument was observed in 5 subjects (11.4%), moderate category in 36 subjects (81.8%) and poor category in 3 subjects (6.8%). Mean serum SP-D levels in the exposed group was 111.027 ng/ml and in control group was 67.648 ng/ml. Serum SP-D levels were significantly higher in the exposed group than control group (P=0.014).Conclusion: Serum SP-D levels was statistically higher in the exposed group than in control group.
The Difference in Serum Levels of IP-10 in Pulmonary Tuberculosis Patients with Positive AFB and AFB Conversion Said Muchsin; Herry Priyanto; Teuku Zulfikar; Novita Andayani; Budi Yanti; Ferry Dwi Kurniawan
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.358

Abstract

Background: Tuberculosis (TB) is caused by Mycobacterium tuberculosis, which most commonly infects the lungs. Diagnostic modalities are required in smear-negative TB. IP-10 is a potent chemokine for detecting the presence of TB infection. This study aimed to determine the difference in serum IP-10 levels in patients with smear-positive pulmonary TB and pulmonary TB patients with AFB conversion after two months of therapy.Methods: This was an analytic observational study with a cross-sectional approach. Sampling was carried out by consecutive sampling methods. AFB examination was performed using Ziehl-Neelsen staining, and serum IP-10 was measured using ELISA.Results: The study results obtained mean IP-10 levels in TB patients with smear positive and AFB conversion after two months of treatment of 459 pg/mL and 204.4 pg/mL, respectively. Statistical analysis using independent t-test received P<0.0001. The optimal cut-off value was 306,1 pg/ml (90% sensitivity; 95% specificity; area under the curve: 0.948, 95% CI=0.88-1; P=0.0001). Conclusion: There was a significant difference between IP-10 levels in TB patients with smear positive and AFB conversion
Characteristics of EGFR Gene Mutation in Lung Adenocarcinoma at Adam Malik General Hospital Novita Margaretta Ambarita; Noni Novisari Soeroso; Setia Putra Tarigan; Fotarisman Zalukhu
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.156

Abstract

Background: Epidermal growth factor (EGFR) is a transmembrane receptor that plays an important role in the development of cancer phenotypes. Some patients with lung cancer have genetic mutations. Several studies have found a close correlation of EGFR gene mutation with 15-20% of lung adenocarcinoma cases. This study aimed to determine the EGFR profile in adenocarcinoma lung cancer patients at Haji Adam Malik General Hospital.Methods: This was a prospective cohort study conducted at Haji Adam Malik General Hospital, Medan. This study used patients data for 3 years, starting from January 1, 2014 to D1ecember 31, 2016. The sample size in this study was 34 patients. The data were then analyzed using SPSS.Results: All patients were adenocarcinoma lung cancer patients with positive EGFR mutation. There were 9 subjects with EGFR mutation in exon 19; 11 subjects with exon 21 L858R mutation; and 3 subjects with exon 21 L861Q mutation. Meanwhile, there were 3 subjects with uncommon EGFR mutations, namely exon 18 mutation. Majority of subjects with exon 19 mutation were male, aged >60 years, smokers with mixed types of cigarettes and severe brinkmann index. In subjects with exon 21 L858R mutation, most of the patients were male, aged 50-60 years, smokers with mixed cigarette types and severe brinkmann index. The same characteristics were also observed in subjects with exon 18 mutation. However, for exon 21 L861Q mutation, the majority of subjects were female with varying ages, and were not smokers.Conclusion: Most of the study subjects profiles were male, aged over 60 years, smokers, with mixed types of cigarettes, and with severe Brinkman Index. The EGFR mutations most commonly occured in exon 21, followed by exon 19 (ins/del exon 19), exon 18, and a combination of 2 exons.
The Effect of Sisha on Respiratory Health Hayatun Naimah; Ami Kallistasari; Cut Rahma Fazwa Emas Anda; Iqbal Mochtar
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.309

Abstract

Smoking sisha is  considered a more socially acceptable activity in Middle East. The prevalence of sisha smokers varies among adolescent in the Middle East. Smoking sisha involves burning tobacco with a certain aroma, commonly referred to as molasses, and burning it using coal. Some people consider sisha a safer alternative to cigarettes, but some of evidence show the harmful and detrimental respiratory health effects associated with the use of sisha.
Factors Affecting the Treatment Success of Short-Term Regimen for Drug Resistant Tuberculosis (DR TB) Patients at Dr. Saiful Anwar General Hospital Malang Fahmi Adhi Prasetya; Yani Jane Sugiri; Teguh Rahayu Sartono; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.360

Abstract

Background: Tuberculosis/TB is a major health problem in the world. Indonesia ranks 3rd in TB cases and 7th in drug resistant (DR) TB cases in the world. In 2016, WHO recommended short term (9–11 month) regimen treatment with a success rate of 84% in several Asian and African countries. The purpose of this study was to determine factors that influence the success and failure of treatment using short-term regimen for DR TB patients at Dr. Saiful Anwar General Hospital Malang.Methods: This was an analytic observational study with retrospective cohort design on 85 short-term regimen DR TB patients who started treatment on October 1, 2017 to September 30, 2018 at the DR TB ward of Dr. Saiful Anwar General Hospital Malang. Data analysis used chi square test with alternative fisher exact test and logistic correlation test.Results: Education level had a significant correlation with treatment success (P=0.036; OR=2.746; CI 95%=1.053-7.165) while Pre XDR TB sputum drug susceptibility test had a significant correlation with treatment failure (P=0.037; OR=1.556; CI 95%=1.180-2.050). Based on logistic correlation test, the predictive variables for treatment outcomes were age, education, criteria for suspected DR TB and drug susceptibility test results of pre XDR TB.Conclusion: The level of education affected the success treatment of DR TB short-term regimen. The results of Pre XDR TB sputum drug susceptibility test influenced the failure of DR TB short-term regimen.
Clinical Characteristic and Outcome of COVID-19 Patients Using High Flow Nasal Oxygen in Persahabatan Hospital, Jakarta Wahyu Soebekti; Feni Fitriani Taufik; Mia Elhidsi
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.367

Abstract

Background: Severe and critical COVID-19 patient need intensive care and even invasive mechanical ventilation. Use of high flow nasal oxygen (HFNO) in acute hypoxemic respiratory failure on non-COVID-19 patient can reduce the need for intubation while in COVID-19 patient the data is still inadequate.Methods: This is a retrospective cohort study in 62 confirmed COVID-19 patient using HFNO and treated at Persahabatan Hospital from March to July 2020. Demographic, clinical and laboratory data before HFNO and vital sign, respiratory index after 24 hours of HFNO was taken from medical record. Results: Majority of patients are men (67%), mean age 57.6 years, comorbidity is mostly hypertension and diabetes. HFNO Success outcome is 45.2%. Statistically significant difference between success and failure group is noted on respiratory rate (24 vs 28.5), pulse rate (88.14 vs 100), oxygen saturation (98 vs 94), PaO2/Fio2 (139.27 vs 73), SpO2/FiO2 (116.98 v 102.78) and ROX index (4.97 vs 3.5). Vital sign and respiratory index measured after 24 hours of HFNO showed statistically significant improvement in success group. Conclusion: HFNO can reduce intubation rate in patient with COVID-19. Vital sign and respiratory index are significantly improved in HFNO success group.
Long COVID: Diagnosis and Treatment of Respiratory Syndrome in Post COVID-19 Conditions Erlina Burhan
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.279

Abstract

The ongoing COVID-19 pandemic has given rise to another medical burden that came from the symptoms experienced by patients after acute infection with SARS-CoV-2, a condition often called as Long COVID. As the number of COVID-19 cases remain rising, various studies and scientific researches are being conducted to understand more about Long COVID, and findings have consistently shown increased burden due to Long COVID that needs more attention from the clinical world. This article review collects various sources regarding the diagnosis and management of respiratory syndrome in post-COVID-19 conditions. Long COVID, currently referred to as a post-COVID-19 condition, consists of symptom(s) that occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, with symptoms lasting at least two months and cannot be explained by any alternative diagnosis. Symptoms that occur are very diverse from various organ systems, including the respiratory system. Knowledge regarding the possible symptoms as well as a thorough evaluation is needed to identify and diagnose post-COVID-19 conditions, and multidisciplinary management through a tiered system may help reach more cases of post-COVID-19 conditions. The treatment for post-COVID-19 conditions needs to be adjusted to the patient's condition, and the administration of pharmacological therapy such as steroids, bronchodilators, and mucolytics/antioxidants has to be based on clinical symptoms and radiological abnormalities.
Comparison of Serum Vitamin C Levels Between Pulmonary Tuberculosis and Healthy Controls in Medan Rizka Helmi; Bintang Yinke Magdalena Sinaga; Parluhutan Siagian; Putri Eyenoer
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.364

Abstract

Background: Pulmonary tuberculosis infection is a high burden, especially in developing country. Vitamin C is a water-soluble micronutrient that contributes to immune defense by supporting avarietyof innate and adaptive immunity. Vitamin C protects the host from reactive oxygen and reactive nitrogen intermediates generated during Mycobacterial infection. Pulmonary tuberculosis patients have lower vitamin C levels because Mycobacterium tuberculosis infection produces reactive oxygen species for replication as well asmetabolism and also because of reduced nutrient intake. Vitamin C as an antioxidant also plays role in killing Mycobacterium tuberculosis by encouraging Fenton reaction.Methods: This is a case control study of serum vitamin C levels in pulmonary tuberculosis patients and healthy controls. Vitamin C levels were measured by ELISA (Enzyme Linked Immunosorbent Assay).Results: The number of subjects was 40 people, divided into 20 subjects of pulmonary tuberculosis as cases and 20 healthy controls, aged between 18–65 years old. Vitamin C levels according to age group were 99.03±38.60 ng/ml and 80.53±27.38 ng/mlfor18–30 years, 84.85±49.69 ng/ml and 82.70±14.93ng/ml for31–40 years, 61.34±25.36 ng/ml and 79.93±22.81 ng/ml for41–50 years, 71.43±18.36 ng/ml and 78.69±54.21 ng/ml for51–65 years. Vitamin C levels of male subjects based on case and control groups were 88.11±42.07 ng/ml and 78.36±28.95 ng/ml while for the female were 73.20±11.56 ng/ml and 83.16±23.77 ng/ml. Mean vitamin C levelin pulmonary tuberculosis patients was 83,64±35,99 ng/ml and in healthy controls was80,22±26,44 ng/ml.Conclusion: There was no significant difference in vitamin C levels between pulmonary tuberculosis patient and healthy people.

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