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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
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Articles 10 Documents
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Search results for , issue "Vol 43, No 1 (2023)" : 10 Documents clear
The Role Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome Widhy Yudistira Nalapraya; Menaldi Rasmin; Zuswayudha Sjamsu
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.436

Abstract

Treatment of oxygen therapy should be based on appropriate indication and dose of administration. British Thoracic Society (BTS) recommends oxygen therapy were administered with a 94–98% saturation target in most acute patients and for patients with hypercapnic respiratory failure, BTS recommends 88-92 saturation target or spesific saturation target. Acute respiratory distress syndrome (ARDS) is characterized by acute, diffuse, inflammatory lung injury leading to increased capillary permeability in the alveolus with clinical manifestations of hypoxemia and bilateral opafication. The use of extracorporeal membrane oxygenation (ECMO) along with mechanical ventilator can be useful for ARDS patients and can improve survival.
High Levels of Leucocyte and Thrombocyte Increasing COVID-19 Mortality Rate in RSUP Dr. M. Djamil Padang Maulana Muharam; Sabrina Ermayanti; Afriani Afriani
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.239

Abstract

Background: Different leukocytosis, leucopenia, thrombocytosis, thrombocytopenia, and clinical severity appear in COVID-19's cases. This study is aimed to identify the association between leucocyte, thrombocyte, and clinical severity in COVID-19's outcome.Methods: A retrospective cohort study involving 121 patients with COVID-19 whom admitted from January to March 2021. Kruskal Wallis test was applied for analysis.Results: The majority of participants were female (55.4%), aged between 18-49 years old (42.1%), and had comorbidities (81.8%). Most participants had a normal range of leucocyte (57.9%), thrombocyte (62.8%), and moderate clinical severity (67.8%). Subjects with full recovery were 79.3%, with sequelae such as weakness, and/or shortness of breath 3.3%, and deceased 17.4%. Leucocyte and thrombocyte had an association with COVID-19 outcome (P=0.045 and P=0.030 respectively). Clinical severity had no association with COVID-19 outcome (P=0.304). Conclusion: Leucocyte and thrombocyte have an association with COVID-19 outcome. Clinical severity has no association with COVID-19 outcome.
p21 Genetic Modification as a Tumor-Suppressor Gene: A Future Target in Lung Cancer Therapy? Adityo Wibowo; Silvana Saputri
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.438

Abstract

Lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Although early diagnosis/screening methods and treatment strategies have developed, lung cancer patient survival rates remain low. However, resistance to chemotherapy and radiotherapy causes tumor recurrence and worsening of the disease, thus being the lead cause of treatment failure. In the growth cycle of lung cancer cells, the highest p21WAF1/CIP1 gene expression was found in early-stage lung cancer and decreased in advanced lung cancer. In addition, the association between CDK inhibitors and patient survival showed that inactivation of the p21WAF1/CIP1 and p16INK4a genes was associated with lower overall survival and poor prognosis. In this review, we will focus on the role of genetic modification in lincRNA-p21 in lung cancer therapy and the importance of a combination therapeutic approach.
Delayed Treatment and Adverse Effects of Drug Resistance Tuberculosis Impact on Outcome, Survival and Quality of Life Linda Soebroto; Reviono Reviono; Yusup Subagio Sutanto; Farih Raharjo; Jatu Aphridasari
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.259

Abstract

Background: Global TB Report 2020 states that 78% of tuberculosis patients experience drug resistancy with a global treatment success rate of 57%. Drug resistance tuberculosis (DR TB) patients whom experience side effects such as arthralgia and hyperuricemia with inadequate treatment will affect the treatment result.Methods: Retrospective cohort study to DR TB patients who underwent treatment from January 2015 to August 2020 at RSUD dr. Moewardi Surakarta. Survival analysis using Kaplan Meier method and Cox regression test for the effect of risk factors on the safety and survival of TB RO patients. Quality of life analysis using Mann Whitney test.Results: From 372 patients, delayed treatment factor (OR=2.906; 95% CI=1.890-4.469; P≤0.001) and arthralgia factor (OR=1.775; 95% CI=1.148-2.744; P=0.010) were variables that had a significant effect on recovery of DR TB patients. Delayed treatment and arthralgia have risk (2,906 times and 1.775 times) for non-recovered DR TB patients. Delayed treatment factor with HR=14.772 (95% CI=13.381-16.163), arthralgia with HR=15.170 (95% CI=13.960-16.379), and anemia with HR=15.304 (95% CI=14.074-16.535; P=0.002) affect on the survival of DR TB patients. Anemia affect on the quality of life DR TB patients.Conclusion: Delayed treatment for more than 14 days and arthralgia that is not treated adequately can affect the recovery of DR TB patients. The survival and quality of life of DR TB patients can be increased by monitoring the time of taking medication, monitoring side effects of drugs such as arthralgia, and adequate nutritional intake so that anemia does not occur.
Pathophysiology of Haemoptysis in Lung Disease Airin Aldiani; Mohamad Fahmi Alatas
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.441

Abstract

Hemoptysis is expectoration of blood with or without sputum originating from the lower airway. Hemoptysis is an alarming symptom that couldlead to massive bleeding and life-threatening condition. Based on the underlying disease, hemoptysis can occur through several differentpathological mechanisms. Mostly, hemoptysis caused by bronchiectasis, pulmonary tuberculosis, lung cancer, and pulmonary fungalinfections. The incidence rate of the causative diseases can differ depending on its geographical location. Pulmonary vascularization consistsof two circulation pathways namely the pulmonary circulation and bronchial circulation, each of which has its own role. As many as 90% ofcases of hemoptysis are caused by collapse of the bronchial arteries, due to increased pressure in its circuit. It is important to understand thepathophysiology and pathomechanism of hemoptysis for further management on both diseases and also the clinical manifestasion.
Change in Exhaled Volatile Organic Compounds (VOC) Profile and Interleukin-17 Serum in Lung Cancer Patient Agil Dananjaya; Ungky Agus Setyawan; Susanthy Djajalaksana; Arinto Yudi Ponco Wardoyo
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.316

Abstract

Background: In recent years, there have been studies regarding biomarkers for early detection of lung cancer. The expansion of tumor is accompanied by distinct metabolic process product, which results in identifiable changes in the volatile organic compounds (VOC) emission profile. The content of such molecules differs between healthy and lung cancer patients. Furthermore, the expression of Interleukin-17 (IL-17) was linked to the clinical and pathological aspects of lung cancer patients. The aim of this study is to profile the exhaled VOC and the level of IL-17 in the serum of lung cancer patient.Methods: Fourty patients with confirmed lung cancer and 42 healthy subjects as control were gathered for this study. VOC was measured using breath analyzer and sensor array, while IL-17 was measured by ELISA. Statistical analysis was conducted using Kruskal-Wallis test and Spearman correlation test with P<0.05 considered significant.Results: We examined 15 VOCs and found that ethanol (C2H5OH), formaldehyde (CH2O), toluene (C7H8) and ammonia (NH3) in lung cancer patient were increased significantly compared to control (P<0.05; P<0.05; P<0.05 and P=0.001 respectively). However, the level of IL-17 in control subjects was higher (P=0.299) than patients with lung cancer. Conclusion: Ethanol, formaldehyde, toluene and ammonia can potentially be used as biomarkers for lung cancer. However, the role of IL-17 in lung cancer screening still needs further investigations.
The Degree of Inflammation and Length of Hospital Stay in Acute Exacerbation of COPD Patients After Secretome Administration Hendrastutik Apriningsih; Yusup Subagio Sutanto; Reviono Reviono; Artrien Adhiputri; Windu Prasetya; Fahlevie Fahlevie; Fitrotin Aziza
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.390

Abstract

Background: Acute exacerbation of COPD (AECOPD) is a decrease in respiratory conditions compared with regular conditions that require additional treatment, increase risk of hospitalization or demand intensive care unit. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system and is considered as an important systemic inflammatory marker. Length of hospital stay (LHS) is important in predicting the severity of AECOPD, in which longer LHS indicates greater severity of AECOPD. Secretome has been shown to have the ability to exert immunomodulatory effects, reduce lung injury and inflammation in several models of lung inflammation and immune-mediated lung disease. This study aimed to assess the differences between NLR and LHS in AECOPD patients who received a secretome and those who did not.Methods: This study involved 30 AECOPD patients whom assigned into two groups. Secretome and standard therapy were administered in the treatment group, whilst the control group only received the standard therapy. Statistical analysis used different test, the unpaired group difference test using Mann Whitney and the independent test, the paired group difference test using Wilcoxon rank test and Pair test. Result is significant if the P<0.05.Results: NLR value in the treatment group experienced a lower increase than the control group, yet statistically insignificant (P=0,187). Secretome decreased the LHS in AECOPD patients, and statistically significant with (P=0,028). Conclusion: Administration of secretome led to a lower increase in NLR value and decreased LHS AECOPD patients.
Risk Factors Associated with 28-Day Mortality of COVID-19 Patients at RSUP Dr. M. Djamil Padang Lusi Agustini Arda; Oea Khairsyaf; Russilawati Russilawati; Tuti Handayani
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.238

Abstract

Background: The COVID-19 mortality rate varies widely around the world. The COVID-19 death rate in Indonesia is currently relatively higher than the world average and is the highest in Southeast Asia. Data regarding risk factors of COVID-19 mortality in Indonesia, particularly West Sumatra, are still scarce. This study aims to determine the risk factors associated with the 28-day mortality of COVID-19 patients at RSUP Dr. M. Djamil Padang.Methods: This was an observational analytic study with a retrospective cohort approach on confirmed COVID-19 inpatients who were treated at RSUP Dr. M. Djamil Padang between January 1 and March 31, 2021. A bivariate analysis using Chi square was calculated to see the correlation between clinical severity, and routine blood values, markers of inflammation, liver function, kidney function, blood gas analysis, the RALE score and comorbidities with a 28-day mortality outcome. To assess the dominant risk factors, multivariate analysis was performed using logistic regression.Results: From 245 samples, patients aged >50 years and women were the most treated group of patients. Bivariate analysis obtained the following critical clinical grade factors: Hb <10 g/dl, leukocyte level >10.0x103/mm3, monocyte level 8.0%, procalcitonin level >0.5 ng/ml, interleukin-6 level >7 pg/ml, ferritin >159/ml, D-Dimer level >500 ng/dl, SGOT level >38 μ/l, urea >50 mg/dl, creatinine >1.3 mg/dl, PO2 <80 mmHg, SO2 ≤90%, PO2/FiO2 ≤300 mmHg, high RALE score, comorbid of chronic renal failure, hypertension, type II DM; and comorbidities >1 were associated with 28 days of death. Multivariate analysis identified critical clinical severity as the dominant risk factor (OR=8.47; 95% CI=2.55–28.14; P<0.001).Conclusion: Critical clinical severity was the dominant risk factor associated with the 28-day mortality of COVID-19 patients at RSUP Dr. M. Djamil.
Remdesivir in COVID-19: A Retrospective Analysis of Remdesivir Effectiveness and the Relation with Blood Type Variation Elsa Vera Denida Purba; Retnosari Andrajati; Nadia Farhanah Syafhan; Aditya Wirawan
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.392

Abstract

identify the profile of the effectiveness of Remdesivir (RDV) therapy and its relationship to blood type variations in COVID-19 patients at Universitas Indonesia Hospital (RSUI).Methods: Variations in blood types were examined for their influence on the effectiveness in Covid-19 infected patients with RDV as an antiviral treatment. Data for this study were acquired at RSUI using a retrospective cross-sectional method. The sample is infected patients with COVID-19 from January 2021 to December 2021 who received RDV therapy. The parameters of the effectiveness of the treatment was a reduction of minimally 2 points on the WHO Clinical Progression Scale after 14 days of Remdesivir administration.Results: RDV effectiveness percentage shows 57.5% of patients experienced clinical improvement. The analysis results of the effect of blood type variations on clinical outcomes significantly affect the effectiveness of RDV therapy (OR: 1.705, 95% CI: 1.091–2.665; p = 0.019) but insignificant in terms of mortality status (OR: 0.654, 95% CI: 0.383–1.117; p = 0.120).Conclusion: Blood type variations significantly affected the effectiveness of RDV therapy in infected COVID-19 patients.
Increasing Serum Levels of Nephronectin Based on Exposure Duration of Marble Dust in Industry Workers Jimmy Akbar; Triwahju Astuti; Ngakan Putu Parsama Putra; Fitri Indah Sari
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.247

Abstract

Background: Exposure to silica dust is still an occupational health problem worldwide. The marble industry is one of the industries at risk of causing respiratory disease in its workers. Exposure to marble dust in the airways triggers pulmonary fibrosis via nephronectin (Npnt) as an α8β1 integrin ligand, which is an extracellular matrix protein. The purpose of this study is to look at how serum nephronectin (NPNT) levels change over time after being exposed to marble dust. Methods: This was a cross sectional analytical study of marble industry workers. A significant difference test is carried out on 4 groups of subjects (n=50), including marble industry workers with exposure durations of 1-5 years (n=12), 6-10 years (n=14) and >10 years (n=14), as well as non-marble industry workers (unexposed) as control subjects (n=10). A correlation test was performed to see the relationship between duration of exposure and serum Npnt levels.Results: The median age value in the exposed group was 40.5 (20-67) years. There was a significant difference (P=0.012) in the median Npnt level of the exposed group [1.699 (0.22–5.27) ng/mL] and the non-exposed group [0.678 (0.21–1.96) ng/mL]. The median value of nephronectin levels in the 10 years exposed group [2.4710 (1.74–5.27) ng/mL] were significantly different with both the 1–5 years exposed group (P=0.0001) with a median value of 0.6960 (0.22–2.27) ng /mL and the 6–10 years exposed group (P=0.039) with a median value of 1.0480 (0.27–4.29) ng/mL. There was a significant (P=0.0001) positive relationship (r=0.633) between the length of exposure and the level of Npnt. Conclusion: The duration of marble dust exposure had a significant effect on serum Npnt levels. The longer the marble industry workers were exposed to marble dust, the higher the serum Nephronectin level.

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