Jurnal Respirologi Indonesia
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Articles
328 Documents
<![CDATA[Correlation Between Copeptin and PSI with Intravenous to Oral Antibiotic Switch Theraphy and Length of Stay in Community-Acquired Pneumonia ]]>
<![CDATA[Risky Irawan]]>;
<![CDATA[Reviono Reviono]]>;
<![CDATA[Harsini Harsini]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 39, No 1 (2019) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v39i1.40
<![CDATA[Background: Pneumonia is a world’s health problem. AVP level in the circulation is difficult to measure therefore copeptin is chosen since it is more comparable in number and more stable. Method: Prospective observational study on 25 patients with community-acquired pneumonia in Dr.Moewardi Hospital from July-August 2017. Result: There were no significant differences between switch therapy duration and length of stay to subject’s characteristic. There was a positive and significant correlation of PSI score to switch therapy and length of stay with a medium to strong correlation strength. Copeptin to switch therapy and length of stay had a positive and significant correlation with a medium to strong correlation strength. Pneumonia patients with PSI Score >90 had a risk of 36.67 times higher with switch therapy duration >4 days and it could be used as a predictor of switch therapy duration. Copeptin >17.23 with switch theraphy duration >4 days on pneumonia patient had a risk of 24.75 times higher and it could be used as a predictor of switch therapy duration. Pneumonia’s patient with PSI Score >100 with length of stay >10 days had a risk of 26.00 times higher and it could be used as a predictor of length of stay. Copeptin >27.39 with length of stay >10 days on pneumonia’s patient had a risk of 36.00 times higher and it could be used as a predictor of length of stay. Conclusion: Both PSI Score and copeptin level had positive and significant correlation to switch theraphy and length of stay. (J Respir Indo 2019; 39(1): 44-53)]]>
<![CDATA[Effect of Tiotropium on Post Pulmonary TB Patients With Obstructive Abnormalities to Lung Function and Quality of Life ]]>
<![CDATA[Romaito Nasution]]>;
<![CDATA[Irvan Medison]]>;
<![CDATA[Deddy Herman]]>;
<![CDATA[Masrul Basyar]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 4 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i4.22
<![CDATA[Background: Post pulmonary tuberculosis (TB) patients could experience pulmonary function declines which affected their quality of life. Obstrucitve abnormalities were found the most after complete TB treatment and the therapeutic guidelines focused in bronchodilators. The use of bronchodilators could improve lung function and quality of life in post TB patients with obstructive abnormalities. Tiotropium is a bronchodilator that has been shown to be effective in chronic obstructive pulmonary disease (COPD) patients, while its use in post TB patients has not been widely studied. Methods: This study design was a clinical trial with pre and post test design in post TB patients in Dr.M.Djamil Padang General Hospital and Lubuk Alung Pulmonary Hospital conducted from November 2016 to June 2017. Results: Of 30 post TB patients, the mean age was 62.77±10.99 years, most were male (63.33%), non-smokers and former smokers (50% each), had interval from complete anti TB drugs to study ≥6 months (53.3%), and moderate level of obstruction (80%). Pulmonary function prior to tiotropium was generally in moderate obstruction (FEV1 68,85±15,77). The mean quality of life prior to tiotropium was 18.27±10.81. There was no improvement in pulmonary function of post TB patients after administration of tiotropium, P=0.920, however, there was an improvement in the quality of life, P=0.009. No adverse events were found in this study. Conclusions: Administration of 2 months tiotropium in post TB patients had no effects on the improvements of lung function but improved the quality of life. More studies were needed using more patients and longer duration of administration. (J Respir Indo. 2018; 38: 203-9)]]>
<![CDATA[The Effect of pncA Gene Mutation of Mycobacterium Tuberculosis to Transaminase and Uric Acid Serum in MDR TB Patient ]]>
<![CDATA[Yeni Vera]]>;
<![CDATA[Bintang YM Sinaga]]>;
<![CDATA[Dedi Ardinata]]>;
<![CDATA[Yahwardiah Siregar]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 3 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i3.4
<![CDATA[Bacground: The common side effects of PZA treatment is the occurrence of hepatotoxicity and blocking the secretion of uric acid. This study aims to determine the effect of the pncA gene mutation of Mycobacterium tuberculosis to serum transaminase and serum uric acid in patients with MDR TB who had receive therapy with PZA. Methods: Quasi-experimental test was conducted at MDR TB polyclinic in H. Adam Malik Medan Hospital of 25 patients with MDR TB. Mutations of genes was assessed by PCR-RFLP method and data of serum transaminase and serum uric acid retrieved from the medical records, between February until June 2015 Result: Thirtysix percent pncA gene mutation founded. Significance statistic test between mutation of pncA gene and SGOT serum in baseline Vs 4 weeks (P=0,007), baseline Vs 8 weeks (P=0,023) and uric acid serum baseline Vs 4 weeks (P=0,011). No statistically difference in SGPT serum. No correlation between pncA gene (mutation and no mutation) with transaminase serum and uric acid serum. Conclusion: Transaminase serum and uric acid elevated in MDR TB patient with mutation in pncA gene.Mutation in pncA gene have a correlation with elevated SGOT serum compared between baseline, 4 and 8 weeks. No correlation between pncA gene mutation and SGPT. Mutation in pncA gene have a correlation with uric acid serum elevated in 4 weeks. No correlation between pncA gene (mutation and no mutation) with transaminase serum and uric acid serum elevated.]]>
<![CDATA[Pathophysiology of Emphysema ]]>
<![CDATA[Steven Jonathan]]>;
<![CDATA[Triya Damayanti]]>;
<![CDATA[Budhi Antariksa]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 39, No 1 (2019) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v39i1.43
<![CDATA[Pulmonary emphysema is part of pathological condition in chronic obstructive pulmonary disease (COPD) which is characterized by lung parenchymal destruction. Morphology classification of emphysema had been made according to histologic structure in pathology. There were some causes known to be the culprit of emphysema; one that caught most attention is protease-antiprotease activity from cigarette smoke exposure. Destructive effect of emphysema gives disturbance of lung function in expiration (obstruction). The primary mechanism is elastic recoil reduction which causes air trapping, lung volume increase, lung compliance increase and airways that is susceptible to collapse. Hyperinflation in emphysema causes some disadvantages which complicate inspiration and give a dyspnea sensation. Equal pressure point drop in emphysema happens because of elastic recoil reduction. This drop may cause early airway closure. (J Respir Indo 2019; 39(1): 60-9)]]>
<![CDATA[Mechanical Ventilation in Non Lung-Post Surgery Patients ]]>
<![CDATA[Ika Yunita Sari]]>;
<![CDATA[Sri Wening Pamungkasningsih]]>;
<![CDATA[Menaldi Rasmin]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 3 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i3.9
<![CDATA[A case of a 41-year-old man, with a lump in his left abdomen since 5 months before admission to the hospital. In the last 2 weeks the patient complained of reddish urine and pain during urination. The diagnosis of the patient is a left kidney tumor, has performed nephrectomy and splenectomy surgery. Postoperative complications include sepsis, anemia and hypoalbuminemia. Sepsis in these patients is caused by colonic perforation leading to intra-abdominal infection. These complications cause patients to get treatment in the intensive care unit longer by using a ventilator for four days.]]>
<![CDATA[Survey of Lung Function and Respiratory Symptoms Among Online Motorcycle Taxi Drivers in Bekasi City ]]>
<![CDATA[Damayanti, Triya]]>;
<![CDATA[Pradipta, Jaka]]>;
<![CDATA[Rahmawati, Ismulat]]>;
<![CDATA[Harlivasari, Annisa Dian]]>;
<![CDATA[Prasetyo, Erry]]>;
<![CDATA[Anggara, Bobby]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 39, No 1 (2019) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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<![CDATA[Background: Online motorcycle taxi drivers have been heavily exposed to high concentration of hazardous air pollutants. This study aimed to describe the lung function and respiratory symptoms among online motorcycle taxi drivers and risk factors which influence them.
Methods: The study design was survey research design with sample number of 99 online motorcycle taxi drivers in Bekasi City. Lung function examination was done using spirometer (Spirolab) and the predicted value of lung function was using Pneumobile Project Indonesia. Risk factors and respiratory symptoms were collected using questionnaire.
Results: There were 10.1% of subjects with restrictive lung function and 5.1% with obstructive impairment. There were significant association between age of the drivers with restrictive disorders (P=0.006) and the mean difference of %FEV1 (P=0.039). There was a significant relationship between sex (P=0.001) and age (P=0.001) with the mean percent of forced vital capacity (%FVC). The respiratory symptoms collected were cough (17.2%) and shortness of breath (6.1%). There were no significant relationship between respiratory symptoms and lung function.
Conclusions: Online motorcycle taxi drivers had respiratory symptoms and lung function impairment, however the causal relationship with the workplace environment is still unclear. Moreover, education about the importance of using personal protective equipment is needed to protect respiratory systems from harmful substances. (J Respir Indo 2019; 39(1))]]>
<![CDATA[The Changes of Interleukin 17 levels On Pulmonary Tuberculosis Patients with AFB Smear-Positive After 2 Months Anti Tuberculosis Drugs Treatment ]]>
<![CDATA[Andy Sulaiman Siregar]]>;
<![CDATA[Soedarsono Soedarsono]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 4 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i4.23
<![CDATA[Background: Tuberculosis still remain as a health problem in the world. No specific biomarkers can be used to monitor the rapid response to TB therapy. This study aims to assess the change of IL-17 levels in pulmonary tuberculosis patients with AFB smear-positive before and after 2 months of anti tuberculosis drugs (ATD) treatment. Method: Design of study is analytic observational with prospective cohort. The subject include 17 new cases of pulmonary tuberculosis patients with AFB smear-positive in Soetomo Hospital Surabaya from July - October 2016. Plasma levels of IL-17 were measured using ELISA technique before treatment and 2 months after the ATD therapy. Results: The mean levels of IL-17 before treatment is 3.510 pg / ml (2.087- 5.051 pg/ml). There were significantly decreament (p = 0.001]]>
<![CDATA[The Effect of Opiocephalus striatus Extract on Leptin, Adiponectin and COPD Assessment Test Scores on Stable COPD Patients Experiencing Muscle Wasting ]]>
<![CDATA[Komang Sri Rahayu Widiasari]]>;
<![CDATA[Susanthy Djajalaksana]]>;
<![CDATA[Harun Al Rasyid]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 3 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i3.5
<![CDATA[Background: Muscle wasting is one of extrapulmonary manifestations that occur in 20-40% of patients with COPD as a result of an imbalance of protein synthesis and degradation, where it is thought to be a consequence of chronic inflammation. One of the factor that affect muscle wasting is nutritional factor. The purpose of this study is to prove that nutrition therapy can improve inflammation (measured by levels of leptin, adiponectin) further improve muscle wasting and improve the quality of life of patients COPD with muscle wasting. Method: The clinical study design is pre and post auto control quasi experimental in stable COPD patients with comorbid muscle wasting. The experiment was conducted in Pulmonary Outpatient Clinic Dr. Saiful Anwar Hospital and Physiology Laboratory of Medical Faculty Brawijaya University. Chronic obstructive pulmonary disease was diagnosed based on 2014 GOLD criteria. Muscle wasting was diagnosed through examination of the BIA. Levels of leptin and adiponectin was measured using ELISA method, and quality of life was assessed using CAT score. We measured BIA, Leptin, Adiponectin and CAT in 32 COPD patients with muscle wasting, before and after 12 weeks supplementation of Opiocephalus striatus extract 3x1000mg/day. Results: There were significant increased of BMI (p = 0.046), no significant increase of FFMI (p = 0506), a significant decrease in leptin levels (p = 0.000) and a significant increase in adiponectin levels (p = 0.048) and improvement of quality of life (score CAT) (p = 0.000) ) after administration of opiocephalus striatus extract for 12 weeks. Conclusion: Suplementation of Opiocephalus striatus extract for 12 weeks can improve BMI, decrease levels of leptin and increase level of adiponectin resulting in improvement of quality of life in stable COPD patients with muscle wasting.]]>
<![CDATA[Immunogenicity Test of ESAT-6/CFP-10 Mycobacterium Tuberculosis (Indonesian Strain) Recombinant Protein Fusion: IFN-γ and CD8+ T Cells Expression in PBMC Culture ]]>
<![CDATA[Anung Sri Handayani]]>;
<![CDATA[Tri Wahju Astuti]]>;
<![CDATA[Teguh Rahayu Sartono]]>;
<![CDATA[Maimun Zulhaidah Arthamin]]>;
<![CDATA[Fransisca Srioetami Tanoerahardjo]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 4 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i4.44
<![CDATA[Background: BCG vaccination is one way to control tuberculosis (TB) but still poor in efficacy thus new vaccine development is needed. Immunogenicity test is needed in developing new vaccine. The aim of this study was to understand whether the recombinant protein fusion of ESAT-6/CFP-10 Mycobacterium tuberculosis (M. tuberculosis) can stimulate cellular immune response, especially IFN-γ and CD8 + T cell expression in PBMC cultures. Methods: This study was an experimental laboratory research conducted on PBMC cultures of 3 groups of subjects (TB patients, latent TB patients and healthy subjects) at RSUD Dr. Saiful Anwar in April-July 2017. The sample of each groups was 8 subjects. Each groups induced by recombinant protein fusion ESAT-6/CFP-10 M. tuberculosis as a standard protocol and to establish the immunogenicity status. CD8+ T cells IFN-γ expressed by C8+ were measured by flowcytometry. Result: Recombinant protein fusion ESAT-6/CFP-10 can stimulate CD8+ T cells and IFN-γ expressed by CD8+ T cells in all group. The highest stimulation of CD8+ percentage was found in healthy subject (37.533 ± 7.264) and IFN-γ expressed by CD8+ T cells was found in healthy subject (7.908 ± 4.457); There are increase significantly CD8+ T cells (p=0.001) and IFN-γ expressed by CD8+ T cells (p=0.217) not significantly in healthy subject compared in PPD and without antigen. Conclusion: Recombinant protein fusion ESAT-6/CFP-10 M. tuberculosis can stimulate CD8+ T cells and IFN-γ expressed by CD8+ T cells in healthy subject. Recombinant protein fusion ESAT-6/CFP-10 M. tuberculosis potential as a new vaccine candidate. (J Respir Indo. 2018;38: 210-8)]]>
<![CDATA[Respiration Status of Asthma Patients Who Get Nebulisation Using Jet Nebulizer Compared to Nebulizer Using Oxygen ]]>
<![CDATA[Agus Santosa]]>;
<![CDATA[Endiyono Endiyono]]>
<![CDATA[ Jurnal Respirologi Indonesia Vol 38, No 4 (2018) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR) ]]>
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DOI: 10.36497/jri.v38i4.19
<![CDATA[Background: Some of regional hospitals still provide oxygen gas for nebulizer to therapies in astma patiens. The study was aimed to observe the effectiveness of jet nebulizer vs oxygen as a driving gas for nebulizer on respiratory parameters of asthma patients which is breath pattern, respiration rate (RR), breath sound, oxygen saturation (SpO2), peak expiratory flow rate (PEF}. Method: The research was an experimental with a combination design, pre-post test with control group and post test only with control group in RSUD dr. R. Goeteng Taroenadibrata Purbalingga consisted of 60 respondents selected by proportional stratified random sampling. Data analysis used was independent t-test and fisher’r exact test. Result: There was no difference in the respiratory pattern variables between jet nebulizer and oxygen as a driving gas nebulizers (p> 0.05). The jet nebulizer was better in reducing RR in asthma patients than the oxygen as a driving gas nebulizer (p]]>
