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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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Comparative Diagnostic Accuracy of LF-LAM TB Antigen and Xpert MTB/RIF in Pulmonary Tuberculosis among Underweight Patients Eksa, Dwi Robbiardy; Hendarto, Gatot Sudiro; Sinaga, Fransisca TY; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Gozali, Achmad; Ajipurnomo, Adhari
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/7brxv447

Abstract

Background: In 2023, the global incidence of tuberculosis (TB) reached 8.2 million cases. It is the highest on record due to delayed diagnoses and a rising number of TB patients. Tuberculosis is more prevalent among patients with compromised immune systems, including those with HIV and malnutrition (BMI <18.5 kg/m2), who exhibit increased vulnerability to infection. The challenge of sputum expulsion impedes diagnosis, requiring a rapid, cost-effective early-detection technique. The lateral flow lipoarabinomannan TB antigen (LF-LAM TB-Ag) assay provides an alternate method for identifying lipoarabinomannan in urine, a constituent of the Mycobacterium tuberculosis cell wall. This study assessed the effectiveness of the LF-LAM TB-Ag assay compared with the Xpert MTB/RIF assay for TB diagnosis. Methods: A comparative cross-sectional study was conducted at Abdul Moeloek Hospital, Lampung Province, from January 2023 to June 2024. A total of 52 suspected pulmonary TB patients with HIV-negative status and underweight BMI were evaluated using both the LF-LAM TB-Ag and Xpert MTB/RIF assays. Results: Chi-square tests were used to compare the performance of LF-LAM TB-Ag with Xpert MTB/RIF. The LF-LAM TB-Ag test had a sensitivity of 79.59% and a specificity of 100% (P=0.002). Conclusion: This study underscores the necessity for early detection of pulmonary TB in underweight individuals. The integration of LF-LAM TB-Ag with Xpert MTB/RIF improves detection, especially in high-risk populations, enabling prompt treatment and enhanced disease management.
Effects of Active Hexose Correlated Compound (AHCC®) on Clinical and Laboratory Response of Pulmonary Tuberculosis Patients Madolangan, Jamaluddin; Yusuf, Irawan; Wahyudin, Elly; Djaharuddin, Irawaty
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.820

Abstract

Backgrounds: Active hexose correlated compound (AHCC), an α-glucan extracted from Lentinula edodes, is known for its immunomodulatory properties. It is suspected that the strong nutrients contained in AHCC are very safe and without side effects, including in tuberculosis patients. This study evaluated the effect of AHCC on clinical and hematologic responses in pulmonary tuberculosis (TB) patients Methods: A double-blind randomized controlled trial was conducted involving 60 pulmonary TB patients receiving standard anti-TB therapy. Participants were randomly assigned to receive either AHCC (3 g/day) or a placebo for six months. Clinical and laboratory parameters were assessed before and after treatment. Results: Patients in the AHCC group showed greater improvement in clinical symptoms (reduced cough, improved appetite, and weight gain) and significant enhancement of hematological and immunological markers compared with placebo (P<0.05). AHCC supplementation significantly increased CD4⁺ and CD8⁺ lymphocyte counts, suggesting improved immune recovery and modulation of host defense against Mycobacterium tuberculosis infection. Conclusion: AHCC supplementation alongside standard anti-TB therapy improves clinical outcomes and immune responses in patients with pulmonary tuberculosis.
Correlation Between Predicted Maximal Oxygen Uptake (VO2 max) from The Six-Minute Walk Test and Reaction Time in Male Security Guards Noor, Amira Ismi; Soehardiman, Dicky; Taufik, Feni Fitriani
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.1015

Abstract

Background: Reaction time, the interval between stimulus and motor response, reflects alertness and is critical in professions such as security guards. Maximal oxygen uptake (VO₂ max), a standard measure of cardiorespiratory fitness, has been linked to improvements in cognitive performance. This study examined the relationship between predicted VO2 max values from the six-minute walk test and reaction time in security guards. Methods: A cross-sectional study was conducted among 33 male security guards at Persahabatan National Respiratory Center between October and November 2024. Participants completed physical activity questionnaires, the six-minute walk test, and audio-visual reaction time assessments. Results: The mean predicted VO2 max was 18.3±2.9 ml/kg/min (metabolic equivalents/METs: 5.2±0.8). Body mass index significantly influenced VO₂ max (p = 0.002). Auditory reaction time was significantly faster than visual reaction time (172.6±25.7 ms vs. 199.8±33.1 ms, p < 0.001). A weak negative correlation was found between predicted VO₂ max and visual reaction time (r = –0.340, p = 0.048), but not with auditory reaction time (r = –0.245, p = 0.169). Conclusion: Higher cardiorespiratory fitness, as reflected by predicted VO₂ max, was not strongly associated with visual reaction time among security guards.
Effect of MgSO4 Administration on The Incidence of Acute Kidney Injury and Renal Function in Lung Cancer Patients Receiving Cisplatin Chemotherapy Lestari, Nastiti; Setiadji, Ana Rima; Suseno, Aryo
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.843

Abstract

Background: Platinum-based chemotherapy is the most common lung cancer therapy currently performed with satisfactory results, but the use of platinum-based chemotherapy, such as cisplatin, can cause cisplatin-induced nephrotoxicity (CIN). MgSO4 is a substance that has been studied and is known to have a protective effect on the kidneys. This study aims to determine the effect of MgSO4 administration on the incidence of CIN in lung cancer chemotherapy patients receiving cisplatin chemotherapy. Methods: This was a quasi-experimental study with a pre-test and post-test control group design. The study group received intravenous MgSO4 20 mEq, and the control group received standard therapy without MgSO4. The incidence of CIN was assessed based on the incidence of acute kidney injury (AKI) and renal function measured by the estimated glomerulus filtration rate (eGFR). Results: The incidence of AKI in the treatment group was 6.67%, whereas the control group had no incidence of AKI (P=0.32). Renal function (eGFR) showed no significant difference between the treatment and control groups (P=0.86), although both groups exhibited improved renal function post-chemotherapy. Conclusion: MgSO4 administration does not affect the incidence of AKI and renal function of lung cancer patients receiving cisplatin chemotherapy.

Page 37 of 37 | Total Record : 364

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