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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Search results for , issue "Vol 7, No 3 (2015)" : 21 Documents clear
STUDI PREVALENSI PENGGUNAAN ALAT DAN OBAT KONTRASEPSI DI MASYARAKAT KABUPATEN BANDUNG Avanti, Christina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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Upaya pemerintah dalam mengendalikan jumlah penduduk adalah dengan program Keluarga Berencana (KB) menggunakan kontrasepsi. Kontrasepsi adalah alat atau obat yang digunakan untuk mencegah konsepsi (kehamilan). Tujuan dari penelitian ini adalah untuk mengetahui prevalensi penggunaan alat dan obat kontrasepsi (Alokon) di masyarakat. Tempat penelitian ini dilakukan di kabupaten Bandung pada bulan Juli-Agustus 2013. Penelitian ini menggunakan metoda observasi krosseksional dengan kuisioner yang berisi pertanyaan yang berkaitan dengan pengetahuan, sikap, dan perilaku dari 300 responden mengenai penggunaan Alokon. Hasil studi dianalisis secara statistik dengan tingkat kepercayaan 95%. Hasil studi menunjukan bahwa 87% responden mengetahui program pemerintah dalam hal jumlah anak yang dianjurkan (dua anak lebih baik). Responden memahami Alakon sebagai sarana menjarangkan kehamilan (78%) dan dapat digunakan sebagai kebutuhan (42%). Jenis kontrasepsi yang paling dikenal dan digunakan oleh responden  adalah : Implant (5%),  IUD (19%), Pil KB (20%) dan Injeksi (23%). Selain itu, responden menyakini bahwa tidak efektif untuk menunda kehamilan (82%). Adanya kekhawatiran responden terhadap efek samping Alokon  (56%), antara lain kegemukan (42%65).  Alokon lebih banyak digunakan oleh wanita (75%) dibandingkan laki-laki (4%). Alokon lebih banyak dipilih (43%) dibandingkan dengan alat (19%). Berdasarkan hasil penelitian dapat disimpulkan bahwa responden telah memiliki pengetahuan yang baik dalam hal Alokon dan penggunaannya. Mengingat Alokon jenis obat (Pil KB) banyak dipilih oleh responden, diperlukan peran apoteker di pelayanan farmasi dalam memberikan informasi yang benar mengenai cara penggunaannya untuk mencapai efektivitasnya sebagai kontrasepsi (pencegah kehamilan).
Karakterisasi Kompleks Inklusi Simvastatin – β-Siklodekstrin yang Dibuat dengan Metoda Kneading Octavia, Maria Dona; Zaini, Erizal; Halim, Auzal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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ABSTRACT : Characterization of Inclusion Complex Simvastatin - β - cyclodextrin prepared by Kneading Method" has been done . This study aims to improve the dissolution rate and characterize inclusion complexes simvastatin - β - cyclodextrin developed into 3 formula , the ratio between the simvastatin and β - cyclodextrin following formula I ( 1 : 1 ), the formula II ( 1 : 2 ), and the formula III ( 2 : 1 ). Inclusion complex prepared by adding water solvent to form a paste and then dried at room temperature. The results of the inclusion complexes were characterized by analysis Differential Thermal Analysis ( DTA ), X-ray diffraction, IR spectrophotometry, Scanning Electron Microscopy ( SEM ), and dissolution rate . The results of this analysis indicate that the inclusion complex formed, characterization and dissolution profiles better than the pure simvastatin and mixed physics simvastatin and β - cyclodextrin.   Key words : Inclusion complex, Simvastatin, β-Cyclodextrin, Kneading Methods   ABSTRAK : Telah dilakukan penelitian dengan judul "Karakterisasi Kompleks Inklusi Simvastatin - β-Siklodekstrin yang dibuat dengan Metoda Kneading". Penelitian ini bertujuan untuk meningkatkan laju disolusi serta mengkarakterisasi kompleks inklusi Simvastatin - β-Siklodekstrin yang dikembangkan menjadi 3 formula, dengan perbandingan antara simvastatin dan β - siklodekstrin sebagai berikut formula I (1 : 1), formula II (1 : 2), dan formula III (2 : 1). Komplek inklusi dibuat dengan cara menambahkan pelarut air hingga terbentuk masa seperti pasta dan kemudian dikeringkan pada suhu kamar. Hasil komplek inklusi ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red, Scanning Electron Microscopy (SEM), dan disolusi. Hasil analisa tersebut menunjukkan bahwa kompleks inklusi yang terbentuk memberikan karakterisasi dan profil disolusi yang lebih baik dibandingkan dengan simvastatin murni dan campuran fisika simvastatin dan β-siklodekstrin yang dibuat dengan penggerusan biasa. Kata Kunci : Kompleks inklusi, Simvastatin, β-Siklodekstrin, Metoda Kneading
Instant Powder Formulation for Anti Anemia and Optimization Exctraction Condition of Moringa pterygosperma Gaertn Leaves Using MAE Anggraeni, Yosita; Jufri, Mahdi Jufri; Munim, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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Abstract

Iron supplement containing ferrous sulfate is commonly used for anaemia. Unfortunately, it has bad taste, can cause nausea, and made adverse effects if taken in large doses for long periods. It is necessary to ????ind an alternative source of raw materials, including those from plants. Moringa pterigospera Gaertn leaves was selected because it contains iron and other nutritions. The purpose of this work was to make instant powder formula for anti anaemia using Moringa leaves extract as an alternative for ferous suphate iron suplementation. The extraction was performed by Microwave Assisted Extraction method. Optimization of extraction condition was performed by creating some variations in solvent composition (0- 70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to10 min). Iron content was determined by Atomic Absorption Spectrophotometer at wave length of 248 nm. Instant powder formula was made in 3 concentrations of sodium CMC as suspending agent. Results of the study showed that the most optimal extraction condition which resulted the highest iron content (2.4 mg/g extracts) achieved with 900 watts microwave power, 10 min extraction time and aqua demineralisata. According to 30 panelists of hedonic test, formula which used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31% of loss on drying and 7.74 g/sec of ????low rate for powder form and pH of 5.78, viscosity of 15.98 cps for reconstituted form.
Kepatuhan Penderita Diabetes Mellitus di Apotik Ubaya Berdasarkan Tinkgkat Kepatuhan dan Motivasi Kristianto, Franciscus Cahyo; Susilo, Astrid Pratidina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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Adherence is one of the important things for diabetic patients to control their blood glucose level and preventing for complications in the future. There are two major factors that influence the adherence, patient’s knowledge and motivation. Design of this study was sequential mixed method. Thirty type 2 diabetes mellitus patients were recruited based on patient medication record prepared by the community pharmacist. At the first stage, subjects were asked to answer four validated questionnaires that related with level of knowledge (health literacy and medication knowledge) and motivation (readiness to change and social support). At the second stage, they were interviewed based on their response to readiness to change questionnaire. All data collected were then analysed descriptively and qualitatively. From knowledge aspects, there were 93% of patients has high level of health literacy and 87% has high medication knowledge. From motivation aspects, there were 70% has changed and maintained their adherence, 20% were still prepare to change (preparation) and 10% were not ready to change (contemplation). Need for social supports were very high (97%) within the diabetic patients. Most of the subjects (80%) have high level of knowledge and motivation. There were 17% who has variable knowledge and motivation and only 3% who has low level of knowledge and motivation.
Studi Interaksi Senyawa Turunan 1,3-Dibenzoiltiourea sebagai Ribonukleotida Reduktase Inhibitor Lestari, Tresna
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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In this research, docking process was carried out from 1,3-dibenzoylthio- urea derivates compound to ribonucleotide reductase receptor. The receptor used was 2EUD with ligand GCQ (Gemsitabine Diphosphate) obtained from the website of protein data bank (PDB). The purpose of this research was to ????ind out the inter- action and toxicity of 1,3-dibenzoylthiourea derivates compound to ribonucleotide reductase receptor. All compounds was docked using ArgusLab 4.0.1 applications. The docking process performed by the method of ArgusDock. The validation of dock- ing used RMSD value gained < 2 that is 1, 704524 on calculate size X=16.5, Y=17.25 and Z=16.75. The analysis of docking result showed that 1,3-bis[(3-methylphenyl) carbonyl]thiourea compound can be predicted to have lowest free binding energy (ΔG) than comparative ligand and parent compound. From this research result can conclude that 1,3-bis[(3-methylphenyl)carbonyl]thiourea to inhibitor activity of ri- bonucleotide reductase receptor. Toxicity test accomplished using ToxTree applica- tion, with parameter such as Cramer Rules, Benigni / Bossa rulebase and Kroes TTC decision tree.  Key word: Docking, 1,3-dibenzoylthiourea, ribonucleotide reductase inhibitor, toxicity
Identifikasi Interaksi Padat Campuran Parasetamol dan Ibuprofen dengan Metode Thermal Noviza, Deni; Zaini, Erizal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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Solid-state interaction between parasetamol and ibuprofen was studied using thermal and spectroscopic techniques. Parasetamol-Ibuprofen binary mixtures were prepared by rotary ball mill grinding method. Differential scanning calorimetry was used to investigate the stoichiometry and thermal properties of the complex between parasetamol and ibuprofen. Powder X-ray diffraction were used to investigate the type of interaction between the two components. Two endothermic peaks in a binary mixture of paracetamol and ibuprofen was observed in DSC thermograph. X-ray powder diffractogram do not shows shift and formation of new peaks and the position of each peak is a super-imposition of each component without dominates. It can be concluded that the solid interaction between paracetamol and ibuprofen for grinding effect is the formation of mixed crystal system.
INSTANT POWDER FORMULATION FOR ANTI ANEMIA AND OPTIMATION EXCTRACTION CONDITION OF Moringa pterigosperma Gaertn LEAVES USING MAE Anggraeni, Yosita -; Munim, Abdul -
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

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Abstract

Iron supplement contains ferrous sulfate is commonly used for  anemia. Unfortunately, it has bad taste, can cause nausea, and made adverse effects if taken in large doses for long periods. It is necessary to find an alternative source of raw materials, including those from plants. Moringa pterigospera Gaertn leaves was selected because it contains iron and other nutritions. The purpose of this work was to make instant powder formula for anti anemia using Moringa leaves extract as an alternative for ferous suphate iron suplementation. The extraction was performed by Microwave Assisted Extraction method. Optimation of extraction condition was performed by creating some variations in solvent composition (0-70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to10 min). Iron content was determined  by Atomic Absorption Spectrophotometer at wavelength of 248 nm. Instant powder formula was made in 3 concentrations of sodium CMC as suspending agent. Results of the study showed that the most optimal extraction condition which resulted the highest iron content (2.4 mg/g extracts) achieved with 900 watts microwave power, 10 min extraction time and aquademineralisata. According to 30 panelists of hedonic test, formula which used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31% of loss on drying and 7.74 g/sec of flow rate for powder form and pH of 5.78, viscosity of 15.98 cps for reconstituted form.
Uji In Vitro dan In Vivo Gel Kombinasi Ekstrak Daun Sirsak (Annona muricata, L) dan Ekstrak Daun Jambu Biji (Psidium guajava, L) Sebagai Obat Anti Jerawat Yulianti, Rika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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ABSTRAK Penelitian ini bertujuan untuk mengetahui formulasi dan uji aktivitas anti jerawat kombinasi gel ekstrak etanol daun sirsak (Annona muricata L.) dan daun jambu biji (Psidium guajava L.) secara in vitro maupun in vivo. Daun sirsak secara tradisional digunakan untuk mengobati jerawat. Diketahui bahwa daun sirsak mengandung senyawa asetogenin, tanin, fitosterol, kalsium oksalat, alkaloid murisin, flavonoida dan steroida. Penelitian mengenai aktivitas anti jerawat ekstrak daun jambu biji telah dilakukan oleh Qa’dan et al pada tahun 2005. Sampel diperoleh dari kombinasi ekstrak daun sirsak (Annona muricata L.) dan daun jambu biji (Psidium guajava L.) menggunakan metode maserasi dengan pelarut etanol 96 %. Sediaan diformulasi dalam bentuk gel dan diuji konsentrasi hambat minimum  dan aktivitas antibakteri terhadap Propionibacterium acne dengan menggunakan gel Cindala® sebagai pembanding. Studi in vivo dilakukan menggunakan tikus (Rattus novergicus) galus Wistar sebagai hewan uji dengan pemberian suspensi koloni Propionibacterium acne sebagai penginduksi. Hasil penelitian menunjukkan bahwa gel kombinasi ekstrak daun sirsak dan ekstrak daun jambu biji memiliki aktivitas antibakteri terhadap Propionibacterium acne dengan formulasi gel menggunakan karbomer sebagai basis. Pengujian secara in vivo menunjukkan hasil bahwa gel tersebut memiliki aktivitas antijerawat dan berbeda secara signifikan secara statistik terhadap kontrol negatif. Kata kunci : jerawat, ekstrak, gel
Pengembangan Metode Ekstraksi dan Analisis Irbesartan dalam Plasma Darah menggunakan High Performance Liquid Chromatography (HPLC) Fluorescence Ratih, -
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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A simple extraction and analysis method by High Performance Liq- uid Chromatography (HPLC) ????luorescence has developed for determination of Irbesartan in plasma sample. The chromatography system were ????luorescence detector at λ ex254nm/em380 nm, ????low rate 1 mL/min, C-18 150 x 4,6 mm; 5μm column and acetonitrile : 0,5% (v/v) H3PO4 pH 3,0 (77:23) as mobile phase by run time not more than 6 minutes. Reliability of the HPLC method was as- sessed by the linearity of 9 levels concentration which be found 10.0 – 5,000.0 ng/mL, r = 0.9996 respectively. Chloroform was used as pretreatment solvent to extract Irbesartan dan Candesartan cilexetil (Internal Standard) from protein binding. The chromatogram of Irbesartan dan Candesartan cilexetil peaks were clearly separated without matrix noises, it was showed by resolution factor > 2.  
Peningkatan Resistensi Kultur Bakteri Staphylococcus aureus terhadap Amoxicillin Menggunakan Metode Adaptif Gradual Setiawati, Agustina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
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Resistensi antibiotik masih menjadi perhatian dalam pengobatan penyakit infeksi. Penggunaan antibiotik yang tidak sesuai meningkatkan kasus terjadinya resistensi antibiotik. Penelitian ini didesain untuk membuat metode yang dapat digunakan untuk membuat kultur Staphycoccus aureus (S.aureus) yang resisten terhadap amoxicillin. Selanjutnya, bakteri tersebut dapat digunakan sebagai model bakteri resisten adaptif dalam penelitian mikrobiologi. Penelitian ini menggunakan metode adaptif gradual dengan sub kultur bakteri pada media mengandung amoxicillin sub-MIC. Konsentrasi sub-MIC ditingkatkan setiap minggu selama tiga minggu. MIC amoxicillin diuji kembali setiap akhir sub kultur sub-MIC pada satu konsentrasi. Amoxicillin bersifat bakterisidal terhadap S.aureus dengan MIC 0,25µg/mL. Konsentrasi amoxicillin sub MIC yang digunakan adalah 0,10; 0,15 dan 0,20 µg/mL. Metode ini berhasil membuat S.aureus resisten dengan meningkatkan MIC 300x pada akhir sub kultur 0,10 µg/mL  dan meningkatkan MIC 400x pada akhir sub kultur 0,15 µg/mL MIC tidak meningkat. Metode adaptif gradual berhasil meningkatkan resistensi S.aureus terhadap amoxicillin.

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