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Oto Rhino Laryngologica Indonesiana

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Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia

ISSN : 02163667 EISSN : 25983970 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.

Arjuna Subject : -

Articles 493 Documents

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Asosiasi antara mutasi gen p16 dengan tipe histopatologi karsinoma nasofaring Muhtarum Yusuf; Sabilarrusydi Sabilarrusydi; Mansur Shidiq Wiyadi
Oto Rhino Laryngologica Indonesiana Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017
Publisher : PERHATI-KL

Latar belakang: Pertumbuhan tumor dan metastasis penderita karsinoma nasofaring (KNF) yangdiduga karena peran beberapa biomarker molekular, dapat diidentifikasi dari spesimen tumor penderitaKNF. Inaktivasi gen p16 akibat mutasi gen p16 dapat digunakan sebagai indikator prognosis dan strategipemberian terapi yang lebih baik pada penderita KNF.Tujuan: Membuktikan asosiasi antara mutasi genp16 dengan tipe histopatologi KNF.Metode: Bahan biopsi dibagi menjadi 2 bagian untuk pemeriksaanhistopatologi dan polymerase chain reaction (PCR). Tipe histopatologi diketahui dari 21 tumor KNFdengan melakukan pengecatan hematoksilin eosin jaringan secara Meyer, terbagi 3 yaitu WHO tipe 1,tipe 2 dan tipe 3. Mutasi gen p16 diperiksa dari jaringan tumor primer KNF dengan PCR, menggunakanmesin Gene Touch Bioneer, dan sekuensing dengan mesin ABI PRISM 310. Analisis statistik menggunakanuji Spearman.Hasil: Didapati sebanyak 21 penderita KNF sesuai kriteria inklusi dan eksklusi. Diketahuisebanyak 19 penderita KNF (90,48%) mengalami mutasi gen p16 negatif. Sebanyak 2 penderita KNF(9,52%) mengalami mutasi gen p16 positif dengan histopatologi WHO tipe 3. Hasil uji Spearmanmendapatkan nilai p=0,568 dan koefisien korelasi sebesar –0,132. Asosiasi antara mutasi gen p16 dengantipe histopatologi (WHO tipe 1, 2, dan 3) pada penderita KNF didapatkan hasil yang tidak bermakna(p>0,05).Kesimpulan: Tidak terdapat asosiasi antara mutasi gen p16 dengan tipe histopatologi KNF.Hal tersebut mungkin oleh karena insidens mutasi gen p16 yang rendah dan faktor etnis.Kata kunci: Karsinoma nasofaring, mutasi gen p16, tipe histopatologi ABSTRACTBackground: Tumor growth and metastasis in nasopharyngeal carcinoma (NPC) patients whichwere presumed caused by the roles of several molecular biomarkers, could be identified in tumor specimensof NPC patients. P16 gene inactivation that was caused by mutation, can be used as an indicator ofprognosis and as strategy for better therapy in NPC. Purpose: To identify the association between p16 genemutation with type of histopathology NPC. Methods: Biopsy specimens were divided for histopathologyexamination and polymerase chain reaction (PCR). Type of histopathology was obtained from 21 NPCtumors by Meyer’s hematoxillin eosin staining, and divided into three types, WHO type 1, type 2 andtype 3. The mutation of p16 gene were identified with PCR from primary tumor tissues by using Bioneertermal cycler machine, and sequencing was performed by ABI PRISM 310. Spearman test was used forstatistical analysis. Results: We found 21 NPC patients who met the inclusion and exclusion criteria.There were 19 (90.48%) NPC patients which had negative mutation of p16 gene. There were 2 NPCpatients (9.52%) who had positive mutation of p16 gene, with histopathology WHO type 3. Spearmantest results showed P=0.568 with a correlation coefficient –0.132. Association of mutation of p16 genewith histopathology type (WHO type 1, 2, 3) in NPC patients was not significant (P>0.05). Conclusion:There was no association found in our study between mutation of p16 gene and histopathological typeof nasopharyngeal carcinoma. It might be caused by low incidence of gene p16 mutation in NPC, andethnic factor.Keywords: Nasopharyngeal carcinoma, mutation of p16 gene, histopathology type

Diagnosis Dan Tatalaksana Karsinoma Tiroid Berdiferensiasi Marlinda Adham; Noval Aldino
Oto Rhino Laryngologica Indonesiana Vol 48, No 2 (2018): Volume 48, No. 2 July - December 2018
Publisher : PERHATI-KL

Latar belakang: Kasus kanker tiroid hanya terjadi sekitar 2,5% dari seluruh kasus tumor dengan mayoritas terjadi pada perempuan, hampir 80% kasus yang terjadi adalah tipe papiler. Ada berbagai panduan klinis untuk diagnosis, terapi, dan follow up untuk Karsinoma tiroid berdifferensiasi (DTC). Tujuan: Menentukan perencanaan operasi serta manajemen pasca operasi untuk mencegah komplikasi dan kekambuhan. Tinjauan pustaka: Pada DTC, operasi dan terapi radioiodine dilanjutkan pemberian substitusi levotiroksin tetap merupakan prosedur terapi yang sudah mapan. Angka kekambuhan yang tinggi dan komplikasi pasca operasi yang bervariasi menyebabkan perlunya diagnosis dan tatalaksana yang tepat. Kesimpulan: Makalah ini dibuat untuk membahas bagaimana cara menegakkan diagnosis dan tatalaksana kasus karsinoma tiroid berdiferensiasi, sehingga pemilihan tatalaksana menjadi lebih tepat dan menekan angka kekambuhan. Background: Thyroid carcinoma cases occur only about 2.5% of all tumor cases with the majority occur in women, almost 80% of cases is the papillary type. There are many clinical practice guidelines for diagnosis, therapy, and follow up of Differentiaied Thyroid Carcinoa (DTC). Purpose: Challenge in the management of thyroid cancer is in determining surgical planning and postoperative management to prevent recurrence. Literature review: For DTC, surgery and radioidodine therapy followed by levothyroxine substitution remain the established therapeutic procedures. High recurrence rates and varied postoperative complications lead to the need for proper diagnosis and management. Conclusion: This paper was made to discuss how to make diagnosis and management of DTC cases to suppress the rate of recurrence.

Perbandingan efektivitas flutikason furoat intranasal dengan dan tanpa loratadin oral pada penderita rinitis alergi Rita Talango; Aminuddin Aminuddin; Abdul Qadar Punagi; Nani Iriani Djufri
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Background: Allergic rhinitis (RA) is a symptomatic disorder of the nose induced by IgE mediatedinflamation. Corticosteroid alone or in combination with antihistamine have been recommended bythe ARIA-WHO and is often used in the management of RA. Purpose: To compare the effectiveness ofa combination therapy of intranasal fluticasone furoate (IFF) and oral loratadine (LO) with a singletherapy of IFF, based on the levels of eosinophils and clinical symptoms patients with RA. Method: Openclinical trial with 40 of patients divided into two groups 20 patients was given a combination therapyand 20 patients was given only IFF. The level of eosinophils and clinical symptoms were examinedbefore and after therapy. Data were analyzed using the Wilcoxon, Friedman and Mann Whitney tests.Results: Showed decrease in eosinophils level and clinical symptoms were significant (p<0.05) in bothtreatment groups, but there was no significant difference (p>0.05) in the effectiveness between bothtreatments. Conclusion: Therapy with IFF, alone or combined with LO were effective to decrease thelevel of eosinophils and clinical symptoms and there was no difference in efficacy, but still combinationtherapy is better than single therapy. Keywords: allergic rhinitis, intranasal fluticasone furoate, oral loratadine Abstrak : Latar belakang: Rinitis alergi (RA) merupakan gangguan fungsi hidung, terjadi setelah pajananalergen melalui inflamasi mukosa hidung yang diperantarai IgE0. Penggunaan kortikosteroid baik tunggalmaupun kombinasi dengan antihistamin telah direkomendasikan oleh ARIA-WHO dan sering digunakandalam penatalaksanaan RA. Tujuan: Untuk membandingkan efektivitas terapi kombinasi flutikason furoatintranasal (FFI) dan loratadin oral (LO) dengan terapi tunggal FFI berdasarkan kadar eosinofil dan gejalaklinis penderita RA. Metode: Uji klinik terbuka pada 40 penderita RA, dibagi menjadi 20 penderita padakelompok pertama diberikan terapi kombinasi FFI dengan LO dan 20 penderita kelompok kedua diberikanterapi tunggal FFI. Pemeriksaan eosinofil dan gejala klinis dilakukan sebelum dan sesudah terapi. Datadianalisis menggunakan uji Wilcoxon, Friedman dan Mann Whitney. Hasil: Terjadi penurunan kadareosinofil dan gejala klinis secara signifikan (p<0,05) pada kedua kelompok terapi, namun tidak adaperbedaan efektivitas secara signifikan (p>0,05) antara kedua kelompok terapi. Kesimpulan: Terapi FFItunggal maupun dikombinasikan dengan LO efektif menurunkan kadar eosinofil dan gejala klinis sertatidak ada perbedaan efektivitas, namun terapi kombinasi masih lebih baik dibanding terapi tunggal. Kata kunci: rinitis alergi, flutikason furoat intranasal, loratadin oral

Sindrom kanalis semisirkularis superior Ekorini, Haris Mayagung
Oto Rhino Laryngologica Indonesiana Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011
Publisher : PERHATI-KL

Background: Superior semicircular canal dehiscence syndrome (SSCD) is a very rare medical condition in which disturbances of balance or vertigo is triggered by loud noise or pressure. This condition is caused by dehiscence of a portion of the temporal bone overlying the superior semicircular canal and may present as the third window. Symptoms of the SCDS are autophony, which the person’s own voice is loudly heard, hyperacusis, tinnitus, vertigo and nystagmus. Diagnosis is made by history, hearing and vestibular examinations, and high resolution CT scan. Its management includes surgery or conservatively. Purpose: To inform ENT specialists and general practitioners about this syndrome.Case: Reported one patient who was diagnosed as SCDS. The patient complain of vertigo when hearing a loud noise or while on an aeroplane, aural fullness, hearing his own footsteps while walking and tinnitus. The audiometric examination showed mild sensory-neural hearing loss, tympanometric and vestibular examination was nomal and nystagmus was found, observed by frenzel in valsava condition. The high resolution CT scan showed dehiscence on the roof of the right superior semicircular canal.Case management: Patient was given advice to avoid loud noise, air pressure changed such as diving, straining and valsava maneuver. Conclusion: SCDS is a rare medical condition, which needs accurate history taking and examination to establish the diagnosis. Keywords: Superior canal dehiscence syndrome, vertigo, autophony Abstrak : Latar belakang: Sindrom kanalis semisirkularis superior (superior semicircular canal dehiscence syndrome)adalah suatu kelainan yang sangat jarang ditemukan. Terjadi gangguan keseimbangan atau vertigo yang dipicu oleh suara keras atau tekanan. Keadaan ini disebabkan karena terjadi dehisensi di daerah os tulang temporal pada kanalis semisirkularis superior, sehingga menjadi jendela ketiga (third window). Gejala klinis dari sindrom kanalis semisirkularis superior (SKSS) adalah autofonia, yaitu suara yang ditimbulkan oleh tubuhnya terdengar lebih keras, hiperakusis, tinitus, vertigo yang dipicu oleh suara keras dan dapat terjadi nistagmus. Diagnosis ditegakkan dengan anamnesis yang cermat, pemeriksaan pendengaran dan keseimbangan serta dilakukan CT scan resolusi tinggi. Penanganan dapat dilakukan dengan operasi atau konservatif. Tujuan: Agar para ahli THT dan dokter umum mengenal sindrom yang jarang ini. Kasus: Dilaporkan satu kasus penderita yang didiagnosis sebagai SKSS. Penderita mengeluh vertigo apabila mendengar suara keras, saat naik pesawat udara, telinga terasa penuh, bila berjalan dapat mendengar langkahnya dan tinitus. Dari pemeriksaan audiometri didapatkan tuli sensorineural ringan, timpanometri dan pemeriksaan keseimbangan sederhana tidak didapatkan kelainan, saat valsava didapatkan nistagmus dilihat dengan kacamata frenzel. Hasil CT scan resolusi tinggi didapatkan dehisensi pada kanalis semisirkularis superior kanan. Penatalaksanaan: Pada penderita ini belum dilakukan operasi tetapi dianjurkan menghindari suara keras dan menghindari perubahan tekanan misal menyelam, mengangkat benda berat, valsava. Kesimpulan: SKSS merupakan suatu kasus yang jarang, yang memerlukan anamnesis dan pemeriksaan yang cermat untuk menegakkan diagnosis penyakit ini. Kata kunci: sindrom kanalis semisirkularis superior, vertigo, bising, tekanan

Pendekatan eksternal dan endonasal dengan atau tanpa endoskopi pada mukosil sinus frontal Abdul Qadar Punagi; Ervina Mariani
Oto Rhino Laryngologica Indonesiana Vol 44, No 2 (2014): Volume 44, No. 2 July - December 2014
Publisher : PERHATI-KL

Latar belakang: Mukosil sinus paranasal merupakan lesi yang sifatnya tumbuh lambat dan bertahap. Mukosil ini biasanya disebabkan oleh obstruksi dari drainase sinus paranasal yang menghambat aliransekret dari sinus. Mukosil sinus paranasal biasanya tidak menunjukkan gejala pada hidung dan sinus, serta sering ditemukan di regio frontoetmoid. Tujuan: Membagi pengalaman dalam penatalaksanaan yang kami lakukan pada beberapa kasus mukosil sinus frontal. Kasus: Tiga kasus mukosil sinus frontal di RSU Wahidin Sudirohusodo Makassar yang ditatalaksana secara bedah dengan pendekatan endoskopik dan eksternal. Penatalaksanaan: Marsupialisasi endoskopik dengan kombinasi pendekatan internal dan eksternal serta identifikasi jalur drenase sinus frontal. Kesimpulan: Penatalaksanaan bedah mukosil sinus frotal dapat dilakukan melalui pendekatan transnasal / endonasal, secara endoskopik dan/atau eksternal.Kata kunci: Mukosil sinus frontal, transnasal, endonasal, endoskopi. ABSTRACTBackground: Paranasal sinus mucoceles are gradually expanding lesion. They usually cause obstruction to the normal drainage channels of paranasal sinuses that leads to accumulation of secretions within the sinus cavity. These patients classically do not presenting nose and sinuses symptoms and 60% of paranasal sinus mucoceles are found in the frontoethmoidal region. Purpose: Sharing experience of the management of frontal sinus mucoceles. Cases: Three cases of frontal sinus mucoceles at WahidinSudirohusodo General Hospital, Makassar which treated by endoscopic and external approach were presented. Management: Endoscopic marsupialitation with combination of internal and external approaches. Conclusion: Endonasal endoscopically management of frontal sinus mucocele with or without external approach is a grave surgical challenge.Keywords: Frontal sinus mucocele, transnasal, endonasal, endocopy.

Keberhasilan jabir bebas forearm dan jabir forehead paramedian pada rekonstruksi defek wajah luas Lina Marlina; Yussy Afriani Dewi; Irra Rubianti; Shinta Fitri Boesoirie
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Latar belakang: Penutupan defek wajah yang luas dengan jabir bebas forearm dan jabir foreheadparamedian merupakan salah satu pilihan pada pasien pasca eksisi luas dan pemberian radioterapi akibatkeganasan kepala leher. Tetapi cara ini bukan merupakan pilihan yang utama, meskipun memiliki tingkatkeberhasilan yang baik, khususnya pasca radioterapi.Tujuan: Kasus ini diajukan untuk memperlihatkankeberhasilan penutupan defek wajah yang luas dengan jabir bebas forearm, jabir forehead paramedianpasca eksisi luas dan radioterapi pada kasus karsinoma sel basal.Laporan kasus: Dilaporkan seorangperempuan 68 tahun dengan karsinoma sel basal yang dilakukan tindakan eksisi luas dan radioterapi.Penatalaksanaan: Setelah 6 bulan pasca radioterapi, dilakukan penutupan defek dengan menggunakanjabir bebas forearm, dan jabir forehead paramedian yang digunakan sebagai pengganti mukosa hidung sertadilakukan anastomosis radial forearm. Bagian dahi ditutup dengan full thickness skin graft (FTSG) yangdiambil dari regio abdominal pasien.Kesimpulan: Jabir bebas forearm dan jabir forehead paramedianmerupakan salah satu alternatif untuk rekonstruksi defek luas pada daerah kepala leher sesudah radioterapi. Kata kunci: Jabir bebas forearm, jabir forehead paramedian, karsinoma sel basal, radioterapi, eksisi luas ABSTRACTBackground: Paramedian forehead flap and radial forearm free flap is one option for reformationof excessive defect caused by tumor extirpation and radiotherapy in head and neck cancer, but not themain option in head neck reconstruction. In some certain condition, it has a better success rate thanother flap techniques, especially in postradiation patients on facial region. Purpose: To present evidencebased case report in order to show the result of reconstruction in a patient with basal cell carcinomawho underwent wide excision with paramedian forehead flap, radial forearm free flap and radiotherapy.Case report: We reported one case, a 68 years old woman who had basal cell carcinoma and underwentwide excision and radiotherapy. Management: Six months later, we performed reconstructive surgeryto close the forehead defect by reverse paramedian forehead flap, and replacing the nasal mucosa withradial forearm anastomosis, on the forehead covered with a full thickness skin graft (FTSG) taken fromabdominal region of the patient. Conclusion: Radial forearm and paramedian forehead flap can beconsidered as an alternative for reconstruction of wide defect of the head pasca radiotherapy. Keywords: Radial forearm flap, and paramedian forehead flap, basal cell carcinoma, radiotherapy, wideexcision Alamat korespondensi: Lina Marlina, Departemen Ilmu Kesehatan Telinga Hidung Tenggorok-BedahKepala Leher, Fakultas Kedokteran Universitas Padjadjaran/RumahSakit Hasan Sadikin, Bandung,e-mail: hendrika.lina@gmail.com.

Karakteristik pasien benda asing trakeobronkial di bagian T.H.T.K.L Rumah Sakit Dr. Mohammad Hoesin Palembang Puspa Zuleika; Abla Ghanie
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Latar belakang: Aspirasi benda asing ialah masuknya benda yang berasal dari luar atau dalam tubuh, ke saluran trakeobronkial. Aspirasi benda asing saluran trakeobronkial merupakan keadaan darurat yang memerlukan tindakan bronkoskopi segera untuk mencegah komplikasi yang lebih serius. Tujuan: Mengidentifikasi karakteristik klinis pasien aspirasi benda asing saluran trakeobronkial di bagian Telinga Hidung Tenggorok – Bedah Kepala Leher (T.H.T.K.L) Fakultas Kedokteran Universitas Sriwijaya/ Rumah Sakit Dr. Mohammad Hoesin Palembang. Metode: Penelitian ini merupakan penelitian observasional deskriptif. Sampel penelitian ini diambil dari data rekam medis pasien aspirasi benda asing pada saluran trakeobronkial di Rumah Sakit Dr. Mohammad Hoesin Palembang periode Januari 2012 - Desember 2016. Hasil: Didapatkan 20 pasien dengan riwayat teraspirasi benda asing di saluran trakeobronkial. Dijumpai 9 orang laki-laki dan 11 orang perempuan dengan perbandingan 1:1,2, di mana usia 0-15 tahun merupakan penderita terbanyak aspirasi benda asing ini. Benda asing yang paling banyak ditemukan adalah mainan dan benda plastik sebanyak 9 kasus, serta jarum pentul sebanyak 6 kasus. Sebanyak 19 pasien diketahui terdapat riwayat tersedak benda asing. Pemeriksaan foto toraks menunjukkan gambaran normal pada 12 pasien. Lokasi benda asing terbanyak ditemukan di trakea sebanyak 8 kasus. Kesimpulan: Aspirasi benda asing di saluran trakeobronkial sering terjadi pada anak-anak yang berusia kurang dari 15 tahun. Benda asing terbanyak adalah anorganik berupa mainan dan benda plastik. Pemeriksaan radiologi paru dalam 24 jam pertama setelah kejadian aspirasi pada umumnya menunjukkan gambaran normal. Lokasi benda asing di saluran trakeobronkial terbanyak pada penelitian ini adalah di trakea. Kata kunci: Aspirasi, bronkoskopi, foto toraks, benda asing, traktus trakeobronkial ABSTRACT Background: Foreign body aspiration is the entrance of foreign objects from outside or inside of the body into the tracheobronchial tract. Aspiration of foreign body in tracheobronchial tract is an emergency condition that needs immediate bronchoscopy procedure to prevent serious complications. Objectives: To identify clinical characteristics of foreign body aspiration patients in ENT Department Sriwijaya Medical Faculty / Dr. Mohammad Hoesin Hospital, Palembang. Method: This study was a descriptive observational study. The sample of this study was taken from the medical record of tracheobronchial foreign body aspiration patients at Dr. Mohammad Hoesin Hospital from January 2012 until December 2016. Result: There were twenty patients with the history of foreign body aspiration in tracheobronchial tract, consisted of 9 male and 11 female, with the ratio 1:1,2, in which 0–15 year-old children were the majority of the patients. The most common foreign bodies were toys and plastic objects in 9 cases and head veil pin in 6 cases. Nineteen cases of the patients had the history of choking as presenting symptom. Chest X-Ray showed normal imaging on twelve patients. The most common site in tracheobronchial tract where foreign bodies found was the trachea, in eight cases. Conclusions: Foreign body aspirations in tracheobronchial tract were most frequently happened in children less than 15 year-old. The most common foreign bodies were anorganic material, such as toys and plastic objects. Lung X-Rays on the first 24 hours commonly showed normal imaging. Foreign bodies in tracheobronchial tracts most frequently were found in the trachea. Keywords: Aspirations, bronchoscopy, chest X-Ray, foreign body, tracheobronchial tree

Hubungan ambang dengar dengan nilai hearing handicap berdasarkan hearing handicap inventory for the elderly-screening (HHIE-S) Wibowo, Suprapto; Soedarmi, Melania; -, Lukmantya
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.7

Background: Hearing impairment in elderly people will reduce their communication ability andimpact their quality of life.Purpose: To know the correlation between hearing threshold with the resultsof hearing handicap using hearing handicap inventory for the elderly-creening (HHIE-S) on presbycusispatients.Method: A cross sectional study of patient with presbycusis at Saiful Anwar Hospital that metthe research criteria, on period March–April 2010. Results: The distribution of presbycusis patients included in this study was 9 persons (37.5%) without handicap, 10 persons (41.7%) with mild-moderate handicap, and 5 persons (20.8%) with severe handicap. Measurement results from two main variables,hearing threshold and hearing handicap was analyzed with Spearman rank correlation. Calculationresults of coefficient Spearman rank correlation was 0.937 with p value = 0.000. Conclusion: There isa significant correlation between hearing threshold with the results of hearing handicap on presbycusispatients.Key words: presbycusis, hearing threshold, hearing handicap inventory for the elderly-screening. Abstrak : Latar belakang: Gangguan pendengaran yang terjadi pada usia lanjut menyebabkan gangguankomunikasi dan berdampak pada kualitas hidup penderita. Tujuan: Mengetahui adanya hubungan ambangdengar dengan hasil penilaian hearing handicap dengan menggunakan hearing handicap inventory for theelderly-screening (HHIE-S) pada penderita presbikusis.Metode: Sebuahstudi cross sectional. Sampeladalah semua penderita yang didiagnosis presbikusis di poliklinik neurotologi THT RS Dr. Saiful AnwarMalang, dan memenuhi kriteria penelitian dengan teknik consecutive sampling mulai Maret–April 2010.Hasil: Pasien presbikusis yang terlibat dalam penelitian ini terdistribusi sebanyak 9 orang (37,5%) tanpahandicap, 10 orang (41,7%) handicap ringan–sedang, dan 5 orang (20,8%) termasuk handicap berat. Hasilpengukuran dari dua variabel utama, yaitu ambang dengar dan hearing handicap dianalisis menggunakankorelasi Spearman rank. Hasil perhitungan koefisien korelasi Spearman rank adalah 0,937 dengan p-value= 0,000. Kesimpulan: Terdapat hubungan yang signifikan antara ambang dengar dengan hasil penilaianhearing handicap pada penderita presbikusis.Kata kunci: presbikusis, ambang dengar, hearing handicap inventory for the elderly-screening.

Faktor yang berpengaruh terhadap kejadian presbikusis di rumah sakit Dr Kariadi Semarang M, Melinda; M, Muyassaroh; Z, Zulfikar
Oto Rhino Laryngologica Indonesiana Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012
Publisher : PERHATI-KL

Background: Age, hypertension, diabetes mellitus, hypercholesterolemia, and smoking could be expected to affect the incidence of presbycusis. There is no data on risk factors of presbycusis in Dr. Kariadi Hospital Semarang. Purpose: To analyze how age, hypertension, diabetes mellitus. hypercholesterolemia, and smoking affect the incidence of presbycusis in Dr. Kariadi Hospital Semarang. Methods: Analytic case-control study on 90 elderly subjects in Geriatry clinic, Kariadi Hospital Semarang from April to June 2011. Basic data and risk factors were taken from medical records. Otoscopy examination performed followed by audiometry and timpanometry tests. Presbycusis was determined if the timpanogram was type-A and the audiogram symmetric bilateral SNHL. Statistical analysis by Chi square test, OR and logistic regression. Results: Obtained 45 subjects presbycusis (+) and 45 subjects presbycusis (-), most presbycusis subjects were in the age <75 years, which were 29 (32.2%). Age found affected the incidence of presbycusis (p = 0.030, OR = 2.995, CI = 1.090 to 8.233), hypertension found affected the incidence of presbycusis (p = 0.018, OR = 2.813, CI = 1.177 to 6.721). Diabetes mellitus, hypercholesterolemia, and smoking habits found had no effect on the incidence of presbycusis. Conclusion: Age and hypertension alone or combined were found to affect the incidence of presbycusis. Diabetes mellitus, hypercholesterolemia, and smoking were not affecting the incidence of presbycusis. Key words: Presbycusis, risk factors, elderly patients, hypertension. Abstrak : Latar belakang: Faktor risiko usia, hipertensi, diabetes melitus, hiperkolesterol dan kebiasaan merokok diduga dapat berpengaruh terhadap kejadian presbikusis. Belum terdapat data mengenai faktor risiko presbikusis di RSUP Dr.Kariadi, Semarang. Tujuan: menganalisis bagaimana pengaruh faktor usia, hipertensi, diabetes melitus (DM), hiperkolesterol, dan kebiasaan merokok terhadap kejadian presbikusis di RSUP DR. Kariadi Semarang. Metode: Penelitian analitik pada 45 kasus dan 45 kontrol pada subyek usia lanjut di klinik Geritatri RSUP Dr. Kariadi, Semarang pada periode April-Juni 2011. Data dasar dan faktor risiko diambil dari rekam medik. Dilakukan pemeriksaan otoskopi dan audiotimpanometri. Presbikusis bila gambaran timpanogram tipe A dan audiogram kurang pendengaran sensorineural simetris bilateral. Analisis statistik dilakukan dengan Uji Chi square, OR dan regresi logistik. Hasil: Didapatkan 45 subyek presbikusis(+) dan 45 subyek presbikusis(-), usia terbanyak yang menderita presbikusis <75 tahun sebanyak 29 (32,2%). Usia berpengaruh terhadap kejadian presbikusis (p=0,030, OR=2,995, CI=1,090–8,233), hipertensi berpengaruh terhadap kejadian presbikusis (p=0,018, OR=2,813, CI=1,177– 6,721). Diabetes melitus, hiperkolesterol, dan kebiasaan merokok tidak berpengaruh terhadap kejadian presbikusis. Kesimpulan: Usia, hipertensi secara sendiri sendiri atau bersama-sama berpengaruh terhadap kejadian presbikusis. Diabetes mellitus, hiperkolesterol, dan kebiasaan merokok tidak berpengaruh terhadap kejadian presbikusis. Kata kunci : Presbikusis, faktor risiko, usia lanjut, hipertensi.

Hubungan ekspresi RANKL dengan derajat destruksi tulang akibat kolesteatoma pada otitis media supuratif kronik Yarisman, Lilia; Asroel, Harry Agustaf; Aboet, Askaroellah; Zaluchu, Fotarisman
Oto Rhino Laryngologica Indonesiana Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017
Publisher : PERHATI-KL

Latar belakang: Otitis media supuratif kronik (OMSK) dengan kolesteatoma merupakan penyakitpada telinga tengah dengan salah satu komplikasi berupa destruksi tulang, yang dapat menyebabkankematian. Receptor Activator of Nuclear Factor Kβ-Ligand (RANKL) merupakan salah satu sitokinyang berperan dalam proses destruksi tulang.Tujuan: Mengetahui hubungan ekspresi RANKL denganderajat destruksi tulang akibat kolesteatoma pada penderita OMSK tipe bahaya.Metode: Penelitian inibersifat analitik dengan desain cross sectional. Sebanyak 40 sampel kolesteatoma dilakukan pemeriksaanimunohistokimia untuk dinilai ekspresi RANKL pada kolesteatoma.Hasil: Terdapat hubungan yangsignifikan antara ekspresi RANKL dengan derajat destruksi tulang dan komplikasi yang terjadi (p<0,05).Tidak terdapat hubungan antara ekspresi RANKL dengan kelompok umur dan jenis kelamin (p>0,05).Kesimpulan: Terdapat hubungan yang signifikan antara derajat destruksi tulang dengan ekspresi RANKLmelalui pemeriksaan imunohistokimia.Kata kunci: RANKL, destruksi tulang, kolesteatoma, OMSK ABSTRACTBackground: Chronic suppurative otitis media (CSOM) with cholesteatoma is a middle ear disease,leading to bone structure destruction which can cause fatal case. Receptor Activator of Nuclear FactorKβ-Ligand (RANKL) is known as one of the cytokine that has important role in the process of bonedestruction.Purpose: To identify an association between RANKL expression with bone destruction leveldue to cholesteatoma in malignant CSOM patients. Method: This was an analytical study with crosssectional design. About 40 cholesteatoma sample was examinated by using immunohistochemistry tomeasure its RANKL expression. Result: There was a significant relationship (p<0.05) between RANKLexpression with bone destruction level and complication. There was no significant relationship betweenRANKL expression with age and sex (p>0.05). Conclusion: There was a significant relationship betweenbone destruction level with the RANKL expression by immunohistochemistry examination.Keywords: RANKL, bone destruction, cholesteatoma, CSOM

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