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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 505 Documents
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Sinonasal schwannoma in a patient with Eisenmenger syndrome Reza Aditya Digambiro; Ashri Yudhistira; David Tjahyadi; Dewi Hastuty
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.765

Abstract

Background: Sinonasal schwannoma is a rare tumor of the nasal cavity and paranasal sinuses, often presenting with recurrent epistaxis and nasal obstruction. Eisenmenger syndrome is a life-threatening cardiopulmonary condition resulting from uncorrected congenital heart disease. Purpose: To report a rare case of sinonasal schwannoma in a patient with Eisenmenger syndrome, and to explore therapeutic considerations. Case report: A 23-year-old male presented with recurrent nasal bleeding and progressive dyspnea. Imaging revealed a lobulated mass in the right nasal cavity. Histopathological evaluation confirmed sinonasal schwannoma. The patient also had an unrepaired secundum atrial septal defect with Eisenmenger physiology, rendering surgical excision high-risk. Clinical question: In patients with sinonasal schwannoma and Eisenmenger syndrome, when is surgical excision appropriate? Can conservative therapy provide adequate control in high-risk cases? Method: A literature search was conducted on PubMed, Medline, and Google Scholar using relevant keywords. Articles were selected based on the last 10 years of publication and full-text availability. Result: No studies specifically addressed this dual pathology. However, available literature emphasized the need for individualized management, with surgery being curative in healthy patients, and conservative observation preferred in high-risk cardiac cases. Conclusion: While surgical excision remains the “In patients with sinonasal hemangiopericytoma (HPC), conservative management may be justified in patients with Eisenmenger syndrome due to the prohibitive cardiopulmonary risks.
The Peran Inflamasi Pepsin dan IL-8 pada Otitis Media Supuratif Kronis Aktif dengan Refluks Laringofaringeal: Studi Cross-Sectional Danni Mahendra; Pratiwi Dewi; Hadi Sudrajad
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.766

Abstract

Background: Chronic suppurative otitis media (CSOM) is a chronic inflammatory condition of the middle ear, characterized by tympanic membrane perforation and persistent or recurrent ear discharge. The active phase of CSOM refers to a period of ongoing intense inflammation, marked by purulent exudate production, active infection, and heightened immune response. One of the contributing factors in CSOM pathogenesis is laryngopharyngeal reflux (LPR). Studies suggest that refluxed pepsin from LPR can reach the middle ear through the Eustachian tube, triggering local inflammation and exacerbating tissue damage during the active phase. Pepsin plays a role in upregulating pro-inflammatory cytokines, such as interleukin-8 (IL-8), thereby intensifying the inflammatory response and worsening CSOM symptoms in this stage. Purpose: To determine the correlation between pepsin and IL-8 levels in middle ear secretions of patients with active CSOM and LPR. Method: This cross-sectional study involved 32 patients with active CSOM and clinical signs of LPR. Middle ear secretions were analyzed for pepsin and IL-8 concentrations using enzyme-linked immunosorbent assay (ELISA). Pearson correlation was used to assess the relationship. Result: The study population was predominantly aged 36-45 years (28.12%) and female (59.4%). The mean pepsin concentration in middle ear secretions was 71.52±84.64 ng/mL, while the mean IL-8 level was 33.47±17.56 pg/mL. A strong and statistically significant positive correlation was observed between pepsin and IL-8 levels (r = 0.682; p = 0.001). Conclusion: Elevated pepsin levels due to LPR, strongly correlate with increased IL-8 expression, suggesting a reflux-mediated inflammatory mechanism in the pathogenesis of active CSOM.
Squamous cell carcinoma of the external auditory canal with intracranial invasion Trining Dyah; Sutji Pratiwi
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.773

Abstract

Background: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare and aggressive malignancy that may resemble chronic ear disease, causing delayed diagnosis and poor prognosis in advanced stages. Purpose: To report a case of SCC of the EAC with temporal bone and intracranial invasion. Case report: A 64-year-old male with chronic otorrhoea and previous mastoidectomy, presented with retroauricular ulcerative mass. Clinical examination found multiple ulcerative masses in the left retroauricular region. MRI showed temporal bone destruction with intracranial extension, and histopathology confirmed well-differentiated SCC, classified as stage IVA (T4N0M0). The patient underwent radical surgical excision, followed by adjuvant chemotherapy and radiotherapy; however, local recurrence occurred within six months. Clinical question: In advanced SCC of the EAC, how does multimodal therapy affect local control and outcomes? Method: A narrative evidence search was conducted through PubMed, Scopus, and Google Scholar for studies from 2016 to 2026 on SCC of the EAC, temporal bone invasion, intracranial extension, surgery, radiotherapy, chemoradiation, and multimodal therapy. Result: Evidences supported MRI for assessing tumor extension and guiding treatment. T4 disease with intracranial invasion remains associated with poor local control despite multimodal therapy. Conclusion: SCC of the EAC should be suspected in chronic otorrhea, non-healing ear lesions, or persistent symptoms after ear surgery. Early recognition, MRI-based staging, and multidisciplinary treatment are essential, although recurrence risk remains high in advanced T4 disease.
The Auditory brainstem response latencies in children with global developmental delay at Dr. Cipto Mangunkusumo Hospital Muhammad Ade Rahman; Tri Juda Airlangga; Fikry Hamdan Yasin; Rini Sekartini; Achmad Rafli; Ferdi Afian
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.790

Abstract

Background: Global developmental delay (GDD) affects multiple developmental domains and remains a major concern in early childhood. The auditory system plays a key role in language development, and the Auditory Brainstem Response (ABR) test provides an objective measure of auditory pathway maturation. However, data on ABR wave latencies among children with GDD who have normal predicted hearing thresholds are limited. Purpose: To describe absolute and interwave latencies of ABR waves I, III, and V, and to compare latencies of ABR waves across demographic and perinatal clinical characteristics in children with GDD. Method: A cross-sectional analytical study was conducted using medical record data from 70 children aged 6 months to 5 years with GDD at Dr. Cipto Mangunkusumo Hospital between January 2021 and May 2025. All subjects had normal predicted hearing thresholds (≤30dB) in ABR result and passed Distortion Product Otoacoustic Emission (DPOAE) screening. Comparations between risk factors (age, gender, gestational age, birth weight, NICU admission, asphyxia, and hyperbilirubinemia) and ABR latencies were analyzed using t-test or Mann–Whitney test. Result: Most subjects were male (71.4%) with a median age of 25 months. The language domain was most frequently affected (92.9%). Male subjects had a significantly longer absolute latency of wave V in the left ear compared to females (6.10±0.31 ms; p < 0.05). Conclusion: Male gender with normal predicted hearing threshold had significant difference in the left-ear wave V latency compared to female. ABR is a valuable tool for early detection of auditory pathway maturation delay in at-risk children.
A Demographic profile and clinical characteristics of patients with age related hearing loss Dofi Pebriadi; Ashadi Prasetyo; Melysa Fitriana
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.803

Abstract

Background: Age-Related Hearing Loss (ARHL), or presbycusis, is a progressive, bilateral sensorineural hearing loss associated with the aging process. It commonly occurs in individuals over 60 years of age and is often linked to metabolic and cardiovascular disorders. Oxidative stress is a key mechanism contributing to cochlear hair cell damage, thinning of the stria vascularis, and neuronal degeneration. Although ARHL is irreversible, controlling risk factors may help slow its progression. Purpose: To determine the demographic profile, clinical characteristics, and the relationship between comorbidities and types of ARHL in patients at Sardjito Hospital, Yogyakarta. Method: This retrospective descriptive study used secondary data from the Neurotology Clinic, Department of Otorhinolaryngology– Head and Neck Surgery, Sardjito Hospital, collected from January 2022 to December 2024. A total of 120 patients diagnosed with ARHL were collected. Bivariate analysis was performed using the Chi- Square test and Fisher’s Exact Test. Result: Among 120 respondents, most were male (57.5%) and aged 60–74 years (73.3%). The most common chief complaint was hearing loss (72.5%), followed by tinnitus (20.8%) and vertigo (6.7%). Audiogram findings showed that strial presbycusis was the most prevalent type (42.5%), followed by sensory (27.5%), neural (21.7%), and cochlear (8.3%) types. Most patients had moderate hearing loss (49.2%). Cardiovascular comorbidities were present in 51.7% of patients. A significant association was found between cardiovascular comorbidities and ARHL type (p < 0.05). Conclusion: Strial presbycusis was the most common type of ARHL, and had a correlation with cardiovascular comorbidities

Page 51 of 51 | Total Record : 505

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