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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 2 No 2 (2004): JIFI" : 9 Documents clear
Karakterisasi Glukoamilase Hasil Produksi Aspergillus niger BCS dengan Penyangga Fermentasi Sekam dan Dedak Mahyudin A. Rahman; Koesnandar Koesnandar; Gany H.; Ahmad Marasabessy; Ali Rohman; Usman Sumo FT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Glucoamylase, the enzyme which converts starch to dextrins and glucose, is used in the starch-processing industry, especially for the production of glucose crystal and high fructose syrup. The aim of this work was to produce glucoamylase by Aspergillus niger BCS using rice husk as solid substrate support. For this purpose, rice husk added to the mixture was optimized on a fixed weight ratio of cassava starch and rice bran. After that, using optimum rice husk concentration, optimization of the weight ratio of cassava starch and rice bran was carried out. Glucoamylase A. niger produced in this work was characterized by determining its optimum pH and temperature, its stability under various pH and temperature, its kinetic parameters, its hydrolysis products using soluble starch as substrate, and its molecular weights. The optimum conditions for glucoamylase production by A. niger obtained when the weight ratio of cassava starch: rice bran was 1:1 (dry basis, db) and the rice husk concentration in the fermentation medium was 20% by weight (db). Under these optimized conditions, enzyme units as high as 1774 U/g dry fermented substrate was obtained when fermentation was carried out for 5 days at 30°C. Optimum pH of glucoamylase A. niger was 4.5 and its optimum temperature activity was 65°C. This enzyme was stable at pH 3.0 - 7.0 and at a temperature up to 50°C.
The Importance of Protein Binding in Drug Monitoring Aluwi Nirwana Sani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ikatan obat dengan protein dalam darah umumnya tidak mempengaruhi efek terapinya. Selama tidak ada pergeseran ikatan, akibat obat lain yang afinitasnya lebih besar terhadap protein atau perubahan kondisi pasien. Terjadinya pergeseran ikatan yang mengakibatkan peningkatan konsentrasi obat tidak terikat juga akan dikompensasi dengan peningkatan volume distribusi sehingga konsentrasi obat tidak terikat kembali normal. Akan tetapi dalam prosedur monitoring obat yang ditetapkan adalah konsentrasi oba total, sehingga salah interprestasi bisa terjadi.
Efek Kurkumin terhadap Aktivitas Enzim Glutation Peroksidase Mitokondria Hati Tikus Syamsudin Syamsudin; Suyatna FD; Ganiswarna S; Sadikin M
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study was conducted to prove the hypothesis that Curcumin could prevent the oxidative damage of rat liver mitochondria induced by t-butylhydroperoxide (t-BHP). The induction of 400 uMt-BHP reduced Gluthatione Peroxidase (GPx) activity from (0.29+0.03) to (0.04+0.01) umol/min/mg protein. Instillation of Curcumin of 1000 uM could elevate GPx activity to (0.16+0.002) umol/min/mg protein.
Efek Imunostimulan Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urban) terhadap IgG Mencit Jantan Shirly Kumala; Aulia Tisna Dewi; Yun Astuti Nugroho
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The immunostimulating effect of an ethanolic extract of Pegagan herbs to male mice has been determined. Thirty male mice divided into five groups (P1-P5) were induced by 1% sheep red cells for 14 days. P1, P2 and P3 were treated with three doses of an ethanolic extract 4.124 mg/20g BW, 8.25 mg/20g BW and 16.5mg/20gBW respectively. P4 was a positive control using Stimuno 0.55 mg/20g BW, and P5 was a negative control using distilled water Blood samples were taken at day 1, 8 and 15, and the concentration of IgG was measured by Radial Immunodiffusion method. A two way Anova showed no significant difference between P1, P2, and P5, but P3 was higher than P4. The obtained results showed that the ethanolic extract of 16,5 mg has a potent immunostimulating effect.
Pengaruh Penambahan Zat-zat Aditif pada Aktivitas Protease Bacillus megaterium DSM 319 Sumaryanto Sumaryanto; Deden RW; Mahyudin A. Rahman
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Bacillus megaterium DSM 319 is a microbial neutral protease producer, which is usually used for food and non food (especially for dehairing and bating processes) industries. It was shown in this experiment, that the addition of some additive substances such as sodium benzoat, ammonium quarterner, calcium chloride and zeolite tested as a stabilizer of the ability for protease enzyme activities maintain comparing with control the application for the leather process was sign the difference performance. By using varian analysis and Duncan methode analysis at the 4 additif substances above from 0%, 0.5%, 1%, and 2% can be seen that the highest activity of protease reached at 0.862 U with sodium benzoat and the lowest activity at 0.636 U with zeolite.
Pengaruh Suhu dan Lama Pemeraman Buah Mengkudu (Morinda citrifolia L.) terhadap Produksi Sari Buah Pertamawati Kartakusumah; Wahono Sumaryono; Defirst Ramadanty
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The influence of temperature and time on ripening of Noni fruits (Morinda citrifolia L.) for the production of Noni juice was determined using mature, but unripe Noni fruits. The design of this experiment was a split-plot. The ripening times used as the main plot were 1, 2 or 3 months, and the ripening temperatures used as the sub-plot were 30°C, 40°C, and 50°C. The results showed that the difference of Noni juice properties at 50°C as ripening temperature during 1, 2 or 3 month were not significant, as were those at 40°C during 2 and 3 months. The concentration of antraquinon increases with the ripening time of Noni fruits.
Isolasi dan Identifikasi Senyawa Hasil Fermentasi Kapang Endofit Pasak Bumi (Eurycoma longifolia Jack) Ratna Djamil; Titi Parwati; Nani Khomeni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Endophytic fungi of Pasak bumi (Eurycoma longifolia Jack). were inoculated to synthetic medium and incubated for 28 days. The fumated medium then were extracted with chloroform. The antioxidant activities by 1,1-diphenyl 2-picrylhidrazyl (DPPH) methods showed that isolated compound has scavenging effect at IC285.7 ppm. Identification by interpretation of infra red spectra showed that the isolated compound was a terpenoid.
Isolasi, Elusidasi Struktur, dan Uji Bioaktivitas Alkaloid dari Akar Kemuning (Murraya exotica L.) Bustanussalam Bustanussalam; Titi Parwati; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Isolation and structure elucidation of an alkaloid, a bioactive compound from the roots of the Indonesian medicinal plant Kemuning, Murraya exotica (Rutaceae), including the brine shrimp lethality test (BSLT) have been carried out. The bioactivity test using Artemia salina, isolation and purification of the ethyl acetate extract performed by column chromatography gave yellow crystals. Based on ultraviolet, infrared, nuclear magnetic resonance (1H-&13C-NMR) and gas chromatographymass spectra the isolated bioactive compound is an indole alkaloid typical to yuehchukene.
Analisis Kandungan Residu Sulfametazin dalam Daging dan Hati Ayam secara Kromatografi Cair Kinerja Tinggi Zuhelmi Aziz; Yulvian Sari; Raphaela Widiastuti; Lydia Septa Desiyana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sulfamethazine is an antimicrobial and anticoccidiocis which usually used in poultry farm. The using of sulfamethazine to cattle has an accumulated residue effect on cattle products. An experiment of the decreasing motive of sulfamethazine residue concentration in chicken meat and liver has been carried out. One day old broiler chicken classified into 4 groups which are negative control, the positive control, the 7 days (7 days before the slaughtering day which on 36th day), and 5 days group (5 days before the slaughtering day which on 36th day). The last three groups are given sulfamethazine solution in oral 3 times a week with 0.2 ml/kg BW or 50 mg/kg BW dosage. After the giving of sulfamethazine stopped, each of those 4 groups slaughtered on 1st, 2nd, 3rd, 4th, 5th, 7th, 24th, 48th, 120th, 168th, 240th hour and then each of chicken meat and liver extracted and analyzed with high performance liquid chromatography (HPLC). The Sulfamethazine residue decreasing along with the increasing of time can be noticed from the experiment. In common, the decreasing of Sulfamethazine can be seen starting form 24th hour, then at 48th hour the sulfamethazine concentration stay at lower state and decrease along with the increasing of time.

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