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ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013 Hidayati, Nur Rahmi; Abdillah, Syamsudin; A. Keban, Sesilia
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%).

ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013 Nur Rahmi Hidayati; Syamsudin Abdillah; Sesilia A. Keban
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%).

KARAKTERISASI SENYAWA PENGHAMBAT POLIMERISASI HEME DARI BATANG BROTOWALI (Tinospora crispa (L.)) (Characterization of Inhibitor Compounds in Heme Polymerization from Brotowali Stem (Tinospora crispa (L.)) Lilik Sulastri; . Syamsudin; Partomuan Simanjuntak
Biopropal Industri Vol 9, No 2 (2018)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

Currently, obstacle in malaria treatment is the emergence of resistance to antimalarials. Brotowali (Tinospora crispa (L.)) is one of the medicinal plant which efficacious as antimalarials. This study aimed to obtain information on the structure prediction of chemical compounds that potential as antimalarials from F.EtOH.4 brotowali stems with heme polymerization inhibition mechanism using Huy method. F.EtOH.4 was fractionated using column chromatography with silica gel 60 as a stationary phase and dichloromethane-methanol eluent. F.EtOH.4.2.1.a has the highest heme polymerization inhibitory activity and chemical structure identification with UV spectroscopy, FTIR and LCMS. The IC50 value of F.EtOH.4.2.1.a was 253.46 ppm and IC50 from chloroquine sulfate was 178.74 ppm as a positive control. Identification of F.EtOH.4.2.1.a isolates based on MS spectrum was the possibility of borapetoside D compounds with molecular formula C33H46O16 and molecular weight of 698. FTIR spectrum results indicated aromatic and alcohol groups and UV spectrum results indicated chromophore groups.Keywords: borapetoside D, heme polymerization, malaria, Tinospora crispa (L.) ABSTRAKMalaria adalah penyakit yang disebabkan oleh parasit Plasmodium falcifarum dan ditularkan oleh nyamuk Anopheles betina. Saat ini, kendala yang dihadapi dalam pengobatan malaria adalah timbulnya resistensi terhadap antimalaria sehingga mendorong penelitian untuk mencari antimalaria baru. Salah satu tanaman obat yang berkhasiat sebagai antimalaria adalah brotowali (Tinospora crispa (L.)) dengan kandungan alkaloid, glikosida pikroretosid, pikroretin, berberin, palmatin dan kolumbin. Penelitian sebelumnya menunjukkan bahwa ekstrak etanol 70% dan F.EtOH.4 batang brotowali memiliki aktivitas penghambatan ß-hematin tertinggi dengan metode Basilico. Penelitian ini bertujuan untuk memperoleh informasi prediksi struktur senyawa kimia yang berpotensi sebagai antimalaria dari F.EtOH.4 batang brotowali dengan mekanisme penghambatan polimerisasi heme menggunakan metode Huy. F.EtOH.4 difraksinasi menggunakan kolom kromatografi dengan fasa diam silika gel 60 dan eluen diklorometana-metanol. Hasil fraksinasi F.EtOH.4.2, F.EtOH.4.2.1 dan F.EtOH.4.2.1.a masing-masing dilakukan pengujian aktivitas penghambatan pelimerisasi heme. F.EtOH.4.2.1.a adalah fraksi yang mempunyai aktivitas penghambatan polimerisasi heme tertinggi dan dilakukan identifikasi struktur kimia dengan Spektroskopi UV, FTIR dan LCMS. Nilai IC50 dari F.EtOH.4.2.1.a sebesar 253,46 ppm dan IC50 dari klorokuin sulfat sebesar 178,74 ppm sebagai kontrol positif. Identifikasi isolat F.EtOH.4.2.1.a berdasarkan spektrum MS adalah kemungkinan senyawa borapetoside D dengan rumus molekul C33H46O16 dan bobot molekul 698. Hasil spektrum FTIR menunjukkan adanya gugus aromatik dan alkohol dan hasil spektrum UV menunjukkan adanya gugus kromofor.Kata kunci: borapetoside D, malaria, polimerisasi heme, Tinospora crispa (L.)

Efek Antioksidan dari Ekstrak Biji Petai Cina (Leucaena leucocephala L.) pada Tikus Putih Fatty Nurhasanah; Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The study deals with the examination of the antioxidative effect of a Leucana leucocephala L. seed extract on diabetic rats induces with streptozotosin. The rats were divided in to 6 groups, each consisting of 5 rats i.e. group 1: normal, group 2: control (chlorpropamide), group 4: low dose of Laucaena seed extract 0,5/kg BW and group 6: high dose of Laucaena seed extract 1 g/kg BW. The malon dialdehyde (MDA) and superoxid dismutase (SOD) contents were analyzed by ANOVA and continued with the ttest. The result obtained shows that an increase of SOD could be observed by a Laucaena seed extract of resp 0.25;0.5 and 1 g/kg BW.

Beberapa Kelainan Genetik yang Bersifat Protektif terhadap Infeksi Malaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Resistance to malarial infection is dependent on the development of an immune response by the host and to a varying extend, a certain innate characteristics possessing protective value against infection. Innate resistance is not always absolute and genetically determined factors, but instead can act to reduce the severity of infection and improve survive. Mechanism of action resistance to malarial infection will be discussed in this article.

Kemotaksonomi dan Farmakologi Tumbuhan Keluarga Guttiferae Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The Guttiferae family has many species with interesting phytochemical properties. Is has been widely used in the traditional medicine and contains xanthones as constituent, exhibiting biological and pharmacological activities for example, e. g. as antimalaria, antimicrobe, antioxidant, anticancer and HIV-1 protease inhibitor.

Penapisan Senyawa Antimalaria yang Berasal dari Tumbuhan SYAMSUDIN SYAMSUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Efforts to discover and develop new antimalarial drugs have increased dramatically in recent years mainly because of the parasites’ resistance to existing antimalarial drugs. Selection of drug candidates for clinical trials in man and the design of clinical protocols are based upon consideration of data from a battery of preclinical test systems. All compounds are assessed initially in one or more primary models. A compound which is considered active by well established criteria in primary screening test is considered for further evaluation in successively more rigorous clinical test. At the end of each stage of testing, a decision is taken to advance the compound to the next stage or to discontinue it. Primary screening tests should have optimal sensitivity, a high degree of reproducibility, high throughput, should require a minimum quantity of test compound and bear low cost. As there is growing need for newer and more efficacious antimalarial drugs escpecially in tropical countries, more sensitive and economical screening models are needed. This review is an update of various conventional and latest in vitro and in vivo screening methods being used for evaluation of antimalarial compounds.

Efek Kurkumin terhadap Aktivitas Enzim Glutation Peroksidase Mitokondria Hati Tikus Syamsudin Syamsudin; Suyatna FD; Ganiswarna S; Sadikin M
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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This study was conducted to prove the hypothesis that Curcumin could prevent the oxidative damage of rat liver mitochondria induced by t-butylhydroperoxide (t-BHP). The induction of 400 uMt-BHP reduced Gluthatione Peroxidase (GPx) activity from (0.29+0.03) to (0.04+0.01) umol/min/mg protein. Instillation of Curcumin of 1000 uM could elevate GPx activity to (0.16+0.002) umol/min/mg protein.

Karakterisasi Nanopartikel dan Uji Antiagregasi Platelet Secara In-Vitro terhadap Ekstrak Rumput Laut Coklat (Sargassum polycystum) Hasil Hidrolisis Enzim Sellulase Kartiningsih Kartiningsih; Syamsudin Abdillah; Partomuan Simanjuntak; Cyntia Cyntia; Haryo Haryo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Brown seaweed contains fucoidan, a large molecular weight sulfate polysaccharide (about 100,000 Da) which has platelet antiagregation activity. This activity is achieved if the fucoidan has a small molecular weight (3900-7600 Da) so this activity can increase by hydrolized with sellulase Enzym. The purpose of this study was to obtain extract nanoparticles that meet physical quality requirements and have a higher platelet antiagregation activity than brown seaweed extract both before and after hydrolysis. Extraction was using kinetic maseration method using 80% ethanol after that using 2% calcium chloride solution. The results were dried and hydrolyzed with cellulase enzyme and nanoparticles were made by ionic gelation method. Nanoparticle characterization results in particle size of 552.8, polydispersity index of 0.569, potential zeta of +53.5 mV, and spherical shape. In-vitro testing results for platelet antiagregation activity showed the percentage of platelet aggregation inhibition of brown seaweed extract with a concentration 500µg / mL is 22.19% and extracts after hydrolysis was 57.94% and nanoparticles extract after hydrolysis was 72.93%. Extract nanoparticles meet physical quality requirements and extracted nanoparticles after hydrolysis have the highest platelet antiagregation activity compared to brown seaweed extract both before and after hydrolysis.

Ekstrak Propolis sebagai Imunomodulator Irma L. M.; Syamsudin Syamsudin; I. W.T. Wibawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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A study was done to evaluate the effect of propolis on phagocytic activity and capacity of cells phagocyts with induction SGB (Streptococcus Grup B). In vivo methods were used on the study. In vivo study treatments were divided in four groups. Each group was inducted by 109 cell/ml of SGB. The group consists of treatment by given propolis at dosage 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, and group control, not given propolis. The result showed activity dosage value of propolis were significantly different (p<0.01) at dosage 50 mg/kgBW and capacity dosage value of propolis were significantly different (p<0.01) at dosage 100 mg/kgBW.

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